Publications
Marcantonio E., Guazzetti D., Bugatti K., Battistini L., Sartori A., Pelosi G., Curti C., Zanardi F. Turning the Imidazole Core into Three-Dimensional Ring Systems: Mild Organocatalytic Entry to Enantiopure 6,7-Dihydrobenzimidazoles, Chem. Eur. J. 2023, e202301200, https://doi.org/10.1002/chem.202301200
Bugatti K., Sartori A., Battistini L., Coppa C., Vanhulle E., Noppen S., Provinciael B., Naesens L., Stevaert A., Contini A., Vermeire K., Zanardi F. Novel Polymyxin-Inspired Peptidomimetics Targeting the SARS-CoV-2 Spike:hACE2 Interface, Int. J. Mol. Sci. 2023, 24(10), 8765, https://doi.org/10.3390/ijms24108765
Marcantonio E., Zanardi F., Curti C. and Lombardo M. Mechanistic Insights into the Stepwise (4+2) Cycloaddition toward Chiral Fused Uracil Derivatives. Adv. Synth. Catal. 2023, 365; https://doi.org/10.1002/adsc.202300045
Andreucci L., Bugatti K., Peppicelli S., Ruzzolini J., Lulli M., Calorini L., Battistini L., Zanardi F., Sartori A. and Bianchini F. Nintedanib-αVβ6 Integrin Ligand Conjugates ReduceTGFβ-Induced EMT in Human Non-Small Cell Lung Cancer. Int. J. Mol. Sci. 2023, 24(2), 1475; https://doi.org/10.3390/ijms24021475
Curti C., Sartori A., Battistini L., Zanardi F. Chapter 14: Merging Organocatalysis with Vinylogy – New Opportunities for Asymmetric, Synthesis, Asymmetric Organocatalysis: New Strategies, Catalysts, and Opportunities, Volume 2, Wiley-VCH, 2022, https://doi.org/10.1002/9783527832217.ch14
Curti C., Marcantonio E., Sartori A., Battistini L., Zanardi F., Accessing Chiral Dihydro- and Tetrahydriquinazoline-2,4-diones via [4+2]-cycloadditions: From Pioneering Studies To Asymmetric Organozatalyzed Syntheses, Targets In Heterocyclic Systems, Vol 26, 2022, Società Chimica Italiana, https://soc.chim.it/it/libri_collane/ths/vol_26_2022
Bugatti, K.; Sartori, A.; Battistini, L.; Ruzzolini, J.; Nediani, C.; Curti, C.; Bianchini, F. and Zanardi, F. Nintedanib-αVβ3 Integrin Ligand Dual-Targeting Conjugates towards Precision Treatment of Melanoma. EurJOC, 2022, e202200765, https://doi.org/10.1002/ejoc.202200765
Bugatti, K.; Andreucci, E.; Monaco, N.; Battistini, L.; Peppicelli, S.; Ruzzolini, J.; Curti, C.; Zanardi, F.; Bianchini, F. and Sartori, A. Nintedanib-Containing Dual Conjugates Targeting αVβ6 Integrin and Tyrosine Kinase Receptors as Potential Antifibrotic Agents. ACS Omega, 2022, 7, 21, 17658–17669, https://doi.org/10.1021/acsomega.2c00535
Valtorta, S.; Toscani, D; Chiu, M.; Sartori, A; Coliva, A.; Brevi, C; Taurino, G.; Grioni, M.; Ruffini, L.; Vacondio, F.; Zanardi, F.; Bellone, M.; Moresco, R.M.; Bussolati, O. and Giuliani, N. [18F] (2S,4R)-4-Fluoroglutamine as a New Positron Emission Tomography Tracer in Myeloma, Frontiers in Oncology, 2021, 11, 760732. https://doi.org/10.3389/fonc.2021.760732
Sartori, A.; Bugatti, K.; Portioli, E.; Baiula, M.; Casamassima, I.; Bruno, A.; Bianchini, F.; Curti, C.; Zanardi, F. and Battistini, L. New 4-Aminoproline-Based Small Molecule Cyclopeptidomimetics as Potential Modulators of α4β1 Integrin. Molecules, 2021, 26(19), 6066. 10.3390/molecules26196066
Battistini, L.; Bugatti, K.; Sartori, A.; Curti, C.; Zanardi, F. RGD Peptide-Drug Conjugates as Effective Dual Targeting Platforms: Recent Advances. Eur. J. Org. Chem. 2021, 2506-2528. doi.org/10.1002/ejoc.202100240.
Marcantonio, E.; Curti, C.; Battistini, L.; Sartori, A.; Cardinale, L.; Pelosi, G.; Zanardi, F. Direct, Asymmetric Synthesis of Carbocycle-Fused Uracils via [4+2] Cycloadditions: a Noncovalent Organocatalysis Approach. Adv. Synth. Catal. 2021, 363; doi: 10.1002/adsc.202100082.
