http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40433498/?sort=date&direction=descending
2022
Evans S, Ma X, Wang X, Chen Y, Weinheimer CJ, Kovacs A, Finck BN, Diwan A, and Mann DL. 2022. Targeting the Autosomal-Lysosome Pathway in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure. JACC: Basic to Translational Science. In Press.
Singer JM, Shew TM, Ferguson D, Renkemeyer MK, Pietka TA, Hall AM, Finck BN, and Lutkewitte AJ. 2022. Monoacylglycerol O-acyltransferase 1 (Mogat1) is required for early adipocyte differentiation in vitro but does not affect adiposity in mice. Obesity (Silver Spring). 30:2122‐2133.
Njoku D, Schilling JD, and Finck BN. 2022. Mechanisms of Non-alcoholic Steatohepatitis-associated Cardiomyopathy: Key Roles for Liver-heart Crosstalk. Current Opinion in Lipidology. In Press. Review.
Yiew NKH and Finck BN. 2022. The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism. Am. J. Physiol: Endo Metab. 323: E33-E52. Review.
Colca JR and Finck BN. 2022. Metabolic mechanisms connecting Alzheimer’s and Parkinson’s Diseases: Potential avenues for novel therapeutic approaches. Front. Mol. Biosci. 9:929328. Review.
Martino MR, Gutiérrez-Aguilar M, Yiew NKH, Lutkewitte AJ, Singer JM, McCommis KS, Ferguson D, Liss KHH, Yoshino J, Renkemeyer MK, Smith GI, Cho K, Fletcher JA, Klein S, Patti GJ, Burgess SC, and Finck BN. 2022. Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids. Cell Reports. 39: 110733. [PMCID: PMC9123568]
Finck BN. 2022. Something to mTORC about in NASH. Cellular and Molecular Gastroenterology and Hepatology. 13:1843-1844. Editorial. [PMCID: PMC912356]
Rudnick DA, Huang J, Hidvegi T, Chu A, Hale P, Munanairi A, Dietzen D, Cliften P, Tycksen E, Lutkewitte AJ, Finck BN, Pak S, Silverman G, Perlmutter DH. 2022. Down-regulation of PGC1α by insulin signaling plays a key role in the hepatic proteotoxicity of misfolded α1-antitrypsin deficiency variant Z. Gastroenterology. 163:270-284.
Hegazy L, Gill LE, Pyles KD, Kaiho C, Kchouk SK, Finck BN, McCommis KS, and Elgendy B. 2022. Identification of novel mitochondrial pyruvate carrier inhibitors by homology modeling and pharmacophore-based virtual screening. Biomedicines. 10, 365. [PMCID: PMC8962382]
Hodges WT, Jarasvaraparn C, Ferguson D, Griffett K, Gill LE, Chen Y, Ilagan MXG, Hegazy L, Elgendy B, Cho K, Patti GJ, McCommis KM, Finck BN. 2022. Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet induced obese mice. J. Biol. Chem. 298: 101554. [PMCID: PMC8808181]
Zhang Y, Finck BN, and Debosch BJ. 2022. Driving arginine catabolism to activate systemic autophagy. Autophagy Rep. 1: 65-69. Commentary.
2021
Clemens MM, Kennon-McGill S, Vazquez JH, Stephens OW, Peterson EA, Johann DJ, Allard FD, Yee EU, McCullough SS, James LP, Finck BN, and McGill MR. 2021. Exogenous phosphatidic acid delays acetaminophen-induced liver injury in mice by increasing systemic interleukin-6. Acta Physiol. 11: 3836-3846. [PMCID: PMC8727922]
Hodges WT, Jarasvaraparn C, Ferguson D, Griffett K, Gill LE, Chen Y, Ilagan MXG, Hegazy L, Elgendy B, Cho K, Patti GJ, McCommis KM, Finck BN. 2021 Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet induced obese mice. J. Biol. Chem. 298: 101554. [PMCID: PMC8808181]
Fang Y, Hegazy L, Finck BN, and Elgendy B. 2021. Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor. J. Med. Chem. Review. 64:17545–17571.
