Organic Synthesis Lab

At OSL, we work towards the development of efficient technologies that would use feedstock materials and thereby maximize the use of renewable resources and minimize the use of hazardous chemicals. We focus on the derivatization of small and volatile molecules to get valuable compounds. Our primary goal is to develop a facile methodology to synthesize the target backbone and also study full mechanism based on physical organic chemistry including chemical kinetics, control experiments as well as labeling experiments.

Dr. Chinmoy K. Hazra

Associate Professor

A-2, Block V, IIT Delhi, Hauz Khas, 

Department of Chemistry, IIT Delhi, New Delhi-110016, India

E-mail: chinmoy[AT]chemistry.iitd.ac.in   

Tel: +91 11 2654 8408 

Web: http://chemistry.iitd.ac.in/faculty/hazra.html

News and Announcements!

May 2024: We are delighted to announce the publication of a collaborative review titled 'Comprehensive Strategies for Synthesizing Ene-Yne Derivatives' in the esteemed SYNTHESIS journal. We sincerely congratulate all the authors involved in this review paper. 

April 2024: I am happy to inform you that Rina's first manuscript on Organic Letters has been successfully published. We extend our warmest congratulations to Rina for your significant contribution.

April 2024: I am pleased to announce that Rahul & Nagaraju's first research manuscript on Advanced Synthesis & Catalysis has been successfully published. We extend our warmest congratulations to Rahul and Nararaju for their exceptional work. This achievement is a testament to their hard work and dedication to the field of catalysis. We look forward to seeing their continued success in this area of study. 

April 2024: We devised an efficient, facile method for C–H/N-H Methylation utilizing (para)formaldehyde as a C1 source and a combination of hydrosilane with HFIP. For more information, see the following link: 10.26434/chemrxiv-2024-t97z6. You can see our preprint in ChemRxiv.  Congratulations to Jabir, Neha and Naveen for this Methylation project.

April 2024: Are you planning to synthesize commercially available drugs such as Adiphenine and Piperidolate and derivatives of Ketoprofen, Ibuprofen, and Flurbiprofen? If you want more information, please refer to the following link: 10.26434/chemrxiv-2024-wmmr7. Please see our preprint in ChemRxiv.  Congratulations to Jabir and Aparna for this work.

April 2024: We welcome Yukta Rana, summer intern to our group.

March 2024: Dr. Hazra presented his recent work on transforming feedstock molecules into value-added products at OCSECR2024. The presentation was organized by the Department of Chemistry at IIT Jammu.

March 2024: Dr. Chinmoy Hazra delivered a special lecture on 'Organocatalytic Transformation of Feedstock Molecules to Value-Added Products and its Mechanistic Investigation' at the IISER Berhampur Chemistry Meet 2024, organized by the Department of Chemical Sciences at IISER, Berhampur, Odisha. 

March 2024: Dr. Hazra delivered a presentation on 'Organocatalytic Transformation of Feedstock Molecules to Value-Added Products and its Mechanistic Investigation' at the International Conference organized by Amity University, Noida Campus.

March 2024: Dr. Hazra delivered a presentation on 'Organocatalytic Transformation of Feedstock Molecules to Value-Added Products and its Mechanistic Investigation' at the International Conference on Emerging Trends in Catalysis & Synthesis (ETCS-2024) at IIT Kharagpur.

Announcement for a Research Associate (RA) position at the Department of Chemistry, IIT Delhi. 

Applications are invited from the citizens of India for a Research Associate position in the Organic Synthesis Lab, Department of Chemistry, IIT Delhi. I'd like to know if interested candidates with a background in synthetic chemistry/medicinal chemistry are asked to contact me directly (chinmoy@chemistry.iitd.ac.in) with their updated CVs. The last date for application is 15th February 2024 by 5.00 p.m. Link for Application: https://ird.iitd.ac.in/vacancies

Details of this RA position: https://ird.iitd.ac.in/sites/default/files/jobs/project/IITD-IRD-037-2024.pdf

Jan 2024: Another publication in Organic Chemistry Frontiers! Congratulations to Aparna for this paper.

Jan 2024: Three talented researchers, Khyati, Rima and Riya, joined our lab. I welcome you all to the OSL lab. I wish you all the best for your PhD program. 

December 2023: I'm glad to share that my PhD students, Pragya And Naveen got the "Best Poster Presentation Award" at the 60th ACC 2023 at IIT Delhi. 


