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During development, many neurons migrate for a long distance to the destination. The guidepost neurons, “lot cells”, for olfactory bulb axons show a dynamic ventral tangential migration in the telencephalon at an early developmental stage. We have been investigating molecular mechanisms of this unique neuronal migration.
Left: Ventral tangential migration of neurons in slice-cultured telencephalons. Migrating neurons are labeled in magenta.
Right: Axon guidance molecule, semaphorin3F repels this migration stream in the opposite direction.
Related Papers
Related Papers
Ito, K., Kawasaki, T., Takashima, S., Matsuda, I., Aiba, A. and Hirata, T. (2008) Semaphorin 3F confines ventral tangential migration of lateral olfactory tract neurons onto the telencephalon surface. J. Neurosci. 28 4414-4422. doi: 10.1523/JNEUROSCI.0372-08.2008.
Kawasaki, T., Ito, K. and Hirata, T. (2006) Netrin 1 regulates ventral tangential migration of guidepost neurons in the lateral olfactory tract. Development 133, 845-853. DOI: 10.1242/dev.02257
Hirata, T., Kumada, T., Kawasaki, T., Furukawa, T., Aiba, A., Conquet, F., Saga, Y. and Fukuda, A. (2012) Guidepost neurons for the lateral olfactory tract: expression of metabotropic glutamate receptor 1 and Iinnervation by glutamatergic olfactory bulb axons. Dev. Neurobiol. 72 1559-1576. doi: 10.1002/dneu.22030.
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