Publications

Plant immune resilience to a changing climate: Molecular insights and biotechnological roadmaps

Castroverde, C.D.M., Kuan, C. and Kim, J.H. (2024) Plant immune resilience to a changing climate: Molecular insights and biotechnological roadmaps. Genome. doi: https://doi.org/10.1139/gen-2024-0088.

• Selected as 1 of 5 articles for the Genome 2024 Publication Awards

• #1 of all outputs of the same age in Genome (Altmetric)

Distinct profiles of plant immune resilience revealed by natural variation in warm temperature-modulated disease resistance among Arabidopsis accessions

Rossi, C.A.M.*, Patel, D.N.* and Castroverde, C.D.M. (2024) Distinct profiles of plant immune resilience revealed by natural variation in warm temperature-modulated disease resistance among Arabidopsis accessions. Plant, Cell & Environment. doi: https://doi.org/10.1111/pce.15098. Preprinted in bioRxiv. *Lab students/trainees

• In the top 25% of all outputs ever tracked (Altmetric)

• #7 of all outputs of the same age in Plant, Cell & Environment

• Source datasets in Borealis Data Repository

Natural allelic diversity of the calcium signaling regulators in plants

Kim, Y., Castroverde, C.D.M. and Kim, J.H. (2024) Natural allelic diversity of the calcium signaling regulators in plants. Molecules and Cells. doi: https://doi.org/10.1016/j.mocell.2024.100104.

• #3 of all outputs of the same age in Molecules & Cells (Altmetric)

The plant disease triangle facing climate change: a molecular perspective

Roussin-Léveillée, C., Rossi, C.A.M.*, Castroverde, C.D.M.** and Peter Moffett** (2024) The plant disease triangle facing climate change: a molecular perspective. Trends in Plant Science. doi: https://doi.org/10.1016/j.tplants.2024.03.004.  *Lab students/trainees; **Co-corresponding authors

• In the top 5% of all outputs ever tracked (Altmetric)

• #1 of all outputs of the same age in Trends in Plant Science (Altmetric)

• Scholars Common link here

NeuroFold: A Multimodal Approach to Generating Novel Protein Variants in silico

Amani, K.*, Fish, M., Smith, M.D. and Castroverde, C.D.M. (2024) NeuroFold: A Multimodal Approach to Generating Novel Protein Variants in silico. Preprinted in bioRxiv. *Lab students/trainees

• In the top 25% of all outputs ever tracked (Altmetric)

Warm temperature suppresses plant systemic acquired resistance by intercepting N-hydroxypipecolic acid biosynthesis

Shields, A.*, Yao, L., Rossi, C.A.M.*, Collado Cordon, P., Kim, J.H., Mudher, W.*, Li, S., Marchetta, E.*, Shivnauth, V.*, Chen, T., He, S.Y., Xin, X.F. and Castroverde, C.D.M. (2024) Warm temperature suppresses plant systemic acquired resistance by intercepting N-hydroxypipecolic acid biosynthesis. Preprinted in bioRxiv. *Lab students/trainees

• In the top 25% of all outputs ever tracked (Altmetric)

25 Years of thermomorphogenesis research: milestones and perspectives

Quint, M., Delker, C., ... Castroverde, C.D.M., ... and van Zanten, M. (2023) 25 Years of thermomorphogenesis research: milestones and perspectives. Trends in Plant Science. doi: https://doi.org/10.1016/j.tplants.2023.07.001. 

• In the top 5% of all outputs ever tracked (Altmetric)

• Science Direct link here

Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions

Rossi, C.A.M.*, Marchetta, E.J.R.*, Kim, J.H. and Castroverde, C.D.M. (2023) Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions. Trends in Biochemical Sciences. doi: https://doi.org/10.1016/j.tibs.2023.05.004. *Lab students/trainees

• Featured on the cover of the August 2023 journal issue:

• In the top 10% of all outputs ever tracked (Altmetric)

• Science Direct link here

• Scholars Common link here

Structural diversity and stress regulation of the plant immunity-associated CALMODULIN-BINDING PROTEIN 60 (CBP60) family of transcription factors in Solanum lycopersicum (tomato)

Shivnauth, V.*, Pretheepkumar, S.*, Marchetta, E.J.R.*, Rossi, C.A.M.*, Amani, K.* and Castroverde, C.D.M. (2023) Structural diversity and stress regulation of the plant immunity-associated CALMODULIN-BINDING PROTEIN 60 (CBP60) family of transcription factors in Solanum lycopersicum (tomato).  Functional and Integrative Genomics. doi: https://doi.org/10.1007/s10142-023-01172-3. Preprinted in bioRxiv. *Lab students/trainees