Curti, C.; Rassu, G.; Lombardo, M.; Zambrano, V.; Pinna, L.; Battistini, L.; Sartori, A.; Pelosi, G.; Zanardi, F. Unlocking Access to Enantiopure Fused Uracils by Chemodivergent [4+2] Cross-Cycloadditions: DFT-Supported Homo-Synergistic Organocatalytic Approach. Angew. Chem. Int. Ed. 2020, 59, 20055–20064. doi: 10.1001/anie.202007509.
Bugatti, K.; Bruno, A.; Arosio, D.; Sartori, A.; Curti, C.; Augustijn, L.; Zanardi, F.; Battistini, L. Shifting Towards αVβ6 Integrin Ligands Using Novel Aminoproline-Based Cyclic Peptidomimetics. Chem. Eur. J. 2020, 26, 13468 – 13475. doi.org/10.1002/chem.202002554
Curti, C.; Battistini, L.; Sartori, A.; Zanardi, F. New Developments of the Principle of Vinylogy as Applied to p-Extended Enolate-Type Donor Systems. Chem. Rev. 2020, 120, 2448-2612. DOI: 10.1021/acs.chemrev.9b00481.
Favari, C.; Mena, P.; Curti, C.; Istas, G.; Heiss, C.; Del Rio, D.; Rodriguez-Mateos, A. Kinetic profile and urinary excretion of phenyl-γ-valerolactones upon consumption of cranberry: a dose–response relationship. Food Funct. 2020,11, 3975-3985. doi.org/10.1039/D0FO00806K
Ruotolo, R.; Minato I.; La Vitola P.; Artioli L.; Curti C.; Franceschi V.; Brindani N.; Amidani D.; Colombo L.; Salmona M.; Forloni G.; Donofrio, G.; Balducci C.; Del Rio, D.; Ottonello S. Flavonoid‐Derived Human Phenyl‐γ‐Valerolactone Metabolites Selectively Detoxify Amyloid‐β Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease. Mol. Nutr. Food Res. 2020, 64, 190890. DOI: 10.1002/mnfr.201900890
Sartori, A.; Corno, C.; De Cesare, M.; Scanziani, E.; Minoli, L.; Battistini, L.; Zanardi, F.; Perego, P. Efficacy of a Selective Binder of αVβ3 Integrin Linked to the Tyrosine Kinase Inhibitor Sunitinib in Ovarian Carcinoma Preclinical Models. Cancers 2019, 11, 531. Doi: 10.3390/cancers11040531.
Bianchini, F.; De Santis, A.; Portioli, E.; Russo Krauss, I.; Battistini, L.; Curti, C.; Peppicelli, S.; Calorini, L.; D’Errico, G.; Zanardi, F.; Sartori, A. Integrin-targeted AmpRGD sunitinib liposomes as integrated antiangiogenic tools. Nanomed-Nanotechnol. 2019, 18, 135-145. Doi: 10.1016/j.nano.2019.02.015.
Dell’Amico L.; Zanardi, F. Acetaldehyde Silyl Enol Ethers in Enantioselective Mukaiyama Aldol Reactions: Enzyme-Lyke Organocatalysis in Action. Angew. Chem. Int. Ed. 2019, 58, 3264-3266. Doi: 10.1002/anie.201812964.
Bianchini, F.; Portioli, E.; Ferlenghi, F.; Vacondio, F.; Andreucci, E.; Biagioni, A.; Ruzzolini, J.; Peppicelli, S.; Lulli, M.; Calorini, L.; Battistini, L.; Zanardi, F.; Sartori, A. Cell-targeted c(AmpRGD)-sunitinib molecular conjugates impair tumor growth of melanoma. Cancer Lett. 2019, 446, 25-37. Doi: 10.1016/j.canlet.2018.12.021.
Angelino, D.; Carregosa, D.; Domenech-Coca, C.; Savi, M.; Figueira, M.; Brindani, N.; Jang, S.; Lakshman, S.; Molokin, A.; Urban Jr., J.; Davis, C.D.; Brito, M.A.; Kim, K.S.; Brighenti, F.; Curti, C.; Bladé, C.; del Bas, J.M; Stilli, D.; Solano-Aguilar, G.I.; dos Santos, G.N.; del Rio, D.; Mena, P.; 5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models. Nutrients 2019, 11, 2678. DOI:10.3390/nu11112678
Mena, P.; Bresciani, L.; Brindani, N.; Ludwig, I.A.; Pereira-Caro, G.; Angelino, D.; Llorach, R.; Calani, L.; Brighenti, F.; Clifford, M.N; Gill, C.I.R.; Crozier, A.; Curti, C.; Del Rio, D. Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity. Nat. Prod. Rep. 2019, 36, 714-752. DOI: 10.1039/c8np00062j
Maggi, V.; Bianchini, F.; Portioli, E.; Peppicelli, S.; Lulli, M.; Bani, D.; Del Sole, R.; Zanardi, F.; Sartori, A.; Fiammengo, R. Gold Nanoparticles Functionalized with RGD-Semipeptides: A Simple yet Highly Effective Targeting System for αVβ3 Integrins. Chem. Eur. J. 2018, 24, 12093-12100. Doi: 10.1002/chem.201801823.
