Publications

Peer-reviewed papers

Alberto Gobbo, Sarah A. P. Pereira, Lorenzo Biancalana, Stefano Zacchini, M. Lúcia M. F. S. Saraiva, Paul Dyson, Fabio Marchetti, Anticancer ruthenium(ii) tris(pyrazolyl)methane complexes with bioactive co-ligands, Dalton Transactions, 51 (44), 17050 – 17063 (2022) DOI: 10.1039/d2dt03009h

Fábio M. S. Costa, M. Lúcia M. F. S. Saraiva*, Marieta L. C. Passos, Ionic liquids and organic salts with antimicrobial activity as a strategy against resistant, Journal of Molecular Liquids, 368, 120750- (2022) DOI: 10.1016/j.molliq.2022.120750

Ana M.O. Azevedo, Clara Sousa*, S. Sofia M. Rodrigues, Mi Chen, Caitlan E. Ayala, Rocío L. Pérez, João L. M. Santos, Isiah M. Warner, M. Lúcia M. F. S. Saraiva*, Combined use of phosphonium-erythrosin B-based nanoGUMBOS, UV–Vis spectroscopy, and chemometrics for discrimination and quantification of proteins, Dyes and Pigments, 207, 110635- (2022) DOI: 10.1016/j.dyepig.2022.110635

Fátima A. R. Mota, Sarah A. P. Pereira, André R. T. S. Araujo, Beatriz Gullon, Marieta L. C. Passos, M. Lúcia M. F. S. Saraiva*, Automatic Identification of Myeloperoxidase Natural Inhibitors in Plant Extracts, Molecules, 27(6), 1825–1839 (2022) DOI: 10.3390/molecules27061825

A. Raquel F. Costa, Andreia R. A. Sousa, Paula C. A. G. Pinto, Marieta L. C. Passos, M. Lúcia M. F. S. Saraiva*, Ionic liquids impact on the catalysis of glucose oxidase and Cu/luminol/H2O2 system, Chemical Papers, 76, 1493-1500 (2022) DOI 10.1007/s11696-021-01950-y

Ana M.O. Azevedo, Clara Sousa*, Mi Chen, Caitlan E. Ayala, Rocío L. Pérez, João L. M. Santos, Isiah M. Warner, M. Lúcia M.F.S. Saraiva*, Protein discrimination using erythrosin B-based GUMBOS in combination with UV–Vis spectroscopy and chemometrics, Talanta, 240, 123164 (2022) 10.1016/j.talanta.2021.123164

Sarah A.P. Pereira, Lorenzo Biancalana, Fabio Marchetti, Paul J. Dyson, M. Lúcia M. F. S. Saraiva*, Assessment of metal-based dihydrofolate reductase inhibitors on a novel mesofluidic platform, Sensors and Actuators B: Chemical, 366, 131978 (2022) doi.org/10.1016/j.snb.2022.131978

Sarah A. P. Pereira , A. Catarina Baptista, Lorenzo Biancalana, Fabio Marchetti, Paul J. Dyson and M. Lúcia M. F. S. Saraiva*, Automated approach for the evaluation of glutathione-S-transferase P1-1 inhibition by organometallic anticancer compounds, Journal of enzyme inhibition and medicinal chemistry, 37(1), 1527–1536 (2022) doi.org/10.1080/14756366.2022.2073443

Fátima A. R. Mota, Sarah A. P. Pereira, André R. T. S. Araújo, Marieta L. C. Passos, M. Lúcia M. F. S. Saraiva*, Biomarkers in the diagnosis of wounds infection: an analytical perspective, TrAC Trends in Analytical Chemistry, 143, 116405-116420 (2021) DOI:10.1016/j.trac.2021.116405

Svitlana Prots, Marieta L. C. Passos, Rui A. S. Lapa, M. Lúcia M. F. S. Saraiva*, Added value of ionic liquids in a biocatalytic process: An automatic approach, Process Biochemistry, 108,121-128 (2021) DOI: 10.1016/j.procbio.2021.06.003