Blackburn CMR, Schilke RM, Vozenilek AE, Finck BN, and Woolard MD. 2021. Macrophage-associated lipin-1 transcriptional co-regulatory is involved in atherosclerosis. Atherosclerosis. 330:76-84. [PMCID: PMC7877246]
Lutkewitte AJ, Singer JM, Shew TM, Martino MR, Hall AM, He M, and Finck BN. 2020. Antisense oligonucleotides against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1. Mol. Metab. 49:101204. [PMCID: PMC8027266]
Chambers KT*, Cooper MA*, Swearingen AR, Brookheart RT, Schweitzer GG, Weinheimer CJ, Kovacs A, Koves TR, Muoio DM, McCommis KS, and Finck BN. 2021. Myocardial lipin 1 knockout in mice approximates the cardiac effects of human LPIN1 mutations. JCI Insight. 6:e134340. [PMCID: PMC8262319]
Ferguson D and Finck BN. 2021. Novel therapeutics for treating NAFLD, type 2 diabetes, and cardiometabolic disease. Nat. Rev. Endocrinol. 17:484–495 Review. [PMCID: PMC8570106]
Liss KHH, Ek SE, Lutkewitte AJ, Pietka TA, He M, Skaria P, Tycksen E, Ferguson D, Graham MJ, Hall AM, McGill MR, McCommis KS, and Finck BN. 2021. Monoacylglycerol acyltransferase 1 knockdown exacerbates hepatic ischemia-reperfusion injury in mice with hepatic steatosis. Liver Transplantation. 27:116-133. [PMCID: PMC7785593]
Daemen S, Gainullina A, Kalugotla G, He L, Chan MM, Beals JW, Liss KHH, Klein S, Feldstein AE, Finck BN, Artyomov MN, and Schilling JD. 2021. Dynamic interplay between resident and recruited macrophage subsets in NASH. Cell Rep. 34:108626 [PMCID: PMC7877246].
Franczyk MP, Qi N, Stromsdorfer KL, Li C, Yamaguchi S, Itoh H, Yoshino M, Sasaki Y, Brookheart RT, Finck BN, DeBosch BJ, Klein S, and Yoshino J. 2021. The importance of adipose tissue NAD+ biology in regulating metabolic flexibility. Endocrinology. 62:bqab006 [PMCID: PMC7853299].
2020
McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, King MT, Veech RL, DeBosch BJ, Muoio DM, Gross RW, and Finck BN. 2020. Nutritional modulation of heart failure in mitochondrial pyruvate carrier deficient mice. Nature Metabolism. 2:1232-1247. [PMCID: pending]
Lutkewitte AJ and Finck BN. 2020. Regulation of signaling and metabolism by lipin-mediated phosphatidic acid phosphohydrolase activity. Biomol. 10:1386. Review. [PMCID: PMC7600782]
Shilke RM, Blackburn CMR, Rao S, Krzywanski D, Finck BN, and Woolard MD. 2020. Lipin-1 regulates lipid catabolism in pro-resolving macrophages. Immunohorizons. 4:659-669.
Chandran S, Schilke RM, Blackburn CMR, Yuochko A, Mirza R, Scott RS, Finck BN, and Woolard MD. 2020. Lipin-1 contributes to IL-4 mediated macrophage polarization. Front Immunol. 11:787 doi:10.3389 [PMCID: PMC7214697]
Gansemer ER, McCommis KS, Martino M, King-McAlpin AQ, Potthoff MJ, Finck BN, Taylor EB, and Rutkowski DT. 2020. NADPH and glutathione redox link TCA cycle activity to ER stress. iScience. 23:101116. doi: 10.1016. [PMCID: PMC7254477]
Kading J, Finck BN, and DeBosch BJ. 2020. Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction. FEBS J. doi:10.1111/febs.15482. Review. [PMCID: pending]
2019
Schweitzer GG, Collier SL, Chen Z, McCommis KS, Pittman SK, Yoshino J, Matkovich SJ, Hsu F, Chrast R, Eaton JM, Harris TE, Weihl CC, Finck BN. 2019. Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice. FASEBJ. 33:652-667. [PMCID: PMC6355067]
Lutkewitte AJ, McCommis KS, Chambers KT, Schweitzer GG, Graham MJ, Wang L, Patti GJ, Hall AM, and Finck BN 2019. Mogat1 is a fasting-induced PPARα target gene that plays a role in coordinating the hepatic response to food deprivation. J. Lipid Res. 60:528-538. [PMCID: PMC6399500]
Clemens MM, Kennon-McGill S, Apte U, Finck BN, and McGill MR. 2019. The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by inhibiting GSK3β and supporting Wnt/β-catenin signaling. Food Chem Tox. 125:279-288. [PMCID: PMC6443093]
Cao T, Liccardo D, LaCanna R, Zhang X, Lu R, Finck BN, Chen X, Drosatos K, and Tian Y. 2019. Fatty acid oxidation promotes cardiomyocyte proliferation rate but does not change cardiomyocyte in infant mice. Front Cell Devel Biol 7:42. [PMCID: PMC6440456]
Aatsinki S-M, Elkhwanky M-S, Kummu O, Karpale M, Buler M, Viitala P, Rinne V, Mutikainen M, Tavi P, Franko A, Chambers KT, Finck BN, and Hakkola J. 2019. Fasting-induced transcription factors repress vitamin D bioactivation, a mechanism for vitamin D deficiency in diabetes. Diabetes. 68:918–931. [PMCID: PMC6477896]
Schweitzer GG, Gan C, Bucelli RC, Shinawi M, Finck BN, and Brookheart RT. 2019. A mutation in Site-1 Protease is associated with a complex phenotype that includes episodic hyperCKemia and focal myoedema. Mol Genet Genom Medicine. 7:e007733 [PMCID: PMC6625134]
Gao GS, Ghoshal S, Stevens JR, Zhang L, Kumar KG, McCommis KS, Finck BN, Lopaschuk GD, and Butler AA. 2019. Adropin treatment ameliorates dysregulation of liver glucose metabolism in diet-induced obese mice. J. Biol. Chem. 294:13366-13377. [PMCID: PMC6737218]
McCommis KS and Finck BN. 2019. Treating Hepatic Steatosis and Fibrosis by Modulating Mitochondrial Pyruvate Metabolism. Cell Mol Gastroenterol Hepatol.7:275-284. Review. [PMCID: PMC6352854]
Lutkewitte AJ, Burgess SC, and Finck BN. 2019. Fatty acid desaturation gets a NAD+ reputation. Cell Metab. 29:790-792. Preview. [PMCID: N/A]
2018
Chen Y, McCommis KS, Ferguson D, Hall AM, Harris CA, and Finck BN. 2018. Inhibition of the mitochondrial pyruvate carrier by tolylfluanid. Endocrinology. 159:609-621. [PMCID: PMC5774852].
