Publications

Guazzetti d., Aimi L., Marcantonio E., Siciliano G.M., Bugatti K., Dobani S., Sartori A., Battistini L., Zanardi F., Curti C., Photoinduced, Chemoselective γ-Alkylation of 2-Silyloxyfurans with α-Bromoketones: A Rapid Entry to Chiral ε-Keto-γ-Butenolides Chem. Eur. J., 2025; 0: e03083,  https://doi.org/10.1002/chem.202503083 

Bugatti K., Ferrini E., Restori M., Bonfini C., Marchese M., Bianchini F., Tomassetti S., Maurizio A., Baiula M., Battistini L., Marcantonio E., Curti C., Civera M., Belvisi L., Sartori A.,Stellari F.F. and Zanardi F., Antifibrotic Efficacy of a Nintedanib–Peptide Conjugate and Diagnostic Potential of a Fluorescent Companion Probe Targeting αVβ6 Integrin in Idiopathic Pulmonary Fibrosis, ACS Pharmacology & Translational Science 2025 8 (10), 3613-3630, 10.1021/acsptsci.5c00457 

Marcantonio E., Guazzetti D., Aimi L., Bugatti K., Mena P., Giannetto M., Fortunati S., Sartori A., Battistini L., Andreoni L., Lombardo M., Zanardi F., Curti C. Harnessing Vinylogy with Radicals: Photoinduced γ-Benzylation Reactions of 2-Silyloxyfurans, Adv. Synth. Catal. 2025, 367, e70035  https://doi.org/10.1002/adsc.70035    

Marcantonio E., Guazzetti D., Coppa C., Battistini L., Sartori A., Bugatti K., Provinciael B., Curti C., Contini A., Vermeire K., Zanardi F. The chiral 5,6-cyclohexane-fused uracil ring-system: A molecular platform with promising activity against SARS-CoV-2, Eur. J. Med.Chem. 2025, 286, 117302, https://doi.org/10.1016/j.ejmech.2025.117302 

Marcantonio E., Guazzetti D., Bugatti K., Battistini L., Sartori A., Pelosi G., Curti C., Zanardi F. Turning the Imidazole Core into Three-Dimensional Ring Systems: Mild Organocatalytic Entry to Enantiopure 6,7-Dihydrobenzimidazoles, Chem. Eur. J. 2023, e202301200, https://doi.org/10.1002/chem.202301200

Bugatti K., Sartori A., Battistini L., Coppa C., Vanhulle E., Noppen S., Provinciael B., Naesens L., Stevaert A.,  Contini A., Vermeire K., Zanardi F. Novel Polymyxin-Inspired Peptidomimetics Targeting the SARS-CoV-2 Spike:hACE2 Interface, Int. J. Mol. Sci. 2023, 24(10), 8765, https://doi.org/10.3390/ijms24108765

Marcantonio E., Zanardi F., Curti C. and Lombardo M. Mechanistic Insights into the Stepwise (4+2) Cycloaddition toward Chiral Fused Uracil Derivatives. Adv. Synth. Catal. 2023, 365; https://doi.org/10.1002/adsc.202300045 

Andreucci L., Bugatti K., Peppicelli S., Ruzzolini J., Lulli M., Calorini L., Battistini L., Zanardi F., Sartori A. and Bianchini F. Nintedanib-αVβ6 Integrin Ligand Conjugates ReduceTGFβ-Induced EMT in Human Non-Small Cell Lung Cancer. Int. J. Mol. Sci. 2023, 24(2), 1475; https://doi.org/10.3390/ijms24021475 

Curti C., Sartori A., Battistini L., Zanardi F. Chapter 14: Merging Organocatalysis with Vinylogy – New Opportunities for Asymmetric,  Synthesis, Asymmetric Organocatalysis: New Strategies, Catalysts, and Opportunities, Volume 2, Wiley-VCH, 2022,  https://doi.org/10.1002/9783527832217.ch14

Curti C., Marcantonio E., Sartori A., Battistini L., Zanardi F., Accessing Chiral Dihydro- and Tetrahydriquinazoline-2,4-diones via [4+2]-cycloadditions: From Pioneering Studies To Asymmetric Organozatalyzed Syntheses, Targets In Heterocyclic Systems, Vol 26, 2022, Società Chimica Italiana, https://soc.chim.it/it/libri_collane/ths/vol_26_2022 

Bugatti, K.; Sartori, A.; Battistini, L.; Ruzzolini, J.; Nediani, C.; Curti, C.; Bianchini, F. and Zanardi, F. Nintedanib-αVβ3 Integrin Ligand Dual-Targeting Conjugates towards Precision Treatment of Melanoma. EurJOC, 2022, e202200765, https://doi.org/10.1002/ejoc.202200765 

Bugatti, K.; Andreucci, E.; Monaco, N.; Battistini, L.; Peppicelli, S.; Ruzzolini, J.; Curti, C.; Zanardi, F.; Bianchini, F. and Sartori, A. Nintedanib-Containing Dual Conjugates Targeting αVβ6 Integrin and Tyrosine Kinase Receptors as Potential Antifibrotic Agents. ACS Omega, 2022, 7, 21, 17658–17669, https://doi.org/10.1021/acsomega.2c00535 

