Microbiota-derived genotoxin tilimycin generates colonic stem cell mutations. 

Pöltl L, Kitsera M, Raffl S, Schild S, Cosic A, Kienesberger S, Unterhauser K, Raber G, Lembacher-Fadum C, Breinbauer R, Gorkiewicz G, Sebastian C, Hoefler G, Zechner EL

Cell Rep. 2023 Mar 2;42(3):112199. doi: 10.1016/j.celrep.2023.112199.

PMID: 36870054 

A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.

Sebastian C, Ferrer C, Serra M, Choi JE, Ducano N, Mira A, Shah MS, Stopka SA, Perciaccante AJ, Isella C, Moya-Rull D, Vara-Messler M, Giordano S, Maldi E, Desai N, Capen DE, Medico E, Cetinbas M, Sadreyev RI, Brown D, Rivera MN, Sapino A, Breault DT, Agar NYR, Mostoslavsky R.

Nat Commun. 2022 Mar 21;13(1):1503. doi: 10.1038/s41467-022-29085-y.

PMID: 35314684 

Sirtuins as metabolic regulators of immune cells phenotype and function

Fortuny L, Sebastian C. 

Genes (Basel). 2021 Oct 26;12(11):1698. doi: 10.3390/genes12111698.

PMID: 34828304

A unique subset of tumor-propagating cells drives squamous cell carcinoma

Choi JE, Sebastian C, Ferrer CM, Lewis CA, Sade-Feldman M, LaSalle T, Gonye A, Lopez BGC, Abdelmoula WM, Regan MS, Cetinbas M, Pascual G, Wojtkiewicz GR, Silveira GG, Boon R, Ross KN, Tirosh I, Saladi SV, Ellisen LW, Sadreyev RI, Benitah SA, Agar NYR, Hacohen N, Mostoslavsky R.

Nat Metab. 2021 Feb;3(2):182-195. doi: 10.1038/s42255-021-00350-6. Epub 2021 Feb 22.

PMID: 33619381

Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming.

Kowalik MA, Puliga E, Cabras L, Sulas P, Petrelli A, Perra A, Ledda-Columbano GM, Morandi A, Merlin S, Orrù C, Sanchez-Martin C, Fornari F, Gramantieri L, Parri M, Rasola A, Bellomo SE, Sebastian C, Follenzi A, Giordano S, Columbano A.

J Hepatol. 2020 Jun;72(6):1159-1169. doi: 10.1016/j.jhep.2019.12.018. Epub 2020 Jan 15.

PMID: 31954205

Metabolic pathways regulating colorectal cancer initiation and progression.

La Vecchia S, Sebastián C.

Semin Cell Dev Biol. 2019 May 27. pii: S1084-9521(18)30168-X. doi: 10.1016/j.semcdb.2019.05.018. [Epub ahead of print] Review.

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity.

Ioris RM, Galié M, Ramadori G, Anderson JG, Charollais A, Konstantinidou G, Brenachot X, Aras E, Goga A, Ceglia N, Sebastián C, Martinvalet D, Mostoslavsky R, Baldi P, Coppari R.

Cell Rep. 2017 Feb 21;18(8):1858-1868. doi: 10.1016/j.celrep.2017.01.065.

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.

Kugel S, Sebastián C, Fitamant J, Ross KN, Saha SK, Jain E, Gladden A, Arora KS, Kato Y, Rivera MN, Ramaswamy S, Sadreyev RI, Goren A, Deshpande V, Bardeesy N, Mostoslavsky R.

Cell. 2016 Jun 2;165(6):1401-1415. doi: 10.1016/j.cell.2016.04.033. Epub 2016 May 12.

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.

Kugel S, Feldman JL, Klein MA, Silberman DM, Sebastián C, Mermel C, Dobersch S, Clark AR, Getz G, Denu JM, Mostoslavsky R.

Cell Rep. 2015 Oct 20;13(3):479-488. doi: 10.1016/j.celrep.2015.09.022. Epub 2015 Oct 8.

The role of mammalian sirtuins in cancer metabolism.

Sebastián C, Mostoslavsky R.

Semin Cell Dev Biol. 2015 Jul;43:33-42. doi: 10.1016/j.semcdb.2015.07.008. Epub 2015 Jul 31. Review.

Tracking down the origin of cancer: metabolic reprogramming as a driver of stemness and tumorigenesis.

Sebastian C.

Crit Rev Oncog. 2014;19(5):363-82. Review.

Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.

Masri S, Rigor P, Cervantes M, Ceglia N, Sebastian C, Xiao C, Roqueta-Rivera M, Deng C, Osborne TF, Mostoslavsky R, Baldi P, Sassone-Corsi P.

Cell. 2014 Jul 31;158(3):659-72. doi: 10.1016/j.cell.2014.06.050.

SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.

Toiber D, Erdel F, Bouazoune K, Silberman DM, Zhong L, Mulligan P, Sebastian C, Cosentino C, Martinez-Pastor B, Giacosa S, D'Urso A, Näär AM, Kingston R, Rippe K, Mostoslavsky R.

Mol Cell. 2013 Aug 22;51(4):454-68. doi: 10.1016/j.molcel.2013.06.018. Epub 2013 Aug 1.

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine.

Jiang H, Khan S, Wang Y, Charron G, He B, Sebastian C, Du J, Kim R, Ge E, Mostoslavsky R, Hang HC, Hao Q, Lin H.

Nature. 2013 Apr 4;496(7443):110-3. doi: 10.1038/nature12038.

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R.

Cell. 2012 Dec 7;151(6):1185-99. doi: 10.1016/j.cell.2012.10.047.

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R.

Cell. 2010 Jan 22;140(2):280-93. doi: 10.1016/j.cell.2009.12.041.

Telomere shortening and oxidative stress in aged macrophages results in impaired STAT5a phosphorylation.

Sebastián C, Herrero C, Serra M, Lloberas J, Blasco MA, Celada A.

J Immunol. 2009 Aug 15;183(4):2356-64. doi: 10.4049/jimmunol.0901131. Epub 2009 Jul 15.

Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells.

Sebastián C, Serra M, Yeramian A, Serrat N, Lloberas J, Celada A.

J Immunol. 2008 May 1;180(9):5898-906.