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Cells are the fundamental units of life. They are controlled by their intrinsic genetics and biochemistry, as well as the extrinsic environment. The extracellular context include interactions with other cells and the surrounding matrix. Mechanobiology studies how cells perceive this world physically: How do the cells in your muscle and bone know that you lift weights and respond with growth? Why do astronauts get osteoporosis when they are in space? As traditional biology examines the chemical processes that take place in cells, mechanobiology investigates how the physical signals are interpreted and turned into chemical and physical responses. To this end, we employ technologies from mechanical, chemical, and material engineering to study cell biology. The knowledge gained from this interdisciplinary research not only will allow us fundamental understanding of our own physiology, but will help us build better replacement tissues and organs.
細胞的內在基因以及外在環境調控此生命的基本單位。力生物學不同於傳統細胞生物學，主要研究細胞外在環境中的各種物理訊號如何被細胞感受，進而轉換成化學與物理反應：例如太空人為何會得骨質疏鬆症？骨骼與肌肉細胞是如何感受承重進而生長？我們利用機械、化工、以及材料科學的跨領域工具來研究細胞，深入了解細胞生理，並可幫助修復組織與器官。
mechanobiology
mechanobiology
力生物學
Cells reside in a great variety of microenvironments, such as the stiff and porous bone that experiences compression and the flexible and organized artery that supports blood flow. Mechanobiology and mechanotransduction studies how cells perceive and respond to the dynamic physical environment. By controlling the cellular microenvironment through tools in microfabrication and biomaterial sciences, we investigate the influence of the physical parameters on cell behaviors and the underlying mechanisms.
tissue engineering
tissue engineering
組織工程
In addition to the static material characteristics, cells can experience dynamic physical loads, such as deformation, fluid shear, and electrical potentials. We build bioreactors to apply well-defined physical stimulation to cells and tissues to promote desirable cell behaviors, such as collagen synthesis in ligament formation, or simulate disease and aging process such as arterial stiffening. These projects can be applied in regenerative medicine or as model systems to understand injury, disease, and aging.
Recent Projects
MOST
Cell Shape Regulation of Nuclear and Chromosomal Dynamics
Interactions of Hydrogel-Fiber Composite with Growth Factors for Functional Ligament Tissue Engineering
NHRI
Multiscale Optimization of Electrospun Fibrous Networks for Functional Ligament Tissue Engineering
Intrinsic and Extrinsic Regulation of Vascular Smooth Muscle Cell Phenotype in Aging
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