T. Moussa Ndongo, Marieta L. C. Passos, Fernando Durães, Diana Resende, Madalena Pinto, Emília Sousa, M. Lúcia M. F. S. Saraiva*, Micro-sequential injection analysis / lab-on-valve system for the automatic evaluation of acetylcholinesterase inhibitors, Archiv der Pharmazie, 354, e2100150 (2021) DOI:10.1002/ardp.202100150

Silvia Schoch, Hadiji Mouna, Sarah A. P. Pereira, M. Lúcia M. F. S. Saraiva, Simona Braccini, Federica Chiellini, Tarita Biver, Stefano Zacchini, Guido Pampaloni, Paul J. Dyson, Fabio Marchetti, A Strategy to Conjugate Bioactive Fragments to Cytotoxic Diiron Bis-Cyclopentadienyl Complexes, Organometallics, 40, 2516–2528, (2021) DOI: 10.1021/acs.organomet.1c00270

Sarah A. P. Pereira, Felix D. Bobbink, Paul J. Dyson, M. Lúcia M. F. S. Saraiva*, Automatic evaluation of cyclooxygenase 2 inhibition induced by metal-based anticancer compounds Journal of Inorganic Biochemistry, 218, 111399 DOI: 10.1016/j.jinorgbio.2021.111399

Ana M. O. Azevedo, André G.Vilaranda, Vilaranda, Ana F.D.C.Neves, Maria João Sousa, Joao L. M. Santos, M. Lúcia M. F. S. Saraiva, Development of an automated yeast-based spectrophotometric method for toxicity screening: application to ionic liquids, GUMBOS, and deep eutectic solvents, Chemosphere, Available online 18 March 2021, 130227 (2021)

Fátima A. R. Mota, Sarah A. P. Pereira, André R. T. S. Araujo and , M. Lúcia M. F. S. Saraiva, Evaluation of Ionic Liquids and Ionic Liquids Active Pharmaceutical Ingredients Inhibition in Elastase Enzyme Activity, Molecules, 26, 200 –214 (2021)

Lorenzo Biancalana, Lucinda K., Sarah A. P. Pereira, Po‐Jen Tseng, Stefano Zacchini, M. Lúcia M. F. S. Saraiva, Paul J. Dyson, Fabio Marchetti, Bis‐conjugation of Bioactive Molecules to Cisplatin‐like Complexes through (2,2′‐Bipyridine)‐4,4′‐Dicarboxylic Acid with Optimal Cytotoxicity Profile Provided by the Combination Ethacrynic Acid/Flurbiprofen, Chem. Eur.J., 26,17525 –17535 (2020)

Ana M. O. Azevedo, Santos, Joao L. M. Santos, Isiah M. Warner, M. Lúcia M. F. S. Saraiva, GUMBOS and nanoGUMBOS in chemical and biological analysis: A review, Anal. Chim. Acta, 1133, 189-198 (2020)

M. Gorgich, M. L. C. Passos, T. M. Mata, A. A. Martins, M. L. M. F. S. Saraiva, N. S. Caetano, Enhancing extraction and purification of phicocyanin from Arthrospira sp with lower energy consumption, Energy Reports, 6, 312–318 (2020).

Marieta L. C. Passos, Emília Sousa, M. Lúcia M. F. S. Saraiva, Immobilized imidazolium-based ionic liquids in C18 for solid-phase extraction, Analyst, 145, 2701 – 2708 (2020).

Sarah A. P. Pereira, P. J. Dyson, M. Lúcia M. F. S. Saraiva, Miniaturized technologies for high-throughput drug screening enzymatic assays and diagnostics – A review, TrAC - Trends in Analytical Chemistry, 126, 115862 (2020).

Sarah A. P. Pereira, Fátima A. R. Mota, Ipek Çay, Marieta L. C. Passos, André R. T. S. Araujo, M. Lúcia M. F. S. Saraiva, Automatic fluorometric lactate determinations in human plasma samples, New. J. Chem., 44, 543 - 548 (2020).

