2025

1. Kanaji S, Zarpellon A, Aiolfi R, Morodomi Y, Orje J, Zampolli A, Won E, Ruggeri ZM, Kanaji T. Human PAR1 expressed on mouse platelets contributes to hemostasis and arterial occlusion. bioRxiv. 2025 Jun 7:2025.06.03.657740. 

2. Anada T, Kawahara M, Shimada T, Kuroda R, Okamura H, Setoyama D, Nagatsugi F, Kunisaki Y, Kage-Nakadai E, Kobayashi S, Tanaka M. A Nucleic Acid Prodrug That Activates Mitochondrial Respiration, Promotes Stress Resilience, and Prolongs Lifespan. J Am Chem Soc. 2025 Jun 25;147(25):22161-22175.

3. Nakagaki H, Yamauchi T, Mukaino T, Sakata A, Watanabe E, Watanabe M, Ishihara D, Imanaga H, Sasaki K, Sakoda T, Jinnouchi F, Miyawaki K, Shima T, Kikushige Y, Mori Y, Hotta T, Kunisaki Y, Shigeto H, Isobe N, Akashi K, Kato K. Objective quantification of pre-CAR-T EEG abnormalities for ICANS prognosis: insights from GTE scoring. Bone Marrow Transplant. 2025 Jul;60(7):1076-1078. 

4. Fukudome Y, Hieda M, Ohte N, Futami S, Kaneko E, Koike A, Kurokawa S, Kunisaki Y, Shiose A, Akashi K. Reproducibility of the systolic and diastolic energy loss of the left ventricle in vector flow mapping. J Echocardiogr. 2025 Apr 25.

5. Tsukahara S, Shiota M, Matsumoto T, Takamatsu D, Nagakawa S, Noda N, Matsumoto S, Yagi M, Uchiumi T, Kunisaki Y, Kang D, Eto M. Monitoring circulating tumor DNA by recurrent hotspot mutations in bladder cancer. BJC Rep. 2025 Apr 24;3(1):26.

6. Sugio T, Miyawaki K, Uchida N, Niemann M, Spierings E, Mori K, Ohno Y, Eto T, Mori Y, Yoshimoto G, Kikushige Y, Kunisaki Y, Mizuno S, Nagafuji K, Iwasaki H, Kamimura T, Ogawa R, Miyamoto T, Taniguchi S, Akashi K, Kato K. Indirect presentation of mismatched human leukocyte antigen-B associates with outcomes of cord blood transplantation. Br J Haematol. 2025 May;206(5):1406-1417.

7. Nomiyama T#, Setoyama D# (#co-first authors), Yamanaka I, Shimo M, Miyawaki K, Yamauchi T, Jinnouchi F, Sakoda T, Sasaki K, Shima T, Kikushige Y, Mori Y, Akashi K, Kato K, Kunisaki Y. Cerebrospinal fluid proteomics exerts predictive potential for immune effector cell-associated neurotoxicity syndrome (ICANS) in CAR-T cell therapy. Leukemia. 2025 Apr;39(4):983-987.

8. Minami M, Sakoda T, Kawano G, Kochi Y, Sasaki K, Sugio T, Jinnouchi F, Miyawaki K, Kunisaki Y, Kato K, Miyamoto T, Akashi K, Kikushige Y. Distinct leukemogenic mechanism of acute promyelocytic leukemia based on genomic structure of PML::RARα. Leukemia. 2025 Apr;39(4):844-853.

9. Sakurai H, Setoyama D, Kato TA, Tachimori H, Murao M, Matsumoto Y, Tada T, Imamura Y, Seki H, Tsuboi T, Uchida H, Watanabe K. Acute and long-term effects of repeated ketamine infusions in treatment-resistant depression and associated metabolite changes. Psychiatry Clin Neurosci. 2025 Jul 15. doi: 10.1111/pcn.13870.

10. Cao Z, Setoyama D, Natsumi Daudelin M, Matsushima T, Yada Y, Watabe M, Hikida T, A Kato T, Naoki H. Leveraging machine learning to uncover the hidden links between trusting behavior and biological markers. Dialogues Clin Neurosci. 2025 Dec;27(1):201-215.

11. Setoyama D, Han D, Tian J, Lee HY, Shin HS, Nga HT, Nguyen TL, Moon JS, Jang HJ, Kim E, Choe SK, Ju SH, Choi DE, Kwon O, Yi HS. Comparative Analysis of Primary Sarcopenia and End-Stage Renal Disease-Related Muscle Wasting Using Multi-Omics Approaches. J Cachexia Sarcopenia Muscle. 2025 Apr;16(2):e13749.

