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Researches

Epigenetic histone modification research

Histone proteins and the nucleosomes are the fundamental building blocks of eukaryotic chromatin. A diverse array of post-translational modifications (PTMs) of histones has been well documented, such as acetylation, methylation, phosphorylation and ubiquitination, etc.

Epigenetic non-histone modifications

Modification of non-histone proteins is involved in various cellular pathways including in the development and progression of various diseases including cancers. An increasing number of non-histone protein substrates are being modified by various histone modifiers.

Epigenetic regulation of leukemogenesis and leukemia cell differentiation

We tried to identify mechanisms of leukemia cell differentiation using ChIP-seq, microarray, and global histone medication changes for combinational effects of leukemia cell differentiation.

Recent Publications

2026

Lim, Y., Jeong, A., Kwon, D. H., Lee, Y. G., Lee, Y. U., Cho, H. J., Kee, H. J., Yoon, S., Yoon, H. G., Kim, Y., Seo, S. B., Nam, K. I., Eom, G. H., Ahn, Y., Yong, J., Kim, Y. K., & Kook, H.* (2026). Loss of p300/CBP-associated factor aggravates cardiac remodeling via regulation of CAMKK2 acetylation. Exp Mol Med., 58(4), 1297–1310. [PubMed] (*Corresponding authors)
Park, J., Kim, Y., Park, H., Yun, G., & Seo, S. B.* (2026). Anticancer agent FTY720 upregulates cell cycle regulator BTG2 via the SET/TAF-Iβ-PP2A-SMAD3 signaling pathway and induces G2/M arrest in leukemia. Genes Genomics., 48(4), 549–558. [PubMed] (*Corresponding author)

2025

Jung, C., Park, J., & Seo, S. B.* (2025). E3 ligase MIB1 regulates STAT1/P21 signaling via regulation of FGFR1 in colorectal cancer. Genes Genomics., 47(6), 663–670. [PubMed] (*Corresponding author)

2024

An, M. J., Kim, J. Y., Kim, J., Kim, D. H., Shin, G. S., Lee, H. M., Jo, A. R., Park, Y., Hwangbo, Y., Kim, C. H., Kim, M. J., Jung, Y. S., Kim, J., Rhee, S., Seo, S. B., and Kim, J. W.* (2024). Reorganization of H3K9me heterochromatin leads to neuronal impairment via the cascading destruction of the KDM3B-centered epigenomic network. iScience., 27(8), 110380. [PubMed] (*Corresponding authors)
Lee, S. Y., Park, J. and Seo, S. B.* (2024). Negative regulation of HDAC3 transcription by histone acetyltransferase TIP60 in colon cancer. Genes Genomics., 46(7), 871–879. [PubMed] (*Corresponding author)

2023

Park, J., Luo, Y., Park, J.W., Kim, S.H., Hong, Y.J., Lim, Y., Seo, Y.J., Bae, J. and Seo, S.B.* (2023). Downregulation of DNA methylation enhances differentiation of THP‑1 cells and induces M1 polarization of differentiated macrophages. Sci Rep., 13(1):13132. [PubMed] (*Corresponding author)
Park, J.†, Kim, J.Y.†, Park, J.W., Kang, J.Y., Oh, H., Hahm, J.Y., Chae, Y.C., Chakravarti, D. and Seo, S.B.* (2023). INHAT subunit SET/TAF-Iβ regulates PRC1 independent H2AK119 mono-ubiquitination via E3 ligase MIB1 in colon cancer. NAR Cancer., 5(3). [PubMed] (†Co-first authors, *Corresponding author)

2022

Hong, Y.J., Park, J., Hahm, J.Y., Kim, S.H., Lee, D.H., Park, K.S. and Seo, S.B.* (2022). Regulation of UHRF1 acetylation by TIP60 is important for colon cancer cell proliferationDM2B and SET7 in the regulation of skeletal muscle differentiation. Genes Genomics., 44(11):1353-1361. [PubMed] (*Corresponding author)
Kim, S.H., Park, J., Park, J.W., Hahm, J.Y., Yoon, S., Hwang, I.J., Kim, K.P. and Seo, S.B.* (2022). SET7-mediated TIP60 methylation is essential for DNA double-strand break repair. BMB Rep., 55(11):541-546. [PubMed] (*Corresponding author)
Hwang, I.J.†, Park, J.† and Seo, S.B.* (2022). Non-canonical transcriptional regulation of INHAT subunit SET/TAF-Iβ by EZH2 . Biochem Biophys Res Commun., 635:136-143. [PubMed] (†Co-first authors, *Corresponding author)

2021

Kwon, D.H.†, Kang, J.Y.†, Joung, H.†, Kim, J.Y., Jeong, A., Min, H.K., Shin, S., Lee, Y.G., Kim, Y.K., Seo, S.B.* and Kook, H.* (2021). SRF is a nonhistone methylation target of KDM2B and SET7 in the regulation of skeletal muscle differentiation. Exp Mol Med., 53(2):250-263. [PubMed] (†Co-first authors, *Corresponding authors)
Kim, H.J., Park, J.W., Kang, J.Y. and Seo, S.B.* (2021). Negative regulation of erythroid differentiation via the CBX8-TRIM28 axis. Mol Cells., 44(7):444-457. [PubMed] (*Corresponding author)
Kang, J.Y.†, Park, J.W.†, Hwang, Y.†, Hahm, J.Y., Park, J., Park, K.S. and Seo, S.B.* (2021). The H3K4 methyltransferase SETD1A is required for proliferation of non-small lung cancer cells by promoting S-phase progression. Biochem Biophys Res Commun., 561:120-127. [PubMed] (†Co-first authors, *Corresponding author)

2020

Hahm, J.Y.†, Kang, J.Y.†, Park, J.W., Jung, H. and Seo, S.B.* (2020). Methylated-UHRF1 and PARP1 interaction is critical for homologous recombination. BMB Rep., 53(2), 112-117. [PubMed] (†Co-first authors, *Corresponding author)
Jung, H. and Seo, S.B.* (2020). Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes. PLoS One., 15(7), e0236403. [PubMed] (*Corresponding author)
Hahm, J.Y., Park, J.W., Kang, J.Y., Park, J., Kim, C.H., Kim, J.Y., Ha, N.C., Kim, J.W. and Seo, S.B.* (2020). Acetylation of UHRF1 Regulates Hemi-methylated DNA Binding and Maintenance of Genome-wide DNA Methylation. Cell Rep., 32(4), 107958. [PubMed] (*Corresponding author)
Park, J.W., Kang, J.Y., Hahm, J.Y., Kim, H.J. and Seo, S.B.* (2020). Proteosomal degradation of NSD2 by BRCA1 promotes leukemia cell differentiation. Commun Biol., 3(1), 462. [PubMed] (*Corresponding author)
Kang, J.Y., Park, J.W., Hahm, J.Y., Jung, H. and Seo, S.B.* (2020). Histone H3K79 demethylation by KDM2B facilitates proper DNA replication through PCNA dissociation from chromatin. Cell Prolif., e12920. [PubMed] (*Corresponding author)

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