(*: corresponding author; +: equal contribution)
NCBI bibliography link: https://www.ncbi.nlm.nih.gov/myncbi/hwan-woo.park.1/bibliography/public/
Kim HW, Lee JW, Yoon HS, Park HW, Lee YI, Lee SK, Whang J, Kim JS. Restriction of mitochondrial oxidation of glutamine or fatty acids enhances intracellular growth of Mycobacterium abscessus in macrophages. Virulence. 2025 Dec;16(1):2454323. doi: 10.1080/21505594.2025.2454323.
Lee HJ, Kim YJ, Park HW, Kim HI, Kim HT, Hong GL, Cho SP, Kim KH, Jung JY. Sestrin2 ameliorates age-related spontaneous benign prostatic hyperplasia via activation of AMPK/mTOR dependent autophagy. Biogerontology. 2025 Jan 24;26(1):48. doi: 10.1007/s10522-025-10184-4.
Shin J, Lim J, Han D, Lee S, Sung NS, Kim JS, Kim DK, Lee HY, Lee SK, Shin J, Kim JS*, Park HW*. TBK1 inhibitor amlexanox exerts anti-cancer effects against endometrial cancer by regulating AKT/NF-κB signaling. Int J Biol Sci. 2025;21(1):143-159. doi: 10.7150/ijbs.100212.
Kim HW, Lee JW, Yu AR, Yoon HS, Kang M, Lee BS, Park HW, Lee SK, Whang J, Kim JS. Isoegomaketone exhibits potential as a new Mycobacterium abscessus inhibitor. Front Microbiol. 2024;15:1344914. doi: 10.3389/fmicb.2024.1344914.
Lee JW, Kim HW, Yu AR, Yoon HS, Kang M, Park HW, Lee SK, Whang J, Kim JS. Differential Immune Responses and Underlying Mechanisms of Metabolic Reprogramming in Smooth and Rough Variants of Mycobacterium peregrinum Infections. Pathogens. 2023 Dec 13;12(12). doi: 10.3390/pathogens12121446.
Han D, Kim D, Kim H, Lee J, Lyu J, Kim JS, Shin J, Kim JS, Kim DK, Park HW*. Methylsulfonylmethane ameliorates metabolic-associated fatty liver disease by restoring autophagy flux via AMPK/mTOR/ULK1 signaling pathway. Frontiers in Pharmacology (IF 5.6) 2023 Nov 30;14:1302227. doi: 10.3389/fphar.2023.1302227.
Kim DK, Han D, Bae J, Kim H, Lee S, Kim JS, Jeong YG, Shin J, Park HW*. Verapamil-loaded supramolecular hydrogel patch attenuates metabolic dysfunction-associated fatty liver disease via restoration of autophagic clearance of aggregated proteins and inhibition of NLRP3. Biomaterials Research (IF 15.863). 2023 Jan 20;27(1):4. doi: 10.1186/s40824-023-00342-5.
Park HW, Han D, Ahn JP, Kim SH, Kang YJ, Jeong YG, Kim DK. Red-Emitting Latex Nanoparticles by Stepwise Entrapment of β-Diketonate Europium Complexes. Int J Mol Sci. 2022 Dec 15;23(24). doi: 10.3390/ijms232415954.
Jung GA, Kim JA, Park HW, Lee H, Chang MS, Cho KO, Song BW, Kim HJ, Kwon YK, Oh IH. Induction of Nanog in neural progenitor cells for adaptive regeneration of ischemic brain. Exp Mol Med. 2022 Nov;54(11):1955-1966. doi: 10.1038/s12276-022-00880-3.
Jeong BY, Cho KH, Jeong KJ, Cho SJ, Won M, Kim SH, Cho NH, Hur GM, Yoon SH, Park HW, Mills GB, Lee HY. Lysophosphatidic acid-induced amphiregulin secretion by cancer-associated fibroblasts augments cancer cell invasion. Cancer Lett. 2022 Oct 7;551:215946. doi: 10.1016/j.canlet.2022.215946.
Yu SL, Lee SI, Park HW, Lee SK, Kim TH, Kang J, Park SR. SIRT1 suppresses in vitro decidualization of human endometrial stromal cells through the downregulation of forkhead box O1 expression. Reprod Biol. 2022 Sep;22(3):100672. doi: 10.1016/j.repbio.2022.100672.
Kang S, Park HW, Han KH. Antibodies Regulate Dual-Function Enzyme IYD to Induce Functional Synergy between Metabolism and Thermogenesis. Int J Mol Sci. 2022 Jul 15;23(14). doi: 10.3390/ijms23147834.
