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Color fundus photos and optical coherence tomography (OCT) of a wildtype (normal) frog retina (left) and a prom1-null mutant retina (right). Mutant retinas begin to form large deposits of cellular debris that resemble reticular pseudodrusen (RPD).
Inherited & Age-Related Retinal Degeneration
Inherited & Age-Related Retinal Degeneration
Publications
Carr BJ, Skitsko D, Song J, Kriese LM*, Li Z*, Ju MJ, Moritz OL. (2024). prominin-1-null Xenopus laevis develop subretinal drusenoid-like deposits, cone-rod dystrophy, and retinal pigment epithelium atrophy. J Cell Science. DOI: 10.1242/jcs.262298
A frog retina that has a mutation in the prom1 gene which causes structural breakdown of the photoreceptor outer segments. Rod outer segments are labelled in magenta, cone opsin is labelled in green, and nuclei are blue.
Photoreceptor Outer Segment Morphogenesis
Photoreceptor Outer Segment Morphogenesis
Publications
Carr BJ, Stanar P, Moritz OL. (2021). Distinct roles for prominin-1 and photoreceptor cadherin in outer segment disc morphogenesis in CRISPR-altered X. laevis. J Cell Sci. DOI: 10.1242/jcs.253906
Carr BJ, Yang LL, Moritz OL. (2019). Prominin-1 and photoreceptor cadherin localization in Xenopus laevis: Protein-protein relationships and function. Adv Exp Med Biol. 1185: 483-487. DOI: 10.1007/978-3-030-27378-1_79
Imaging Methods
Imaging Methods
Publications
Kothurkar A, Patient GS, Noel N, Krzywańska AM, Carr BJ, Chu CJ, MacDonald RB. (2024). Iterative Bleaching Extends Multiplexity (IBEX) imaging facilitates simultaneous identification of all cell types in the vertebrate retina. J Cell Science. DOI: 10.1242/jcs263407
A human eye labeled with markers for photoreceptor outer segments (magenta), nuclei (blue), and polySia (green).
Two chicks wearing a type of plastic diffuser goggle that is used to induce experimental myopia.
Myopia
Myopia
Publications
Carr BJ, Nguyen CT, Stell WK. (2019). Alpha2-adrenoceptor agonists inhibit form-deprivation myopia in the chick. Clin Exp Optom. DOI: 10.1111/cxo.12871. Invited research.
Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD. (2018). Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors in Vitro. Invest Ophthalmol Vis Sci. 1;59(7):2778-2791. DOI: 10.1167/iovs.17-22562
Carr BJ & Stell WK. (2016). Nitric Oxide (NO) Mediates the Inhibition of Form-Deprivation Myopia by Atropine in Chicks. Sci Rep, 6, 9, DOI: 10.1038/s41598-016-0002-7
Carr BJ & Stell WK. (2017). The Science Behind Myopia. Webvision: The Organization of the Retina and the Visual System. (Online)
McBrien NA, Stell WK, Carr BJ. (2013). How Does Atropine Exert its Anti-Myopia Effects? Ophthalmic Physiol Opt. 33(3): 373-8, DOI: 10.1111/opo.12052
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