Curti, C.; Battistini, L.; Sartori, A.; Rassu, G.; Pelosi, G.; Lombardo, M.; Zanardi, F. (E)-3-(Alkoxycarbonyl-2-alkyliden)-2-oxindoles: multidentate pronucleophiles for the organocatalytic, vinylogous Michael addition to nitroolefins. Adv. Synth. Catal. 2018, 360, 711-721. Doi: 10.1002/adsc.201701164.
Curti, C.; Sartori, A.; Battistini, L.; Zanardi, F. Exploring the remote reactivity of p-extended carbonyl compounds: the vinylogous alkylidene malononitrile activation strategy. Synlett 2018, 29, 266-281. doi: 10.1055/s-0036-1589125.
Brindani, N.; Mena, P.; Calani, L.; Benzie, I.; Choi, S.-W.; Brighenti, F.; Zanardi, F.; Curti, C.; Del Rio, D. Synthetic and analytic strategies for the quantification of phenyl-g-valerolactone conjugated metabolites in human urine. Mol. Nutr. Food Res. 2017, doi: 10.1002/mnfr.201700077.
Mena, P.; González de Llano, D.; Brindani, N.; Esteban-Fernández, A.; Curti, C.; Moreno-Arribas, M. V.; Del Rio, D.; Bartolomé, B. 5-(3′,4′-Dihydroxyphenyl)-g-valerolactone and its sulphate conjugates, representative circulating metabolites of flavan-3-ols, exhibit anti-adhesive activity against uropathogenic Escherichia coli in bladder epithelial cells. J. Funct. Foods 2017, 29, 275-280. doi: 10.3390/nu11112678
Battistini, L.; Curti, C.; Rassu, G.; Sartori, A.; Zanardi, F. Enolizable Alkylidene Heterocyclic and Carbocyclic Carbonyl Systems: Valuable Vinylogous Donor Substrates in Synthesis. Synthesis 2017, 49, 2297-2336. Doi: 10.1055/s-0036-1589487.
Sartori, A.; Portioli, E.; Battistini, L.; Calorini, L.; Pupi, A.; Vacondio, F.; Arosio, D.; Bianchini, F.; Zanardi, F. Synthesis of Novel c(AmpRGD)-Sunitinib Dual Conjugates as Molecular Tools Targeting the αVβ3 Integrin/VEGFR2 Couple and Impairing Tumor-Associated Angiogenesis. J. Med. Chem. 2017, 60 (1), 248-262. doi: 10.1021/acs.jmedchem.6b01266.
Curti, C.; Rassu, G.; Zambrano, V.; Pinna, L.; Brindani, N.; Pelosi, G.; Zanardi, F. Exploiting the Distal Reactivity of Indolyl-methylenemalononitriles: an Asymmetric Organocatalyzed [4+2] Cycloaddition with Enals Enables the Assembly of Elusive Dihydrocarbazoles. Chem. Eur. J. 2016, 22, 12637-12640. doi: 10.1002/chem.201602793
Spadoni, G.; Bedini, A.; Lucarini, S.; Mari, M.; Caignard, D.-H.; Boutin, J. A.; Delagrange, P.; Lucini, V.; Scaglione, F.; Lodola, A.; Zanardi, F.; Pala, D.; Mor, M.; Rivara, S. Highly potent and selective MT melatonin receptor full agonists from conformational analysis of 1-benzyl-2-acylaminomethyl-tetrahydroquinolines. J. Med. Chem. 2015, 58, 7512-7525. doi: 10.1021.acs.jmedchem.5b01066.
Curti, C.; Brindani, N.; Battistini, L.; Sartori, A.; Pelosi, G.; Mena, P.; Brighenti, F.; Zanardi, F.; Del Rio, D. Catalytic, Enantioselective, Vinylogous Mukaiyama Aldol Reaction of Furan-Based Dienoxy Silanes: A Chemodivergent Approach to γ-Valerolactone Flavan-3-ol Metabolites and δ-Lactone Analogues. Adv. Synth. Catal. 2015, 357, 4082-4092. DOI: 10.1002/adsc.201500705.