F. Nunes, M. Rodrigues, M. P. Ribeiro, E. Ugazio, R. Cavalli, O. Abollino, P. Coutinho, A. R. T. S. Araujo, Incorporation of Cro thermal water in a dermocosmetic formulation: cytotoxicity effects, characterization and stability studies and efficacy evaluation, International Journal of Cosmetic Science, 41, 604-612 (2019).

M. Prata, A. Ribeiro, D. Figueirinha, T. Rosado, D. Oppolzer, J. Restolho, A. R. T. S. Araújo, S. Costa, M. Barroso, E. Gallardo, Determination of opiates in whole blood using microextraction by packed sorbent and gas chromatography-tandem mass spectrometry, Journal of Chromatography A, 1602, 1-10 (2019).

Ribeiro, M. Prata, C. Vaz, T. Rosado, J. Restolho, M. Barroso, A. R. T. S. Araujo, E. Gallardo, Determination of methadone and EDDP in oral fluid using the dried saliva spots sampling approach and gas chromatography-tandem mass spectrometry, Analytical and Bioanalytical Chemistry, 411, 2177-2187 (2019).

Marieta L.C.Passos, M. Lúcia M.F.S.Saraiva, Detection in UV-visible spectrophotometry:Detectors, detection systems,and detection strategies, Measurement, 135, 896-904 (2019).

Sarah A.P.Pereira, Marieta L.C.Passos, Alexandra Correia, Ermei Makila, Jarno Salonen, André R.S.T.Araujo, Hélder A. Santos, M. Lúcia M.F.S.Saraiva, Automatic methodologies to perform loading loading and release assays of anticancer drugs from mesoporous silicon nanoparticles, Talanta, 196, 277-283 (2019).

Jucineide S.Barbosa, Marieta L.C.Passos,M.das Graças A. Korn and M.Lúcia M.F.S.Saraiva, Enzymatic reactions in a Lab-on-Valve System:Cholesterol Evaluations, Molecules, 24, 2890-13086 (2019).

Sarah A. P. Pereira, Susana P. F. Costa, Edite Cunha, Marieta L. C. Passos, André R. S. T. Araújo, M. Lúcia M. F. S. Saraiva, Biodegradability of several antipsychotic drugs: manual and automatic assessment, New. J. Chem., 42, 13081-13086 (2018).

Antti Rahikkala, Sarah A. P. Pereira, Patrícia Figueiredo, Marieta L.C. Passos, André R. T. S. Araújo, M. Lúcia M. F. S. Saraiva*, Hélder A. Santos, Mesoporous Silica Nanoparticles for Targeted and Stimuli-responsive Delivery of Chemotherapeutics: a Review, Adv. Biosystems, 2, 1800020- 1800053 (2018).

Ana Raquel Costa, Marieta L. C. Passos, Paula C. A. G. Pinto, Sarah A. P. Pereira, M. Lúcia M. F. S. Saraiva, The role of ionic liquids in the biocatalytic evaluation of bisphenol levels as contaminant: an automatic approach, Analyst, 143, 2426-2434 (2018).

Susana P. F. Costa, Edite Cunha, Ana M. O. Azevedo, Sarah A. P. Pereira, Ana F. D. C. Neves, André G. Vilaranda, Paula C. A. G. Pinto, André R. T. S. Araujo, Marieta L. C. Passos, M. Lúcia M. F. S. Saraiva, Microfluidic chemiluminescence system with yeast Saccharomyces cerevisiae for rapid biochemical oxygen demand measurement, ACS Sustain Chem Eng., 6, 6094–6101 (2018).

Sarah A. P. Pereira, Susana P. F. Costa, Edite Cunha, Marieta L. C. Passos, André R. S. T. Araújo, M. Lúcia M. F. S. Saraiva, Manual or automated measuring of antipsychotics´ chemical oxygen demand, Ecot. Env. Safety, 152, 55-60 (2018).

