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Professors
Tenure Track Researcher (RTT)
Post Docs
PhD students
Gaia Meloni
Project: Project: Study of the interactions between bovine serum albumin and mesoporous silica nanoparticles at the isoelectric point.
Her MSc thesis concerns the study of interactions between a model protein (bovine serum albumine, BSA) and bare and functionalized mesoporous silica nanoparticles (MSN). Her tasks consists of: synthesis and charaterization of MSN using light scattering techniques (DLS, ELS), SAXS, nitrogen physisorption (BET), determination of kinetics and equilibrium parameters through UV-vis adsorption isotherms at BSA's isoelectric pointStructure and function of the protein corona on the surface of nanoparticles.
Matteo Farci
email: matteofarci.chem@gmail.com
Project: Theoretical and computational studies of elecrochemical systems
Matteo got his bachelor's and master's degrees, in chemistry and chemical science respectively, at University of Cagliari.
In his bachelor and master thesis he worked in the field of molecular modeling under the supervision of Prof. P. Ruggerone at the Department of Physics in Cagliari, with the aim of assessing different open-source software of protein-ligand and protein-protein docking and use them to investigate biological systems.In his master's thesis titled "Protein-protein interactions in synaptic junctions" he studied the interaction between Shank3 and Homer1, two proteins involved in various neurological and neurodevelopmental diseases.
Matteo also collaborated with Prof.ssa F. Mocci (Department of Chemistry in Cagliari) to study the stability of DNA G-quadruplex with different ligands. In this work he used the method of molecular dynamic.
In November 2022 Matteo won a PhD. scholarship in Chemical Sciences and Technologies at the University of Cagliari under the supervision of Prof. D. F. Parsons. His research work consists of developing codes, mainly in Python, and mathematical models for the study of electrochemical systems.
Visiting PhD students
Master Students
Giorgia Tanca
Project: Formulation of sponge-phase lipid nanoparticles for biomolecular delivery
Her Master thesis is being carried out through an Erasmus+ traineeship program in collaboration with the Physical Chemistry division of Lund university. The project is focused on the effects of buffers, concentration of the aqueous medium, and ionic strength on the structure of sponge-phase lipid nanoparticles (L3LNP). An innovative method for producing L3LNP was studied by adopting a microfluidic pump and comparing it with the traditional protocol. Subsequently, the encapsulation of myoglobin and polyadenilic acid (polyA) was studied to evaluate its impact on the structure. The encapsulation efficiency of myoglobin into the nanoparticles was quantified through Uv-vis measurements. Characterization of the samples was performed with DLS, ELS, SAXS and cryo-Tem analysis.
Giorgia Liori
Project: Fibrinogen
Alessandra Ballicu
Project: Structure and function of the protein corona on the surface of nanoparticles
Alessandra Ballicu graduated from the University of Cagliari in 2022 with a thesis titled "Study of the mobility and potential bioavailability of arsenic and some metals in solid matrices from abandoned mining areas".
Currently, she is carrying out a thesis internship within Erasmus+ program within a collaboration between Bionanointerfaces Group and the Jerzy Haber Institute of Catalysis and Surface Chemistry at the Polish Academy of Sciences in Kraków, Poland. Her research project focuses on studying the structure and function of the protein corona on the surface of nanoparticles, with significant implications for the biocompatibility, using phisico-chemical techniques like DLS, zeta potential, QCM, FTIR and Circular Dicroism spectroscopies.
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