Sartori, A.; Bianchini, F.; Migliari, S.; Burreddu, P.; Curti, C.; Vacondio, F.; Arosio, D.; Ruffini, L.; Rassu, G.; Calorini, L.; Pupi, A.; Zanardi, F.; Battistini, L. Synthesis and Preclinical Evaluation of a Novel, Selective 111In-labelled Aminoproline-RGD-peptide For Non-invasive Melanoma Tumor Imaging. Med. Chem. Commun. 2015, 6, 2175-2183. doi.org/10.1039/C5MD00301F
Brindani, N.; Rassu, G.; Dell’Amico, L.; Zambrano, V.; Pinna, L.; Curti, C.; Sartori, A.; Battistini, L.; Casiraghi, G.; Pelosi, G.; Greco, D.; Zanardi, F. Organocatalytic, Asymmetric Eliminative [4+2] Cycloaddition of Allylidene Malononitriles with Enals: Rapid Entry to Cyclohexadiene-Embedding Linear and Angular Polycycles. Angew. Chem. Int. Ed. 2015, 54, 7386-7390. doi: 10.1002/anie.201501894.
Curti, C.; Sartori, A.; Battistini, L.; Brindani, N.; Rassu, G.; Pelosi, G.; Lodola, A.; Mor, M.; Casiraghi, G.; Zanardi, F. Pushing the Boundaries of Vinylogous Reactivity: Catalytic Enantioselective Mukaiyama Aldol Reactions of Highly Unsaturated 2-Silyloxyindoles. Chem. Eur. J. 2015, 21, 6433-6442. doi: 10.1002/chem.201500083
Sartori, A.; Dell’Amico, L.; Battistini, L.; Curti, C.; Rivara, S.; Pala, D.; Kerry, P. S.; Pelosi, G.; Casiraghi, G.; Rassu, G.; Zanardi, F. Synthesis, structure and inhibitory activity of a stereoisomer of oseltamivir carboxylate. Org. Biomol. Chem. 2014, 12, 1561-1569. doi.org/10.1039/C3OB42069H
Ranieri, B.; Sartori, A.; Curti, C.; Battistini, L.; Rassu, G.; Pelosi, G.; Casiraghi, G.; Zanardi, F. 3-Alkenyl-2-silyloxyindoles in Vinylogous Mannich Reactions: Synthesis of Aminated Indole-Based Scaffolds and Products. Org. Lett. 2014, 16, 932-935. DOI 10.1021/ol4036598.
Battistini, L.; Burreddu, P.; Sartori, A.; Arosio, D.; Manzoni, L.; Paduano, L.; D’Errico, G.; Sala, R.; Reia, L.; Bonomini, S.; Rassu, G.; Zanardi, F. Enhancement of the Uptake and Cytotoxic Activity of Doxorubicin in Cancer Cells by Novel cRGD-Semipeptide-Anchoring Liposomes. Mol. Pharm. 2014, 11, 2280-2293. doi: 10.1021/mp400718j
Rassu, G.; Zambrano, V.; Pinna, L.; Curti, C.; Battistini, L.; Sartori, A.; Pelosi, G.; Casiraghi, G.; Zanardi, F. Direct and Enantioselective Vinylogous Michael Addition of α-Alkylidenepyrazolinones to Nitroolefins Catalyzed by Dual Cinchona Alkaloid Thioureas. Adv. Synth. Catal. 2014, 356, 2330-2336. doi: 10.1002/adsc.201300964
Dell’Amico, L.; Zanardi, F. The 1,4- and 1,6-Addition of Vinylogous Donor Systems in on-Water and Organocatalyzed Reactions. La Chimica e l’Industria 2014, n.3, 52-53.
Dell’Amico, L.; Rassu, G.; Zambrano, V.; Sartori, A.; Curti, C.; Battistini, L.; Pelosi, G.; Casiraghi, G.; Zanardi, F. Exploring the Reactivity of Cyclohexenylidene Malononitriles: Switchable Regioselectivity in the Organocatalytic Asymmetric Addition to Enals Giving Highly Enantioenriched Carbabicyclic Structures. J. Am. Chem. Soc. 2014, 136, 11107-11114. doi: 10.1021/ja5054576l.
Rassu, G.; Zambrano, V.; Pinna, L.; Curti, C.; Battistini, L.; Sartori, A.; Pelosi, G.; Zanardi, F.; Casiraghi, G. Direct Regio-, Diastereo-, and Enantioselective Vinylogous Michael Addition of Prochiral 3-Alkylidene Oxindoles to Nitroolefins. Adv. Synth. Catal. 2013, 355, 1881-1886. DOI: 10.1002/adsc.201300168.
Rassu, G.; Zambrano, V.; Tanca, R.; Sartori, A.; Battistini, L.; Zanardi, F.; Curti, C.; Casiraghi, G. 3-Alkenyl-2-silyloxyindoles: an Enabling, yet Understated Progeny of Vinylogous Carbon Nucleophiles. Eur. J. Org. Chem. 2012, 466-470. DOI: 10.1002/ejoc.201101446.
