RESEArCH

What do we do? 

Our research focuses on understanding the cellular and molecular mechanisms that regulate stem cell behavior and tissue regeneration, with particular emphasis on ocular and neural repair. The specific microenvironments regulating stem cells, commonly referred to as niches, comprise multiple cell populations whose precise contributions are under active current exploration. Understanding the cross talk between stem cells and their niche components is essential for the development of therapies against disorders in which stem cell function is altered. The research here integrates stem cell biology, neurobiology and biomaterials to investigate mechanisms underlying tissue injury, repair and regeneration. Currently, the laboratory focuses on investigating injury and its repair mechanisms under various physiological and pathological conditions. Using advanced 2D and 3D cell culture systems, organoid platforms, and animal model systems, the group studies how cellular microenvironments, biomaterials, and molecular signaling pathways influence stem cell differentiation, survival, and tissue repair. These studies employ advanced microscopy along with modern molecular and cellular biology techniques to dissect the underlying mechanisms of regeneration. The long-term goal of this research is to develop translational therapeutic strategies and novel bioactive molecules for the treatment of ocular and central nervous system disorders.