S.P.F. Costa, A.M.O. Azevedo, P:C:A:G: Pinto, M.L.M.F.S. Saraiva, Environmental Impact of Ionic Liquids: Recent Advances in (Eco)toxicology and (Bio)degradability, ChemSusChem.,10, 2321-2347 (2017).

Nuno Faustino, Paula C.A.G. Pinto, Marieta L.C. Passos, M. Lúcia M.F.S. Saraiva, Automatic ionic liquid-enhanced membrane microextraction for the determination of melamine in food samples, Food Control,79, 162-168 (2017).

Diana Costa, Marieta L. C. Passos, Ana M. O. Azevedo, M. Lúcia M. F. S. Saraiva, Automatic evaluation of peroxidase activity using different substrates under a micro sequential injection analysis/lab-on-valve (µSIA-LOV) format, Microchem. Journal, 134, 98-103 (2017).

Susana P. F. Costa, Sarah A. P. Pereira, Paula C. A. G. Pinto, André R. T. S. Araujo, Marieta L. C. Passos, M. Lúcia M. F. S. Saraiva, Environmental impact of ionic liquids: Automated evaluation of chemical oxygen demand of photochemical degradated compounds, ChemPhysChem, 18, 1351-1357 (2017).

Ana M. O. Azevedo, Susana P.F. Costa, Ana F. V. Dias, Alexandre H. O. Marques, Paula C. A. G. Pinto, Katharina Bica, Anna K. Ressmann, Marieta L. C. Passos, André R. T. S. Araújo, Salette Reis, M. Lúcia M. F. S. Saraiva, Anti-inflammatory choline based ionic liquids: Insights into their lipophilicity, solubility and toxicity parameters, J. Mol. Liq., 232, 20-26 (2017).

Ana M. O. Azevedo, Sarah A. P. Pereira, Marieta L. C. Passos, Susana P. F. Costa, Paula C. A. G. Pinto, André R. T. S. Araújo, M. Lúcia M. F. S. Saraiva, Assessment of ionic liquids' toxicity through the inhibition of acylase I activity on a microflow system, Chemosphere, 173, 351-358 (2017).

Carla Fernandes, Andreia Palmeira, Inês I. Ramos, Carla Carneiro, Carlos Afonso, Maria Elizabeth Tiritan, Honorina Cidade, Paula C. A. G. Pinto, M. Lúcia M.F.S. Saraiva, Salette Reis and Madalena M.M. Pinto, Chiral Derivatives of Xanthones: Investigation of the Effect of Enantioselectivity on Inhibition of Cyclooxygenases (COX-1 and COX-2) and Binding Interaction with Human Serum Albumin, Pharmaceuticals, 10, 50-63 (2017).

S. Sofia M. Rodrigues, David S. M. Ribeiro, José X. Soares, Marieta L.C. Passos, M. Lúcia M. F. S. Saraiva, João L. M. Santos “Application of nanocrystalline CdTe quantum dots in chemical analysis: implementation of chemo-sensing schemes based on analyte-triggered photoluminescence modulation, Coordination Chemistry Reviews, 330, 127-143 (2017).

Marieta L. C. Passos, David S. M. Ribeiro, João L. M. Santos, M. Lúcia M. F. S. Saraiva, Physical and chemical immobilization of choline oxidase onto different porous solid supports: Adsorption studies, Enzyme and Microbial Technology, 90, 76-82 (2016).

Costa. SPF, Martins. BSF; Pinto. PCAG, Saraiva. MLMFS Automated cytochrome c oxidase bioassay developed for ionic liquids' toxicity assessment, Journal of Hazardous Materials, 309, 165-172 (2016).

R. Ribeiro, P. C. A. G. Pinto, A. M. O. Azevedo, K. Bica, A. K. Ressmann, S. Reis, M. L. M. F. S. Saraiva, Automated evaluation of protein binding affinity of anti-inflammatory choline based ionic liquids, Talanta, 150, 226 (2016)

Edite Cunha, Marieta L. C. Passos, Paula C. A. G. Pinto and M. Lúcia M. F. S. Saraiva, Automated evaluation of the inhibition of glutathione reductase activity: application to the prediction of ionic liquids' toxicity, RSC Adv., 5, 78971 (2015).

