Publications
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Publications and Patents
Publications and Patents
After joining the Indian Institute of Technology Delhi, India
69. Tripathi, K.; Khan, J.; Ali, W.; Shareef, S.; Hazra, C. K.* Divergent Synthesis of Oxindole Derivatives via Cascade deoxygenative Friedel-Crafts Cyclization of α-Ketoamides. Manuscript is under review.
68. Parvez, A.; Mahato, R.; Tejveer; A.; Hamrah, A.; Hazra, C. K.* Singh, M.* Solution processable organic-inorganic hybrid POSS-MFPy as a blue emitter in OLEDs. Manuscript is under review.
67. Rakheja, R.; Maity, S.; Sharma, P.; Hazra, C. K.* B(C6F5)3-Catalyzed Cross-Dehydrogenative Coupling of Arenes with Tetrahydroisoquinolines. Manuscript is under revision.
66. Sharma, P.; Pasricha, S.;†Singh, S.;† Dey, M.; Hazra, C. K.* ''Solvent-Switchable Regiodivergent Chlorination of Quinone Monoacetals: A Practical Route to 2-and 3-Chlorophenols.'' Adv. Synth. Catal. 2025; accepted; doi: 10.1002/adsc.70234. [†equally contributed]
65. Vishwakarma, R.; Singh, S.; Vodnala, N.; Singh, S.; Hazra, C. K.* ''Organocatalytic Reductive Amination of Aldehydes with 2-Propanol: Efficient Access to N-Alkylated Amines.'' J. Org. Chem. 2025, 90, 10392−10401.
64. Yadav, N.†; Mahato, R.†; Pal, S.†; Dey, M.; Hazra, C. K.* ''One-Pot Regioselective Functionalization of Quinone Imine Ketals: Direct Access to ortho-Substituted Anilines from Arylamines''. Org. Lett. 2025, 27, 6566. [†equally contributed]
63. Mahato, R.; Samanta, R.; Musib, D.; Hazra, C. K.* ''Acid-Catalyzed Solvent-Switchable Chemoselective N-Alkylation and para C-Alkylation of Unprotected Arylamines Utilizing ortho Quinone Methides.'' J. Org. Chem. 2025, 90, 7221.
62. Review on ''Quinone Monoacetals: Building Blocks for Regioselective Synthesis of Complex Aromatics''. Sharma, P.; Pasricha, S.; Hazra, C. K.* Prayogik Rasayan, 2025, 09, 20.
61. Saha, T. N.; Mondal, B.; Mahato, R.; Naskar, R.; Hazra, C. K.; Maity, R.* ''Cyclometalated IrIII Complex Possessing Chiral MIC ligand: Regiospecific sp3 C−H Activation and Asymmetric Transfer Hydrogenation of Ketone.'' Chem. Eur. J. 2025, 31, e202403516.
60. Review: K. Kant, C. K. Patel, R. Reetu, Y. A. Teli, P. Naik, S. Some, C. K. Hazra, N. Aljaar, A. K. Atta, C. Malakar,* ''Comprehensive Strategies for the Synthesis of 1, 3-Enyne Derivatives.'' Synthesis 2025, 57, 39-70.
59. P. Sharma, R. Vishwakarma,† R. Rakheja,† S. Pasricha,* C. K. Hazra,* ''A Regioselective, One-Pot, Transition-Metal-Free α-Alkylation of Quinone Monoacetals for Various Organic Transformations.'' Org. Lett. 2024, 26, 9682. [†equally contributed]
58. R. Vishwakarma, P. Sharma, C. K. Hazra,* ''Lewis Acid‐Promoted C− H Chalcogenation of Arenes and Heteroarenes.'' Eur. J. Org. Chem. 2024. 27, e202400894.
57. A. Tyagi, H. Gautam,† K. Tripathi,† C. K. Hazra,* ''Nondirected Ortho C–H Arylation for One-Pot Synthesis of Biaryl Scaffolds via In Situ Generated Mixed Acetal.'' J. Org. Chem. 2024, 90, 124. [†equally contributed]
56. J. Khan, R. Mahato, Kanhaiya, C. K. Hazra,* ''Silane‐Mediated Alkylation of Arenes via Reductive Friedel‐Crafts Reaction Using Carbonyl Compounds.'' Asian J. Org. Chem. 2024, 13, e202400347.
