Publications

Ryan KT, Wheeler NJ, Kamara IK, Johnson H, Humphries JE, Zamanian M, Chan JD (2023) Phenotypic profiling of macrocyclic lactones on parasitic Schistosoma flatworms. Antimicrobial Agents and Chemotherapy. Feb 16;67(2):e0123022. doi: 10.1128/aac.01230-22.

Wheeler NJ, Ryan KT, Gallo KJ, Henthorn CR, Ericksen SS, Chan JD, Zamanian M. (2022) Multivariate chemogenomic screening prioritizes new macrofilaricidal leads. Communications Biology.  Jan 13;6(1):44. doi: 10.1038/s42003-023-04435-8.

Wheeler NJ, Gallo KJ, Garncarz E, Ryan KT, Chan JD, Zamanian M. (2022) wrmXpress: A modular package for high-throughput image analysis of parasitic and free-living worms. PLoS Neglected Tropical Diseases. Nov 18;16(11):e0010937. doi: 10.1371/journal.pntd.0010937.

Mian Y Md, Mondal P, Sharmin D, Pandey KP, Rashid F, Rezvanian S, Golani LK, Tiruveedhula VVNPB, Rajaratnam V, Mirza SP, Chan JD, Witkin JM and Cook JM. (2022) An efficient debromination technique using PMHS with a number of ligands containing different functional groups. Apr 7; https://doi.org/10.24820/ark.5550190.p011.712.

Zamanian M and Chan JD. (2021) High-content approaches to anthelmintic drug screening. Trends in Parasitology. Jun 3;S1471-4922(21)00113-6. doi: 10.1016/j.pt.2021.05.004.

McCusker P, Rohr CM, Chan JD. (2021) Schistosoma mansoni alter transcription of immunomodulatory gene products following in vivo praziquantel exposure. PLoS Neglected Tropical Diseases. Mar 3;15(3):e0009200.

McCusker P, Mian Y Md, Li G, Olp MD, Tiruveedhula VVNPB, Rashid F, Golani LK, Verma RS, Smith BC, Cook JM, Chan JD. (2019) Non-sedating benzodiazepines cause contractile paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni. PLoS Neglected Tropical Diseases. Nov 15;13(11):e0007826.

Park SK, Gunaratne GS, Chulkov EG, Moehring F, McCusker P, Dosa PI, Chan JD, Stucky CL, Marchant JS (2019) The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel. The Journal of Biological Chemistry. Oct 25. pii: jbc.AC119.011093.

McCusker P and Chan JD (2019) Anti-schistosomal action of the calcium channel agonist FPL-64176. International Journal for Parasitology – Drugs and Drug Resistance. Sep 14;11:30-38.

Marchant JS, Harding WW, Chan JD (2018) Structure-activity profiling of alkaloid natural product pharmacophores against a Schistosoma serotonin receptor. International Journal for Parasitology – Drugs and Drug Resistance. 12;8(3):550-558.

Micropublications

Johnson H, VanHooreweghe M, Satori JA, Chan JD. (2023) Schistosomes contain divergent ligand-gated ion channels with an atypical Cys-loop motif. MicroPublication Biology. Jan 11; 10.17912/micropub.biology.000694. doi: 10.17912/micropub.biology.000694.

Kamara IK, Thao JT, Kaur K, Wheeler NJ, Chan JD. (2023) Annotation of G-Protein Coupled Receptors in the Genomes of Parasitic Blood Flukes. MicroPublication Biology. Jan 11; 10.17912/micropub.biology.000704. doi: 10.17912/micropub.biology.000704.

Post-doc

Chan JD, Day TA, Marchant JS (2018) Coalescing beneficial host and deleterious antiparasitic actions as an antischistosomal strategy. Elife. Jul 30;7. pii: e35755.

Camicia F, Celentano AM, Johns ME, Chan JD, Maldonado L, Vaca H, Di Siervi N, Kamentezky L, Gamo AM, Ortega-Gutierrez S, Martin-Fontecha M, Davio C, Marchant JS, Rosenzvit MC. (2018) Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes. PLoS Neglected Tropical Diseases. 12(2):e0006267.

Chan JD, Cupit PM, Gunaratne GS, McCorvy JD, Yang Y, Stoltz K, Webb TR, Dosa PI, Roth BL, Abagyan R, Cunningham C, Marchant JS (2017) The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand. Nature communications. 8(1):1910.

Chan JD, Zhang D, Liu X, Zarowiecki MZ, Berriman M, Marchant JS (2017) Utilizing the planarian voltage-gated ion channel transcriptome to resolve a role for a Ca2+ channel in neuromuscular function and regeneration. Biochim Biophys Acta. Jun;1864(6):1036-1045.

Chan JD, Acharya S, Day TA, Marchant JS (2016) Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist. International Journal for Parasitology – Drugs and Drug Resistance. Jun 23. pii: S2211-3207(16)30037-9.

Chan JD, Grab T, Marchant JS (2016) Kinetic profiling an abundantly expressed planarian serotonergic GPCR identifies bromocriptine as a perdurant antagonist. International Journal for Parasitology – Drugs and Drug Resistance. Jun 23. pii: S2211-3207(16)30036-7.

Chan JD, McCorvy JD, Acharya S, Johns ME, Day TA, Roth BL, Marchant JS (2016) A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. PLoS Pathogens. May 17;12(5):e1005651.

Chan JD, Agbedanu PN, Grab T, Zamanian M, Dosa PI, Day TA, Marchant JS (2015) Ergot Alkaloids (Re)generate New Leads as Antiparasitics. PLoS Neglected Tropical Diseases. Sep 14;9(9):e0004063.

Graduate School

Chan JD, Agbedanu PN, Zamanian M, Gruba SM, Haynes CL, Day TA, Marchant JS (2014) ‘Death and axes’: unexpected Ca2+ entry phenologs predict new anti-schistosomal agents. PLoS Pathogens. Feb 20;10(2): e1003942.

Srougi MC, Thomas-Swanik J, Chan JD, Marchant JS, Carson S (2014) Making Heads or Tails:  Planarian Stem Cells in the Classroom. J Microbiol Biol Educ. May;15(1): 18–25.

Chan JD, Zarowiecki M, Marchant JS (2013) Ca2+ channels and Praziquantel: A view from the free world. Parasitology International. Dec; 62(6):619-28.

Zhang D, Liu X, Chan JD, Marchant JS (2013) Characterization of a flatworm inositol (1,4,5) trisphosphate receptor (IP3R) reveals a role in reproductive physiology. Cell Calcium. May-Jun;53(5-6):307-14.

Zhang D, Chan JD, Nogi T, Marchant JS (2011) Opposing roles of voltage-gated Ca2+ channels in neuronal control of regenerative patterning. Journal of Neuroscience. Nov 2;31(44):15983-95.

Chan JD and Marchant JS (2011) Pharmacological and functional genetic assays to manipulate regeneration of the planarian Dugesia japonica. Journal of Visualized Experiments. Aug 31;(54).

Undergraduate

Nogi T, Zhang D, Chan JD, Marchant JS (2009) A Novel Biological Activity of Praziquantel Requiring Voltage-Operated Ca2+ Channel β-subunits: Subversion of Flatworm Regenerative Polarity. PLoS Neglected Tropical Diseases. Jun 23;3(6): e464.

Chan JD (2009) Modulation of Praziquantel-Evoked Planarian Bipolarity by Pharmacological Targeting of Glycogen Synthase Kinase. Proceedings of the National Conference on Undergraduate Research (NCUR) 2009. Ashville, NC: University of North Carolina.