Kim HW, Yu AR, Lee JW, Yoon HS, Lee BS, Park HW, Lee SK, Lee YI, Whang J, Kim JS. Aconitate Decarboxylase 1 Deficiency Exacerbates Mouse Colitis Induced by Dextran Sodium Sulfate. Int J Mol Sci. 2022 Apr 15;23(8). doi: 10.3390/ijms23084392.
An JH, Hong SE, Yu SL, Kang J, Park CG, Lee HY, Lee SK, Lee DC, Park HW, Hwang WM, Yun SR, Park Y, Park MH, Yoon KR, Yoon SH. Ceria-Zirconia nanoparticles reduce intracellular globotriaosylceramide accumulation and attenuate kidney injury by enhancing the autophagy flux in cellular and animal models of Fabry disease. J Nanobiotechnology. 2022 Mar 9;20(1):125. doi: 10.1186/s12951-022-01318-8.
Han D+, Lee J+, Kim H, Hong SP, Ahn JP, Kang YJ, Lee S, Jeong YG, Lee SK, Park HW*, DK Kim*. Cytotoxicity and cellular uptake of red-emitting organic-inorganic hybrid nanoparticles. Colloids Surf A Physicochem Eng Asp. (IF 5.292) in press
Han D+, Kim H+, Kim S, Le QA, Bae J, Han SY, Shin HW, Kang HG, Han KH, Shin J, Park HW*. Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis. Experimental and Molecular Medicine (IF 12.153). 2022 Mar 54(3):239-251. doi: 10.1038/s12276-022-00737-9
Lee S+, Shin J+, Kim JS, Shin J, Lee SK*, Park HW*. Targeting TBK1 Attenuates LPS-Induced NLRP3 Inflammasome Activation by Regulating of mTORC1 Pathways in Trophoblasts. Front. Immunol. (IF 7.561). 2021 Nov 9;12:743700. doi: 10.3389/fimmu.2021.743700.
Hwang I, Lee EJ, Park H, Moon D, Park JN, Kim KC, Cha A, Yun H, Lee J, Park HW, Chang MS, Kim HS. Endothelin-1 enhances the regenerative capability of human bone marrow-derived mesenchymal stem cells in a sciatic nerve injury mouse model. Biomaterials. 2021 Aug;275:120980. doi: 10.1016/j.biomaterials.2021.120980.
Jeong BY, Cho KH, Yoon SH, Park CG, Park HW, Lee HY. Discoidin Domain Receptor 2 Mediates Lysophosphatidic Acid-Induced Ovarian Cancer Aggressiveness. Int J Mol Sci. 2021 May 20;22(10). doi: 10.3390/ijms22105374.
Shin J+, Bae J+, Park S, Kang HG, Shin SM, Won G, Kim JS, Cho SG, Choi Y, Oh SM, Shin J, Kim JS*, Park HW*. mTOR-dependent role of Sestrin2 in regulating tumor progression of human endometrial cancer. Cancers (IF: 6.126). 2020 Sep 4;12(9). doi: 10.3390/cancers12092515.
Lee JS, Park HW, Cho KJ, Lyu J. Sestrin2 inhibits YAP activation and negatively regulates corneal epithelial cell proliferation. Exp Mol Med. 2020 Jun;52(6):951-962. doi: 10.1038/s12276-020-0446-5
Park JH, Park SA, Lee YJ, Park HW, Oh SM. PBK attenuates paclitaxel-induced autophagic cell death by suppressing p53 in H460 non-small-cell lung cancer cells. FEBS Open Bio. 2020;10(5):937-950. doi: 10.1002/2211-5463.12855
Park S+, Shin J+, Bae J, Han D, Park SR, Shin J, Lee SK*, Park HW*. SIRT1 alleviates LPS-induced IL-1β production by suppressing NLRP3 inflammasome activation and ROS production in trophoblasts. Cells (IF: 5.656). 2020 Mar 16;9(3). doi: 10.3390/cells9030728
Lee S, Shin J, Hong Y, Shin SM, Shin HW, Shin J, Lee SK*, Park HW*. Sestrin2 alleviates palmitate-induced endoplasmic reticulum stress, apoptosis, and defective invasion of human trophoblast cells. American Journal of Reproductive Immunology (IF: 3.091). 2020 Apr;83(4):e13222. doi: 10.1111/aji.13222
Shim YS, Lee S, Park HW, Park SR. Sestrin2 Mediates IL-4-induced IgE Class Switching by Enhancing Germline ε Transcription in B Cells. Immune Netw. 2020 Apr;20(2):e19. doi: 10.4110/in.2020.20.e19
Kowalsky AH, Namkoong S, Mettetal E, Park HW, Kazyken D, Fingar DC, Lee JH. The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation. Journal of Biological Chemistry. 2020;295(7):1769-80. doi: 10.1074/jbc.RA119.010857
Han Y, Kang Y, Yu J, Yu SL, Park HW, Shin J, Park SR, Kang J. Increase of Hspa1a and Hspa1b Genes in the Resting B Cells of Sirt1 Knockout Mice. Molecular Biology Reports. 2019;46(4):4225-34. doi: 10.1007/s11033-019-04876-7
Lee S+, Han D+, Kang HG, Jeong SJ, Jo JE, Shin J, Kim DK*, Park HW*. Intravenous Sustained-Release Nifedipine Ameliorates Nonalcoholic Fatty Liver Disease by Restoring Autophagic Clearance. Biomaterials (IF: 10.273). 2019;197:1-11. doi: 10.1016/j.biomaterials.2019.01.008.