Vozenilek AE, Navratil AR, Green JM, Coleman DT, Finney AC, Blackburn CMR, Chrast R, Finck BN, Klein RL, Orr AW, and Woolard M. 2018. Macrophage-associated lipin-1 enzymatic activity contributes to modified LDL-induced pro-inflammatory signaling and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 38: 324-334. [PMCID: PMC5785462].
Lutkewitte AJ, Schweitzer GG, Kennon-McGill S, James LP, Jaeschke H, Finck BN, and McGill MR. 2018. Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration. Food Chem Tox. 115: 273-283. [PMCID: PMC5935563].
Liss KHH, McCommis KS, Chambers KT, Pietka TA, Schweitzer GG, Park SL, Nalbantoglu I, Weinheimer CJ, Hall AM, and Finck BN. 2018. The impact of diet-induced hepatic steatosis in a murine model of hepatic ischemia-reperfusion injury. Liver Transplantation. 24: 908-921. [PMCID: PMC6097916]
Liss KHH, Lutkewitte AJ, Pietka TA, Finck BN, McDonald WG, Wolfe C, Cole S, Franczk M, Yoshino J, Klein S, and Hall AM. 2018. Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans. J. Lipid Res. 59: 1630-1639. [PMCID: PMC6121930]
Yan Z, Shyr ZA, Fortunato M, Welscher A, Alisio M, Martino M, Finck BN, Conway H, and Remedi MS. 2018. High fat diet induced remission of diabetes in a subset of KATP-GOF insulin- secretory-deficient mice. Diabetes Obes. Metab. 20:2574-2584. [PMCID: PMC6407888]
Sawicki KT, Chang H-S, Shapiro JS, Bayeva M, DeJesus A, Landsberg L, Finck BN, Weitheim J, Blackshear PJ, and Ardehali H. 2018. Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21. JCI Insight. 3: 95948. [PMCID: PMC6124529] McCommis KS, Colca JR, and Finck BN. 2018. Reply to: Targeting mitochondrial pyruvate carrier (MPC) in NASH: growing evidence and future challenges. Hepatol. 67:2055-2056. Letter to the Editor.
Finck BN. 2018. Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis. Diabetes. 67:2485-2493. Perspective. [PMCID: PMC6245219]
2017
McCommis KM, Hodges WT, Brunt EM, Nalbantoglu I, McDonald WG, Holley C, Fujiwara H, Schaffer JE, Colca JR, and Finck BN. 2017. Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis. Hepatology. 65:1543-1556. [PMCID: PMC5397348].
Vigueira PA, McCommis KS, Hodges WT, Schweitzer GG, Cole SL, Oonthonpan L, Taylor EB, McDonald WG, Kletzien RF, Colca JR, and Finck BN. 2017. The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp. Physiol. 102:985-999. [PMCID: PMC5667918].