Valtorta, S.; Toscani, D; Chiu, M.; Sartori, A; Coliva, A.; Brevi, C; Taurino, G.; Grioni, M.; Ruffini, L.; Vacondio, F.; Zanardi, F.; Bellone, M.; Moresco, R.M.; Bussolati, O. and Giuliani, N. [18F] (2S,4R)-4-Fluoroglutamine as a New Positron Emission Tomography Tracer in Myeloma, Frontiers in Oncology, 2021, 11, 760732. https://doi.org/10.3389/fonc.2021.760732  

Sartori, A.; Bugatti, K.; Portioli, E.; Baiula, M.; Casamassima, I.; Bruno, A.; Bianchini, F.; Curti, C.; Zanardi, F. and Battistini, L. New 4-Aminoproline-Based Small Molecule Cyclopeptidomimetics as Potential Modulators of α4β1 Integrin. Molecules, 2021, 26(19), 6066. 10.3390/molecules26196066 

Battistini, L.; Bugatti, K.; Sartori, A.; Curti, C.; Zanardi, F. RGD Peptide-Drug Conjugates as Effective Dual Targeting Platforms: Recent Advances. Eur. J. Org. Chem. 2021, 2506-2528. doi.org/10.1002/ejoc.202100240.

Marcantonio, E.; Curti, C.; Battistini, L.; Sartori, A.; Cardinale, L.; Pelosi, G.; Zanardi, F. Direct, Asymmetric Synthesis of Carbocycle-Fused Uracils via [4+2] Cycloadditions: a Noncovalent Organocatalysis Approach. Adv. Synth. Catal. 2021, 363; doi: 10.1002/adsc.202100082.

Curti, C.; Rassu, G.; Lombardo, M.; Zambrano, V.; Pinna, L.; Battistini, L.; Sartori, A.; Pelosi, G.; Zanardi, F. Unlocking Access to Enantiopure Fused Uracils by Chemodivergent [4+2] Cross-Cycloadditions: DFT-Supported Homo-Synergistic Organocatalytic Approach. Angew. Chem. Int. Ed. 2020, 59, 20055–20064. doi: 10.1001/anie.202007509.

Bugatti, K.; Bruno, A.; Arosio, D.; Sartori, A.; Curti, C.; Augustijn, L.; Zanardi, F.; Battistini, L. Shifting Towards αVβ6 Integrin Ligands Using Novel Aminoproline-Based Cyclic Peptidomimetics. Chem. Eur. J. 2020, 26, 13468 – 13475. doi.org/10.1002/chem.202002554

Curti, C.; Battistini, L.; Sartori, A.; Zanardi, F. New Developments of the Principle of Vinylogy as Applied to p-Extended Enolate-Type Donor Systems. Chem. Rev. 2020, 120, 2448-2612. DOI: 10.1021/acs.chemrev.9b00481.

Favari, C.; Mena, P.; Curti, C.; Istas, G.; Heiss, C.; Del Rio, D.; Rodriguez-Mateos, A. Kinetic profile and urinary excretion of phenyl-γ-valerolactones upon consumption of cranberry: a dose–response relationship. Food Funct. 2020,11, 3975-3985. doi.org/10.1039/D0FO00806K 

Ruotolo, R.; Minato I.; La Vitola P.; Artioli L.; Curti C.; Franceschi V.; Brindani N.; Amidani D.; Colombo L.; Salmona M.; Forloni G.; Donofrio, G.; Balducci C.; Del Rio, D.; Ottonello S. Flavonoid‐Derived Human Phenyl‐γ‐Valerolactone Metabolites Selectively Detoxify Amyloid‐β Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease. Mol. Nutr. Food Res. 2020, 64, 190890. DOI: 10.1002/mnfr.201900890

Sartori, A.; Corno, C.; De Cesare, M.; Scanziani, E.; Minoli, L.; Battistini, L.; Zanardi, F.; Perego, P. Efficacy of a Selective Binder of  αVβ3 Integrin Linked to the Tyrosine Kinase Inhibitor Sunitinib in Ovarian Carcinoma Preclinical Models. Cancers 2019, 11, 531. Doi: 10.3390/cancers11040531.

Bianchini, F.; De Santis, A.; Portioli, E.; Russo Krauss, I.; Battistini, L.; Curti, C.; Peppicelli, S.; Calorini, L.; D’Errico, G.; Zanardi, F.; Sartori, A. Integrin-targeted AmpRGD sunitinib liposomes as integrated antiangiogenic tools. Nanomed-Nanotechnol. 2019, 18, 135-145. Doi: 10.1016/j.nano.2019.02.015.

Dell’Amico L.; Zanardi, F. Acetaldehyde Silyl Enol Ethers in Enantioselective Mukaiyama Aldol Reactions: Enzyme-Lyke Organocatalysis in Action. Angew. Chem. Int. Ed. 2019, 58, 3264-3266. Doi: 10.1002/anie.201812964.

