Complex mental activity induces improvements in cognition, brain function, and structure in animals and young adults. It is not clear to what extent the aging brain is capable of such plasticity. This study expands previous evidence of generalized cognitive gains after mental training in healthy seniors. Using 3 MRI-based measurements, that is, arterial spin labeling MRI, functional connectivity, and diffusion tensor imaging, we examined brain changes across 3 time points pre, mid, and post training (12 weeks) in a randomized sample (n = 37) who received cognitive training versus a control group. We found significant training-related brain state changes at rest; specifically, 1) increases in global and regional cerebral blood flow (CBF), particularly in the default mode network and the central executive network, 2) greater connectivity in these same networks, and 3) increased white matter integrity in the left uncinate demonstrated by an increase in fractional anisotropy. Improvements in cognition were identified along with significant CBF correlates of the cognitive gains. We propose that cognitive training enhances resting-state neural activity and connectivity, increasing the blood supply to these regions via neurovascular coupling. These convergent results provide preliminary evidence that neural plasticity can be harnessed to mitigate brain losses with cognitive training in seniors.

Federal guidelines recommend that all adults get at least 150 minutes (2.5 hours) of physical activity each week. Walking is a good start. You can also join programs that teach you to move safely and prevent falls, which can lead to brain and other injuries. Check with your health care provider if you haven't been active and want to start a vigorous exercise program.


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Being intellectually engaged may benefit the brain. People who engage in personally meaningful activities, such as volunteering or hobbies, say they feel happier and healthier. Learning new skills may improve your thinking ability, too. For example, one study found that older adults who learned quilting or digital photography had more memory improvement than those who only socialized or did less cognitively demanding activities. Some of the research on engagement in activities such as music, theater, dance, and creative writing has shown promise for improving quality of life and well-being in older adults, from better memory and self-esteem to reduced stress and increased social interaction.

Some scientists have argued that such activities may protect the brain by establishing "cognitive reserve." They may help the brain become more adaptable in some mental functions so it can compensate for age-related brain changes and health conditions that affect the brain.

Be wary of claims that playing certain computer and online games can improve your memory and other types of thinking as evidence to back up such claims is evolving. There is currently not enough evidence available to suggest that computer-based brain training applications offered commercially have the same impact on cognitive abilities as the ACTIVE study training. NIA and other organizations are supporting research to determine whether different types of cognitive training have lasting effects.

Connecting with other people through social activities and community programs can keep your brain active and help you feel less isolated and more engaged with the world around you. Participating in social activities may lower the risk for some health problems and improve well-being.

It's important to prevent or seek treatment for these health problems. They affect your brain as well as your body and receiving treatment for other conditions may help prevent or delay cognitive decline or thinking problems.

Some drugs and combinations of medicines can affect a person's thinking and the way the brain works. For example, certain ones can cause confusion, memory loss, hallucinations, and delusions in older adults.

Medicines can also interact with food, dietary supplements, alcohol, and other substances. Some of these interactions can affect how your brain functions. Drugs that can harm older adults' cognition include:

A number of studies link eating certain foods with keeping the brain healthy and suggest that other foods can increase health risk. For example, high-fat and high-sodium foods can lead to health problems, such as heart disease and diabetes, that can harm the brain.

Drinking too much alcohol affects the brain by slowing or impairing communication among brain cells. This can lead to slurred speech, fuzzy memory, drowsiness, and dizziness. Long-term effects may include changes in balance, memory, emotions, coordination, and body temperature. Staying away from alcohol can reverse some of these changes.

Aging may also bring positive cognitive changes. For example, many studies have shown that older adults have larger vocabularies and greater knowledge of the depth of meaning of words than younger adults. Older adults may also have learned from their many years of accumulated knowledge and experiences. Whether and how older adults apply this knowledge, and how the brain changes as a result, is an area that researchers are actively exploring.

Volunteers are needed for clinical trials to understand normal brain aging and why some people stay cognitively healthy longer than others. By joining one of these studies, you may learn more about what might protect your brain as you age.