Marieta L. C. Passos, Paula C. A. G. Pinto, João L. M. Santos, M. Lúcia M. F. S. Saraiva, Andre R. T. S. Araujo, Nanoparticle-based assays in automated flow systems: A review, Anal. Chim. Acta, , 889, 22-34 (2015).

Carina F. Nascimento, Marcos A.S. Brasil, Susana P.F. Costa, Paula C.A.G. Pinto, M. Lúcia M.F.S. Saraiva, Fábio R.P. Rocha, Exploitation of pulsed flows for on-line dispersive liquid–liquid microextraction: Spectrophotometric determination of formaldehyde in milk, Talanta, 144, 1189–1194 (2015).

Susana P.F. Costa, Paula C.A.G. Pinto, M. Lúcia M.F.S. Saraiva, Fábio R.P. Rocha, Joyce R.P. Santos, Regina T.R. Monteiro, The aquatic impact of ionic liquids on freshwater organisms, Chemosphere, 139, 288-294 (2015).

Edite Cunha, Marieta L.C. Passos, Paula C.A.G. Pinto, M. Lúcia M.F.S. Saraiva, Evaluation of ionic liquids as alternative solventes for aldolase activity: Use of a new automated SIA methodology, Talanta, 141, 293-299 (2015).

S. Sofia M. Rodrigues, David S. M. Ribeiro, Susana P. F. Costa, João A. V. Prior, Paula C. A. G. Pinto, João L. M. Santos, M. Lúcia M. F. S. Saraiva, Marieta L. C. Passos, Immobilization of distinctly capped CdTe quantum dots onto porous aminated solid supports; ChemPhysChem, 16, 1880-1888 (2015).

Susana P.F. Costa, Paula C.A.G. Pinto, Rui A.S. Lapa, M. Lúcia M.F.S. Saraiva, Toxicity assessment of ionic liquids with Vibrio fischeri: An alternative fully automated methodology, Journal of Hazardous Materials, 284,136-142 (2015).

Marieta L. C. Passos, Diana Costa, José L.F.C. Lima, M. Lúcia M.F.S. Saraiva, Sequential injection technique as a tool for the automatic synthesis of silver nanoparticles in a greener way; Talanta, 133, 45-51 (2015).

Susana P.F. Costa, Vanessa de la Justina, Katharina Bica, Maria Vasiloiu, Paula C.A.G. Pinto, M. Lúcia M.F.S. Saraiva, Automated evaluation of pharmaceutically active ionic liquids' (eco)toxicity through the inhibition of human carboxylesterase and Vibrio fischeri, Journal of Hazardous Materials, 265,133-141 (2014).

Edite Cunha, Marieta L.C. Passos, Paula C.A.G. Pinto, M. Lúcia M.F.S. Saraiva, Improved activity of α-chymotrypsin in mixed micelles of cetyltrimethylammonium bromide (CTAB) and ionic liquids: A kinetic study resorting to sequential injection analysis, Colloids and Surfaces B: Biointerfaces, 118,172-178 (2014).

Marieta L. C. Passos, Mariana Pereira, M. Lúcia M. F. S. Saraiva, Maria Rangel, Tania Moniz, João L. M. Santos and Christian Frigerio, Silica nanostructures synthesis and CdTe quantum dots immobilization for photocatalytical applications, RSC Advances, 4 (104), 59697 – 59705 (2014).

Edite Cunha, Marieta L. C. Passos, Paula C. A. G. Pinto, M. Lucia M. F. S. Saraiva, Improved activity of α-chymotrypsin in mixed micelles of cetyltrimethylammonium bromide (CTAB) and ionic liquids: A kinetic study resorting to sequential injection analysis, Colloids and Surfaces B: Biointerfaces, 118, 172-178 (2014).

