Macromolecular Engineering of Organic–Inorganic Networks
We fabricate thermoresponsive, hydrophobic, programmable, customizable particle systems through the coordination networks between metal ions and phenolic groups in diverse polymer building blocks. This approach provides a synthetic strategy for developing dynamic and smart systems, which have potential in materials science and biomedical applications.
Related Publications
Chan-Jin Kim, Francesca Ercole, Jingqu Chen, Shuaijun Pan, Yi Ju, John F. Quinn, Frank Caruso "Macromolecular Engineering of Thermoresponsive Metal−Phenolic Networks", J. Am. Chem. Soc. 2022, 144, 503–514. [Link]
Chan-Jin Kim, Eirini Goudeli, Francesca Ercole, Yi Ju, Yuang Gu, Wanjun Xu, John F. Quinn, Frank Caruso “Particle Engineering via Supramolecular Assembly of Macroscopic Hydrophobic Building Blocks”, Angew. Chem., Int. Ed. 2024, 136, e202315297. [Link]
Yi Ju,† Chan-Jin Kim,† Frank Caruso (†Equally contributed) “Functional Ligand-Enabled Particle Assembly for Bio–Nano Interactions” Acc. Chem. Res. 2023, 56, 1826−1837. Featured as Supplementary Cover. [Link]
Chan-Jin Kim, Francesca Ercole, Eirini Goudeli, Sukhvir Kaur Bhangu, Jingqu Chen, Matthew Faria, John F. Quinn, Frank Caruso “Engineering Programmable DNA Particles and Capsules using Catechol-Functionalized DNA Block Copolymers”, Chem. Mater. 2022, 34, 7468−7480. [Link]
Chan-Jin Kim,† Francesca Ercole,† Yi Ju, Shuaijun Pan, Jingqu Chen, Yijiao Qu, John F. Quinn, Frank Caruso (†Equally contributed) “Synthesis of Customizable Macromolecular Conjugates as Building Blocks for Engineering Metal−Phenolic Network Capsules with Tailorable Properties”, Chem. Mater. 2021, 33, 8477-8488. [Link]
DNA Block Copolymer Assemblies
We designed and synthesized functional DNA block copolymers such as DNA–thermoresponsive polymer and DNA-poly(amino acid). The prepared DNA block copolymers assemble into dynamic nanostructures showing multidimensional shape changes in response to external stimuli (i.e., temperature change and DNA hybridization) and various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino acid interactions.
Related Publications
Chan-Jin Kim, Xiaole Hu, So-Jung Park “Multimodal Shape Transformation of Dual-Responsive DNA Block Copolymers”, J. Am. Chem. Soc. 2016, 138, 14941-14947. [Link]
Chan-Jin Kim, Ji-eun Park, Xiaole Hu, Shine K. Albert, So-Jung Park “Peptide-Driven Shape Control of Low-Dimensional DNA Nanostructures”, ACS Nano 2020 14, 2276-2284. [Link]
Chan-Jin Kim, Francesca Ercole, Eirini Goudeli, Sukhvir Kaur Bhangu, Jingqu Chen, Matthew Faria, John F. Quinn, Frank Caruso “Engineering Programmable DNA Particles and Capsules using Catechol-Functionalized DNA Block Copolymers”, Chem. Mater. 2022, 34, 7468−7480. [Link]
Chan-Jin Kim, Ga-Hyun Kim, Eun Hye Jeong, Hyukjin Lee, So-Jung Park “The Core Composition of DNA Block Copolymer Micelles Dictates DNA Hybridization Properties, Nuclease Stabilities, and Cellular Uptake Efficiencies”, Nanoscale 2021, 13, 13758-13763. [Link]
Chan-Jin Kim, Eun Hye Jeong, Hyukjin Lee, So-Jung Park “A Dynamic DNA Nanostructure with Switchable and Size-Selective Molecular Recognition Properties”, Nanoscale 2019, 11, 2501-2509. [Link]
Chan-Jin Kim, Zhangyong Si, Sheethal Reghu, Zhong Guo, Kaixi Zhang, Jianghua Li, Mary B Chan-Park “DNA-derived Nanostructures Selectively Capture Gram-Positive Bacteria”, Drug Delivery Transl. Res. 2021, 11, 1438–1450. [Link]
Biofunctional Materials
Functional bio-ligands consisting of a wide range of small or large molecules (e.g., peptide, protein, polyphenol, and nucleic acid) can be assembled into biofunctional materials with diverse physical, chemical, and biological properties. The assembly behaviors of biomolecules could be tuned by controlling the non-covalent interactions between these building blocks. This work provides a variable pathway for the rational design of biofunctional materials for biological science and biotechnology.
Related Publications
Yi Ju,† Chan-Jin Kim,† Frank Caruso (†Equally contributed) “Functional Ligand-Enabled Particle Assembly for Bio–Nano Interactions” Acc. Chem. Res. 2023, 56, 1826−1837. Featured as Supplementary Cover. [Link]
Jingqu Chen, Christina Cortez-Jugo, Chan-Jin Kim, Zhixing Lin, Tianzheng Wang, Robert de Rose, Wanjun Xu, Yuang Gu, and Frank Caruso “Metal–Phenolic‐Mediated Assembly of Functional Small Molecules into Nanoparticles: Assembly and Bioapplications”, Angew. Chem., Int. Ed. 2024, 136, e202319583. [Link]
Wanjun Xu, Shuaijun Pan, Benjamin Noble, Zhixing Lin, Sukhvir K. Bhangu, Chan-Jin Kim, Jingqu Chen, Yiyuan Han, Irene Yarovsky, Frank Caruso “Engineering Flexible Metal‒Phenolic Networks with Guest Responsiveness via Intermolecular Interactions”, Angew. Chem., Int. Ed. 2023, 62, e202302448. [Link]
Yijiao Qu, Robert De Rose, Chan-Jin Kim, Jiajing Zhou, Zhixing Lin, Yi Ju, Sukhvir Kaur Bhangu, Christina Cortez-Jugo, Francesca Cavalieri, Frank Caruso “Supramolecular Polyphenol–DNA Microparticles for In Vivo Adjuvant and Antigen Co-Delivery and Immune Stimulation”, Angew. Chem., Int. Ed. 2023, 135, e202214935. [Link]
Sukhvir Kaur Bhangu, Patrick Charchar, Benjamin B. Noble, Chan-Jin Kim, Shuaijun Pan, Irene Yarovsky, Francesca Cavalieri, Frank Caruso "Origins of Structural Elasticity in Metal–Phenolic Networks Probed by Super-Resolution Microscopy and Multiscale Simulations", ACS Nano 2022, 16, 89–97. [Link]
Chan-Jin Kim, Dong-Ik Lee, Cheonghee Kim, Kangtaek Lee, Chang-Ha Lee, Ik-Sung Ahn “Gold Nanoparticles-Based Colorimetric Assay for Cathepsin B Activity and the Efficiency of Its Inhibitors”, Anal. Chem. 2014, 86, 3825-3833. [Link]