Curti, C.; Rassu, G.; Zambrano, V.; Pinna, L.; Pelosi, G.; Sartori, A.; Battistini, L.; Zanardi, F.; Casiraghi, G. Bifunctional Cinchona Alkaloid/Thiourea Catalyzes Direct and Enantioselective Vinylogous Michael Addition of 3-Alkylidene Oxindoles to Nitroolefins. Angew. Chem. Int. Ed. 2012, 51, 6200-6204. Doi: 10.1002/anie.201202027
Pilkington-Miksa, M.; Arosio, D.; Battistini, L.; Belvisi, L.; De Matteo, M.; Vasile, F.; Burreddu, P.; Carta, P.; Rassu, G.; Perego, P.; Carenini, N.; Zunino, F.; De Cesare, M.; Castiglioni, V.; Scanziani, E.; Scolastico, C.; Casiraghi, G.; Zanardi, F.; Manzoni L. Design, Synthesis and Biological Evaluation of Novel cRGD-Paclitaxel Conjugates for Integrin-Assisted Drug Delivery. Bioconj. Chem. 2012, 23, 1610-1622. DOI: 10.1021/bc300164t
Zanardi, F.; Rassu, G.; Battistini, L.; Curti, C.; Sartori, A.; Casiraghi, G. The Principle of Vinylogy as Applied to Heterocyclic Donor Systems. In Targets in Heterocyclic Systems – Chemistry and Properties (Attanasi, O. A., Spinelli, D. Eds.); Società Chimica Italiana: Roma, 2012, Vol. 16, p 56-89.
Casiraghi, G.; Battistini, L.; Curti, C.; Rassu, G.; Zanardi, F. The Vinylogous Aldol and Related Reactions: Ten Years of Progress. Chem. Rev. 2011, 111, 3076-3154. DOI: 10.1021/cr100304n.
Curti, C.; Battistini, L.; Ranieri, B.; Pelosi, G.; Rassu, G.; Casiraghi, G.; Zanardi, F. anti-Selective, Catalytic Asymmetric Vinylogous Mukaiyama Mannich Reactions of Pyrrole-Based Silyl Dienolates with N-Aryl Aldimines. J. Org. Chem. 2011, 76, 2248-2252. doi: 10.1021/jo1021234.
Battistini, L.; Dell’Amico L.; Sartori, A.; Curti, C.; Pelosi, G.; Casiraghi, G.; Attanasi, O.A.; Favi, G.; Zanardi, F. On-Water Vinylogous Mukaiyama-Michael Addition of Heterocyclic 2-Silyloxydienes to 1,2-Diaza-1,3-dienes: One-Pot Three-Step Entry to Functionality-Rich Pyrroles. Adv. Synth. Catal. 2011, 353, 1966-1972. doi: 10.1002/adsc.201100296.
Curti, C.; Battistini, L.; Sartori, A.; Lodola, A.; Mor, M.; Rassu, G.; Pelosi, G.; Zanardi, F.; Casiraghi, G. Catalytic, Asymmetric Hypervinylogous Mukaiyama Aldol Reactions of Extended Furan-Based Silyl Enolates. Org. Lett. 2011, 13, 4738-4741. Doi: 10.1021/ol2020626.
Sartori, A.; Dell’Amico, L.; Curti, C.; Battistini, L.; Pelosi, G.; Rassu, G.; Casiraghi, G.; Zanardi, F. Aqueous and Solvent-Free Uncatalyzed Three-Component Vinylogous Mukaiyama-Mannich Reactions of Pyrrole-Based Silyl Dienolates. Adv. Synth. Catal. 2011, 353, 3278-3284. DOI: 10.1002/adsc.201100572.
Ranieri, B.; Curti, C.; Battistini, L.; Sartori, A.; Pinna, L.; Casiraghi, G.; Zanardi, F. Diastereo- and Enantioselective Catalytic Vinylogous Mukaiyama-Mannich Reactions of Pyrrole-Based Silyl Dienolates with Alkyl-Substituted Aldehydes. J. Org. Chem., 2011, 76, 10291-10298. DOI: 10.1021/jo201875a.
Auzzas, L.; Zanardi, F.; Battistini, L.; Burreddu, P.; Carta, P.; Rassu, G.;Curti, C.; Casiraghi, G. Targeting αVβ3 Integrin: Design and Applications of Mono- and Multifunctional RGD-Based Peptides and Semipeptides. Curr. Med. Chem. 2010, 17, 1255-1299. DOI: 10.2174/092986710790936301
Zambrano, V.; Rassu, G.; Roggio, A.; Pinna, L.; Zanardi, F.; Curti, C.; Casiraghi, G.; Battistini, L. Asymmetric Total Synthesis of 1-Deoxy-7,8-di-epi-castanospermine. Org. Biomol. Chem. 2010, 8, 1725-1730. DOI: 10.1039/b924721a.