Bianchini, F.; Portioli, E.; Ferlenghi, F.; Vacondio, F.; Andreucci, E.; Biagioni, A.; Ruzzolini, J.; Peppicelli, S.; Lulli, M.; Calorini, L.; Battistini, L.; Zanardi, F.; Sartori, A. Cell-targeted c(AmpRGD)-sunitinib molecular conjugates impair tumor growth of melanoma. Cancer Lett. 2019, 446, 25-37. Doi: 10.1016/j.canlet.2018.12.021.

Angelino, D.; Carregosa, D.; Domenech-Coca, C.; Savi, M.; Figueira, M.; Brindani, N.; Jang, S.; Lakshman, S.; Molokin, A.; Urban Jr., J.; Davis, C.D.; Brito, M.A.; Kim, K.S.; Brighenti, F.; Curti, C.; Bladé, C.; del Bas, J.M; Stilli, D.; Solano-Aguilar, G.I.; dos Santos, G.N.; del Rio, D.; Mena, P.; 5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models. Nutrients 2019, 11, 2678. DOI:10.3390/nu11112678

Mena, P.; Bresciani, L.; Brindani, N.; Ludwig, I.A.; Pereira-Caro, G.; Angelino, D.; Llorach, R.; Calani, L.; Brighenti, F.; Clifford, M.N; Gill, C.I.R.; Crozier, A.; Curti, C.; Del Rio, D. Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity. Nat. Prod. Rep. 2019, 36, 714-752.  DOI: 10.1039/c8np00062j

 Maggi, V.; Bianchini, F.; Portioli, E.; Peppicelli, S.; Lulli, M.; Bani, D.; Del Sole, R.; Zanardi, F.; Sartori, A.; Fiammengo, R. Gold Nanoparticles Functionalized with RGD-Semipeptides: A Simple yet Highly Effective Targeting System for  αVβ3 Integrins. Chem. Eur. J. 2018, 24, 12093-12100. Doi: 10.1002/chem.201801823.

Curti, C.; Battistini, L.; Sartori, A.; Rassu, G.; Pelosi, G.; Lombardo, M.; Zanardi, F. (E)-3-(Alkoxycarbonyl-2-alkyliden)-2-oxindoles: multidentate pronucleophiles for the organocatalytic, vinylogous Michael addition to nitroolefins. Adv. Synth. Catal. 2018, 360, 711-721. Doi: 10.1002/adsc.201701164.

Curti, C.; Sartori, A.; Battistini, L.; Zanardi, F. Exploring the remote reactivity of p-extended carbonyl compounds: the vinylogous alkylidene malononitrile activation strategy. Synlett 2018, 29, 266-281. doi: 10.1055/s-0036-1589125.

Brindani, N.; Mena, P.; Calani, L.; Benzie, I.; Choi, S.-W.; Brighenti, F.; Zanardi, F.; Curti, C.; Del Rio, D. Synthetic and analytic strategies for the quantification of phenyl-g-valerolactone conjugated metabolites in human urine. Mol. Nutr. Food Res. 2017, doi: 10.1002/mnfr.201700077.

Mena, P.; González de Llano, D.; Brindani, N.; Esteban-Fernández, A.; Curti, C.; Moreno-Arribas, M. V.; Del Rio, D.; Bartolomé, B. 5-(3′,4′-Dihydroxyphenyl)-g-valerolactone and its sulphate conjugates, representative circulating metabolites of flavan-3-ols, exhibit anti-adhesive activity against uropathogenic Escherichia coli in bladder epithelial cells. J. Funct. Foods 2017, 29, 275-280. doi: 10.3390/nu11112678 

Battistini, L.; Curti, C.; Rassu, G.; Sartori, A.; Zanardi, F. Enolizable Alkylidene Heterocyclic and Carbocyclic Carbonyl Systems: Valuable Vinylogous Donor Substrates in Synthesis. Synthesis 2017, 49, 2297-2336. Doi: 10.1055/s-0036-1589487.

Sartori, A.; Portioli, E.; Battistini, L.; Calorini, L.; Pupi, A.; Vacondio, F.; Arosio, D.; Bianchini, F.; Zanardi, F. Synthesis of Novel c(AmpRGD)-Sunitinib Dual Conjugates as Molecular Tools Targeting the  αVβ3 Integrin/VEGFR2 Couple and Impairing Tumor-Associated Angiogenesis. J. Med. Chem. 2017, 60 (1), 248-262. doi: 10.1021/acs.jmedchem.6b01266.

Curti, C.; Rassu, G.; Zambrano, V.; Pinna, L.; Brindani, N.; Pelosi, G.; Zanardi, F. Exploiting the Distal Reactivity of Indolyl-methylenemalononitriles: an Asymmetric Organocatalyzed [4+2] Cycloaddition with Enals Enables the Assembly of Elusive Dihydrocarbazoles. Chem. Eur. J. 2016, 22, 12637-12640. doi: 10.1002/chem.201602793

Spadoni, G.; Bedini, A.; Lucarini, S.; Mari, M.; Caignard, D.-H.; Boutin, J. A.; Delagrange, P.; Lucini, V.; Scaglione, F.; Lodola, A.; Zanardi, F.; Pala, D.; Mor, M.; Rivara, S. Highly potent and selective MT melatonin receptor full agonists from conformational analysis of 1-benzyl-2-acylaminomethyl-tetrahydroquinolines. J. Med. Chem. 2015, 58, 7512-7525. doi: 10.1021.acs.jmedchem.5b01066.