2024

12. Aihara M, Gotoh Y, Shirahama S, Matsushima Y, Uchiumi T, Kang D, Hayashi T. Generation and maintenance of the circularized multimeric IS26-associated translocatable unit encoding multidrug resistance. communications biology. 2024;7:597.

13. Jones JA, Zhou J, Dong J, Huitron-Resendiz S, Boussaty E, Chavez E, Wei N, Dumitru CD, Morodomi Y, Kanaji T, Ryan AF, Friedman R, Zhou T, Kanaji S, Wortham M, Schenk S, Roberts AJ, Yang XL. Murine nuclear tyrosyl-tRNA synthetase deficiency leads to fat storage deficiency and hearing loss. J Biol Chem. 2024 Oct;300(10):107756. 

14. Miki K, Yagi M, Hatae R, Otsuji R, Miyazaki T, Goto K, Setoyama D, Fujioka Y, Sangatsuda Y, Kuga D, Higa N, Takajo T, Hajime Y, Akahane T, Tanimoto A, Hanaya R, Kunisaki Y, Uchiumi T, Yoshimoto K. Glutaminolysis is associated with mitochondrial pathway activation and can be therapeutically targeted in glioblastoma. Cancer Metab. 2024 Nov 19;12(1):35. 

15. Tsurui R, Yamada H, Natori T, Yoshimura M, Akasaki Y, Kawahara S, Niiro H, Kunisaki Y, Nakashima Y. Homeostatic signals, including IL-7 and self-MHC recognition, induce the development of peripheral helper T cells, which are enriched in the joints of rheumatoid arthritis. J Transl Autoimmun. 2024 Oct 30;9:100258. 

16. Matsumoto S, Uchiumi T, Ueyanagi Y, Noda N, Sakai A, Hotta T, Kato K, Ohga S, Kunisaki Y, Kang D. Long-range and real-time PCR identification of a large SERPINC1 deletion in a patient with antithrombin deficiency. Int J Hematol. 2024 Aug;120(2):179-185.

17. Toshima T, Yagi M, Do Y, Hirai H, Kunisaki Y, Kang D, Uchiumi T. Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3β-Srebp2 axis. Life Sci Alliance. 2024 May 8;7(7):e202302423. 

18. Miki K, Yagi M, Kang D, Kunisaki Y, Yoshimoto K, Uchiumi T. Glucose starvation causes ferroptosis-mediated lysosomal dysfunction. iScience. 2024 Apr 12;27(5):109735. 

19. Do Y, Yagi M, Hirai H, Miki K, Fukahori Y, Setoyama D, Yamamoto M, Furukawa T, Kunisaki Y, Kang D, Uchiumi T. Cardiomyocyte-specific deletion of the mitochondrial transporter Abcb10 causes cardiac dysfunction via lysosomal-mediated ferroptosis. Biosci Rep. 2024 May 29;44(5):BSR20231992. 

20. Song X, Nihashi Y, Imai Y, Mori N, Kagaya N, Suenaga H, Shin-Ya K, Yamamoto M, Setoyama D, Kunisaki Y, Kida YS. Collagen Lattice Model, Populated with Heterogeneous Cancer-Associated Fibroblasts, Facilitates Advanced Reconstruction of Pancreatic Cancer Microenvironment. Int J Mol Sci. 2024 Mar 27;25(7):3740. 

21. Sugio T, Uchida N, Miyawaki K, Ohno Y, Eto T, Mori Y, Yoshimoto G, Kikushige Y, Kunisaki Y, Mizuno S, Nagafuji K, Iwasaki H, Kamimura T, Ogawa R, Miyamoto T, Taniguchi S, Akashi K, Kato K. Prognostic impact of HLA supertype mismatch in single-unit cord blood transplantation. Bone Marrow Transplant. 2024 Apr;59(4):466-472.

22. Hatakeyama K, Kikushige Y, Ishihara D, Yamamoto S, Kawano G, Tochigi T, Miyamoto T, Sakoda T, Christoforou A, Kunisaki Y, Fukata M, Kato K, Ito T, Handa H, Akashi K.  Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug-induced thromboembolism. Blood Adv. 2024 Feb 13;8(3):785-796.