55. N. Yadav, J. Khan, C. K. Hazra,* ''Catalytic Deoxygenative Transformation of Ketoacids/Esters for the Synthesis of Coumarin, Benzofuranone, and Dihydrobenzo[b]oxepin‐2(3H)‐one Derivatives.'' Adv. Synth. Catal. 2024, 366, 4178.
54. J. Khan, N. Taneja,† N. Yadav,† C. K. Hazra,* ''Silane-mediated, facile C–H and N–H methylation using formaldehyde.'' Chem. Commun. 2024, 60, 11367. [†equally contributed]
53. J. Khan,† A. Tyagi,† R. Samanta, C. K. Hazra,* ''Chemoselective deoxygenative α-arylation of carboxylic acids, amides, and esters: synthesis of anesthetic and anti-inflammatory compounds.'' Chem. Commun. 2024. 60, 10688. [†equally contributed]
52. J. Khan, A. Tyagi, C. K. Hazra,* ''Silylium Ion-Catalyzed α-Arylation of Carboxylic Acids, Amides, and Esters: Efficient Synthesis of Anesthetic and Anti-inflammatory Drugs.'' ChemRxiv, 2024, doi: 10.26434/chemrxiv-2024-wmmr7.
51. N. Yadav, R. Mahato, J. Khan, H. Jaiswal, C. K. Hazra,* ''Synthesis of tetralone and indanone derivatives via cascade reductive Friedel–Crafts alkylation/cyclization of keto acids/esters.'' Chem. Commun. 2024, 60, 9274.
50. S. Singh, P. Sharma,† S. Dutta,†R. Vishwakarma, C. K. Hazra,* ''An organocatalytic domino annulation approach via C (sp2)–OMe cleavage to unlock the synthesis of pyranochromenones enabled by HFIP.'' Chem. Commun. 2024, 60, 7200. [†equally contributed]
49. J. Khan, N. Taneja, N. Yadav, C. K. Hazra,* ''Silane-mediated, Facile and Selective C (sp²)− H and N− Methylation using Formaldehyde.'' ChemRxiv, 2024, doi:10.26434/chemrxiv-2024-t97z6.
48. R. Mahato, N. Yadav, C. K. Hazra,* ''Synthesis of Azepinoindoles and Oxepinoindoles through Brønsted-Acid-Catalyzed Cyclization of an In Situ Generated Dihydrospiroquinoline Intermediate.'' Org. Lett. 2024, 26, 3911.
47. R. Vishwakarma,† N. Vodnala,† D. Musib, S. Singh, C. K. Hazra,* ''Lewis Acid-Promoted Domino Processes for the Synthesis of Homoallylic Amines, Quinolines and Tetrahydroquinolines.'' Adv. Synth. Catal. 2024, 366, 3010. [†equally contributed]
46. A. Tyagi, C. K. Hazra,* ''Direct access to hydrazides and amides from carboxylic acids via acyloxyphosphonium ion.'' Org. Chem. Front. 2024, 11, 1450.
45. S. Singh, A. Kumar, L. Nebhani,* C. K. Hazra,* ''Sustainable sulfonic acid functionalized tubular shape mesoporous silica as a heterogeneous catalyst for selective unsymmetrical Friedel–Crafts alkylation in one pot.'' JACS Au, 2023, 3, 3400.
44. Review: S. Singh, C. K. Hazra,* ''Recent advancements in typical friedel–crafts alkylation reactions focused on targeting arene nucleophiles.'' Synthesis 2023, 56, 368.
43. P. Sharma, S. Singh, C. K. Hazra,* ''Brønsted Acid-Mediated Multicomponent One-Pot Approach to Direct Construction of 4-Aryl-hydrocoumarin Derivatives.'' J. Org. Chem. 2023, 88, 16104.
42. N. Taneja,† P. Sharma,† N. Yadav, D. Musib, C. K. Hazra,* ''Nondirected, Site-Selective Arylation of Quinone Imine Ketals Derived from Arylamines: One-Pot Access to meta-Substituted Anilines.'' Org. Lett. 2023, 25, 6029. [†equally contributed].
41. A. Tyagi, N. Taneja, J. Khan, C. K. Hazra,* ''I2‐Catalyzed/Mediated C−S and C−I Bond Formation: Solvent‐ and Metal‐Free Approach for the Synthesis of β‐Keto Sulfones and Branched Sulfones.'' Adv. Synth. Catal. 2023, 365, 1247.