In another study, older adults with higher levels of physical activity showed slower rates of cognitive decline than peers who were less active. Another example of how physical health can affect brain health has to do with the heart. Observational studies have found that high blood pressure in middle age, along with other cerebrovascular risk factors, such as diabetes and smoking, increase the risk of developing dementia.

Objectives:  To evaluate effects of a six-month intensive dance-exercise intervention (DI) on cognition and brain structure in a mixed group of healthy seniors and people with mild cognitive impairment.

Methods:  Subjects (aged  60 years with no dementia or depression) were randomly assigned to either a DI group or a life as usual (LAU) group. Detailed neuropsychological testing, measures of physical fitness and brain MRI encompassing T1 structural and diffusion tensor imaging (DTI) were performed at baseline and after 6 months. We assessed changes in cortical thickness and DTI parameters derived from tract-based spatial statistics.

Symptoms of some vitamin deficiencies and medical conditions such as vitamin B12 deficiency, infections, hypothyroidism (underactive thyroid), or normal pressure hydrocephalus (a neurological condition caused by the build-up of fluid in the brain) can mimic dementia. Some prescription and over-the-counter medicines can cause dementia-like symptoms. If you have these symptoms, it is important to talk to your health care provider to find out if there are any underlying causes for these symptoms.

A healthcare provider can perform tests on attention, memory, problem solving and other cognitive abilities to see if there is cause for concern. A physical exam, blood tests, and brain scans like a CT or MRI can help determine an underlying cause.

A team of neuroscientists led by Drs. Bryce Mander and Matthew Walker at the University of California, Berkeley, set out to explore whether age-related changes in sleep and brain structure are linked to impaired memory. Their study included 18 healthy young adults (ages 18 to 25) and 15 healthy older adults (ages 61 to 81).

Older adults, the fMRI scans revealed, relied more heavily on their hippocampus, a brain region crucial for memory formation, to perform memory tasks. Younger adults, on the other hand, relied more on the mPFC.

Taken together, these findings suggest that, as we age, changes in the mPFC reduce slow-wave activity during sleep, which contributes to a decline in establishing long-term memory. As slow-wave activity wanes, the brain must rely more heavily for memory tasks on the hippocampus, a structure designed for short-term memory storage.

This study helps explain the relationship between brain deterioration, sleep disruption and memory loss as we get older. The findings may give researchers insight into designing new approaches for treatment.

Learning something new is not only fun, but it can also help stimulate the brain. Studies have shown that older adults who learned a new skill had more memory improvement than those who only socialized or did less cognitive-related activities.

Even seniors living life free of chronic conditions and disease can experience changes in certain mental capacities. It's a natural part of growing older. In fact, most people describe declines in memory for names and recent events as they age. But when such lapses create health and quality-of-life issues that affect their ability to remain active, it's time to seek help.

This highly distinctive integration of science and medicine, along with our unending dedication to improving patient outcomes, allows the Center to offer treatments based on advanced research and studies into the aging brain, while pulling in the expertise of:

Brain mass: While brain volume decreases overall with age, the frontal lobe and hippocampus - specific areas of the brain responsible for cognitive functions - shrink more than other areas. 

 The frontal lobes are located directly behind the forehead. They are the largest lobes in the human brain and are considered to be the human behavior and emotional control centers for our personalities.

 The hippocampus is a complex brain structure embedded deep into the temporal lobe. It plays a major role in learning and memory. Studies have shown that the hippocampus is susceptible to a variety of neurological and psychiatric disorders.

Cortical density: This refers to the thinning of the outer corrugated surface of the brain due to decreasing synaptic connections. Our cerebral cortex, the wrinkled outer layer of the brain that contains neuronal cell bodies, also thins with age. Cortical thinning follows a pattern similar to volume loss and is particularly pronounced in the frontal lobes and parts of the temporal lobe. Lower density leads to fewer connections, which could contribute to slower cognitive processing. 2351a5e196

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