23. Tian J, Moon JS, Nga HT, Lee HY, Nguyen TL, Jang HJ, Setoyama D, Shong M, Lee JH, Yi HS. Brown fat-specific mitoribosomal function is crucial for preventing cold exposure-induced bone loss. Cell Mol Life Sci. 2024 Jul 27;81(1):314.

24. Okuzono S, Fujii F, Setoyama D, Taira R, Shinmyo Y, Kato H, Masuda K, Yonemoto K, Akamine S, Matsushita Y, Motomura Y, Sakurai T, Kawasaki H, Han K, Kato TA, Torisu H, Kang D, Nakabeppu Y, Ohga S, Sakai Y. An N-terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice. Genes Cells. 2024 Sep;29(9):746-756.

25. Fujii F, Kanemasa H, Okuzono S, Setoyama D, Taira R, Yonemoto K, Motomura Y, Kato H, Masuda K, Kato TA, Ohga S, Sakai Y. ATP1A3 regulates protein synthesis for mitochondrial stability under heat stress. Dis Model Mech. 2024 Jun 1;17(6):dmm050574.

2023

26. Song X, Nihashi Y, Yamamoto K, Setoyama D, Kunisaki Y, Kida Y. Exploring the role of desmoplastic physical stroroma in pancreatic cancer progression using a three-dimensional collagen matrix model. Bioengineering. 2023 Dec 18;10(12):1437.

27. Nakashima K, Kunisaki Y, Hosokawa K, Gotoh K, Yao H, Yuta R, Semba Y, Nogami J, Kikushige Y, Stumpf PS, MacArthur BD, Kang D, Akashi K, Ohga S, Arai F. POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis. Commun Biol. 2023 Sep 29;6(1):996.

28. Irifune H, Kochi Y, Miyamoto T, Sakoda T, Kato K, Kunisaki Y, Akashi K, Kikushige Y. GPAM mediated lysophosphatidic acid synthesis regulates mitochondrial dynamics in acute myeloid leukemia.  Cancer Sci. 2023 May 17. doi: 10.1111/cas.15835. 

29. Murakami K, Hamazaki N, Hamada N, Nagamatsu G, Okamoto I, Ohta H, Nosaka Y, Ishikura Y, Kitajima TS, Semba Y, Kunisaki Y, Arai F, Akashi K, Saitou M, Kato K, Hayashi K. Generation of functional oocytes from male mice in vitro. Nature. 2023 Mar;615(7954):900-906. doi: 10.1038/s41586-023-05834-x.

30. Sakoda T, Kikushige Y, Miyamoto T, Irifune H, Harada T, Hatakeyama K, Kunisaki Y, Kato K, Akashi K. TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia. Blood Adv. 2023 Feb 6:bloodadvances.2022008405. doi: 10.1182/bloodadvances.2022008405. 

31. Taniguchi S, Utsumi S, Kochi Y, Taya Y, Mori Y, Semba YI, Sugio T, Miyawaki K, Kikushige Y, Kunisaki Y, Yoshimoto G, Numata A, Kato K, Uchida N, Maeda T, Miyamoto T, Taniguchi S, Akashi K. Successful pseudo-autologous stem cell transplantation for donor-derived Burkitt lymphoma occurring 9 years after allogeneic transplantation. Int J Hematol. 2023 Feb;117(2):287-292. doi: 10.1007/s12185-022-03458-x. 

32. Yagi M, Do Y, Hirai H, Miki K, Toshima T, Fukahori Y, Setoyama D, Abe C, Nabeshima YI, Kang D, Uchiumi T. Improving lysosomal ferroptosis with NMN administration protects against heart failure. Life Sci Alliance. 2023 Oct 4;6(12):e202302116.

33. Sada M, Matsushima S, Ikeda M, Ikeda S, Okabe K, Ishikita A, Tadokoro T, Enzan N, Yamamoto T, Miyamoto HD, Tsutsui Y, Miyake R, Setoyama D, Kang D, Ide T, Tsutsui H. IFN-γ-STAT1-ERK Pathway Mediates Protective Effects of Invariant Natural Killer T Cells Against Doxorubicin-Induced Cardiomyocyte Death. JACC Basic Transl Sci. 2023 Jun 21;8(8):992-1007.

34. Nihashi Y, Song X, Yamamoto M, Setoyama D, Kida YS. Decoding Metabolic Symbiosis between Pancreatic Cancer Cells and Cancer-Associated Fibroblasts Using Cultured Tumor Microenvironment. Int J Mol Sci. 2023 Jul 3;24(13):11015. doi: 10.3390/ijms241311015.

