How do cells sense and respond to their environment? With tools in mechanics, microfabrication, polymer science, and cell biology, we try to answer these questions in mechanobiology and cell-material interactions. Some of our main focus are how dimensionality (2D vs 3D), mechanics (stiffness), and organization (topography, anisotropy) influence cell behaviors and phenotype. We also stimulate the cell through deformation, fluid flow and electric fields, to understand the dynamic effects of physical forces on cells. These understandings can help us better control the cells and optimize tissue regeneration, with applications in ligament/tendon and arterial tissue engineering.

利用力學、微製程、材料科學與細胞生物學等工具，我們由韌帶及血管組織工程出發，研究物理化學等環境因子如何調控細胞， 例如維度(2D vs 3D)、機械性質 (軟硬度)、結構 (表面結構、異等向性) 如何改變細胞行為，或形變、液體剪力、電場等動態物理力對細胞之影響。這些研究可以幫助了解正常生理現象和疾病及老化的過程，也有助組織工程和再生醫學之進步。

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• 誠徵各階段大專生與研究生！若是你對組織工程或是力生物學有興趣的話，請與趙老師聯絡。

Our international collaboration has been publised on Nature Materials: " Tension anisotropy drives fibroblast phenotypic transition by self-reinforcing cell–extracellular matrix mechanical feedback". 

Shin-min's research, 'Zyxin and Actin Structure Confer Anisotropic YAP Mechanotransduction' is available on Acta Biomaterialia.

Congratulations to Kim and Howard on successfully defending their Master thesis!

Our work in collaboration with University of Pennsylvania, Aberrant mechanosensing in injured intervertebral discs as a result of boundary-constraint disruption and residual-strain loss,  is now published in Nature Biomedical Engineering! Congrats Eddie!

Our latest work, 'Chemical Optimization for Functional Ligament Tissue Engineering' is published on Tissue Engineering Part A! Congratulations to Willy and Frica!