Christian Frigerio, João L. M. Santos, João A. C. Barbosa, Peter Eaton, M. Lúcia M. F. S. Saraiva, Marieta L. C. Passos, A soft strategy for covalent immobilization of glutathione and cysteine capped quantum dots onto amino functionalized surfaces, Chemical Communications, 49, 2518-2520 (2013).

Paula C.A.G. Pinto, Diogo M.G.P. Ribeiro, Ana M.O. Azevedo, Vanessa Dela Justina, E. Cunha, K. Bica, M. Vasiloiu, Salette Reis, M. Lúcia M.F.S. Saraiva, Active pharmaceutical ingredients based on salicylate ionic liquids: insights into the evaluation of pharmaceutical profiles, New J. Chem.,37, 4095-4102 (2013)

Marieta L.C. Passos, José L.F.C. Lima, M. Lúcia M.F.S. Saraiva, Laccase–biosilica nanostructures — A miniaturized automatic approach; Canadian Journal of Chemistry, 91(2): 113-119 (2013).

Ana M.O. Azevedo, Diogo M.G. Ribeiro, Paula C.A.G. Pinto, Marlene Lúcio, Salette Reis, M. Lúcia M.F.S. Saraiva, Imidazolium ionic liquids as solvents of pharmaceuticals: influence on HSA binding and partition coefficient of nimesulide, International Journal of Pharmaceutics, 443, Issues 1–2, 25 February 2013, Pages 273-278 (2013).

Edite Cunha, Paula C.A.G. Pinto, José P.S. Carvalho, M. Lúcia M.F.S. Saraiva, Automated carboxylesterase assay for the evaluation of ionic liquids human toxicity, Journal of Hazardous Materials, 244–245, 15, 563-569(2013).

A. Margarida Vaz; André R.T.S. Araújo; João L.M. Santos; José L.F.C. Lima; M. Lúcia M.F.S. Saraiva, Automatic miniaturized flow methodology with in-line solid-phase extraction for quinine determination in biological samples, Analytical Methods 4, 1681-1686 (2012).

Paula C.A.G. Pinto, Susana P.F. Costa, Andreia D.F. Costa, Marieta L.C. Passos, José L.F.C. Lima, M. Lúcia M.F.S. Saraiva, Trypsin activity in imidazolium based ionic liquids: evaluation of free and immobilized enzyme, Journal of Molecular Liquids, 171, 16–22 (2012).

Paula C. A. G. Pinto, Susana P. F. Costa, José L. F. C. Lima, M. Lúcia M. F. S. Saraiva, Automated high-throughput Vibrio fischeri assay for (eco)toxicity screening: application to ionic liquids, Ecotoxicology and Environmental Safety, 80, 97–102 (2012).

Paula C. A. G. Pinto, Susana P. F. Costa, José L. F. C. Lima, M. Lúcia M. F. S. Saraiva, ß-Galactosidase activity in mixed micelles of imidazolium ionic liquids and sodium dodecylsulfate: a sequential injection kinetic study, Talanta (2012) 96, 26-33 (2012).

A.R.T.S. Araujo, F.Maya, M.L.M.F.S. Saraiva, J.L.F.C. Lima, J.M. Estela and V. Cerdà, Flow system for the automatic screening of the effect of phenolic compounds on the luminol–hydrogen peroxide–peroxidase chemiluminescence system, Luminescence, 26, 571–578 (2011).

A.R.T.S. Araujo, M.L.M.F.S. Saraiva, J.L.F.C. Lima, Automatic flow methodology for kinetic and inhibition studies of reactions with poorly-water soluble substrates in ionic liquid systems, Analytica Chimica Acta 690, 101–107(2011).

J.L.Rufino, H.R. Pezza, L. Pezza, M.L.M.F.S. Saraiva, J.L.F.C. Lima, P.C.A.G. Pinto, Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulations, Quimica Nova, 34(2), 256-261 (2011).

C.I.C. Silvestre, P.C.A.G. Pinto, M.A. Segundo, M. L.M.F.S. Saraiva, José L. F. C. Lima, Enzyme based assays in a sequential injection format: A review, Analytica Chimica Acta, 689 (2011) 160–177.

