Schedule

  • 17-03-2022 at 1100h IST: "DNA-polymer architecture orchestrates the segregation and spatio-temporal organization of E. coli chromosomes during replication in slow growth." by Dr. Apratim Chatterji, IISER Pune

  • Winter break- we will be back in Mar-2022

  • 22-09-2021 at 1200h IST: "In vitro reconstitutions to dissect cellular functions" by Dr. Renu Maan, Delft Univ. of Technology, The Netherlands.

  • 27-07-2021 at 1100h IST: Measurement of forces to position the cell nucleus at the cell center using centrifuge polarization microscope (CPM) by Dr. Akatsuki (Aki) Kimura, (National Institute of Genetics, Japan.

  • 25-05-2021 at 1500h IST: "Modeling Population Dynamics in Bacterial Colonies" by Dr. Prasad Perlekar, TIFR Hyderabad, India

  • 18-05-2021 at 1500h IST: "On the control of epithelial mechanics during morphogenesis: How to seal epithelial gaps" by Dr. Jerome Solon, Bilbao, Spain.

  • 17-05-2021 at 1800h IST: "Blebs lead the way: Plasma membrane signalling segregation during migration"by Dr. Ankita Jha, NIH, Bethesda, MA, USA

  • 19-04-2021 at 1500h IST: "Kinesin motor mechanics" by Dr. Anita Jannasch, Univ. of Tuebingen, Germany



  • Upcoming speakers: Dr. Sivaraj Sivaramakrishnan, Dr. Keith Pardee, Dr. Vikram Padbidri, Dr. Mark Bathe, Dr. Apratim Chatterjee and more. Watch this space.


Abstract

Title: In vitro reconstitutions to dissect cellular functions

Speaker: Dr. Renu Maan, TU Delft, The Netherlands

Abstract: Bottom-up biology is an approach toconstruct/ build cellular complexity from its building blocks. Thisinterdisciplinary approach is increasingly gaining popularity among thescientific communities involved in the building of an artificial cell. Withbottom up biology a cellular function is mimicked using minimum set of componentsin a well-controlled and well-characterized environment. The bottom up biologyallows to dissect a single cellular function at a time and helps to pin pointthe precise molecular mechanisms of the individual components involved. Onesuch cellular process is microtubule based motor driven transport. Using the invitro reconstitutions we show how the microtubule based plus end tracking mayestablish a protein gradient in the fission yeast cells. With the help of my own research work I will also be speaking about the use of bottom up biology to understand cellular adhesion.