Publications

2019

Ferreira AC, Castellano, JM. Leaving the lights on using gamma entrainment to protect against neurodegeneration. Neuron. 2019; 102(5):901-902. doi: 10.1016/j.neuron.2019.05.020.

Castellano JM. Blood-based therapies to combat aging. Gerontology. 2019;65(1):84-89. doi: 10.1159/000492573. PubMed PMID: 30196300.

2017

Castellano JM, Mosher KI, Abbey RJ, McBride AA, James ML, Berdnik D, Shen JC, Zou B, Xie XS, Tingle M, Hinkson IV, Angst MS, Wyss-Coray T. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature. 2017;544(7651):488-92. doi: 10.1038/nature22067. PubMed PMID: 28424512.

Czirr E, Castello NA, Mosher KI, Castellano JM, Hinkson IV, Lucin KM, Baeza-Raja B, Ryu JK, Li L, Farina SN, Belichenko NP, Longo FM, Akassoglou K, Britschgi M, Cirrito JR, Wyss-Coray T. Microglial complement receptor 3 regulates brain Abeta levels through secreted proteolytic activity. J Exp Med. 2017;214(4):1081-92. doi: 10.1084/jem.20162011. PubMed PMID: 28298456; PubMed Central PMCID: PMC5379986.

2016

Castellano JM, Palner M, Freeman GM, Li S, Nguyen A, Shen B, Stan T, Mosher KI, Chin F, de Lecea L, Luo J, Wyss-Coray T. In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model. Scientific reports. 2016;6:29015. doi: 10.1038/srep29015. PubMed PMID: 27364522; PubMed Central PMCID: PMC4929497.


Zhang X, Wang H, Antaris AL, Li L, Diao S, Ma R, Nguyen A, Hong G, Ma Z, Wang J, Zhu S, Castellano JM, Wyss-Coray T, Liang Y, Luo J, Dai H. Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore. Advanced materials. 2016;28(32):6872-9. doi: 10.1002/adma.201600706. PubMed PMID: 27253071; PubMed Central PMCID: PMC5293734.

2015

Castellano JM, Kirby ED, Wyss-Coray T. Blood-Borne Revitalization of the Aged Brain. JAMA neurology. 2015;72(10):1191-4. doi: 10.1001/jamaneurol.2015.1616. PubMed PMID: 26237737; PubMed Central PMCID: PMC4867550.


Shieh P, Dien VT, Beahm BJ, Castellano JM, Wyss-Coray T, Bertozzi CR. CalFluors: A Universal Motif for Fluorogenic Azide Probes across the Visible Spectrum. Journal of the American Chemical Society. 2015;137(22):7145-51. doi: 10.1021/jacs.5b02383. PubMed PMID: 25902190; PubMed Central PMCID: PMC4487548.

2014

Villeda SA, *Plambeck KE, *Middeldorp J, *Castellano JM, *Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo F, Wyss-Coray T. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med. 2014;20(6):659-63. doi: 10.1038/nm.3569. PubMed PMID: 24793238; PubMed Central PMCID: PMC4224436.


Baruch K, Deczkowska A, David E, Castellano JM, Miller O, Kertser A, Berkutzki T, Barnett-Itzhaki Z, Bezalel D, Wyss-Coray T, Amit I, Schwartz M. Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science. 2014;346(6205):89-93. doi: 10.1126/science.1252945. PubMed PMID: 25147279; PubMed Central PMCID: PMC4869326.


Luo J, Nguyen A, Villeda SA, Zhang H, Ding Z, Derek L, Bieri G, Castellano JM, Beaupre G, Wyss-Coray T. Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury. Front Neurol. 2014;5:12. doi: 10.3389/fneur.2014.00012. PubMed PMID: 24550885; PubMed Central PMCID: PMC3912443.


Mak A CY, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz J-M, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Miller BL, Jane JP, Kwok P-Y, Malloy MJ. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function. JAMA neurology. 2014;71(10):1228-36. doi: 10.1001/jamaneurol.2014.2011. PubMed PMID: 25111166; PubMed Central PMCID: PMC4714860.

2013

Verghese PB, Castellano JM, Garai K, Wang Y, Jiang H, Shah AR, Bu G, Frieden C, Holtzman DM. ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association in physiological conditions. Proc Natl Acad Sci U S A. 2013;110(19):E1807-16. doi: 10.1073/pnas.1220484110. PubMed PMID: 23620513; PubMed Central PMCID: PMC3651443.


Ulrich JD, Burchett III JM, Restivo JL, Schuler DR, Verghese PB, Mahan TE, Landreth GE, Castellano JM, Jiang H, Cirrito JR, Holtzman DM. In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis. Molecular neurodegeneration. 2013;8:13. doi: 10.1186/1750-1326-8-13. PubMed PMID: 23601557; PubMed Central PMCID: PMC3640999.

2012

Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti A, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM. Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Abeta clearance in a mouse model of beta-amyloidosis. Proc Natl Acad Sci U S A. 2012;109(38):15502-7. doi: 10.1073/pnas.1206446109. PubMed PMID: 22927427; PubMed Central PMCID: PMC3458349.

2011

Castellano JM, Kim J, Stewart FR, Jiang H, DeMattosRB, Patterson BW, FaganAM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM. Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance. Sci Transl Med. 2011;3(89):89ra57. doi: 10.1126/scitranslmed.3002156. PubMed PMID: 21715678; PubMed Central PMCID: PMC3192364.


Verghese PB, Castellano JM, Holtzman DM. Apolipoprotein E in Alzheimer's disease and other neurological disorders. Lancet Neurol. 2011;10(3):241-52. doi: 10.1016/S1474-4422(10)70325-2. PubMed PMID: 21349439; PubMed Central PMCID: PMC3132088.

2009

Kim J, Castellano JM, Jiang H, Basak J, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron. 2009;64(5):632-44. doi: 10.1016/j.neuron.2009.11.013. PubMed PMID: 20005821; PubMed Central PMCID: PMC2787195.