Cell-substrate interactions

Substrate properties such as topography and compliance can influence cell behavior. Specifically, we are interested in understanding how biomimicking nanofiber structures can alter cell fate commitment; gene transfection and gene silencing. 

Controlled delivery scaffolds 

In order to better understand and modulate cellular behavior, we design bio-functional scaffolds to deliver synergistic micro/nano-topographical features and sustained drug delivery to cells. We are currently interested in delivering small non-coding RNAs for long-term gene silencing applications. We are also interested in additive manufacturing of scaffolds for human stem cell transplantation. 

Tissue regeneration & host-implant integration

Traumatic nerve injuries in the peripheral and central nervous systems lead to devastating outcomes of functional impairment.  Mediating host-implant integration and implant/tissue fibrosis are also critical concerns in regenerative medicine. We focus on translational studies to explore potential solutions for these healthcare problems. Our solutions include drug/gene delivery, as well as cell transplantation.