35. Ueda S, Yagi M, Tomoda E, Matsumoto S, Ueyanagi Y, Do Y, Setoyama D, Matsushima Y, Nagao A, Suzuki T, Ide T, Mori Y, Oyama N, Kang D, Uchiumi T. Mitochondrial haplotype mutation alleviates respiratory defect of MELAS by restoring taurine modification in tRNA with 3243A > G mutation. Nucleic Acids Res. 2023 Jul 13:gkad591. doi: 10.1093/nar/gkad591.

36. Choi J, Matoba N, Setoyama D, Watanabe D, Ohnishi Y, Yasui R, Kitai Y, Oomachi A, Kotobuki Y, Nishiya Y, Pieper MP, Imamura H, Yanagita M, Yamamoto M. The SGLT2 inhibitor empagliflozin improves cardiac energy status via mitochondrial ATP production in diabetic mice. Commun Biol. 2023 Mar 17;6(1):278. doi: 10.1038/s42003-023-04663-y.

37. Takenaka T, Ohnishi Y, Yamamoto M, Setoyama D, Kishima H. Glycolytic System in Axons Supplement Decreased ATP Levels after Axotomy of the Peripheral Nerve. eNeuro. 2023 Mar 20;10(3):ENEURO.0353-22.2023. doi: 10.1523/ENEURO.0353-22.2023.

38. Okuzono S, Fujii F, Matsushita Y, Setoyama D, Shinmyo Y, Taira R, Yonemoto K, Akamine S, Motomura Y, Sanefuji M, Sakurai T, Kawasaki H, Han K, Kato TA, Torisu H, Kang D, Nakabeppu Y, Sakai Y, Ohga S. Shank3a/b isoforms regulate the susceptibility to seizures and thalamocortical development in the early postnatal period of mice. Neurosci Res. 2023 Mar 5:S0168-0102(23)00051-2. doi: 10.1016/j.neures.2023.03.001.

39. Wakeham D, Ivey E, Saland S, Lewis J, Palmer D, Morris M, Bleich J, Weyand P, Brazile P, Hearon CJr., Sarma S, MacNamara J,Hieda M, and Levine DB The effects of synchronizing foot strike and cardiac phase on exercise hemodynamics in patients with cardiac resynchronization therapy: a within-subjects pilot-study to fine-tune cardio-locomotor coupling for heart failure Circulation 2023 (in Press) 

40. MacNamara J, Dias K, Hearon C Jr., Ivey E, Delgado V, Saland S, Samels M, Hieda M, Turer A, Link M, Sarma S, Levine DBRandomized Controlled Trial of Moderate and High Intensity Exercise Training in Patients with Hypertrophic Cardiomyopathy: Effects on Fitness and Cardiovascular Response to Exercise Journal of American Heart Association 2023 (in Press) 

41. Futami S, Hieda M, Fukata M, Shiose A. A rare case of cardiac myxoma with light bulb-like cystic morphology: a case report. Eur Heart J Case Rep. 2023;7:ytad331. PMID: 37547377 

42. Sarma S, MacNamara JP, Hieda M, et al. SERCA2a Agonist Effects on Cardiac Performance During Exercise in Heart Failure With Preserved Ejection Fraction. JACC: Heart Failure;2023;11:760-771.

43. Sato T, Hieda M, Futami S, Fukata M, Shiose A. Evaluation of coronary flow is useful in patients with left coronary cusp thrombus formation after left ventricular assist device implantation. European Heart Journal - Case Reports 2023;7:ytad025.
    * Corresponding author 

44. McKenna ZJ, Moralez G, Romero SA, Hieda M, Huang M, Cramer MN, Sarma S, MacNamara JP, Jaffery MF, Atkins WC, Foster J, Crandall CG.　Cardiac Remodeling in Well-Healed Burn Survivors after Six Months of Unsupervised Progressive Exercise Training　Journal of Applied Physiology 2023 Jan 12.

45. Maruyama T, Hieda M, Eiraku K, Uozumi Y, Nomura H Constipation and heart failure: An overlooked but important linkage.Geriatrics & Gerontology International 2023 Jan 25.

46. Nishida R, Eriguchi Y, Miyake N, Nagasaki Y, Yonekawa A, et al: Breakthrough candidemia with hematological disease: Results from a single-center retrospective study in Japan, 2009–2020. Medical Mycology 61 (6): myad056, 2023