40. N. Yadav,† N. Taneja,† D. Musib, C. K. Hazra,* ''Practical Access to meta‐Substituted Anilines by Amination of Quinone Imine Ketals Derived from Anisidines: Efficient Synthesis of Anti‐Psychotic Drugs.'' Angew. Chem. Int. Ed. 2023, 62, e202301166. [†equally contributed].
39. R. Mahato, C. K. Hazra,* ''Pentafluorophenol (C6F5OH) Catalyzed Pictet‐Spengler Reaction: A Facile and Metal‐Free Approach Towards Tetrahydro‐β‐Carbolines.'' Chem. -Eur. J. 2023, e202203924.
38. J. Khan, A. Tyagi, D. Ghosh,* C. K. Hazra,* ''HFIP-assisted reductive C–S, C–N, and C–X coupling of carbonyl compounds: a combined computational and experimental mechanistic study.'' Org. Chem. Front. 2023, 10, 1275.
37. S. Singh, S. Mondal, N. Vodnala, C. K. Hazra,* ''Hydrogen bonding network-enabled Brønsted acid-catalyzed Friedel–Crafts reactions: a green approach to access unsymmetrical diaryl-and triarylmethanes.'' Green Chemistry 2023, 25, 1014.
36. S. Singh, S. Mondal,† V. Tiwari,† T. Karmakar,* C. K. Hazra,* ''Cooperative Friedel–Crafts Alkylation of Electron‐Deficient Arenes via Catalyst Activation with Hexafluoroisopropanol.'' Chem. -Eur. J. 2023, 29, e202300180. [†equally contributed].
35. R. Mahato, J. Khan, A. Tyagi, C. K. Hazra,* ''Lewis Acid Promoted Homodimerization of Styrene Diols: An Efficient Approach toward 2-Phenylnaphthalenes.'' Synlett 2022, 33, A-F.
34. P. Sharma, N. Taneja, S. Singh, C. K. Hazra,* ''Brønsted‐Acid‐Catalyzed One‐Pot Synthesis of β, β‐Diaryl Esters: Direct Regioselective Approach to Diverse Arrays of 3‐Aryl‐1‐indanone Cores.'' Chem. -Eur. J. 2022, 29, e202202956.
33. N. Yadav, A. Tyagi,† J. Khan,† C. K. Hazra,* ''Brookhart's Acid‐Catalyzed Switchable Regioselective N‐Alkylation of Arylamines/Heterocyclic Amines with Cyclopropylcarbinols by Temperature Regulation.'' Chem. Eur. J. 2022, 28, e2022019. [†equal contribution]
32. S. Singh, S. Mondal, V. Tiwari, N. Vodnala, T. Karmakar,* C. K. Hazra,* ''Tandem Cooperative Friedel-Crafts Reaction of Aldehydes with Electron Deficient Arenes Through Catalyst-Activation via Hydrogen Bonding Network.'' ChemRxiv, July, 2022, doi: 10.26434/chemrxiv-2022-w56tj-v2.
31. J. Khan, N. Yadav, A. Tyagi, C. K. Hazra,* ''Silyl Cation-Initiated, Brønsted Acid-Catalyzed Strategy toward Unsymmetrical 3, 3-Disubstituted 2-Oxindoles and Azonazine Cores.'' J. Org. Chem. 2022, 87, 11097.
30. A. Tyagi, J. Khan,† N. Yadav,† R. Mahato, C. K. Hazra,* ''Catalyst-Switchable Divergent Synthesis of Bis (indolyl) alkanes and 3-Alkylated Indoles from Styrene Oxides.'' J. Org. Chem. 2022, 87, 10229. [†equally contributed]
29. N. Vodnala,† S. Singh,† C. K. Hazra,* ''Lewis Acid-Promoted Typical Friedel–Crafts Reactions Using DMSO as a Carbon Source.'' J. Org. Chem. 2022, 87, 10044. [†equally contributed]
28. N. Yadav, J. Khan, A. Tyagi, S. Singh, C. K. Hazra,* ''Rapid Access to Arylated and Allylated Cyclopropanes via Brønsted Acid-Catalyzed Dehydrative Coupling of Cyclopropylcarbinols.'' J. Org. Chem. 2022, 87, 6886.
27. A. Tyagi, N. Yadav, J. Khan, S. Mondal, C. K. Hazra,* ''Brønsted Acid‐Catalysed Epoxide Ring‐Opening Using Amine Nucleophiles: A Facile Access to β‐Amino Alcohols.'' Chem. Asian J. 2022, 17, e202200379.