December 2023: Dr. Chinmoy Hazra received a Sponsored Grant (Approved grant: Rs. 47,84,835/-) from the Core Research Grant  (SERB), Govt. of India.

Nov. 2023: Delighted to share that I've been awarded the Merck Young Scientist Award 2023. This award is particularly special because it recognises early career scientists for their breakthrough research in the fields of Biological Science, Chemical Science and Sustainability.

Nov. 2023: I am pleased to share that our latest paper titled "Sustainable Sulphonic Acid Functionalized Mesoporous Silica Heterogeneous Catalysis for Selective Unsymmetrical Friedel-Crafts Alkylation in One-pot" was accepted in the Journal of the American Chemical Society-Au (JACS Au). This is my first independent paper in JACS Au. This was possible only because of my sincere students, especially Sanjay. Also, thanks to our collaborators, Amit and Prof. Leena Nebhani. Many Congratulations to All of them. 

Nov. 2023: Our other Journal of Organic Chemistry  (JOC) paper is accepted. Congratulations to Pragya & Sanjay for your contribution.

Nov. 2023: Dr. Chinmoy Hazra delivered a presentation on 'Organocatalytic Transformation of Feedstock Molecules to Value-Added Products and its Mechanistic Investigation' organized by the International Conference on Organometallics and Catalysis (ICOC-Goa).

Oct. 2023: Dr. Bulti Pramanick joined our group. Welcome Dr. Bulti to our group!

Oct. 2023: Dr. Chinmoy Hazra presented an invited talk on 'Organocatalytic Transformation of Feedstock Molecules to Value-Added Products and its Mechanistic Investigation' organized by the Dept. of Chemistry, Indian Institute of Technology Goa.

Oct. 2023: Our other review paper is online. Congratulations to Sanjay for the nice review article on ''Recent Advancements in Typical Friedel–Crafts Alkylation Reactions Focused on Targeting Arene Nucleophiles'' in the Synthesis journal

Sept. 2023: We welcome Priyadarshini Naik to the CKH group.

Sept. 2023: Dr. Chinmoy Hazra presented an invited talk on 'Organocatalytic Transformation of Feedstock Molecules to Value-Added Products and its Mechanistic Investigation' organized by the Dept. of Chemistry, Indian Institute of Technology Bombay .

Sept. 2023: Dr. Chinmoy Hazra delivered an invited talk on 'Organocatalytic Transformation of Feedstock Molecules to Value-Added Products and its Mechanistic Investigation' organized by the Dept. of Chemistry, Institute of Chemical Technology, Mumbai.

August 2023: Congrats to my MSc student, Mr. Sagar Bhowmick (Entry no. 2021CYS7049), for winning the JAGAT RAM CHOPRA award! This prestigious award recognizes the best M.Sc. project demonstrating a process/equipment device/software in Physics, Mathematics, and Chemistry. The award is valued at Rs. 15,000/-. Wishing you all the best in your future endeavours.

August 2023: Dr. Chinmoy Hazra delivered a lecture at the NATIONAL WEBINAR IN CHEMISTRY organized by the Dept. of Chemistry, Hansraj College (Delhi University).

August 2023: Our first publication in 'Organic Letters' titled Nondirected, Site-Selective Arylation of Quinone Imine Ketals Derived from Arylamines: One-Pot Access to meta-Substituted Anilines, Congratulations to Dr. Neha Taneja, Pragya, Naveen and our collaborator, Dr. Dulal Musib for their hard work and dedication!

August 2023: Dr. Chinmoy Hazra received a Sponsored Grant (Approved grant: Rs. 40,000,00/-) from the Scheme for Transformational and Advanced Research in Sciences (STARS), Ministry of Human Resource Development (MHRD), India.

August 2023: Dr. Chinmoy Hazra delivered an online lecture on 'Organocatalytic Transformation of Feedstock Molecules to Value-Added Products and its Mechanistic Investigation' organized by the Dept. of Chemistry, Amity University.

July 2023: Another Indian patent was filed on July 28 on ''PRACTICAL, SCALABLE, AND TRANSITION METAL-FREE REDUCTIVE FRIEDEL-CRAFTS REACTION: EFFICIENT SYNTHESIS OF ANAESTHETIC DRUGS''. Congratulations, Jabir and Naveen, for your recent development on Active pharmaceutical ingredients (APIs).

July 2023: We welcome two M.Sc. students, HARSHIT and KANHAIYA, and two M. Tech. students Smritikana and Himanshu to CKH group.