Curti, C.; Brindani, N.; Battistini, L.; Sartori, A.; Pelosi, G.; Mena, P.; Brighenti, F.; Zanardi, F.; Del Rio, D. Catalytic, Enantioselective, Vinylogous Mukaiyama Aldol Reaction of Furan-Based Dienoxy Silanes: A Chemodivergent Approach to γ-Valerolactone Flavan-3-ol Metabolites and δ-Lactone Analogues. Adv. Synth. Catal. 2015, 357, 4082-4092. DOI: 10.1002/adsc.201500705.

Sartori, A.; Bianchini, F.; Migliari, S.; Burreddu, P.; Curti, C.; Vacondio, F.; Arosio, D.; Ruffini, L.; Rassu, G.; Calorini, L.; Pupi, A.; Zanardi, F.; Battistini, L. Synthesis and Preclinical Evaluation of a Novel, Selective 111In-labelled Aminoproline-RGD-peptide For Non-invasive Melanoma Tumor Imaging. Med. Chem. Commun. 2015, 6, 2175-2183. doi.org/10.1039/C5MD00301F 

Brindani, N.; Rassu, G.; Dell’Amico, L.; Zambrano, V.; Pinna, L.; Curti, C.; Sartori, A.; Battistini, L.; Casiraghi, G.; Pelosi, G.; Greco, D.; Zanardi, F. Organocatalytic, Asymmetric Eliminative [4+2] Cycloaddition of Allylidene Malononitriles with Enals: Rapid Entry to Cyclohexadiene-Embedding Linear and Angular Polycycles. Angew. Chem. Int. Ed. 2015, 54, 7386-7390. doi: 10.1002/anie.201501894.

Curti, C.; Sartori, A.; Battistini, L.; Brindani, N.; Rassu, G.; Pelosi, G.; Lodola, A.; Mor, M.; Casiraghi, G.; Zanardi, F. Pushing the Boundaries of Vinylogous Reactivity: Catalytic Enantioselective Mukaiyama Aldol Reactions of Highly Unsaturated 2-Silyloxyindoles. Chem. Eur. J. 2015, 21, 6433-6442. doi: 10.1002/chem.201500083

Sartori, A.; Dell’Amico, L.; Battistini, L.; Curti, C.; Rivara, S.; Pala, D.; Kerry, P. S.; Pelosi, G.; Casiraghi, G.; Rassu, G.; Zanardi, F. Synthesis, structure and inhibitory activity of a stereoisomer of oseltamivir carboxylate. Org. Biomol. Chem. 2014, 12, 1561-1569. doi.org/10.1039/C3OB42069H 

Ranieri, B.; Sartori, A.; Curti, C.; Battistini, L.; Rassu, G.; Pelosi, G.; Casiraghi, G.; Zanardi, F. 3-Alkenyl-2-silyloxyindoles in Vinylogous Mannich Reactions: Synthesis of Aminated Indole-Based Scaffolds and Products. Org. Lett. 2014, 16, 932-935. DOI 10.1021/ol4036598.

Battistini, L.; Burreddu, P.; Sartori, A.; Arosio, D.; Manzoni, L.; Paduano, L.; D’Errico, G.; Sala, R.; Reia, L.; Bonomini, S.; Rassu, G.; Zanardi, F. Enhancement of the Uptake and Cytotoxic Activity of Doxorubicin in Cancer Cells by Novel cRGD-Semipeptide-Anchoring Liposomes. Mol. Pharm. 2014, 11, 2280-2293. doi: 10.1021/mp400718j

Rassu, G.; Zambrano, V.; Pinna, L.; Curti, C.; Battistini, L.; Sartori, A.; Pelosi, G.; Casiraghi, G.; Zanardi, F. Direct and Enantioselective Vinylogous Michael Addition of α-Alkylidenepyrazolinones to Nitroolefins Catalyzed by Dual Cinchona Alkaloid Thioureas. Adv. Synth. Catal. 2014, 356, 2330-2336. doi: 10.1002/adsc.201300964

Dell’Amico, L.; Zanardi, F. The 1,4- and 1,6-Addition of Vinylogous Donor Systems in on-Water and Organocatalyzed Reactions. La Chimica e l’Industria 2014, n.3, 52-53.

Dell’Amico, L.; Rassu, G.; Zambrano, V.; Sartori, A.; Curti, C.; Battistini, L.; Pelosi, G.; Casiraghi, G.; Zanardi, F. Exploring the Reactivity of Cyclohexenylidene Malononitriles: Switchable Regioselectivity in the Organocatalytic Asymmetric Addition to Enals Giving Highly Enantioenriched Carbabicyclic Structures. J. Am. Chem. Soc. 2014, 136, 11107-11114. doi: 10.1021/ja5054576l.