26. S. Singh, R. Mahato, P. Sharma, N. Yadav, N. Vodnala, C. K. Hazra,* ''Development of Transition‐Metal‐Free Lewis Acid‐Initiated Double Arylation of Aldehyde: A Facile Approach Towards the Total Synthesis of Anti‐Breast‐Cancer Agent.'' Chem. -Eur. J. 2022, 28, e2021045.
25. J. Khan, A. Tyagi, N. Yadav, R. Mahato, C. K. Hazra,* ''Lambert salt-initiated development of Friedel–Crafts reaction on isatin to access distinct derivatives of oxindoles.'' J. Org. Chem. 2021, 86, 17833.
24. A. Tyagi, N. Yadav,† J. Khan,† S. Singh, C. K. Hazra,* ''Transition‐Metal‐Free C− H Silylation: An Emerging Strategy.'' Asian J. Org. Chem. 2021, 10, 334. [†equally contributed]
23. R. Gujjarappa, N. Vodnala, A. Garg, C. K. Hazra, S. Gupta, C. C. Malakar, ''Amino‐Acid‐Mediated Aerobic Oxidation of Organoborons for the Synthesis of Phenolic Derivatives Using Single Electron Transfer.'' ChemistrySelect 2020, 5, 2419.
22. J. Jeong, H. Kim, C. K. Hazra, S. Chang, M.-H. Baik, ''Metal‐Free Carbocyclization of Homoallylic Silyl Ethers Leading to Cyclopropanes and Cyclobutanes.'' J. Org. Chem. 2019, 84, 1106.
21. J. Zhang,† C. K. Hazra,† S. Park, S. Chang, ''Metal‐Free Carbocyclization of Homoallylic Silyl Ethers Leading to Cyclopropanes and Cyclobutanes.'' Asian J. Org. Chem. 2019, 8, 1637. [†equally contributed]
Before joining the Indian Institute of Technology Delhi, India
20. D. Kaldhi, N. Vodnala, R. Gujjarappa, S Nayak, V. Ravichandiran, D. Gupta, C. K. Hazra*, C. C. Malakar*, ''Organocatalytic oxidative synthesis of C2-functionalized benzoxazoles, naphthoxazoles, benzothiazoles and benzimidazoles'', Tetrahedron Lett. 2019, 60, 223.
19. N. Vodnala, R. Gujjarappa, C. K. Hazra, D. Kaldhi, A. K. Kabi, U. Beifuss, C. C. Malakar, ''Copper‐Catalyzed Site‐Selective Oxidative C−C Bond Cleavage of Simple Ketones for the Synthesis of Anilides and Paracetamol'', Adv. Synth. & Catal. 2019, 361, 135.
18. R. Gujjarappa, S. K. Maity, C. K. Hazra, N.Vodnala, S. Dhiman, A. Kumar, U. Beifuss, C. C. Malakar, ''Divergent Synthesis of Quinazolines Using Organocatalytic Domino Strategies under Aerobic Conditions'', Eur. J. Org. Chem. 2018, 2018, 4628.
17. D. Singh, C. K. Hazra, C. C. Malakar, S. K. Pandey, B. S. Kaitha, V. Singh, ''Indium‐Mediated Domino Allylation‐Lactonisation Approach: Diastereoselective Synthesis of β‐Carboline C‐3 Tethered α‐Methylene γ‐Butyrolactones'', ChemistrySelect 2018, 3, 4859.
16. C. K. Hazra, J. Jeong, H. Kim, M. -H. Baik, S. Park, S. Chang, ''Reductive Carbocyclization of Homoallylic Alcohols to syn‐ Cyclobutanes by a Boron‐Catalyzed Dual Ring‐Closing Pathway'', Angew. Chem. Int. Ed. 2018, 57, 2692.
15. C. K. Hazra, N. Gandhamsetty, S. Park, S. Chang, ''Borane catalyzed ring opening and closing cascades of furans leading to silicon functionalized synthetic intermediates'', Nat. Comm. 2016, 7, 13431. [Highlighted in SYNFORM 2017]
14. Q. Dherbassy, G. Schwertz, M. Chessé, C. K. Hazra, J. Wencel-Delord, F. Colobert, ''1, 1, 1, 3, 3, 3‐Hexafluoroisopropanol as a Remarkable Medium for Atroposelective Sulfoxide‐Directed Fujiwara–Moritani Reaction with Acrylates and Styrenes'', Chem. Eur. J. 2016, 22, 1735.