July 2023: Dr. Hazra joined the Chemistry Department at IIT Delhi as an Associate Professor. 

June 2023: Dr. Hazra's Angewandte Author Profile was published. Thanks to Angew Chem for this great opportunity.


June 2023: We welcome Vidushi, Sayantan, and Prof. Joshi to the CKH group as summer interns. Best of luck!


May 2023: We welcome Durba, Mahak Chhabra, and Prof. Sharda Pasricha, a summer intern, to our research group. Good luck!

Announcement for a Research Associate (RA) position for one year at the Department of Chemistry, IIT Delhi. 

Applications are invited from the citizens of India for a Research Associate position in the Organic Synthesis Lab, Department of Chemistry, IIT Delhi. Interested candidates with a background in synthetic chemistry are requested to contact me directly (chinmoy@chemistry.iitd.ac.in) with their updated CVs. The last date for submitting the completed application by email is 22nd May 2023 by 5.00 p.m. Details of this RA position: file:///C:/Users/iitd/Downloads/ird-IITD-IRD-100-2023.pdf

April 2023: Dr. Chinmoy Hazra delivered a talk on 'Organocatalytic Transformation of Feedstock Molecules to Value-Added Products and its Mechanistic Investigation' organized by the Dept. of Chemistry, Sri Venkateswara College, Delhi University.

April 2023: Dr. Hazra delivered an interesting presentation on 'Career/Research opportunities' organized by the Dept. of Chemistry, HNB Garhwal University, Uttarakhand.

April 2023: Dr. Chinmoy Hazra delivered a special lecture on 'Organocatalytic Transformation of Feedstock Molecules to Value-Added Products and its Mechanistic Investigation' organized by the Dept. of Chemistry, Dyal Singh College, New Delhi.


March 2023: Our first Advanced Synthesis & Catalysis paper is now online. Congratulations to Aparna, Dr. Taneja, and Jabir for their valuable contributions!


March 2023: I am absolutely thrilled and delighted to share that our latest paper titled "Practical Access to meta-Substituted Anilines by Amination of  Quinone Imine Ketals Derived from Anisidines: Efficient Synthesis of  Anti-Psychotic Drugs" has been published in Angewandte Chemie International Edition (Impact factor 16.82!). This is my group's first independent paper in one of the topmost journals in our field, and I couldn’t have been prouder. This feat has been possible only because of my hardworking, motivated and sincere students, especially Mr. Naveen and Dr. Neha, who are the joint first authors of this paper. Also, thanks to our collaborator, Dr. Dulal Musib, for the DFT studies. Many Congratulations to All of them. 


March 2023: We welcome Smritikana (M.Tech), & Himanshu (M.Tech) to our research group. Good luck!


March 2023: Rina has developed a nice protocol entitled ''Pentafluorophenol (C6F5OH) Catalyzed Pictet-Spengler Reaction: A facile and Metal-free Approach Towards (Spirocyclic)Tetrahydro-β-carbolines'', Chemistry–A European Journal. Congratulations Rina!

Feb. 2023: Dr. Hazra delivered a Flash Presentation at the XXII NOST - Organic Chemistry Conference, Aurangabad, India.

Jan. 2023: Our first groundbreaking work on ccoperative Friedel-Crafts alkylation of Electron-Deficient arenes via catalyst activation with hexafluoroisopropanol (HFIP), Chemistry–A European Journal! Congratulations to Sanjay, Dr Sankalan, Vikas and our collaborator, Prof. Tarak Karmakar, for their valuable contributions!


Jan. 2023: Our first publication in 'Organic Chemistry Frontiers'  (Impact factor: 5.46)! Congratulations to Jabir, Aparna and our collaborator, Prof. Dibyajyoti Ghosh, for their hard work and dedication!


Jan. 2023: Our first publication of the year in 'Green Chemistry' (Impact factor: 11.03)! Congratulations to Sanjay, Sankalan and Nagaraj for this work. 


Jan. 2023:  Prof. Hazra has been selected as one of the Thieme Chemistry Journals Awardees 2023. Prof. Hazra is one of the 86 young investigators worldwide selected by the editors of SYNTHESIS, SYNLETT, SYNFACTS, SynOpen and Organic Materials, and Thieme for significant contributions to the field of Chemistry. 


Dec. 2022: Rina won the best poster prize at the 59th Annual Convention of Chemists 2022 (ACC-2022) & International Conference on Recent Trends in Chemical Science 2022 (RTCS-2022).


