For terminally differentiated neurons, the “birthdate” when they become post-mitotic has a special meaning; it can determine the neuronal fates and influence their connection patterns. We have been developing the “birthdate tagging system”, which consists of several transgenic mouse lines in which loxP recombination can be induced in a neuronal birthdate-dependent manner. This system enables manipulation of neurons based on the new classification “birthdate”.

reference

A Novel Birthdate-Labeling Method Reveals Segregated Parallel Projections of Mitral and External Tufted Cells in the Main Olfactory System

Tatsumi Hirata, Go Shioi, Takaya Abe, Hiroshi Kiyonari, Shigeki Kato, Kazuto Kobayashi, Kensaku Mori and Takahiko Kawasaki

eNeuro 31, ENEURO.0234-19.2019, 2019 DOI:10.1523/ENEURO.0234-19.2019