Liss KHH and Finck BN. 2017. PPARs and nonalcoholic fatty liver disease. Biochimie. 136:65-74. Review. [PMCID: PMC5380579]
Colca JR, McDonald WG, McCommis KS, and Finck BN. 2017. Treating Fatty Liver Disease by Modulating Mitochondrial Pyruvate Metabolism. Hepatol. Commun. 1:193-197. Commentary. [PMCID: PMC721453]
Hall AM and Finck BN. 2017. ChREBP refines the hepatic response to fructose to protect the liver from injury. J. Clin. Invest. 127:2533-2535. Commentary. [PMCID: PMC5490753]
2016
DeBosch BJ, Heitmeier M, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, and Moley KH. 2016. Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Science Signal. 9: pp. ra21. [PMCID: PMC4816640]
Lam WY, Becker AM, Kennerly KM, Wong R, Curtis JD, McCommis KS, Fahrmann J, Nunley RM, Finck BN, Pearce EL, and Bhattacharya D. 2016. Plasma cell mitochondrial pyruvate transport controls the duration of humoral immunity. Immunity. 45:60-73. [PMCID: PMC4956536]
McCommis KM, Hodges WT, Bricker D, Wisidagama DR, Remedi MS, Thummel C, and Finck BN. 2016. An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion. Mol. Metab. 5:602-614. [PMCID: PMC4816640]
Wang J, Kim C, Jogasuria A, Han Y, Hu X, Wu J, Shen H, Chrast R, Finck BN, and You M. 2016. Myeloid cell-specific lipin-1 deficiency stimulates endocrine adiponectin-FGF15 axis and ameliorates ethanol-induced liver injury in mice. Sci. Rep. 6:34117. [PMCID: PMC5036185].
2015
Schweitzer GG, Chen Z, Gan C, McCommis KS, Soufi N, Chrast R, Mitra MS, Gross RW, and Finck BN. 2015. Liver-specific loss of lipin 1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic triglyceride accumulation in mice. J. Lipid Res. 56: 848–858. [PMCID: PMC4373742]
Schweitzer GG, Collier S, Chen Z, Eaton JM, Bucelli RC, Connolly AM, Pestronk A, Harris TE, and Finck BN. 2015. Rhabdomyolysis-associated mutations in human lipin 1 Lead to defective phosphatidic acid phosphohydrolase activity. J. Inherit. Metab. Dis. Reports 23:113-22. [PMCID: PMC4484911]
McCommis KS, Chen Z, Fu X, McDonald WG, Colca JR, Kletzien RF, Burgess SC, and Finck BN. 2015. Loss of mitochondrial pyruvate carrier 2 in liver leads to defects in gluconeogenesis and compensation via pyruvate-alanine cycling. Cell Metabolism. 22:682-94 [PMCID: PMC4598280]
McCommis KS and Finck BN. 2015. Mitochondrial pyruvate transport: A historical perspective and recent research directions. Biochem J. 466:443-454. [PMCID: PMC4464838]
Finck BN and Hall AM. 2015. Does diacylglycerol accumulation in fatty liver disease cause hepatic insulin resistance? Biomed Res International. Article ID 104132, 6 pages [PMCID:PMC4529893]
2014
DeBosch BJ, Chen Z, Saben JL, Finck BN, and Moley KH. 2014. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J. Biol. Chem. 289:10989-98. [PMCID: PMC4036240]
Hall AM, Soufi N, Chambers KT, Chen Z, Schweitzer GG, McCommis KS, Erion DM, Graham MJ, Su X, and Finck BN. 2014. Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice. Diabetes. 63:2284-2296. [PMCID: PMC4066334]
Vigueira PA, McCommis KS, Schweitzer GG, Remedi MS, Chambers KT, Fu X, McDonald WC, Cole S, Colca JR, Kletzien RF, Burgess SC, and Finck BN. 2014. Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion. Cell Reports. 7:2042-2053. [PMCID: PMC4074444]
Eaton JM, Takkellapati S, Lawrence RT, McQueeney KE, Boroda S, Mullins GR, Sherwood SG, Finck BN, Villen J, and Harris TE. 2014. Lipin 2 binds phosphatidic acid by the electrostatic-hydrogen bond switch mechanism independent of phosphorylation. J. Biol. Chem. 289: 18055-18066. [PMCID: PMC4140300]
Devanathan S, Whitehead T, Schweitzer G, Kovacs A, Korach K, Finck BN, and Shoghi KI. 2014. Network and pathway microarray expression analysis of cardiac-specific estrogen receptor alpha knockout mice. PLoS ONE. 9: e101900. [PMCID: PMC4085004]
Mazar J, Zhao W, Khalil AM, Lee B, Shelley J, Govindarajan S, Yamamoto F, Ratnam M, Brill LM, Collins S, Finck BN, Mattick JS, Dinger ME, and Perera RJ. 2014. Molecular function of the long noncoding RNA SPRY4-IT1 in human melanocytes. Oncotarget. 15:8959-8969. [PMCID: PMC4253410]
Soufi N, Hall AM, Chen Z, Yoshino J, Collier SL, Matthews JC, Brunt EM, Albert CV, Graham MJ, Ford DA, and Finck BN. 2014. Inhibiting monoacylglycerol acyltransferase 1 reduces hepatic triacylgycerol content, but not inflammation and injury in mice. J. Biol. Chem. 289:30177-30188. [PMCID: PMC4208022]
Schweitzer GG and Finck BN. 2014 Targeting hepatic glycerolipid synthesis and turnover to treat fatty liver disease. Adv. Hepatol. vol 2014, Article ID 498369, doi:10.1155/2014/498369.
