Publications and Patents
Publications
After joining the Indian Institute of Technology Delhi, India
58. J. Khan, R. Mahato, Kanhaiya, C. K. Hazra,* ''One-Pot Synthesis of 1,1-Unsymmetrical di-aryl Alkanes and α-Aryl Oxindoles via Reductive Friedel−Crafts Alkylation of Arenes.'' The manuscript is under review.
57. A. Tyagi, H. Gautam, K. Tripathi, C. K. Hazra,* ''Non-directed Ortho C–H Functionalization for One-Pot Synthesis of Biaryl Scaffolds via In-Situ Generated Mixed Acetal.'' The manuscript is under review.
56. N. Yadav, J. Khan, C. K. Hazra,* ''Catalytic Deoxygenative Transformation of Ketoacids/Esters for the Synthesis of Coumarin, Benzofuranone, and Dihydrobenzo[b]oxepin-2(3H)-one Derivatives.'' The manuscript is under review.
55. J. Khan, N. Taneja, N. Yadav, C. K. Hazra,* ''Silane-mediated, Facile C−H and N−H Methylation using Formaldehyde.'' The manuscript is under review.
54. J. Khan, A. Tyagi, C. K. Hazra,* ''Silylium Ion-Catalyzed α-Arylation of Carboxylic Acids, Amides, and Esters: Efficient Synthesis of Anesthetic and Anti-inflammatory Compounds.'' The manuscript is under review.
53. Review: K. Kant, C. K. Patel, R. Reetu, Y. A. Teli, P. Naik, S. Some, C. K. Hazra, N. Aljaar, A. K. Atta, C. Malakar,* ''Comprehensive Strategies on the Synthesis of Ene-Yne Derivatives.'' Synthesis 2024, doi: 10.1055/a-2317-7262.
52. J. Khan, A. Tyagi, C. K. Hazra,* ''Chemoselective Deoxygenating α-Arylation of Carboxylic Acids, Amides, and Esters: Efficient Synthesis of Anesthetic and Anti-inflammatory Compounds.'' ChemRxiv, 2024, doi: 10.26434/chemrxiv-2024-wmmr7.
51. N. Yadav, R. Mahato, H. Jaiswal, C. K. Hazra,* ''Synthesis of Tetralones and Indanones Derivatives via Cascade Reductive Friedel−Crafts Alkylation/Cyclization of Keto Acids/Esters.'' The manuscript is under review.
50. S. Singh, P. Sharma,† S. Dutta,†R. Vishwakarma, C. K. Hazra,* ''Organocatalytic Domino Annulation Approach via C(sp2)-OMe Cleavage to Unlock the Synthesis of Pyranochromenones Enabled by HFIP.'' Chem. Commun. 2024, 60, 7200. [†equally contributed]
49. J. Khan, N. Taneja,† N. Yadav,† C. K. Hazra,* ''Silane-mediated, Facile and Selective C(sp²)−H and N−Methylation using Formaldehyde.'' ChemRxiv, 2024, doi:10.26434/chemrxiv-2024-t97z6.
48. R. Mahato, N. Yadav, C. K. Hazra,* ''A Facile Synthesis of Azepinoindoles and Oxepinoindoles through Brønsted-Acid Catalyzed Cyclization of in-Situ Generated Dihydrospiro Quinoline Intermediate.'' Org. Lett. 2024, doi: 10.1021/acs.orglett.4c01091.
47. R. Vishwakarma,† N. Vodnala,† D. Musib, S. Singh, C. K. Hazra,* ''A Tandem Versatile Method to Synthesize Homoallylic amines, Quinolines and Tetrahydroquinolines via One-pot Multi-Component Strategy under Oxidant-Free Conditions.'' Adv. Synth. Catal. 2024, doi:10.1002/adsc.202301405. [†equally contributed]
46. A. Tyagi, C. K. Hazra,* ''Direct Access to Hydrazides and Amides from Carboxylic Acids via Acyloxyphosphonium ion.'' Org. Chem. Front. 2024, 11, 1450–1455.
45. S. Singh, A. Kumar, L. Nebhani,* C. K. Hazra,* ''Sustainable Sulfonic Acid Functionalized Tubular Shape Mesoporous Silica as a Heterogeneous Catalyst for Selective Unsymmetrical Friedel–Crafts Alkylation in One Pot.'' JACS Au, 2023, 3, 3400–3411.
44. Review: S. Singh, C. K. Hazra,* ''Recent Advancements in Typical Friedel–Crafts Alkylation Reactions Focused on Targeting Arene Nucleophiles.'' Synthesis 2023, doi: 10.1055/s-0042-1751492.