Curti, C.; Ranieri, B.; Battistini, L.; Gloria Rassu, G.; Zambrano, V.; Pelosi, G.; Casiraghi, G.; Zanardi, F. Catalytic, Asymmetric Vinylogous Mukaiyama Aldol Reactions of Pyrrole- and Furan-Based Dienoxy Silanes: How the Diene Heteroatom Impacts Stereocontrol. Adv. Synth. Catal. 2010, 352, 2011-2022. doi: 10.1002/adsc.201000189.
Battistini, L.; Zanardi, F.; Curti, C.; Casiraghi, G. The Vinylogous Mannich Reaction: an Asymmetric Journey. Chemtracts Org. Chem. 2010, 23, 141-152.
Curti, C.; Battistini, L.; Zanardi, F.; Rassu, G.; Zambrano, V.; Pinna, L.; Casiraghi, G. Uncatalyzed, Diastereoselective Vinylogous Mukaiyama Aldol Reactions on Aqueous media: Pyrrole vs Furan 2-Silyloxy Dienes. J. Org. Chem. 2010, 75, 8681-8684. doi: 10.1021/jo101799e.
Casiraghi, G.; Zanardi, F.; Battistini, L.; Rassu, G. Advances in Exploring Heterocyclic Dienoxysilane Nucleophiles in Asymmetric Synthesis. Synlett 2009, 1525-1542.
Curti, C.; Sartori, A.; Battistini, L.; Rassu, G.; Zanardi, F.; Casiraghi, G. Asymmetric, catalytic, vinylogous aldol reactions using pyrrole-based dienoxy silanes. Enantioselective synthesis of a,b-unsaturated g-butyrolactam synthons. Tetrahedron Lett. 2009, 50, 3428-3431. doi.org/10.1016/j.tetlet.2009.02.181
Battistini, L.; Burreddu, P.; Carta, P.; Rassu, G.; Auzzas, L.; Curti, C.; Zanardi, F.; Manzoni, L.; Araldi, E. M. V.; Scolastico, C.; Casiraghi, G. 4-Aminoproline-Based Arginine-Glycine-Aspartate Integrin Binders with Exposed Ligation Points: Practical in-Solution Synthesis, Conjugation and Binding Affinity Evaluation. Org. Biomol. Chem. 2009, 7, 4924-4935. doi: 10.1039/b914836a.
Zanardi, F.; Burreddu, P.; Rassu, G.; Auzzas, L.; Battistini, L.; Curti, C.; Sartori, A.; Nicastro, G.; Menchi, G.; Cini, N.; Bottoncetti, A.; Raspanti, S.; Casiraghi, G. Discovery of Subnanomolar Arginine-Glycine-Aspartate-Based αVβ3/αVβ5 Integrin Binders Embedding 4-Aminoproline Residues. J. Med. Chem. 2008, 51 (6), 1771-1782 (corrigendum J. Med. Chem. 2008, 51, 2870).
Zanardi, F.; Curti, C.; Sartori, A.; Rassu, G.; Roggio, A.; Battistini, L.; Burreddu, P.; Pinna, L.; Pelosi, G.; Casiraghi, G. Further Uses of Pyrrole-Based Dienoxysilane Synthons: A Full Aldol Approach to Azabicyclo[x.2.1]alkane Systems. Eur. J. Org. Chem. 2008, 2273-2287. doi.org/10.1002/ejoc.200800040
Curti, C.; Sartori, A.; Battistini, L.; Rassu, G.; Burreddu, P.; Zanardi, F.; Casiraghi, G. Vicarious Silylative Mukaiyama Aldol Reaction: A Vinylogous Extension. J. Org. Chem. 2008, 73, 5446-5451. DOI: 10.1021/jo800741c
Sartori, A.; Curti, C.; Battistini, L.; Burreddu, P.; Rassu, G.; Pelosi, G.; Casiraghi, G.; Zanardi, F. Direct-type vinylogous Mukaiyama-Michael addition reactions involving pyrrolinone donors. Tetrahedron 2008, 64, 11697-11705. doi: 10.1016/j.tet.2008.10.007
Zanardi, F.; Sartori, A.; Curti, C.; Battistini, L.; Rassu, G.; Nicastro, G.; Casiraghi, G. Diastereoselective Synthesis of 4,5'-Bis-Proline Compounds via Reductive Dimerization of N-Acyloxyiminium Ions. J. Org. Chem. 2007, 72, 1814-1817. doi.org/10.1021/jo062406l
Curti, C.; Zanardi, F.; Battistini, L.; Sartori, A.; Rassu, G.; Auzzas, L.; Roggio, A.; Pinna, L.; Casiraghi, G. New Enantioselective Entry to Cycloheptane Amino Acid Polyols. J. Org. Chem. 2006, 71, 225-230. doi.org/10.1021/jo0520137
Vicini, P.; Incerti, M.; Ferretti, R.; Zanardi, F. A one-pot entry to a novel 3H-benzo[d]pyrazolo[1,5-b]isothiazole ring system. Molecular Diversity 2006, 10, 251-253. DOI: 10.1007/s11030-005-9011-3
Curti, C.; Zanardi, F.; Battistini, L.; Sartori, A.; Rassu, G.; Pinna, L.; Casiraghi, G. Streamlined, Asymmetric Synthesis of 8,4'-Oxyneolignans. J. Org. Chem. 2006, 71, 8552-8558.