Dec. 2022: Aparna won the best poster prize at the 59th Annual Convention of Chemists 2022 (ACC-2022) & International Conference on Recent Trends in Chemical Science 2022 (RTCS-2022).


Dec. 2022: Jabir won the award in memory of Chittaranjan Roy Chowdhury & Manju Roy Chowdhury, Sponsored by Dr. Samar Chowdhury for poster presentation at the 59th Annual Convention of Chemists 2022 (ACC-2022) & International Conference on Recent Trends in Chemical Science 2022 (RTCS-2022). 


Dec. 2022: S. Singh, C. K. Hazra*, ''Outer-Sphere C-H Bond Activation, Wiley-VCH, 2022 (Handbook of CH-Functionalization; Invited book Chapter). Congratulations to Sanjay.


Dec. 2022: R. Mahato, Pragya, C. K. Hazra*, ''Inner-Sphere C-H Bond Activation”, Wiley-VCH, 2022 (Handbook of CH-Functionalization; Invited book Chapter). Congratulations to Rina and Pragya,


Oct. 2022: Rina's 1st Paper on 'Lewis Acid Promoted Homodimerization of Styrene Diols: An Efficient Approach toward 2-Phenylnaphthalenes' is online. Congratulations to Rina and other coauthors for the nice article in Synlett Journal.


Oct. 2022: Dr. Anju Singh joined the group for her project work as a senior research associate. Best of luck!


Oct. 2022: Sunaina joined the group for her project work. Good luck!

Sept. 2022: Dr. Chinmoy Hazra delivered a special lecture on 'metal-free activation of small molecules for the conversion of small molecules to value-added products' organized by the Dept. of Chemistry,  St. Stephen's College, India.


Sept. 2022: Pragya's 1st Paper on 'Brønsted-Acid Catalyzed One-pot Synthesis of β,β-Di-aryl esters: Direct Regioselective Approach to Diverse Arrays of 3-Aryl-1-indanone Cores' is online now. Congratulations to Pragya and other coauthors for the nice article in Chemistry–A European Journal.


August 2022: Naveen's 2nd Paper on Brookhart’s Acid-Catalyzed Switchable Regioselective N-Alkylation of Arylamines/ Heterocyclic Amines with Cyclopropylcarbinols by Temperature Regulation is online now. Congratulations to Naveen and other coauthors for the nice article in Chemistry–A European Journal.


Aug. 2022: We welcome Divleen (M.Sc.), Sagar (M.Sc.) & Vrinda (M.Tech.) to our research group. Best of luck!

July 2022: Mr. Rahul joined the group for his doctoral research. The CKH team wishes him good luck.


July 2022: Aparna's second paper on Catalyst-Switchable Divergent Synthesis of Bis(indolyl)alkanes and 3-Alkylated Indoles from Styrene Oxides is online. Congratulations to Aparna and other coauthors for the nice article in the Journal of Organic Chemistry


July 2022: We welcome Riya to our research group as a summer intern. Good luck!


July 2022: Nagaraju's first paper on Lewis Acid-Promoted Typical Friedel–Crafts Reactions Using DMSO as a Carbon Source

 is online. Congratulations to Nagaraju and Sanjay for the nice article in the Journal of Organic Chemistry


June 2022: We welcome Swagatam to our research group as a summer intern. Best of luck!


May 2022: Naveen's first impactful paper is online. Congratulations to Naveen and other coauthors for the nice article in the Journal of Organic Chemistry


April 2022: We welcome Divleen & Sagar as summer interns to our research group. Good luck!


April 2022:  Our first patent on ''Synthesis of New Organic-Inorganic Hybrid Materials as Light-Emitting Lumophores, and Designing OLED Devices Using the Same'',  Filed in Controller General of Patents, Designs & Trade Marks, Intellectual Property of India.


April 2022: Aparna's first exciting paper is online. Congratulations to Aparna and other coauthors for the nice article in Chemistry–An Asian Journal


March 2022: Our second experimental paper is online. Congratulations to Sanjay and other coauthors for the nice article in Chemistry–A European Journal.

Dec. 2021: We welcome Dr. Sankalan Mondal (Research Associate) to our research group. Best of luck!

Dec. 2021: Our first experimental paper is online. Congratulations to Jabir, Aparna, Naveen, and Rina for the nice article in the Journal of Organic Chemistry

Sept. 2021: We welcome Dr. Neha Taneja (Institute Post-doctoral fellow) to our research group. Good luck!