• In the top 25% of all outputs ever tracked (Altmetric)

• Altmetric link for final published version

• Scholars Common link here

CBP60-DB: An AlphaFold-predicted plant kingdom-wide database of the CALMODULIN-BINDING PROTEIN 60 (CBP60) protein family with a novel structural clustering algorithm

Amani, K.*, Shivnauth, V.* and Castroverde, C.D.M. (2023) CBP60-DB: An AlphaFold-predicted plant kingdom-wide database of the CALMODULIN-BINDING PROTEIN 60 (CBP60) protein family with a novel structural clustering algorithm. Plant Direct. doi: https://doi.org/10.1002/pld3.509. Prepinted in bioRxiv. *Lab students/trainees

• In the top 25% of all outputs ever tracked (Altmetric)

• Altmetric link for final published version

• CBP60-DB Website

• Scholars Common link here

Increasing the resilience of plant immunity to a warming climate

Kim, J.H.*, Castroverde, C.D.M.*, Huang, S., Li, C., Hilleary, R., Seroka, A., Sohrabi, R., Medina-Yerena, D., Huot, B., Wang, J., Nomura, K., Marr, S.K., Wildermuth, M.C., Chen, T., MacMicking, J.D., and He, S.Y. (2022) Increasing the resilience of plant immunity to a warming climate. Nature. https://doi.org/10.1038/s41586-022-04902-y. *Co-first authors

• In the top 1% of all research outputs ever tracked and top 5% of outputs from Nature (Altmetric)

• Recommended "Exceptional" in Faculty Opinions

• Featured in Nature Reviews Molecular Cell Biology: Focus on "Plant stress responses"

• Highlighted in Cell Research: Sustaining plant immunity in rising temperature

• Highlighted in Trends in Plant Science: Too hot to defend: a tale of salicylic acid

• Highlighted in Trends in Microbiology: Shedding light on immune suppression at high temperature

• Highlighted in Life Metabolism: Impaired condensate formation is to blame for failed disease resistance in plants

• Highlighted in Molecules and Cells: How Does Global Warming Sabotage Plant Immunity?

• Highlighted in Laurier News Hub: New discovery by Laurier researcher may strengthen resilience of plants in a warming climate

• Highlighted in The Toronto Star: Laurier professor working to make plants more heat-resilient amid rising temperatures

• Highlighted in Duke Today: Climate Change is Making Plants More Vulnerable to Disease. New Research Could Help Them Fight Back

• Highlighted in HHMI News: A Souped-Up Gene Promoter Stops Heat from Sapping Plant Defenses

• Highlighted in NPR Science Friday: Can Genetic Modification Help Plants Survive Climate Change?

• Highlighted in ASPB Plantae Network: Increasing the resilience of plant immunity to a warming climate

• Highlighted in The Record Waterloo: Laurier professor working to make plants more heat-resilient amid rising temperatures

• Highlighted in The Independent: Scientists engineer heatwave-resistant plants to help them survive climate change

• Highlighted in MIT Technology Review: Heat is bad for plant health. Here’s how gene editing could help.

• Highlighted in WIRED Magazine: Climate Change Breaks Plant Immune Systems. Can They Be Rebooted?

• Highlighted in City News Kitchener: New discovery by Laurier researcher may help plants be more resilient to warming climate

• Highlighted in Cosmos Magazine: Genetic discovery may help plants survive heatwaves

• Highlighted in Genetic Engineering and Biotechnology News: Safeguarding Plant Immunity against Climate Change

• Highlighted in Earth.com: Plant immune defenses are weakened by rising temperatures

• Highlighted in Seed World: Scientists Discover Protein that Fights Heat Stress in Plants

• Highlighted in The Science Times: Bolstering Plant Immunity Vs Climate Change Could Help Plants Fight Back Diseases

• PubMed Central (Free) link here

• Scholars Common link here

Salicylic Acid and N-Hydroxypipecolic Acid at the Fulcrum of the Plant Immunity-Growth Equilibrium

Shields, A.*, Shivnauth, V.* and Castroverde, C.D.M. (2022) Salicylic Acid and N-Hydroxypipecolic Acid at the Fulcrum of the Plant Immunity-Growth Equilibrium.  Frontiers in Plant Science. https://www.frontiersin.org/articles/10.3389/fpls.2022.841688/abstract. *Lab students/trainees

• Highlighted in Frontiers in Plant Science Editorial: On the frontier of a plant’s dilemma: Exploring the molecular basis of growth versus defense antagonism

• In the top 10% of all outputs ever tracked (Altmetric)

• PubMed Central (Free) link here

• Scholars Common link here

Salicylic acid: A key regulator of redox signalling and plant immunity

Saleem, M., Fariduddin, Q. and Castroverde, C.D.M. (2021) Salicylic acid: A key regulator of redox signalling and plant immunity.  Plant Physiology and Biochemistry. 168:381–397.