Potthoff MJ and Finck BN. 2014. Head over hepatocytes for FGF21. (Commentary) Diabetes. 63:4013-4015. [PMCID: PMC4237992]
2013
Mitra MS, Chen Z, Ren H, Harris TE, Chambers KT, Hall AM, Nadra K, Chrast R, Su X, Morris AJ, and Finck BN. 2013. Mice with an adipocyte separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation. Proc. Natl. Acad. Sci. USA. 110:642-647. [PMCID: PMC3545773]
Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie P, Gracheva E, Karr R, Wiley SE, Murphy AN, Finck BN, and Kletzien RF. 2013. Identification of a mitochondrial target of thiazolidinediones insulin sensitizers (mTOT) – relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS ONE. 8:e61551. [PMCID: PMC3655167]
Fabbrini E, Cella M, McCartney S, Fuchs A, Abumrad NA, Chen Z, Finck BN, Han DH, Magkos F, Conte C, Bradley D, Fraterrigo G, Eagon JC, Patterson BW, Colonna M, and Klein S. 2013. Adipose tissue CD4 lymphocyte polarization toward IL-17 and IL-22 producing cells links obesity with insulin resistance. Gastroenterology. 145: 366-374. [PMCID: PMC3756481]
Magkos F, Bradley D, Schweitzer G, Finck BN, Eagon JC, Ilkayeva O, Newgard CB, and Klein S. 2013. Effect of roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism. Diabetes. 62: 2757-2761. [PMCID: PMC3717831]
Chambers KT, Chen Z, Lai L, Leone TC, Towle HC, Kralli A, Crawford PA, and Finck BN. 2013. PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner. Mol. Metab. 2:194-204. [PMCID: PMC3773825]
Debosch BJ, Chi M, Chen Z, Finck BN, and Moley KH. 2013. GLUT8 mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice. Mol. Endocrinol. 27:1887-1896. [PMCID: PMC3805847]
Hu M, Yin H, Mitra MS, Liang X, Ajmo JM, Nadra K, Chrast R, Finck BN, and You M. 2013. Hepatic-specific lipin-1 deficiency exacerbates experimental alcoholic steatohepatitis in mice. Hepatology 58: 1958-1968. [PMCID: PMC3835749]
2012
Hu M, Wang F, Li X, Rogers CQ, Liang X, Finck BN, Mitra MS, Mitchell DA, and You M. 2012. Regulation of hepatic lipin-1 by ethanol: role of AMPK-SREBP1 signaling in mice. Hepatol. 55:437-446. [PMCID: PMC3253249]
Hall AM, Kou K, Chen Z, Pietka TA, Kumar M, Korenblat KM, Ahn K, Fabbrini E, Klein S, Goodwin B, and Finck BN. 2012. Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver. J. Lipid Res. 53:990-999. [PMCID: PMC3329399]
Smith GI, Reeds DN, Hall AM, Chambers KT, Finck BN, and Mittendorfer B. 2012. Sexually dimorphic effect of aging on skeletal muscle protein synthesis. Biol. Sex Diff. 3:11. [PMCID:PMC3467175]
Chen Z, Vigueira PA, Chambers KT, Hall AM, Mitra MS, McDonald W, Colca J, Kletzien RF, and Finck BN. 2012. Hepatic insulin resistance and metabolic derangements in obese mice are ameliorated by a novel thiazolidinedione via PPARg-independent effects. J. Biol. Chem. 287:23537-23548. [PMCID: PMC3390629]
Wang S, Chen Z, Lam V, Han J, Hassler J, Finck BN, Davidson NO, and Kaufman RJ. 2012. IRE1a-XBP1 pathway induces PDI expression to increase MTP activity for hepatic VLDL production and lipid homeostasis. Cell Metabolism. 16:473-486. [PMCID: PMC3569089]
Solingapuram Sai KK, Kil KE, Tu Z, Chu W, Finck BN, Rothfuss JM, Shoghi KI, Welch MJ, Gropler RJ, and Mach RH. 2012. Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors. Bioorg. Med. Chem. Lett. 22:6233-6236. [PMCID: PMC3477601]
Chen Z, Gropler MC, Mitra MS, and Finck BN. 2012. Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 a (HNF4a) pathways to regulate liver lipid metabolism. PLoS ONE. 7:e51320. [PMCID: PMC3517414]
Chambers KT, Chen Z, Crawford PA, Fu X, Burgess SC, Lai L, Leone TC, Kelly DP, and Finck BN. 2012. Liver-specific PGC-1b deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding. PLoS ONE. 7: e52645. [PMCID: PMC3532159]
Finck BN. 2012. A sweet new role for ubiquitin-specific protease 2 in controlling hepatic gluconeogenesis. (Commentary) Diabetes. 61:993-994.