43. P. Sharma, S. Singh, C. K. Hazra,* ''Brønsted Acid-Mediated Multicomponent One-Pot Approach to Direct Construction of 4-Aryl-hydrocoumarin Derivatives.'' J. Org. Chem. 2023, 88, 16104–16115.
42. N. Taneja,† P. Sharma,† N. Yadav, D. Musib, C. K. Hazra,* ''Non-directed, site-Selective C–H Arylation of Arylamines: A Practical Access to meta-Substituted Anilines.'' Org. Lett. 2023, 25, 6029–6034. [†equally contributed].
41. A. Tyagi, N. Taneja, J. Khan, C. K. Hazra,* ''I2‐Catalyzed/Mediated C−S and C−I Bond Formation: Solvent‐ and Metal‐Free Approach for the Synthesis of β‐Keto Sulfones and Branched Sulfones.'' Adv. Synth. Catal. 2023, 365, 1247-1254.
40. N. Yadav,† N. Taneja,† D. Musib, C. K. Hazra,* ''Practical Access to meta‐Substituted Anilines by Amination of Quinone Imine Ketals Derived from Anisidines: Efficient Synthesis of Anti‐Psychotic Drugs.'' Angew. Chem. Int. Ed. 2023, 62, e202301166. [†equally contributed].
39. R. Mahato, C. K. Hazra,* ''Pentafluorophenol (C6F5OH) Catalyzed Pictet‐Spengler Reaction: A facile and Metal‐free Approach Towards Tetrahydro‐β‐carbolines.'' Chem. -Eur. J. 2023, e202203924.
38. J. Khan, A. Tyagi, D. Ghosh,* C. K. Hazra,* ''HFIP-assisted reductive C–S, C–N, and C–X coupling of carbonyl compounds: a combined computational and experimental mechanistic study.'' Org. Chem. Front. 2023, 10, 1275.
37. S. Singh, S. Mondal, N. Vodnala, C. K. Hazra,* ''Hydrogen bonding network-enabled Brønsted acid-catalyzed Friedel–Crafts reactions: a green approach to access unsymmetrical diaryl- and triarylmethanes.'' Green Chemistry 2023, 25, 1014–1022.
36. S. Singh, S. Mondal,† V. Tiwari,† T. Karmakar,* C. K. Hazra,* ''Cooperative Friedel–Crafts Alkylation of Electron‐Deficient Arenes via Catalyst Activation with Hexafluoroisopropanol.'' Chem. -Eur. J. 2023, 29, e202300180. [†equally contributed].
35. R. Mahato, J. Khan, A. Tyagi, C. K. Hazra,* ''Lewis Acid Promoted Homodimerization of Styrene Diols: An Efficient Approach toward 2-Phenylnaphthalenes.'' Synlett 2022, 33, A-F.
34. P. Sharma, N. Taneja, S. Singh, C. K. Hazra,* ''Brønsted‐Acid‐Catalyzed One‐Pot Synthesis of β,β‐Diaryl Esters: Direct Regioselective Approach to Diverse Arrays of 3‐Aryl‐1‐indanone Cores.'' Chem. -Eur. J. 2022, 29, e202202956.
33. N. Yadav, A. Tyagi,† J. Khan,† C. K. Hazra,* ''Brookhart's Acid‐Catalyzed Switchable Regioselective N‐Alkylation of Arylamines/ Heterocyclic Amines with Cyclopropylcarbinols by Temperature Regulation.'' Chem. Eur. J. 2022, 28, e2022019. [†equal contribution]
32. S. Singh, S. Mondal, V. Tiwari, N. Vodnala, T. Karmakar,* C. K. Hazra,* ''Tandem Cooperative Friedel-Crafts Reaction of Aldehydes with Electron Deficient Arenes Through Catalyst-Activation via Hydrogen Bonding Network.'' ChemRxiv, July, 2022, doi: 10.26434/chemrxiv-2022-w56tj-v2.
31. J. Khan, N. Yadav, A. Tyagi, C. K. Hazra,* ''Silyl Cation-Initiated, Brønsted Acid-Catalyzed Strategy towards Unsymmetrical 3, 3-disubstituted 2-Oxindoles and Azonazine Cores.'' J. Org. Chem. 2022, 87, 11097–11111.
30. A. Tyagi, J. Khan,† N. Yadav,† R. Mahato, C. K. Hazra,* ''Catalyst-Switchable Divergent Synthesis of Bis (indolyl) alkanes and 3-Alkylated Indoles from Styrene Oxides.'' J. Org. Chem. 2022, 87, 10229–10240. [†equally contributed]
29. N. Vodnala,† S. Singh,† C. K. Hazra,* ''Lewis Acid-Promoted Typical Friedel–Crafts Reactions Using DMSO as a Carbon Source.'' J. Org. Chem. 2022, 87, 10044–10053. [†equally contributed]
28. N. Yadav, J. Khan, A. Tyagi, S. Singh, C. K. Hazra,* ''Rapid Access to Arylated and Allylated Cyclopropanes via Brønsted Acid-Catalyzed Dehydrative Coupling of Cyclopropylcarbinols.'' J. Org. Chem. 2022, 87, 6886.