• #5 of all outputs of the same age in Plant Physiology and Biochemistry (Altmetric)

• Scholars Common link here

Molecular Mechanisms of Nitric Oxide (NO) Signaling and Reactive Oxygen Species (ROS) Homeostasis during Abiotic Stresses in Plants

Wani, K.I., Naeem, M., Castroverde, C.D.M., Kalaji, H.M., Albaqami, M. and Aftab, T. (2021) Molecular Mechanisms of Nitric Oxide (NO) Signaling and Reactive Oxygen Species (ROS) Homeostasis during Abiotic Stresses in Plants.  International Journal of Molecular Sciences. 22:9656.

• PubMed Central (Free) link here

• Scholars Common link here

Temperature regulation of plant hormone signaling during stress and development

Castroverde, C.D.M. and Dina, D. (2021) Temperature regulation of plant hormone signaling during stress and development.  Journal of Experimental Botany, erab257. 

• Highlighted in JXB Special Issue: High and low temperature signalling and response

• Showcased in the Celebrating Laurier Achievements 2022 Event

• In the top 25% of all research outputs ever tracked (Altmetric)

• Scholars Common link here

Mechanistic Insights into Strigolactone Biosynthesis, Signaling, and Regulation During Plant Growth and Development

Wani, K.I., Zehra, A., Choudhary, S., Naeem, M., Khan, M.M.A., Castroverde, C.D.M. and Aftab, T. (2020) Mechanistic Insights into Strigolactone Biosynthesis, Signaling, and Regulation During Plant Growth and Development. Journal of Plant Growth Regulation. 40:1836–1852. 

• #1 of all outputs of the same age in the Journal of Plant Growth Regulation (Altmetric)

• Scholars Common link here

Diversity, Function and Regulation of Cell Surface and Intracellular Immune Receptors in Solanaceae

Kim, J.H. and Castroverde, C.D.M. (2020) Diversity, Function and Regulation of Cell Surface and Intracellular Immune Receptors in Solanaceae. Plants. 9:434.

• In the top 25% of all research outputs ever tracked (Altmetric)

• PubMed Central (Free) link here

• Scholars Common link here

Wounding induces tomato Ve1 R-gene expression

Nazar, R.N., Castroverde, C.D.M., Xu, X., Kurosky, A. and Robb, J. (2019) Wounding induces tomato Ve1 R-gene expression. Planta. 249:1779-1797.

It’s an uphill battle: The MYB59-NPF7.3 regulatory module and its role in nutrient transport

Castroverde, C.D.M. (2019) It’s an uphill battle: The MYB59-NPF7.3 regulatory module and its role in nutrient transport. Plant Cell. 31:561-562.

Differential repression of the Ve R-genes in tomato

Castroverde, C.D.M., De Avila, L.G.M., Amaya Romero, V., Blaya-Fernandez, J., Nazar, R.N. and Robb, J. (2019) Differential repression of the Ve R-genes in tomato. Plant Gene. 18:100174.

The AREB1-ADA2b-GCN5 Complex Regulates Gene Expression during Drought Stress

Castroverde, C.D.M. (2018) The AREB1-ADA2b-GCN5 Complex Regulates Gene Expression during Drought Stress. Plant Cell 31:559-560.

Plant–pathogen warfare under changing climate conditions

Velásquez, A.C., Castroverde, C.D.M. and He, S.Y. (2018) Plant–pathogen warfare under changing climate conditions. Current Biology. 28:pR619–R634.

• Featured in The Economist: Understanding how crop diseases and climate change interact is vital

• Featured in National Geographic: ROTTING-FRUIT ART POINTS UP PLANTS IN PERIL

• Featured in Center for Strategic & International Studies: Plant Diseases and Pests Are Oft-Ignored Climate-Linked National Security Risks

• Featured in Medium: How CRISPR Can Help Combat the Effects of Climate Change

• In the top 2% of all research outputs ever tracked (Altmetric)

Worming into the Plant Chromatin: A Nematode Effector Influences Host Histone Acetylation

Castroverde, C.D.M. (2018) Worming into the Plant Chromatin: A Nematode Effector Influences Host Histone Acetylation. Plant Cell. 30:2883-2884. 