2011
Chambers KT, Leone TC, Sambandam N, Kovacs A, Wagg CS, Lopashuk GD, Finck BN, and Kelly DP. 2011. Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response. J. Biol. Chem. 286:11155–11162. [PMCID: PMC3064169]
Mitra MS, Chen Z, Schilling JD, Wang X, Jay PY, Huss JM, Su X, and Finck BN. 2011. Cardiac lipin 1 expression is regulated by the peroxisome proliferator-activated receptor g coactivator 1a/estrogen related receptor axis. J. Mol. Cell. Cardiol. 51:120-128. [PMCID: PMC3104300]
Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, Satapati S, Suino-Powell K, Xu HE, Gerard RD, Finck BN, Burgess SC, Mangelsdorf DJ, Kliewer SA. 2011. FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1a pathway. Cell Metab.13:729-738. [PMCID: PMC3131185]
Peterson TR, Sengupta SS, Harris TE, Laplante M, Yesilaltay A, Madden K, Carpenter AE, Finck BN, and Sabatini DM. 2011. mTORC1 regulates lipin 1 nuclear localization to control lamin A structure and the SREBP pathway. Cell. 146:408-420.
Gan Z, Burkart-Hartmann E, Han D-H, Finck BN, Leone TC, Holloszy JO, and Kelly DP. 2011. PPARb/d drives exercise-related muscle glucose utilization programs in cooperation with AMP-activated protein kinase and MEF2. Genes Devel. 25:2619-2630. [PMCID: PMC3248683]
Harris TE and Finck BN. 2011. Dual Function Lipin Proteins and Glycerolipid Metabolism. Trends Endocrinol. Metab. 22:226-233. [PMCID: PMC3118913]
2010
Hall AM, Brunt EM, Klein S, and Finck BN. 2010. Hepatic expression of cell death-inducing DFFA-like effector C in obese subjects is reduced by marked weight loss. Obesity. 18:417-419. [PMCID: PMC2957480]
Hall AM, Brunt EM, Chen Z, Viswakarma N, Reddy JK, Wolins NE, and Finck BN. 2010. Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic (fld) mice. J. Lipid Res. 51:554-563. [PMCID: PMC2817585]
Beitelshees AL, Finck BN, Cresci S, Brown M, Wu J, Minton MR, Province M, Spertus JA, Kelly DP. 2010. Interaction between the UCP2 -866 G>A polymorphism, diabetes, and β-blocker use among patients with acute coronary syndromes. Pharmacogenet Genomics. 20:231-238. [PMCID: PMC2842450]
Yue P, Chen Z, Nassir F, Bernal-Mizrachi C, Finck B, Azhar S, and Abumrad N. 2010. Enhanced hepatic apoA secretion and peripheral efflux of cholesterol and phospholipid in CD36 deficiency. PLOS One. 5:e9906. [PMCID: PMC2845618]
Kim HB, Kumar A, Wang L, Lawrence JC, Finck BN, and Harris TE. 2010. Lipin 1 represses NFATc4 transcriptional activity to inhibit adipocyte secretion of inflammatory factors. Mol Cell Biol. 30: 3126-3139. [PMCID: PMC2876672]
Kars M, Yang L, Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, and Klein S. 2010. Tauroursodeoxycholic acid improves liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes. 59:1899–1905. [PMCID: PMC2911053]
Chen Z, Norris J-Y, and Finck BN. 2010. Peroxisome proliferator-activated receptor g coactivator-1a (PGC-1a) Stimulates VLDL Assembly Through Activation of Cell Death-inducing DFFA-like Effector B (CideB). J. Biol. Chem. 285:25996-26004. [PMCID: PMC2923994]
Liu H-G, Qu J, Carmack AE, Kim HB, Chen C, Ren H, Morris AJ, Finck BN, and Harris TE. 2010. Lipin proteins form homo- and hetero-oligomers. Biochem J. 432:65-76. [PMCID: PMC3117669]
Gazit V, Weymann A, Hartman E, Finck BN, Hruz PW, Tzekov A, and Rudnick DA. 2010. Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice. Hepatology. 52:2109-2117. [PMCID: PMC2991544]
2009
Gropler MC, Hall AM, Han X, Gross RW, Harris TE, Chen Z, and Finck BN. 2009. Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice. J. Biol. Chem. 284:6763-6772. [PMCID: PMC2652272]
Kirk E, Reeds DN, Finck BN, Mitra MS, Patterson BW, and Klein S. 2009. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology. 136:1552-1560. [PMCID: PMC2677125]