Rassu, G.; Zambrano, V.; Pinna, L.; Curti, C.; Battistini, L.; Sartori, A.; Pelosi, G.; Zanardi, F.; Casiraghi, G. Direct Regio-, Diastereo-, and Enantioselective Vinylogous Michael Addition of Prochiral 3-Alkylidene Oxindoles to Nitroolefins. Adv. Synth. Catal. 2013, 355, 1881-1886. DOI: 10.1002/adsc.201300168.

Rassu, G.; Zambrano, V.; Tanca, R.; Sartori, A.; Battistini, L.; Zanardi, F.; Curti, C.; Casiraghi, G. 3-Alkenyl-2-silyloxyindoles: an Enabling, yet Understated Progeny of Vinylogous Carbon Nucleophiles. Eur. J. Org. Chem. 2012, 466-470. DOI: 10.1002/ejoc.201101446.

Curti, C.; Rassu, G.; Zambrano, V.; Pinna, L.; Pelosi, G.; Sartori, A.; Battistini, L.; Zanardi, F.; Casiraghi, G. Bifunctional Cinchona Alkaloid/Thiourea Catalyzes Direct and Enantioselective Vinylogous Michael Addition of 3-Alkylidene Oxindoles to Nitroolefins. Angew. Chem. Int. Ed. 2012, 51, 6200-6204. Doi: 10.1002/anie.201202027

Pilkington-Miksa, M.; Arosio, D.; Battistini, L.; Belvisi, L.; De Matteo, M.; Vasile, F.; Burreddu, P.; Carta, P.; Rassu, G.; Perego, P.; Carenini, N.; Zunino, F.; De Cesare, M.; Castiglioni, V.; Scanziani, E.; Scolastico, C.; Casiraghi, G.; Zanardi, F.; Manzoni L. Design, Synthesis and Biological Evaluation of Novel cRGD-Paclitaxel Conjugates for Integrin-Assisted Drug Delivery. Bioconj. Chem. 2012, 23, 1610-1622. DOI: 10.1021/bc300164t

Zanardi, F.; Rassu, G.; Battistini, L.; Curti, C.; Sartori, A.; Casiraghi, G. The Principle of Vinylogy as Applied to Heterocyclic Donor Systems. In Targets in Heterocyclic Systems – Chemistry and Properties (Attanasi, O. A., Spinelli, D. Eds.); Società Chimica Italiana: Roma, 2012, Vol. 16, p 56-89.

Casiraghi, G.; Battistini, L.; Curti, C.; Rassu, G.; Zanardi, F. The Vinylogous Aldol and Related Reactions: Ten Years of Progress. Chem. Rev. 2011, 111, 3076-3154. DOI: 10.1021/cr100304n.

Curti, C.; Battistini, L.; Ranieri, B.; Pelosi, G.; Rassu, G.; Casiraghi, G.; Zanardi, F. anti-Selective, Catalytic Asymmetric Vinylogous Mukaiyama Mannich Reactions of Pyrrole-Based Silyl Dienolates with N-Aryl Aldimines. J. Org. Chem. 2011, 76, 2248-2252. doi: 10.1021/jo1021234.

Battistini, L.; Dell’Amico L.; Sartori, A.; Curti, C.; Pelosi, G.; Casiraghi, G.; Attanasi, O.A.; Favi, G.; Zanardi, F. On-Water Vinylogous Mukaiyama-Michael Addition of Heterocyclic 2-Silyloxydienes to 1,2-Diaza-1,3-dienes: One-Pot Three-Step Entry to Functionality-Rich Pyrroles. Adv. Synth. Catal. 2011, 353, 1966-1972. doi: 10.1002/adsc.201100296.

Curti, C.; Battistini, L.; Sartori, A.; Lodola, A.; Mor, M.; Rassu, G.; Pelosi, G.; Zanardi, F.; Casiraghi, G. Catalytic, Asymmetric Hypervinylogous Mukaiyama Aldol Reactions of Extended Furan-Based Silyl Enolates. Org. Lett. 2011, 13, 4738-4741. Doi: 10.1021/ol2020626.

Sartori, A.; Dell’Amico, L.; Curti, C.; Battistini, L.; Pelosi, G.; Rassu, G.; Casiraghi, G.; Zanardi, F. Aqueous and Solvent-Free Uncatalyzed Three-Component Vinylogous Mukaiyama-Mannich Reactions of Pyrrole-Based Silyl Dienolates. Adv. Synth. Catal. 2011, 353, 3278-3284. DOI: 10.1002/adsc.201100572.

Ranieri, B.; Curti, C.; Battistini, L.; Sartori, A.; Pinna, L.; Casiraghi, G.; Zanardi, F. Diastereo- and Enantioselective Catalytic Vinylogous Mukaiyama-Mannich Reactions of Pyrrole-Based Silyl Dienolates with Alkyl-Substituted Aldehydes. J. Org. Chem., 2011, 76, 10291-10298. DOI: 10.1021/jo201875a.