Plant Systemic Immunity Comes Full Circle: A Positive Regulatory Loop for Defense Amplification

Castroverde, C.D.M. (2018) Plant Systemic Immunity Comes Full Circle: A Positive Regulatory Loop for Defense Amplification. Plant Cell. 30:2238-2239. 

CDL1-OST1 Interaction as a Focal Point of Brassinosteroid-Abscisic Acid Hormone Signaling Crosstalk

Castroverde, C.D.M. (2018) CDL1-OST1 Interaction as a Focal Point of Brassinosteroid-Abscisic Acid Hormone Signaling Crosstalk. Plant Cell. 30:1668-1669.

Heat Trims the Fat: HIL1 Functions in Lipid Homeostasis

Castroverde, C.D.M. (2018) Heat Trims the Fat: HIL1 Functions in Lipid Homeostasis. Plant Cell. 30:1670-1671.

Dual impact of elevated temperature on plant defence and bacterial virulence in Arabidopsis

Huot, B., Castroverde, C.D.M., Velásquez, A., Hubbard, E., Pulman, J.A., Yao, J., Childs, K.L., Tsuda, K., Montgomery, B.L. and He, S.Y. (2017) Dual impact of elevated temperature on plant defence and bacterial virulence in Arabidopsis. Nature Communications. 8:1808.

• Featured in MSUToday News: FIGHTING PLANT DISEASE AT WARM TEMPERATURES KEEPS FOOD ON THE TABLE

• Featured in The Food Fix: Crops vs. Disease: How Heat changes Bio-Warfare

• Featured in Plantae Network: Plant Science Research Weekly

• Featured in Futurity: HIGH TEMPS POSE DOUBLE THREAT TO CROPS

• In the top 5% of all research outputs ever tracked (Altmetric)

Biotic factors that induce the tomato Ve1 R-gene

Castroverde, C.D.M., Xu, X., Nazar, R.N. and Robb, J. (2017) Biotic factors that induce the tomato Ve1 R-gene. Plant Science. 265:61-69.

Epistatic influence in tomato Ve1-mediated resistance

Castroverde, C.D.M., Xu, X., Blaya Fernández, J., Nazar, R.N. and Robb, J. (2017) Epistatic influence in tomato Ve1-mediated resistance. Plant Biology. 19:843-847.

Verticillium Ave1 effector induces defence genes independent of Ve1

Castroverde, C.D.M., Nazar, R.N. and Robb, J. (2016) Verticillium Ave1 effector induces defence genes independent of Ve1. Plant Signaling and Behavior. 11:e1245254.

Defense Genes in Tomato

Robb J., Nazar R.N. and Castroverde, C.D.M. (2010) Defense Genes in Tomato. Hauppage, New York: Nova Publishers.

Tomatoes: Agricultural Procedures, Pathogen Interactions and Health Effects (Chapter: Defense Genes in Tomato)

Castroverde, C.D.M., Nazar R.N. and Robb J. (2010) Defense genes in tomato. In Tomatoes: Agricultural Procedures, Pathogen Interactions and Health Effects. Hauppage, New York: Nova Publishers.

Patterns of defence gene expression in the tomato-Verticillium interaction

Robb, J., Castroverde, C.D.M., Shittu, H.O. and Nazar, R.N. (2009) Patterns of defence gene expression in the tomato-Verticillium interaction. Botany. 87:1-14.

Genetic dissection of Verticillium wilt resistance mediated by tomato Ve1

Fradin, E.F., Zhang, Z., Juarez-Ayala, J.C., Castroverde, C.D.M., Nazar, R.N., Robb, J., Liu, C.-M. and Thomma, B. (2009) Genetic dissection of Verticillium wilt resistance mediated by tomato Ve1. Plant Physiology. 150:320-332.

Plant-endophyte interplay protects tomato against a virulent Verticillium

Shittu, H.O., Castroverde, C.D.M., Nazar, R.N. and Robb, J. (2009) Plant-endophyte interplay protects tomato against a virulent Verticillium. Planta. 229:415-426.

Differential detection of vibrios pathogenic to shrimp by multiplex PCR

Castroverde, C.D.M., San Luis, B.B., Monsalud, R.G. and Hedreyda, C.T. (2006) Differential detection of vibrios pathogenic to shrimp by multiplex PCR. Journal of General and Applied Microbiology. 52:273-280.