Potthoff MJ, Inagaki T, Sapati S, Ding X, He T, Goetz R, Mohammadi M, Finck BN, Mangelsdorf DJ, Kliewer SA, and Burgess SC. 2009. FGF21 induces PGC-1a and regulates carbohydrate metabolism during the adaptive starvation response. Proc. Natl. Acad. Sci. USA. 106:10853-10858. [PMCID: PMC2705613]
Shoghi KI, Finck BN, Sharp T, Schechtman KB, Herrero P, Gropler RJ, Welch MJ. 2009. Noninvasive assessment of myocardial bioenergetics following monotherapy with metformin or rosiglitazone in an animal model of type 2 diabetes. Circ. Cardiovasc. Imaging. 2:373-381. [PMCID: PMC2760020]
2008
Marionneau C, Aimond F, Brunet S, Niwa N, Finck B, Kelly DP, and Nerbonne JM. 2008. PPARalpha-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy. J. Mol. Cell. Cardiol. 44: 1002-1015. [PMCID: PMC2577840]
Shoghi KI, Gropler RJ, Sharp T, Herrero P, Fettig N, Su Y, Mitra MS, Kovacs A, Finck BN, and Welch MJ. 2008. Time-course of alterations in myocardial glucose utilization in the Zucker Diabetic Fatty (ZDF) rat with correlation to gene expression of glucose transporters: A small animal PET investigation. J. Nucl. Med. 49:1320-1327. [PMCID: PMC2857655]
Lambert CP, Wright NR, Finck BN, and Villareal DT. 2008. Effects of weight loss or exercise on the expression of cytokine and growth factor mRNAs in skeletal muscle of the frail obese elderly. J. Appl. Physiol. 105: 473-478. [PMCID: PMC2519937]
Chen Z, Gropler MA, Norris J, Lawrence JC, Harris TE, Finck BN. 2008. Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride metabolism. Arterioscler. Thromb. Vasc. Biol. 28: 1738-1744. [PMCID: PMC2655237]
Duncan JG and Finck BN. 2008. The PPARa-PGC-1a axis controls cardiac energy metabolism in healthy and diseased myocardium. PPAR Res. Volume 2008, Article ID 253817. [PMCID: PMC2225461]
2007
Duncan JG, Fong JL, Medeiros DM, Finck BN, and Kelly DP. 2007. Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the PPARa-PGC-1a gene regulatory pathway. Circulation. 115: 909-917.
Coughlin CC, Finck BN, Eagon JC, Halpin V, Magkos F, Mohammed BS, and Klein S. 2007. Effect of marked weight loss on adiponectin gene expression and plasma concentrations. Obesity. 15:640-645.
Yang J, Sambandam N, Han X, Gross RW, Courtois M, Kovacs A, Febbraio M, Finck BN, and Kelly DP. 2007. CD36 deficiency rescues lipotoxic cardiomyopathy. Circ. Res. 100:1208-1217.
Croce MA, Eagon CJ, LaRiviere LL, Korenblat KM, Klein S, and Finck BN. 2007. Hepatic lipin 1b expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss. Diabetes. 56: 2395-2399.
Finck BN. 2007. The PPAR regulatory system in cardiac physiology and disease. Cardiovasc. Res. 73:269-277.
Finck BN and Kelly DP. 2007. The peroxisome proliferator-activated receptor g coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. Circulation. 115:2540-2548.
2006
Sambandam N, Morabito D, Wagg C, Finck BN, Kelly DP, Lopashuk GD. 2006. Chronic activation of PPARa is detrimental to cardiac recovery following ischemia. Am. J. Physiol. 290: H87-H95.
Burgess SC, Leone TC, Wende AR, Croce MA, Chen Z, Sherry AD, Malloy CR, and Finck BN. 2006. Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor g coactivator-1a (PGC-1a)-deficient mice J. Biol. Chem. 281: 19000-19008.
Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC, and Kelly DP. 2006. Lipin 1 is an inducible amplifier of the hepatic PGC-1a/PPARa regulatory pathway. Cell Metab. 4: 199-210.
Lee H, Finck BN, Jones LA, Welch, MJ, and Mach RH. 2006. Synthesis and evaluation of a bromine-76-labeled PPARg antagonist, 2-bromo-5-nitro-N-phenylbenzamide. Nucl. Med. Biol. 33: 847-854.
Schneider JG, Finck BN, Ren J, Standley KN, Takagi M, Bernal-Mizrachi C, Muslin AJ, Kastan MB, and Semenkovich CF. 2006. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab. 4: 377-389.