Casiraghi, G.; Zanardi, F. Enantioselective Organocatalytic Formal [3 + 3]-Cycloaddition of α,β-Unsaturated Aldehydes and Application to the Asymmetric Synthesis of (-)-Isopulegol Hydrate and (-)-Cubebaol. Chemtracts Org. Chem. 2006, 19, 136-142.
Casiraghi, G.; Rassu, G.; Auzzas, L.; Burreddu, P.; Gaetani, E.; Battistini, L.; Zanardi, F.; Curti, C.; Nicastro, G.; Belvisi, L.; Motto, I.; Castorina, M.; Giannini, G.; Pisano, C. Grafting Aminocyclopentane Carboxylic Acids onto the RGD Tripeptide Sequence Generates Low Nanomolar αVβ3/αVβ5 Integrin Dual Binders. J. Med. Chem. 2005, 48, 7675-7687.
Rassu, G.; Auzzas, L.; Battistini, L.; Casiraghi, G. Advances in The Chemical Synthesis of Medium-Sized Cyclitols. Mini-Reviews in Organic Chemistry 2004, 1, 343-357.
Battistini, L.; Curti, C.; Zanardi, F.; Rassu, G.; Auzzas, L.; Casiraghi, G. Enantioselective Total Synthesis of (1R,3S,4R,5R)-1-Amino-4,5-dihydroxycyclopentane-1,3-dicarboxylic Acid. A Full-Aldol Access to Carbaketose Derivatives. J. Org. Chem. 2004, 69, 2611-2613.
Appendino, G.; Casiraghi, G.; Zanardi, F. Resurrecting the Cornforth Model for Carbonyl Addition: Studies on the Origin of the 1,2-Asymmetric Induction in Enolate Addition to Heteroatom-Substituted Aldehydes. Chemtracts Org. Chem. 2004, 17, 242-249.
Zanardi, F.; Appendino, G.; Casiraghi, G. The Synthesis of the Anti-Malarial Natural Product Polysphorin and Analogues Using Polymer-Supported Reagents and Scavengers. Chemtracts Org. Chem. 2004, 17, 587-592.
Appendino, G.; Prosperini, S.; Zanardi, F.; Casiraghi, G. The Synthesis of Thapsigargins. Chemtracts Org. Chem. 2004, 17, 627-637.
Rassu, G.; Auzzas, L.; Zambrano, V.; Burreddu, P.; Pinna, L.; Battistini, L.; Zanardi, F.; Casiraghi, G. Variable Strategy towards Carbasugars and Relatives. 6. Diastereoselective Synthesis of 2-Deoxy-2-amino-5a-carba-b-L-mannopyranuronic Acid and 2-Deoxy-2-amino-5a-carba-b-L-mannopyranose. J. Org. Chem., 2004, 69, 1625-1628.
Battistini, L.; Casiraghi, G.; Curti, C.; Rassu, G.; Zambrano, V.; Zanardi, F. Silylative N-hydroxyalkylation of amide compounds: application to the synthesis of acyclic alditol-based nucleoside analogues. Tetrahedron 2004, 60, 2957-2964.
Rassu, G.; Auzzas, L.; Pinna, L.; Battistini, L.; Curti, C. Advances in Chemical Synthesis of Carbasugars and Analogues. In Studies in Natural Products Chemistry; Atta-ur-Rahman, Ed.; Elsevier Science B. V.: Amsterdam; 2003, Vol. 29: Bioactive Natural Products (Part J), pp 449-520 (ISBN : 0-444-51510-0).
Casiraghi, G.; Zanardi, F.; Auzzas, L.; Appendino, G. Isopavines as a New Class of Morphinomimetics. Chemtracts Org. Chem. 2003, 16, 830-837.
Rassu, G.; Auzzas, L.; Pinna, L.; Zambrano, V.; Zanardi, F.; Battistini, L.; Gaetani, E.; Curti, C.; Casiraghi, G. Variable Strategy towards Carbasugars and Relatives. 5. Focus on Preparation of Chiral Nonracemic Medium-Sized Carbocycles. J. Org. Chem., 2003, 68, 5881-5885.
Rassu, G.; Auzzas, L.; Zambrano, V.; Burreddu, P.; Battistini, L.; Curti, C. A Short Entry to Novel C(2)-Methyl Branched 4a-Carbafuranoses. Tetrahedron: Asymmetry 2003, 14, 1665-1670.
