The increasing prevalence of overweight and obesity is a major public health concern in these days. Recently, growing evidence indicate that the obese population are more susceptible to some neurological conditions such as cognitive disorders, including Alzheimer’s disease (AD) or mood disorders, including major depression disorder (MDD). These evidences indicate that changes in the organism that accompany overweight and obesity can ultimately lead to CNS dysfunction. However, the pathophysiological mechanisms and molecular players underlying this connection are poorly known. In this study, I focus on the mechanistic correlation between obesity and neurological disorders (such as Alzheimer’s disease or Depression). To address this correlation, I approach using multidisciplinary way from gene to behavior level. Using this systematic exploration of this relationship would help to elucidate causal mechanism and opportunities for prevention and treatment.

Neurodegenerative disorder, Stress, Obesity, Depression, Mental illness, Feeding behavior, Impulsive control disorder, Neurometabolic disorder, Eating disorder (anorexia nervosa, bulimia nervosa)

Behavioral modeling, Genetic modification (cre/lox), Transcriptomics, Epigenomics, Viral gene transfer, Optogenetics, Chemogenetics, FACs, Cell-type specificity, Single cell seq

• Mechanistic cross-talk among Neurodegenerative disease, Mental illness and Obesity

• Study of correlation between neurological disorders and environmental factors

(ex. stress, environmental endocrine disruptors, etc.)

• Molecular mechanisms of eating behaviors in impulse disorder

• Study of neurological disorders using multiple approach of behavior analyses

• Study of transcriptome and epigenome in neurodegenerative/neurometabolic disorders