Wolins NE, Quaynor BK, Skinner JR, Tzekov A, Croce MA, Gropler MC, Rasouli N, Yao-Borengasser A, Varma V, Kern PA, Finck BN, and Bickel PE. 2006. OXPAT/PAT1 is a novel PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes. 55: 3418-3428.
Finck BN and Kelly DP. 2006. PGC-1 Coactivators: Inducible Regulators of Energy Metabolism in Health and Disease. J. Clin. Invest. 116:615-622. [PMCID: PMC1386111]
2005
Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, and Kelly DP. 2005. A potential link between muscle peroxisome proliferator-activated receptor a signaling and obesity-induced insulin resistance. Cell Metab. 1:133-144.
Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, and Kelly DP. 2005. PGC-1a deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control, and hepatic steatosis. PLoS Biol. 3:e101. [PMCID: PMC1064854]
Park S-Y, Cho Y-R, Finck BN, Kim H-J, Higashimori T, Dong J, Lee M-K, Cline G, Russell K, Kim Y-B, Kelly DP, and Kim JK. 2005. Cardiac-specific overexpression of peroxisome proliferator-activated receptor-a causes insulin resistance in heart and liver. Diabetes. 54: 2514-2524.
2004
Harris IS, Treskov I, Rowley MW, Heximer S, Kaltenbronn K, Finck BN, Gross RW, Blumer KG, Kelly DP, and Muslin AJ. 2004. G protein signaling participates in the development of diabetic cardiomyopathy. Diabetes. 53:3082-90.
2003
Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, Kovacs A, Gross RW, and Kelly DP. 2003. A critical role for PPARa-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content. Proc. Natl. Acad. Sci. USA 100:1226-1231. [PMCID: PMC298755]
Bernal-Mizrachi C, Weng S, Feng C, Finck BN, Knutsen RH, Leone TC, Coleman T, Mecham RP, Kelly DP, and Semenkovich CF. 2003. Dexamethasone induction of hypertension and diabetes is PPARa-dependent in LDL receptor-null mice. Nat. Med. 9:1069-1075.
Finck BN, Lehman JJ, Barger PM, and Kelly DP. 2003. Regulatory networks controlling mitochondrial energy production in the developing, hypertrophied, and diabetic heart. Cold Spring Harbor Symposia on Quantitative Biology: The Cardiovascular System. 67:371-382.
2002
Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, Kovacs A, Han X, Gross RW, Kozak R, Lopaschuk GD, and Kelly DP. 2002. The cardiac phenotype induced by PPARa overexpression mimics that caused by diabetes mellitus. J. Clin. Invest. 109:121-130.[PMCID: PMC150824]
Finck BN and Johnson RW. 2002. Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor a. Am. J. Physiol. 282:R1429-R1435.
Finck BN and Kelly DP. 2002. Peroxisome Proliferator-Activated Receptor a (PPARa) signaling in the gene regulatory control of cardiac energy metabolism. J. Mol. Cell. Cardiol. 34:1249-1257.
2000
Finck BN and Johnson RW. 2000. Tumor necrosis factor (TNF)-a induces leptin production through the p55 TNF receptor. Am. J. Physiol. 278:R537-R543.
Heyen JRR, Ye SM, Finck BN, and Johnson RW. 2000. Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kB. Mol. Brain Res. 77:138-147.
1999
Finck BN and Johnson RW. 1999. Intracerebroventricular injection of lipopolysaccharide increases plasma leptin levels. Neuroreport. 10:153-156.
1998
Finck BN, Dantzer R, Kelley KW, and Johnson RW. 1998. In vitro and in vivo evidence for the involvement of tumor necrosis factor-α in the induction of leptin by lipopolysaccharide. Endocrinology. 139:2278-2283.
Matteri RL, Klir JJ, Finck BN, and Johnson RW. 1998. Neuroendocrine-immune interactions in the neonate. Dom. Anim. Endocrinology. 15:397-405.
1997
Finck BN, Dantzer R, Kelley KW, Woods JA, and Johnson RW. 1997. Central lipopolysaccharide elevates plasma interleukin-6 concentrations by an a-adrenergic mechanism. Am. J. Physiol. 41:R1880-R1886.
Webel DM, Finck BN, Baker DH, and Johnson RW. 1997. Time course of elevated cytokines, cortisol, and urea nitrogen in pigs following intraperitoneal injection of lipopolysaccharide. J. Anim. Sci. 75:1514-1520.
Warren EJ, Finck BN, Arkins S, Kelley KW, Scamurra RW, Murtaugh MP, and Johnson RW. 1997. Coincidental changes in behavior and plasma cortisol in unrestrained pigs following intracerebroventricular injection of tumor necrosis factor-a Endocrinology. 138:2365-2371.
Finck BN and Johnson RW. 1997. Anorexia and cachexia caused by chronic intracerebroventricular infusion of interleukin-1b in the rat. Brain Res. 761:333-337.