13. Q. Dherbassy, G. Schwertz, C. K. Hazra, T. Wesch, J. Wencel-Delord, F. Colobert, ''Enantiopure Sulfoxides: Efficient Chiral Directing Group for Stereoselective C‒H Bond Activation: Towards the Control of Axial Chirality'', J. Phosphorus Sulfur 2015, 190, 1339.
12. C. K. Hazra, Q. Dherbassy, J. Wencel-Delord, F. Colobert, ''Synthesis of Axially Chiral Biaryls through Sulfoxide‐Directed Asymmetric Mild C H Activation and Dynamic Kinetic Resolution'', Angew. Chem. Int. Ed. 2014, 53, 13871. [Highlighted in SYNFACTS 2015, 11 (1), 65]
11. C. K. Hazra, C. Fopp, M. Oestreich, ''Copper (I)‐Catalyzed Regioselective Addition of Nucleophilic Silicon Across Terminal and Internal Carbon–Carbon Triple Bonds'', Chem. Asian. J. 2014, 9, 3005.
10. C. K. Hazra, E. Irran, M. Oestreich, ''Regio‐and Diastereoselective Copper (I)‐Catalyzed Allylic Substitution of δ‐Hydroxy Allylic Chlorides by a Silicon Nucleophile'', Eur. J. Org. Chem. 2013, 4903.
9. P. Shanbhag, V. Mane, C. K. Hazra, I. N. N. Namboothiri, ''Diastereoselective Synthesis of Substituted Decalins from Rauhut—Currier Adducts of Conjugated Nitroalkenes”, J. Ind. Chem. Soc. 2013, 90, 1713.
8. C. K. Hazra, M. Oestreich, ''Copper (I)-Catalyzed Regio-and Chemoselective Single and Double Addition of Nucleophilic Silicon to Propargylic Chlorides and Phosphates'', Org. Lett. 2012, 14, 4010. [Highlighted in SYNFACTS 2012, 1239]
7. D. J. Vyas, C. K. Hazra, M. Oestreich, ''Copper (I)-Catalyzed Regioselective Propargylic Substitution Involving Si–B Bond Activation'', Org. Lett. 2011, 13, 4462.
Patents
6. C. K. Hazra, J. Khan, N. Yadav, ''PRACTICAL, SCALABLE, AND TRANSITION METAL-FREE REDUCTIVE FRIEDEL-CRAFTS REACTION: EFFICIENT SYNTHESIS OF ANAESTHETIC DRUGS'', Controller General of Patents, Designs & Trade Marks, Intellectual Property of India, filed, July 28, 2023, File No. 202311051075.
5. C. K. Hazra, S. Singh, S. Mondal, N. Vodnala, Filed. ''GREEN CHEMISTRY METHOD FOR ONE-POT SYNTHESIS OF BIOLOGICALLY ACTIVE 1,1-DI-, TRI-, AND TETRA-SUBSTITUTED ALKANES", Controller General of Patents, Designs & Trade Marks, Intellectual Property of India, filed June 02, 2022, File No. 202211031721.
4. C. K. Hazra, M. Singh, R, Mahato, P. Akhtar, Filed. ''Synthesis of New Organic-Inorganic Hybrid Materials as Light-Emitting Lumophores, and Designing OLED Devices Using the Same'', Controller General of Patents, Designs & Trade Marks, Intellectual Property of India, filed April 9, 2022, File No. 202211021313.
3. S. Chang, C. K. Hazra, N. Gandhamsetty ''Method for preparing silane derivatives from furan derivatives in presence of borane catalyst'', US Patent App. 16/304,662, 2020. Publication date: May, 26, 2020. https://patents.google.com/patent/US10662206B2/en
Book Chapters
2. S. Singh, C. K. Hazra*, ''Outer-Sphere C-H Bond Activation'', Wiley-VCH, 2022 (Handbook of CH-Functionalization; Invited book Chapter). https://onlinelibrary.wiley.com/doi/full/10.1002/9783527834242.chf0199
1. R. Mahato, Pragya, C. K. Hazra*, ''Inner-Sphere C-H Bond Activation'', Wiley-VCH, 2022 (Handbook of C-H-Functionalization; Invited book Chapter). https://onlinelibrary.wiley.com/doi/full/10.1002/9783527834242.chf0200
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