27. A. Tyagi, N. Yadav, J. Khan, S. Mondal, C. K. Hazra,* ''Brønsted Acid‐Catalysed Epoxide Ring‐Opening Using Amine Nucleophiles: A facile access to β‐amino alcohols.'' Chem. Asian J. 2022, 17, e202200379.
26. S. Singh, R. Mahato, P. Sharma, N. Yadav, N. Vodnala, C. K. Hazra,* ''Development of Transition‐Metal‐Free Lewis Acid‐Initiated Double Arylation of Aldehyde: A Facile Approach Towards the Total Synthesis of Anti‐Breast‐Cancer Agent.'' Chem. -Eur. J. 2022, 28, e2021045.
25. J. Khan, A. Tyagi, N. Yadav, R. Mahato, C. K. Hazra,* ''Lambert Salt-Initiated Development of Friedel–Crafts Reaction on Isatin to Access Distinct Derivatives of Oxindoles.'' J. Org. Chem. 2021, 86, 17833.
24. A. Tyagi, N. Yadav,† J. Khan,† S. Singh, C. K. Hazra,* ''Transition Metal‐Free C–H Silylation: An Emerging Strategy.'' Asian J. Org. Chem. 2021, 10, 334. [†authors are equally contributed]
23. R. Gujjarappa, N. Vodnala, A. Garg, C. K. Hazra, S. Gupta, C. C. Malakar, ''Amino‐Acid‐Mediated Aerobic Oxidation of Organoborons for the Synthesis of Phenolic Derivatives Using Single Electron Transfer.'' ChemistrySelect 2020, 5, 2419.
22. J. Jeong, H. Kim, C. K. Hazra, S. Chang, M.-H. Baik, ''Disrotatory Ring Opening of Furans Gives Stereocontrol.'' J. Org. Chem. 2019, 84, 1106.
21. J. Zhang,† C. K. Hazra,† S. Park, S. Chang, ''Metal‐Free Carbocyclization of Homoallylic Silyl Ethers Leading to Cyclopropanes and Cyclobutanes.'' Asian J. Org. Chem. 2019, 8, 1637. [†equally contributed]
Before joining the Indian Institute of Technology Delhi, India
20. D. Kaldhi, N. Vodnala, R. Gujjarappa, S Nayak, V. Ravichandiran, D. Gupta, C. K. Hazra*, C. C. Malakar*, ''Organocatalytic oxidative synthesis of C2-functionalized benzoxazoles, naphthoxazoles, benzothiazoles and benzimidazoles'', Tetrahedron Lett. 2019, 60, 223.
19. N. Vodnala, R. Gujjarappa, C. K. Hazra, D. Kaldhi, A. K. Kabi, U. Beifuss, C. C. Malakar, ''Copper‐Catalyzed Site‐Selective Oxidative C−C Bond Cleavage of Simple Ketones for the Synthesis of Anilides and Paracetamol'', Adv. Synth. & Catal. 2019, 361, 135.
18. R. Gujjarappa, S. K. Maity, C. K. Hazra, N.Vodnala, S. Dhiman, A. Kumar, U. Beifuss, C. C. Malakar, ''Divergent Synthesis of Quinazolines Using Organocatalytic Domino Strategies under Aerobic Conditions'', Eur. J. Org. Chem. 2018, 2018, 4628.
17. D. Singh, C. K. Hazra, C. C. Malakar, S. K. Pandey, B. S. Kaitha, V. Singh, ''Indium‐Mediated Domino Allylation‐Lactonisation Approach: Diastereoselective Synthesis of β‐Carboline C‐3 Tethered α‐Methylene γ‐Butyrolactones'', ChemistrySelect 2018, 3, 4859.
16. C. K. Hazra, J. Jeong, H. Kim, M. -H. Baik, S. Park, S. Chang, ''Reductive Carbocyclization of Homoallylic Alcohols to syn‐ Cyclobutanes by a Boron‐Catalyzed Dual Ring‐Closing Pathway'', Angew. Chem. Int. Ed. 2018, 57, 2692.
