95% of all fungicides are protectants to best prevent a disease such as Cherry Leaf Spot. Fungicides that treat Cherry Leaf Spot most often have an active ingredient of myclobutanil or captan. For organic options, there is an active ingredient of copper. The best way to deal with infectious diseases is to spray a lot on the plants in order to have a high residue to protect it. All fungicides and other chemicals have a FRAC number which stands for Fungicide Resistance Action Committee. The numbers within the FRAC system represent a specific group of chemicals with certain active ingredients within them. The numbers do not necessarily define a rating of effectiveness for the group. When fighting infectious diseases it is best to spray with different FRAC groups, so the plant does not start to resist the fungicide.

There are some ways to manage Cherry Leaf Spot without the use of chemicals. Which include proper pruning, collection and compositing of infected leaves that fell on the ground and burning of infected leaves on the ground. The best time to collect leaves is in September or October (Grabowski). Although, the pruning and collection process can be rather impractical for any farm with several trees all the way up to a farm with thousands of acres.