North America Botulinum Toxin Market Key Futuristic Trends and Opportunities by 2031

The North America botulinum toxin market was valued at US$ 4,801.29 million in 2023 and is expected to reach US$ 12,072.60 million by 2031; it is estimated to register a CAGR of 12.2% from 2023 to 2031.

North America botulinum toxin market, particularly types A and B, are increasingly being recognized for their diverse therapeutic applications beyond their well-known cosmetic uses. These toxins work by blocking acetylcholine release at neuromuscular and neurosecretory junctions, offering powerful outcomes for various conditions.

Expanding Therapeutic Uses of North America botulinum toxin market

North America botulinum toxin market is proving to be a versatile treatment option for a range of medical conditions. Clinical reports highlight its effectiveness against ailments such as headaches, sialorrhea (excessive salivation), and hyperhidrosis (excessive sweating). It offers a promising alternative to surgical interventions, for instance, replacing sphincterotomy in patients with chronic anal fissures.

Patients suffering from certain autonomic disorders, including ptyalism and gustatory sweating, as well as glandular hypersecretion (often a post-surgical complication of parotid gland procedures), have also shown positive responses to botulinum toxin treatment.

Beyond these applications, botulinum toxins are making strides in assisted reproductive technology. Despite advancements, repeated implantation failure remains a challenge for many patients. Adequate endometrial growth is crucial for successful embryo implantation and pregnancy. Research indicates that botulinum toxins can positively influence the re-epithelialization of human keratinocytes and the angiogenesis of endothelial cells. Clinical data suggests that botulinum toxin administration can facilitate the recovery of damaged thin endometrium by boosting cellular proliferation and vessel formation, reducing collagen-accumulated lesions, and ultimately enhancing the chances of successful embryo implantation. These expanding therapeutic applications are expected to drive new market trends for botulinum toxins in the coming years.

North America Botulinum Toxin Market Snapshot

The North America botulinum toxin market, encompassing the US, Canada, and Mexico, is experiencing significant growth. This growth is primarily fueled by an economically stable population and a rising number of non-surgical or minimally invasive cosmetic procedures.

In the US, the reduction of facial wrinkles using botulinum toxin injections remains the most frequently performed cosmetic procedure. It's often an entry-level procedure for clinicians venturing into aesthetic treatments. According to the International Society of Aesthetic Plastic Surgery (ISAPS), almost 2.5 million botulinum toxin procedures were performed in the US in 2021 alone. Treatments for FDA-approved cosmetic indications like frown lines and crow's feet, along with horizontal forehead wrinkles, consistently deliver predictable results, have minimal side effects, and lead to high patient satisfaction.

Several commercially available North America botulinum toxin market products dominate the US market, including BOTOX Cosmetic/Vistabel (Allergan), Dysport/Azzalure (Galderma and Ipsen), Xeomin/Bocouture (Merz), and Jeuveau (Evolus, manufactured by Daewoong). The US FDA has approved BOTOX Cosmetic for individuals aged 18 to 65. The American Society for Aesthetic Plastic Surgery highlights botox injections as the fastest-growing procedure in the cosmetic industry.

Recently, in August 2023, Daxxify (daxibotulinumtoxinA-lanm) received FDA approval for its first therapeutic indication: treating adult cervical dystonia. This condition, affecting around 60,000 Americans, involves uncontrollable neck muscle spasms, leading to unusual movements, awkward posture, and pain. Botulinum toxin injections help relax the affected muscles, reducing stiffness and spasms, although patients require frequent retreatments as the effect gradually wears off.

Further expanding its reach, in July 2021, the FDA approved Allergan's (an AbbVie company) label expansion for BOTOX Cosmetic to treat eight new muscle conditions related to adult upper limb spasticity.

North America Botulinum Toxin Market Segmentation

The North America botulinum toxin market is segmented by product, application, end user, and country.

North America botulinum toxin market By Product

• Botulinum Toxin A (Dominates the market share as of 2023)

• Botulinum Toxin B

North America botulinum toxin market By Application

1. Medical (Holds the largest market share)

   • Chronic Migraine

   • Muscle Spasm

   • Overactive Bladder

   • Hyperhidrosis

   • Others

2. Aesthetic

   • Frown Lines / Glabellar

   • Forehead Lines

   • Crow’s Feet

   • Square Jaw / Masseter

   • Others

North America botulinum toxin market By End User

• Specialty & Dermatology Clinics (Largest market share in 2023)

• Hospitals & Clinics

• Others

North America botulinum toxin market By Country

• United States (Dominates the regional market share)

• Canada

• Mexico

North America botulinum toxin market Key Market Players

Leading companies in the North America botulinum toxin market include:

• Merz Pharma GmbH & Co. KGaA

• AbbVie Inc.

• Ipsen SA

• Evolus Inc.

• Aquavit

• Revance Therapeutics Inc.

• Medytox Inc.

• Galderma SA

• Hugel Inc.

• Lanzhou Institute of Biological Products Co. Ltd.

This segmentation highlights the market structure, key applications, and major players driving growth in the North America botulinum toxin industry.

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Author’s Bio:

Suryakant Gadekar

Senior Market Research Expert at Business Market Insights