15. C. K. Hazra, N. Gandhamsetty, S. Park, S. Chang, ''Borane catalyzed ring opening and closing cascades of furans leading to silicon functionalized synthetic intermediates'', Nat. Comm. 2016, 7, 13431. [Highlighted in SYNFORM 2017]
14. Q. Dherbassy, G. Schwertz, M. Chessé, C. K. Hazra, J. Wencel-Delord, F. Colobert, ''1, 1, 1, 3, 3, 3‐Hexafluoroisopropanol as a Remarkable Medium for Atroposelective Sulfoxide‐Directed Fujiwara–Moritani Reaction with Acrylates and Styrenes'', Chem. Eur. J. 2016, 22, 1735.
13. Q. Dherbassy, G. Schwertz, C. K. Hazra, T. Wesch, J. Wencel-Delord, F. Colobert, ''Enantiopure Sulfoxides: Efficient Chiral Directing Group for Stereoselective C‒H Bond Activation: Towards the Control of Axial Chirality'', J. Phosphorus Sulfur 2015, 190, 1339.
12. C. K. Hazra, Q. Dherbassy, J. Wencel-Delord, F. Colobert, ''Synthesis of Axially Chiral Biaryls through Sulfoxide‐Directed Asymmetric Mild C H Activation and Dynamic Kinetic Resolution'', Angew. Chem. Int. Ed. 2014, 53, 13871. [Highlighted in SYNFACTS 2015, 11 (1), 65]
11. C. K. Hazra, C. Fopp, M. Oestreich, ''Copper (I)‐Catalyzed Regioselective Addition of Nucleophilic Silicon Across Terminal and Internal Carbon–Carbon Triple Bonds'', Chem. Asian. J. 2014, 9, 3005.
10. C. K. Hazra, E. Irran, M. Oestreich, ''Regio‐and Diastereoselective Copper (I)‐Catalyzed Allylic Substitution of δ‐Hydroxy Allylic Chlorides by a Silicon Nucleophile'', Eur. J. Org. Chem. 2013, 4903.
9. P. Shanbhag, V. Mane, C. K. Hazra, I. N. N. Namboothiri, ''Diastereoselective Synthesis of Substituted Decalins from Rauhut—Currier Adducts of Conjugated Nitroalkenes”, J. Ind. Chem. Soc. 2013, 90, 1713.
8. C. K. Hazra, M. Oestreich, ''Copper (I)-Catalyzed Regio-and Chemoselective Single and Double Addition of Nucleophilic Silicon to Propargylic Chlorides and Phosphates'', Org. Lett. 2012, 14, 4010. [Highlighted in SYNFACTS 2012, 1239]
7. D. J. Vyas, C. K. Hazra, M. Oestreich, ''Copper (I)-Catalyzed Regioselective Propargylic Substitution Involving Si–B Bond Activation'', Org. Lett. 2011, 13, 4462.
Patents
6. C. K. Hazra, J. Khan, N. Yadav, ''PRACTICAL, SCALABLE, AND TRANSITION METAL-FREE REDUCTIVE FRIEDEL-CRAFTS REACTION: EFFICIENT SYNTHESIS OF ANAESTHETIC DRUGS'', Controller General of Patents, Designs & Trade Marks, Intellectual Property of India, filed, July 28, 2023, File No. 202311051075.
5. C. K. Hazra, S. Singh, S. Mondal, N. Vodnala, Filed. ''GREEN CHEMISTRY METHOD FOR ONE-POT SYNTHESIS OF BIOLOGICALLY ACTIVE 1,1-DI-, TRI-, AND TETRA-SUBSTITUTED ALKANES", Controller General of Patents, Designs & Trade Marks, Intellectual Property of India, filed June 02, 2022, File No. 202211031721.
4. C. K. Hazra, M. Singh, R, Mahato, P. Akhtar, Filed. ''Synthesis of New Organic-Inorganic Hybrid Materials as Light-Emitting Lumophores, and Designing OLED Devices Using the Same'', Controller General of Patents, Designs & Trade Marks, Intellectual Property of India, filed April 9, 2022, File No. 202211021313.
3. S. Chang, C. K. Hazra, N. Gandhamsetty ''Method for preparing silane derivatives from furan derivatives in presence of borane catalyst'', US Patent App. 16/304,662, 2020. Publication date: May, 26, 2020. https://patents.google.com/patent/US10662206B2/en
Book Chapters
2. S. Singh, C. K. Hazra*, ''Outer-Sphere C-H Bond Activation'', Wiley-VCH, 2022 (Handbook of CH-Functionalization; Invited book Chapter). https://onlinelibrary.wiley.com/doi/full/10.1002/9783527834242.chf0199
1. R. Mahato, Pragya, C. K. Hazra*, ''Inner-Sphere C-H Bond Activation'', Wiley-VCH, 2022 (Handbook of C-H-Functionalization; Invited book Chapter). https://onlinelibrary.wiley.com/doi/full/10.1002/9783527834242.chf0200