Auzzas, L.; Zanardi, F.; Battistini, L.; Burreddu, P.; Carta, P.; Rassu, G.;Curti, C.; Casiraghi, G. Targeting αVβ3 Integrin: Design and Applications of Mono- and Multifunctional RGD-Based Peptides and Semipeptides. Curr. Med. Chem. 2010, 17, 1255-1299.  DOI: 10.2174/092986710790936301 

Zambrano, V.; Rassu, G.; Roggio, A.; Pinna, L.; Zanardi, F.; Curti, C.; Casiraghi, G.; Battistini, L. Asymmetric Total Synthesis of 1-Deoxy-7,8-di-epi-castanospermine. Org. Biomol. Chem. 2010, 8, 1725-1730. DOI: 10.1039/b924721a.

Curti, C.; Ranieri, B.; Battistini, L.; Gloria Rassu, G.; Zambrano, V.; Pelosi, G.; Casiraghi, G.; Zanardi, F. Catalytic, Asymmetric Vinylogous Mukaiyama Aldol Reactions of Pyrrole- and Furan-Based Dienoxy Silanes: How the Diene Heteroatom Impacts Stereocontrol. Adv. Synth. Catal. 2010, 352, 2011-2022. doi: 10.1002/adsc.201000189.

Battistini, L.; Zanardi, F.; Curti, C.; Casiraghi, G. The Vinylogous Mannich Reaction: an Asymmetric Journey. Chemtracts Org. Chem. 2010, 23, 141-152.

Curti, C.; Battistini, L.; Zanardi, F.; Rassu, G.; Zambrano, V.; Pinna, L.; Casiraghi, G. Uncatalyzed, Diastereoselective Vinylogous Mukaiyama Aldol Reactions on Aqueous media: Pyrrole vs Furan 2-Silyloxy Dienes. J. Org. Chem. 2010, 75, 8681-8684. doi: 10.1021/jo101799e.

Casiraghi, G.; Zanardi, F.; Battistini, L.; Rassu, G. Advances in Exploring Heterocyclic Dienoxysilane Nucleophiles in Asymmetric Synthesis. Synlett 2009, 1525-1542.

Curti, C.; Sartori, A.; Battistini, L.; Rassu, G.; Zanardi, F.; Casiraghi, G. Asymmetric, catalytic, vinylogous aldol reactions using pyrrole-based dienoxy silanes. Enantioselective synthesis of a,b-unsaturated g-butyrolactam synthons. Tetrahedron Lett. 2009, 50, 3428-3431. doi.org/10.1016/j.tetlet.2009.02.181 

Battistini, L.; Burreddu, P.; Carta, P.; Rassu, G.; Auzzas, L.; Curti, C.; Zanardi, F.; Manzoni, L.; Araldi, E. M. V.; Scolastico, C.; Casiraghi, G. 4-Aminoproline-Based Arginine-Glycine-Aspartate Integrin Binders with Exposed Ligation Points: Practical in-Solution Synthesis, Conjugation and Binding Affinity Evaluation. Org. Biomol. Chem. 2009, 7, 4924-4935. doi: 10.1039/b914836a.

Zanardi, F.; Burreddu, P.; Rassu, G.; Auzzas, L.; Battistini, L.; Curti, C.; Sartori, A.; Nicastro, G.; Menchi, G.; Cini, N.; Bottoncetti, A.; Raspanti, S.; Casiraghi, G. Discovery of Subnanomolar Arginine-Glycine-Aspartate-Based αVβ3/αVβ5 Integrin Binders Embedding 4-Aminoproline Residues. J. Med. Chem. 2008, 51 (6), 1771-1782 (corrigendum J. Med. Chem. 2008, 51, 2870).

Zanardi, F.; Curti, C.; Sartori, A.; Rassu, G.; Roggio, A.; Battistini, L.; Burreddu, P.; Pinna, L.; Pelosi, G.; Casiraghi, G. Further Uses of Pyrrole-Based Dienoxysilane Synthons: A Full Aldol Approach to Azabicyclo[x.2.1]alkane Systems. Eur. J. Org. Chem. 2008, 2273-2287. doi.org/10.1002/ejoc.200800040 

Curti, C.; Sartori, A.; Battistini, L.; Rassu, G.; Burreddu, P.; Zanardi, F.; Casiraghi, G. Vicarious Silylative Mukaiyama Aldol Reaction: A Vinylogous Extension. J. Org. Chem. 2008, 73, 5446-5451. DOI: 10.1021/jo800741c

Sartori, A.; Curti, C.; Battistini, L.; Burreddu, P.; Rassu, G.; Pelosi, G.; Casiraghi, G.; Zanardi, F. Direct-type vinylogous Mukaiyama-Michael addition reactions involving pyrrolinone donors. Tetrahedron 2008, 64, 11697-11705. doi: 10.1016/j.tet.2008.10.007

Zanardi, F.; Sartori, A.; Curti, C.; Battistini, L.; Rassu, G.; Nicastro, G.; Casiraghi, G. Diastereoselective Synthesis of 4,5'-Bis-Proline Compounds via Reductive Dimerization of N-Acyloxyiminium Ions. J. Org. Chem. 2007, 72, 1814-1817. doi.org/10.1021/jo062406l 