Han D, Han SY, Lee NS, Shin J, Jeong YG, Park HW*, Kim DK*. Magnetofluorescent Nanocomposite Comprised of Carboxymethyl Dextran coated Superparamagnetic Iron Oxide Nanoparticles and β-diketon Coordinated Europium Complexes. Nanomaterials (IF: 4.034). 2019;9(1). doi: 10.3390/nano9010062.
Park HW, Oh S, Lee KH, Lee BH, Chang MS*. Olig2-expressing Mesenchymal Stem Cells Enhance Functional Recovery after Contusive Spinal Cord Injury. International Journal of Stem Cells. 2018;11(2):177-86. doi: 10.15283/ijsc18071
• Article chosen for journal cover image
Cho CS+, Park HW+, Ho A, Kim B, Jang I, Park H, Reilly S, Saltiel A, Lee JH*. Lipotoxicity induces hepatic protein inclusions through TBK1-mediated p62/SQSTM1 phosphorylation. Hepatology (IF:14.079). 2018;68(4):1331-46. doi: 10.1002/hep.29742
Hong YG, Ahn HJ, Shin J, Lee JH, Kim JH, Park HW*, Lee SK*. Unsaturated fatty acids protect trophoblast cells from saturated fatty acid-induced autophagy defects. Journal of Reproductive Immunology. 2018;125:56-63. doi: 10.1016/j.jri.2017.12.001.
Kim S, Han SY, Yu KS, Han D, Ahn HJ, Jo JE, Kim JH, Shin J, Park HW*. Impaired autophagy promotes bile acid-induced hepatic injury and accumulation of ubiquitinated proteins. Biochem. Biophys. Res. Commun. 2018;495(1):1541-7. doi: 10.1016/j.bbrc.2017.11.202
Kang MH, Das J, Gurunathan S, Park HW, Song H, Park C, Kim JH*. The cytotoxic effects of dimethyl sulfoxide in mouse preimplantation embryos: a mechanistic study. Theranostics. 2017;7(19):4735-52. doi: 10.7150/thno.21662
Park HW, Jeon HJ, Chang MS*. Vascular endothelial growth factor enhances axonal outgrowth in organotypic spinal cord slices via vascular endothelial growth factor receptor 1 and 2. Tissue Eng Regen Med. 2016;13:601
Ro SH, Xue X, Ramakrishnan SK, Cho CS, Namkoong S, Jang I, Semple IA, Ho A, Park HW, Shah YM*, Lee JH*. Tumor suppressive role of Sestrin2 during colitis and colon carcinogenesis. Elife. 2016;5. doi: 10.7554/eLife.12204
Kim M, Semple I, Kim B, Kiers A, Nam S, Park HW, Park H, Ro SH, Kim JS, Juhasz G, Lee JH.* Drosophila gyf/grb10 interacting gyf protein is an autophagy regulator that controls neuron and muscle homeostasis. Autophagy. 2015:0. doi: 10.1080/15548627.2015.1063766
Ro SH, Semple I, Ho A, Park HW, Lee JH*. Sestrin2, a regulator of thermogenesis and mitohormesis in brown adipose tissue. Frontiers in endocrinology. 2015;6:114. doi: 10.3389/fendo.2015.00114
Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH*. Sestrin2 inhibits mtorc1 through modulation of gator complexes. Scientific reports. 2015;5:9502. doi: 10.1038/srep09502
Park HW, Lee JH*. Calcium channel blockers as potential therapeutics for obesity-associated autophagy defects and fatty liver pathologies. Autophagy. 2014;10(12):2385-6. doi: 10.4161/15548627.2014.984268
Park HW, Park H, Semple IA, Jang I, Ro SH, Kim M, Cazares VA, Stuenkel EL, Kim JJ, Kim JS, Lee JH*. Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers. Nature communications. 2014;5:4834. doi: 10.1038/ncomms5834
