Epigenetic histone modification research

Histone proteins and the nucleosomes are the fundamental building blocks of eukaryotic chromatin. A diverse array of post-translational modifications (PTMs) of histones has been well documented, such as acetylation, methylation, phosphorylation and ubiquitination, etc.

Epigenetic non-histone modifications

Modification of non-histone proteins is involved in various cellular pathways including in the development and progression of various diseases including cancers. An increasing number of non-histone protein substrates are being modified by various histone modifiers.

Epigenetic regulation of leukemogenesis and leukemia cell differentiation

We tried to identify mechanisms of leukemia cell differentiation using ChIP-seq, microarray, and global histone medication changes for combinational effects of leukemia cell differentiation.