Curti, C.; Zanardi, F.; Battistini, L.; Sartori, A.; Rassu, G.; Auzzas, L.; Roggio, A.; Pinna, L.; Casiraghi, G. New Enantioselective Entry to Cycloheptane Amino Acid Polyols. J. Org. Chem. 2006, 71, 225-230. doi.org/10.1021/jo0520137 

Vicini, P.; Incerti, M.; Ferretti, R.; Zanardi, F. A one-pot entry to a novel 3H-benzo[d]pyrazolo[1,5-b]isothiazole ring system. Molecular Diversity 2006, 10, 251-253. DOI: 10.1007/s11030-005-9011-3

Curti, C.; Zanardi, F.; Battistini, L.; Sartori, A.; Rassu, G.; Pinna, L.; Casiraghi, G. Streamlined, Asymmetric Synthesis of 8,4'-Oxyneolignans. J. Org. Chem. 2006, 71, 8552-8558. 

Casiraghi, G.; Zanardi, F. Enantioselective Organocatalytic Formal [3 + 3]-Cycloaddition of α,β-Unsaturated Aldehydes and Application to the Asymmetric Synthesis of (-)-Isopulegol Hydrate and (-)-Cubebaol. Chemtracts Org. Chem. 2006, 19, 136-142.

Casiraghi, G.; Rassu, G.; Auzzas, L.; Burreddu, P.; Gaetani, E.; Battistini, L.; Zanardi, F.; Curti, C.; Nicastro, G.; Belvisi, L.; Motto, I.; Castorina, M.; Giannini, G.; Pisano, C. Grafting Aminocyclopentane Carboxylic Acids onto the RGD Tripeptide Sequence Generates Low Nanomolar αVβ3/αVβ5 Integrin Dual Binders. J. Med. Chem. 2005, 48, 7675-7687.

Rassu, G.; Auzzas, L.; Battistini, L.; Casiraghi, G. Advances in The Chemical Synthesis of Medium-Sized Cyclitols. Mini-Reviews in Organic Chemistry 2004, 1, 343-357.

Battistini, L.; Curti, C.;  Zanardi, F.; Rassu, G.; Auzzas, L.; Casiraghi, G. Enantioselective Total Synthesis of (1R,3S,4R,5R)-1-Amino-4,5-dihydroxycyclopentane-1,3-dicarboxylic Acid. A Full-Aldol Access to Carbaketose Derivatives. J. Org. Chem. 2004, 69, 2611-2613.

Appendino, G.; Casiraghi, G.; Zanardi, F. Resurrecting the Cornforth Model for Carbonyl Addition: Studies on the Origin of the 1,2-Asymmetric Induction in Enolate Addition to Heteroatom-Substituted Aldehydes. Chemtracts Org. Chem. 2004, 17, 242-249.

Zanardi, F.; Appendino, G.; Casiraghi, G. The Synthesis of the Anti-Malarial Natural Product Polysphorin and Analogues Using Polymer-Supported Reagents and Scavengers. Chemtracts Org. Chem. 2004, 17, 587-592.

Appendino, G.; Prosperini, S.; Zanardi, F.; Casiraghi, G. The Synthesis of Thapsigargins. Chemtracts Org. Chem. 2004, 17, 627-637.

Rassu, G.; Auzzas, L.; Zambrano, V.; Burreddu, P.; Pinna, L.; Battistini, L.; Zanardi, F.; Casiraghi, G. Variable Strategy towards Carbasugars and Relatives. 6. Diastereoselective Synthesis of 2-Deoxy-2-amino-5a-carba-b-L-mannopyranuronic Acid and 2-Deoxy-2-amino-5a-carba-b-L-mannopyranose. J. Org. Chem., 2004, 69, 1625-1628.

Battistini, L.; Casiraghi, G.; Curti, C.; Rassu, G.; Zambrano, V.; Zanardi, F. Silylative N-hydroxyalkylation of amide compounds: application to the synthesis of acyclic alditol-based nucleoside analogues. Tetrahedron 2004, 60, 2957-2964.

Rassu, G.; Auzzas, L.; Pinna, L.; Battistini, L.; Curti, C. Advances in Chemical Synthesis of Carbasugars and Analogues. In Studies in Natural Products Chemistry; Atta-ur-Rahman, Ed.; Elsevier Science B. V.: Amsterdam; 2003, Vol. 29: Bioactive Natural Products (Part J), pp 449-520 (ISBN : 0-444-51510-0).

Casiraghi, G.; Zanardi, F.; Auzzas, L.; Appendino, G. Isopavines as a New Class of Morphinomimetics. Chemtracts Org. Chem. 2003, 16, 830-837.

Rassu, G.; Auzzas, L.; Pinna, L.; Zambrano, V.; Zanardi, F.; Battistini, L.; Gaetani, E.; Curti, C.; Casiraghi, G. Variable Strategy towards Carbasugars and Relatives. 5. Focus on Preparation of Chiral Nonracemic Medium-Sized Carbocycles. J. Org. Chem., 2003, 68, 5881-5885.