Aug. 2021: We welcome Urvashi and Shobha to our research group. Best of luck with your M.Sc. project.

Announcement for a Research Associate (RA) position at the Department of Chemistry, IIT Delhi. 

Applications are invited from the citizens of India for a Research Associate position in the Organic Synthesis Lab, Department of Chemistry, IIT Delhi. I'd like to know if interested candidates with a background in synthetic chemistry/medicinal chemistry are asked to contact me directly (chinmoy@chemistry.iitd.ac.in) with their updated CVs. The last date of application is 25th July 2021.

Link for Application: https://ird.iitd.ac.in/vacancies

Details of this RA position: https://ird.iitd.ac.in/sites/default/files/jobs/project/IITD-IRD-104-2021.pdf

Kindly spread the word.

July 2021: We welcome Anzalna Hamrah (Ph.D., UQIDAR) to our research group. Good luck!

Feb. 2021: We welcome Deepak, Pankaj, Anshika, and Ruchika to our research group. Good luck with your M.Sc./M.Tech thesis.

Jan. 2021: We welcome Dr. Nagaraju Vodnala (Research Associate) to our research group. Good luck!

Jan. 2021: Our first review paper is online. Congratulations to Aparna, Naveen, Jabir, and Sanjay for the nice review article in the Asian Journal of Organic Chemistry

Announcement for a Postdoctoral position at the Department of Chemistry, IIT Delhi.

Applications are invited from the citizens of India for a Postdoctoral Fellow position in the Organic Synthesis Lab, Department of Chemistry, IIT Delhi. Interested candidates with a background in organic synthesis and catalysis are requested to contact me directly (chinmoy[AT]chemistry.iitd.ac.in) with their updated CVs. The last date of application is 31st December 2020.

Link for Application: https://home.iitd.ac.in/jobs-iitd/index.php

Kindly spread the word.

Oct. 2020: Dr. Chinmoy Hazra delivered a lecture at the NATIONAL WEBINAR IN CHEMISTRY organized by the Dept. of Chemistry,  National Institute of Technology, Manipur, India.

Oct. 2020:  Dr. Chinmoy Hazra delivered a special lecture at the NATIONAL WEBINAR IN CHEMISTRY organized by the Dept. of Chemistry, Mercy College, Kerala, India.

Sept. 2020:  Dr. Chinmoy Hazra delivered a lecture at the NATIONAL WEBINAR IN CHEMISTRY organized by Jabalpur Engineering College, MP, India.

Sept. 2020: The group welcomes Pragya, who will be working on the conversion of small molecules to value-added compounds. I wish you all the best for your Ph.D. thesis.

August 2020: Dr. Chinmoy Hazra delivered an interesting lecture at the NATIONAL WEBINAR IN CHEMISTRY organized by the St. Joseph’s College of Engineering, Chennai, India.

July 2020: Dr. Chinmoy Hazra delivered a special lecture at the NATIONAL WEBINAR IN CHEMISTRY organized by the Bhawanipur Education Society College, Kolkata, India.

June 2020: Dr. Chinmoy Hazra delivered a lecture at the NATIONAL WEBINAR IN CHEMISTRY organized by the Dept. of Chemistry, Don Bosco College, Meghalaya, India.

June 2020: Dr. Chinmoy Hazra delivered a specific lecture at the 4th National Symposium on ‘Shaping the Energy Future: Challenges & Opportunities’ CSIR-Indian Institute of Petroleum, Dehradun, India.

Jan 2020: Rina joined OSL to conduct her PhD research. The CKH team welcomes her and wishes her a productive research tenure.

Jan 2020: Dr. Chinmoy Hazra delivered a notable lecture at the Vidyasagar University, India.

Jan 2020: Dr. Chinmoy Hazra delivered a distinct lecture at the International Conference on Chemistry for Human Development (ICCHD), Heritage Institute of Technology, Kolkata, India.

Dec 2019: Sanjay joined the group for his doctoral research on the metal-free new synthetic methodology. The CKH team wishes him good luck.

July 2019: OSL welcomes the new Ph.D. students Aparna, Jabir, and Naveen. Wish you all the best in your doctoral research.

May 2019: Dr. Chinmoy Hazra delivered a unique lecture at the National Institute of Technology, Manipur, India.

Jan 2024: Three talented researchers, Khyati, Rima and Riya, joined our lab. I welcome you all to the OSL lab. I wish you all the best for your PhD program.