Ro SH, Semple IA, Park H, Park H, Park HW, Kim M, Kim JS, Lee JH*. Sestrin2 Promotes Unc-51-like Kinase 1 (ULK1)-Mediated Phosphorylation of p62/sequestosome-1. The FEBS journal. 2014;281(17):3816-27. doi: 10.1111/febs.12905
Park HW, Park H, Ro SH, Jang I, Semple IA, Kim DN, Kim M, Nam M, Zhang D. Yin L, Lee JH*. Hepatoprotective role of Sestrin2 against chronic ER stress. Nature communications. 2014;5:4233. doi: 10.1038/ncomms5233
• BRIC-한국을 빛내는 사람들 논문 선정 link; BRIC-한국을 빛내는 사람들 인터뷰 link
Ro SH, Nam M, Jang I, Park HW, Park H, Semple IA, Kim M, Kim JS, Park H, Einat P, Damari G, Golikov M, Feinstein E, Lee JH*. Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2014;111(21):7849-54. doi: 10.1073/pnas.1401787111
Kim M+, Park HL+, Park HW+, Ro SH, Nam SG, Reed JM, Guan JL, Lee JH*. Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging. Autophagy. 2013;9(8):1201-13. doi: 10.4161/auto.24811
Lee EJ+, Park HW+, Jeon HJ, Kim HS, Chang MS*. Potentiated therapeutic angiogenesis by primed human mesenchymal stem cells in a mouse model of hindlimb ischemia. Regenerative medicine. 2013;8(3):283-93. doi: 10.2217/rme.13.17
Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M*. Maintenance of metabolic homeostasis by sestrin2 and sestrin3. Cell Metabolism. 2012;16(3):311-21. doi: 10.1016/j.cmet.2012.08.004
Park HW, Cho JS, Park CK, Jung SJ, Park CH, Lee SJ, Oh SB, Park YS, Chang MS. Directed induction of functional motor neuron-like cells from genetically engineered human mesenchymal stem cells. PLoS One. 2012;7(4):e35244. doi: 10.1371/journal.pone.0035244
Park HW, Lim MJ, Jung H, Lee SP, Paik KS, Chang MS. Human mesenchymal stem cell-derived schwann cell like cells exhibit neurotrophic effects, via distinct growth factor production in a model of spinal cord injury. Glia. 2010;58(9):1118-32. doi: 10.1002/glia.20992.
Park HJ, Park HW, Lee SJ, Arevalo JC, Park YS, Lee SP, Paik KS, Chao MV, Chang MS. Ankyrin repeat-rich membrane spanning/kidins220 protein interacts with mammalian septin 5. Molecules and cells. 2010;30(2):143-8. doi: 10.1007/s10059-010-0099-7
Cho JS, Park HW, Park SK, Roh S, Kang SK, Paik KS, Chang MS. Transplantation of mesenchymal stem cells enhances axonal outgrowth and cell survival in an organotypic spinal cord slice culture. Neuroscience letters. 2009;454(1):43-8. doi: 10.1016/j.neulet.2009.02.024
Oh S, Park HW, Cho JS, Jung H, Lee SP, Paik KS, Chang MS. Induction of a neuronal phenotype from human bone marrow-derived mesenchymal stem cells. International J. of Oral Biology. 2009; 34:717-183
Patents
TBK1 억제제를 포함하는 태반 염증의 예방 또는 치료용 조성물. 특허출원 10-2022-0009460 (2022-01-21)
란타나이드 금속 착제 및 자성 나노입자가 포함된 무독성 형광자성나노입자 및 이의 제조방법. 특허출원 10-2018-0173039 (2018-12-28), 특허등록 10-2162923 (2020-09-28)
니페디핀 함유 나노입자를 포함하는 지방간 질환 및 인슐린 저항성 예방 또는 치료용 조성물 . 특허출원 10-2018-0150071 (2018-11-28), 특허등록 10-2162921 (2020-09-28)