Rassu, G.; Auzzas, L.; Zambrano, V.; Burreddu, P.; Battistini, L.; Curti, C. A Short Entry to Novel C(2)-Methyl Branched 4a-Carbafuranoses. Tetrahedron: Asymmetry 2003, 14, 1665-1670.

Zanardi, F.; Appendino, G.; Casiraghi, G. The Vinylogous Intramolecular Morita-Baylis-Hillman Reaction. Chemtracts Org. Chem. 2002, 15, 490-497.

Appendino, G.; Zanardi, F.; Casiraghi, G. The First Stereoselective Total Synthesis of Quinine. Chemtracts Org. Chem. 2002, 15, 175-182.

Rassu, G.; Auzzas, L.; Pinna, L.; Zambrano, V.; Zanardi, F.; Battistini, L.; Marzocchi, L.; Acquotti, D.; Casiraghi, G. Variable Strategy toward Carbasugars and Relatives. 4. Viable Access to (4a-Carbapentofuranosyl)amines, (5a-Carbahexopyranosyl)amines, and Amino Acids Thereof. J. Org. Chem. 2002, 67, 5338-5342.

Zanardi, F.; Battistini, L.; Marzocchi, L.; Acquotti, D.; Rassu, G.; Pinna, L.; Auzzas, L.; Zambrano, V.; Casiraghi, G. Synthesis of a Small Repertoire of Non-Racemic 5a-Carbahexopyranoses and 1-Thio-5a-carbahexopyranoses. Eur. J. Org. Chem. 2002, 1956-1964.

Rassu, G.; Auzzas, L.; Pinna, L.; Zambrano, V.; Battistini, L.; Zanardi, F.; Marzocchi, L.; Acquotti, D.; Casiraghi, G. Variable Strategy toward Carbasugars and Relatives. 2. Diversity-Based Synthesis of b-D-Xylo, b-D-Ribo, b-L-Arabino, and b-L-Lyxo 4a-Carbafuranoses, and (4a-Carbafuranosyl)thiols. J. Org. Chem. 2001, 66, 8070-8075.

Appendino, G.; Casiraghi, G.; Zanardi, F. A New Method for the one-Step Synthesis of a,b-Unsaturated Carbonyl Systems from Saturated Alcohols and Carbonyl Compounds. Chemtracts-Org. Chem. 2001, 14, 181-185.

Casiraghi, G.; Zanardi, F.; Appendino, G. Molecular Recognition of Carbonyl Compounds Using Aluminum Tris(2,6-diphenylphenoxide) (ATPH): New Regio- and Stereoselective Alkylation of a,b-Unsaturated Carbonyl Compounds. Chemtracts-Org. Chem. 2001, 14, 106-112.

Appendino, G.; Casiraghi, G.; Zanardi, F. The Total Synthesis of Frondosin B. Chemtracts Org. Chem. 2000, 13, 741-745.

Casiraghi, G.; Zanardi, F.; Rassu, G. The Vinylogous Aldol Reaction of Heterocyclic Silyloxy Dienes: Application in Synthesis. Pure Appl. Chem 2000, 72, 1645-1648.

Appendino, G.; Casiraghi, G.; Zanardi, F. The synthesis of Bisorbicillinoids. An Amazing Self-Assembly of Simple Compounds into Highly Complex Natural Products. Chemtracts-Org. Chem. 2000, 13, 456-463.

Rassu, G.; Auzzas, L.; Pinna, L.; Battistini, L.; Zanardi, F.; Marzocchi, L.; Acquotti, D.; Casiraghi, G. Variable Strategy toward Carbasugars and Relatives. 1. Stereocontrolled Synthesis of Pseudo-b-D-gulopyranose, Pseudo-b-D-xylofuranose, (Pseudo-b-D-gulopyranosyl)amine, and (Pseudo-b-D-xylofuranosyl)amine. J. Org. Chem. 2000, 65, 6307-6318.

Casiraghi, G.; Zanardi, F.; Appendino, G.; Rassu, G. The Vinylogous Aldol Reaction: a Valuable, yet Understated Carbon–Carbon Bond–Forming Maneuver. Chem. Rev. 2000, 100, 1929-1972.

Cornia, M.; Menozzi, M.; Ragg, E.; Mazzini, S.; Scarafoni, A.; Zanardi, F.; Casiraghi, G. Synthesis and Utility of Novel C-meso-Glycosylated Metalloporphyrins. Tetrahedron 2000, 56, 3977-3983.

Zanardi, F.; Battistini, L.; Rassu, G.; Auzzas, L.; Pinna, L.; Marzocchi, L.; Acquotti, D.; Casiraghi, G. The Utility of Furan, Pyrrole, and Thiophene 2-Silyloxy Dienes as Demonstrated by Modular Synthesis of Annonaceous Acetogenin Core Units and Their Pyrrolidine and Thiolane Analogues. J. Org. Chem. 2000, 65, 2048-2064.

 Rassu, G.; Zanardi, F.; Battistini, L.; Casiraghi, G. The Synthetic Utility of Furan-, Pyrrole- and Thiophene-Based 2-Silyloxy Dienes. Chem. Soc. Rev. 2000, 109-118.