Schistosomiasis
Infection with blood-dwelling parasitic flatworms
Over 200 million people are infected worldwide - mostly children in the developing world.
There is just one drug on the market to treat this neglected tropical disease, and no human vaccine.
Our lab is searching for new anti-schistosomal druggable targets and lead compounds.
Schistosomes parasitize the host circulatory system. They can survive for years. (Someone in Wisconsin was even found with an infection lasting over three decades).
Each female worm can lay 100's-1000's of eggs each day within the infected host. Eggs cause disease pathology, such as irreversible organ scarring and fibrosis.
A nice background on the disease can be found at the Global Schistosomiasis Alliance.
March 2023
Master's degree student Isaac Kamara succesfully defends his thesis!
February 2023
Antimicrobial Agents and Chemotherapy publication on the effects of macrocylic lactones on schistosomes, in collaboration with Zamanian and Humphries labs.
September 2023
Lab alum Hailey Johnson begins Postbaccalaureate position within the Laboratory of Parasitic Diseases at the National Institutes of Health
April 2022
Awarded UW Regent Scholar Grant to continue work on antischistosomal benzodiazepines.
March 2021
PLoS Neglected Tropical Diseases publication on the transcriptional response of parasites to in vivo chemotherapy.
Contact Us
Email: chanj@uwosh.edu
Office Phone: (920) 424-2039
Lab Address:
Chan Lab
Department of Chemistry
Halsey Science Center Room 417
921 Elmwood Ave
Oshkosh, WI 54901