Daniele C. M. B. dos Santos, M. Graças A. Korn, Mauro Korn, Paula C.A.G. Pinto, M. L.M.F.S. Saraiva, José L.F.C. Lima, Sequential injection chemiluminescence methodology for ozone evaluation, Analytical Letters 117–126, (2011).

P.C.A.G. Pinto, M.L.M.F.S. Saraiva, J.L.F.C. Lima, Sequential injection analysis hyphenated with other flow techniques: a review, Analytical Letters, 44: 374–397, (2011).

P.C.A.G. Pinto, A.D.F. Costa, J.L.F.C. Lima, M.L.M.F.S. Saraiva, Automated evaluation of the effect of ionic liquids on catalase activity, Chemosphere 82 (2011) 1620–1628.

M.G.A. Korn, D. C.M. B. Santos, M.A. B. Guida, I.S. Barbosa,M. L. C. Passos, M.L.M. F. S. Saraiva and J.L. F. C. Lima, Evaluation of Digestion Procedures for Simultaneous Determination of Ca, P, Mg, K and Na in Biodiesel by Inductively Coupled Plasma Optical Emission Spectrometry, J. Braz. Chem. Soc., 21 (12), 2278-2284, (2010).

A.R.T.S. Araújo; M.L.M.F.S. Saraiva; J.L.F.C. Lima, Flow injection analysis with immobilized enzymes in nonaqueous media, Curr. Anal. Chem. 6, 193 (2010).

Marieta L.C. Passos; M.L. M.F.S. Saraiva; José L.F.C. Lima, A thionine-based reversible redox sensor in a sequential injection system, Anal. Chim. Acta. 668, 41 (2010).

C.I.C. Silvestre, M.A. Segundo, M.L.M.F.S. Saraiva, J.L.F.C. Lima, Indirect Sequential Injection Enzymatic Determination of Allopurinol in Pharmaceuticals Based on Xanthine Oxidase Inhibition, Spect. Letters, 42, 341-350 (2009).

Alberto N. Araujo, José L.F.C. Lima, Paula C.A.G. Pinto, M. Lúcia M.F.S. Saraiva, Enzymatic of determination of glucose in milk samples by sequential injection analysis, Anal. Sci., 25,687-692

(2009).

André R.T.S. Araujo, Diana Gaspar, Marlene Lúcio, Salette Reis, M. Lúcia M.F.S. Saraiva, José L.F.C. Lima, Sequential injection system for phospholipase A2 activity evaluation: Studies on liposomes using an environment-sensitive fluorescent probe, Talanta, 79, 1125-1129 (2009).

Marieta L.C. Passos, Ana M. Santos, Ana I. Pereira, J. Rodrigo Santos, Agostinho J.C. Santos, M. Lúcia M.F.S. Saraiva, José L.F.C. Lima, Estimation of postmortem interval by hypoxanthine and potassium evaluation in vitreous humor with a sequential injection system, Talanta, 79, 1094-1099 (2009).

Elane S. Boa Morte, Maria Graças A. Korn, M. Lúcia M.F.S. Saraiva, José L.F.C. Lima, Paula C.A.G. Pinto, Sequential injection fluorimetric determination of Sn in juices of canned fruits, Talanta, 79, 1100-1103 (2009).

Eliana S. Silva, Paula C.A.G. Pinto, José L.F.C. Lima, M. Lúcia M.F.S. Saraiva, Sequential injection spectrophotometric determination of V(V) in environmental polluted waters, Water SA, 35(3), 283-287 (2009).

P.C.A.G.Pinto, M.L.M.F.S. Saraiva, J.L.F.C. Lima, Oxidoreductase behaviour in ionic liquids: a review, Anal. Sci., 24, 1231-1238 (2008).

P.C.A.G.Pinto, M.L.M.F.S. Saraiva, J.L.F.C. Lima, Sequential injection analysis as a tool for implementation of enzymatic assays in ionic liquids, Talanta, 77, 479-483(2008).