Zanardi, F.; Appendino, G.; Casiraghi, G. The Vinylogous Intramolecular Morita-Baylis-Hillman Reaction. Chemtracts Org. Chem. 2002, 15, 490-497.
Appendino, G.; Zanardi, F.; Casiraghi, G. The First Stereoselective Total Synthesis of Quinine. Chemtracts Org. Chem. 2002, 15, 175-182.
Rassu, G.; Auzzas, L.; Pinna, L.; Zambrano, V.; Zanardi, F.; Battistini, L.; Marzocchi, L.; Acquotti, D.; Casiraghi, G. Variable Strategy toward Carbasugars and Relatives. 4. Viable Access to (4a-Carbapentofuranosyl)amines, (5a-Carbahexopyranosyl)amines, and Amino Acids Thereof. J. Org. Chem. 2002, 67, 5338-5342.
Zanardi, F.; Battistini, L.; Marzocchi, L.; Acquotti, D.; Rassu, G.; Pinna, L.; Auzzas, L.; Zambrano, V.; Casiraghi, G. Synthesis of a Small Repertoire of Non-Racemic 5a-Carbahexopyranoses and 1-Thio-5a-carbahexopyranoses. Eur. J. Org. Chem. 2002, 1956-1964.
Rassu, G.; Auzzas, L.; Pinna, L.; Zambrano, V.; Battistini, L.; Zanardi, F.; Marzocchi, L.; Acquotti, D.; Casiraghi, G. Variable Strategy toward Carbasugars and Relatives. 2. Diversity-Based Synthesis of b-D-Xylo, b-D-Ribo, b-L-Arabino, and b-L-Lyxo 4a-Carbafuranoses, and (4a-Carbafuranosyl)thiols. J. Org. Chem. 2001, 66, 8070-8075.
Appendino, G.; Casiraghi, G.; Zanardi, F. A New Method for the one-Step Synthesis of a,b-Unsaturated Carbonyl Systems from Saturated Alcohols and Carbonyl Compounds. Chemtracts-Org. Chem. 2001, 14, 181-185.
Casiraghi, G.; Zanardi, F.; Appendino, G. Molecular Recognition of Carbonyl Compounds Using Aluminum Tris(2,6-diphenylphenoxide) (ATPH): New Regio- and Stereoselective Alkylation of a,b-Unsaturated Carbonyl Compounds. Chemtracts-Org. Chem. 2001, 14, 106-112.
Appendino, G.; Casiraghi, G.; Zanardi, F. The Total Synthesis of Frondosin B. Chemtracts Org. Chem. 2000, 13, 741-745.
Casiraghi, G.; Zanardi, F.; Rassu, G. The Vinylogous Aldol Reaction of Heterocyclic Silyloxy Dienes: Application in Synthesis. Pure Appl. Chem 2000, 72, 1645-1648.
Appendino, G.; Casiraghi, G.; Zanardi, F. The synthesis of Bisorbicillinoids. An Amazing Self-Assembly of Simple Compounds into Highly Complex Natural Products. Chemtracts-Org. Chem. 2000, 13, 456-463.
Rassu, G.; Auzzas, L.; Pinna, L.; Battistini, L.; Zanardi, F.; Marzocchi, L.; Acquotti, D.; Casiraghi, G. Variable Strategy toward Carbasugars and Relatives. 1. Stereocontrolled Synthesis of Pseudo-b-D-gulopyranose, Pseudo-b-D-xylofuranose, (Pseudo-b-D-gulopyranosyl)amine, and (Pseudo-b-D-xylofuranosyl)amine. J. Org. Chem. 2000, 65, 6307-6318.
Casiraghi, G.; Zanardi, F.; Appendino, G.; Rassu, G. The Vinylogous Aldol Reaction: a Valuable, yet Understated Carbon–Carbon Bond–Forming Maneuver. Chem. Rev. 2000, 100, 1929-1972.
Cornia, M.; Menozzi, M.; Ragg, E.; Mazzini, S.; Scarafoni, A.; Zanardi, F.; Casiraghi, G. Synthesis and Utility of Novel C-meso-Glycosylated Metalloporphyrins. Tetrahedron 2000, 56, 3977-3983.
Zanardi, F.; Battistini, L.; Rassu, G.; Auzzas, L.; Pinna, L.; Marzocchi, L.; Acquotti, D.; Casiraghi, G. The Utility of Furan, Pyrrole, and Thiophene 2-Silyloxy Dienes as Demonstrated by Modular Synthesis of Annonaceous Acetogenin Core Units and Their Pyrrolidine and Thiolane Analogues. J. Org. Chem. 2000, 65, 2048-2064.
Rassu, G.; Zanardi, F.; Battistini, L.; Casiraghi, G. The Synthetic Utility of Furan-, Pyrrole- and Thiophene-Based 2-Silyloxy Dienes. Chem. Soc. Rev. 2000, 109-118.