M.L.C. Passos, M.L.M.F.S. Saraiva, J.L.F.C. Lima , Enzymatic Oxidation in aqueous and micellar media based on horseradish-peroxidase system using a SIA manifold, Talanta, 77, 484-489 (2008).

M.L.C. Passos, M.L.M.F.S. Saraiva, J.L.F.C. Lima , M.G.A. Korn, Determination of metoprolol, acebutolol, and propanolol in pharmaceutical formulations using the same SIA system, J. Braz. Chem. Soc., 19(3), 563-568 (2008).

A.R.T.S. Araújo, M.L.M.F.S. Saraiva, J.L.F.C. Lima, M.G.A. Korn, Flow methodology for methanol determination in biodiesel exploiting membrane-based extraction, Anal. Chim. Acta, 613(2), 177-183 (2008).

A.R.T.S. Araújo, M.L.M.F.S. Saraiva, J.L.F.C. Lima, Determination of total and oxidized glutathione in human whole blood with a sequential injection analysis system, Talanta, 74(5), 1511-1519 (2008).

M.L.M.F.S. Saraiva, P.C.A.G.Pinto, J.L.F.C. Lima, Evaluation of the relative antioxidant capacity of wine samples and pharmaceutical formulations by sequential injection analysis, Free Radical Research, 41, S53-S54 (2007).

V. Vasiliki, P.C.A.G.Pinto, M.L.M.F.S. Saraiva, J.L.F.C. Lima, Sequential injection determination of meloxicam in pharmaceutical formulations with spectrophotometric detection, Can. J. Anal. Sci. Spect., 52(6), 351-358 (2007).

C.M.P.V. Lopes, A.A. Almeida, M.L.M.F.S. Saraiva, J.L.F.C. Lima, Determination of Rh, Pd and Pt in urine samples using a pre-concentration sequential injection analysis system coupled to a quadrupole-inductively coupled plasma-mass spectrometer, Anal. Chim. Acta, 600, 226-232 (2007).

I.D. Pinto, M.L.M.F.S. Saraiva, J.L.M. Santos, J.L.F.C. Lima, Sequential injection spectrophotometric determination of metoclopramide in pharmaceutical preparations. Spectroscopy Letters 40(1), 51-61 (2007).

J.B. Garcia, M.L.M.F.S. Saraiva, J.L.F.C. Lima, Determination and antioxidant activity evaluation of etodolac, an anti-inflammatory drug, by sequential injection analysis, Anal. Chim. Acta, 573-574, 371-375 (2006).

S. Vicente, E.A.G. Zagatto, P.C.A.G. Pinto, M.L.M.F.S. Saraiva, J.L.F.C. Lima, Exploiting gas diffusion for non-invasive sampling in flow analysis: determination of ethanol in alcoholic beverages, Anais Academia Brasileira de Ciências,78 ,23-29(2006).

P.C.A.G.Pinto, M.L.M.F.S. Saraiva, J.L.F.C. Lima, A flow sampling strategy for the analysis of oil samples without pre-treatment in a sequential injection analysis system, Anal. Chim. Acta,555 (2), 377-383 (2006).

P.C.A.G. Pinto, M.L.M.F.S. Saraiva, J.L.M. Santos, J.L.F.C. Lima, Fluorimetric determination of aminocaproic acid in pharmaceutical formulations using a sequential injection analysis system, Talanta, 68 ,857-862 (2006).

E. Zisiou, P.C.A.G. Pinto, M.L.M.F.S. Saraiva, C. Siquet and J.L.F.C. Lima, Sensitive sequential injection determination of naproxen based on interaction with ß-cyclodextrin, Talanta, 68 (2),226-230 (2005).

M.L.C. Passos, M.L.M.F.S. Saraiva, J.L.F.C. Lima, Application of sequential injection analysis (SIA) to the determination of cationic surfactants based on the sensitised molybdenum – bromopyrogallol red reaction, Anal. Sci., 21 ,1509-1514 (2005).

P.C.A.G. Pinto, M.L.M.F.S. Saraiva, J.L.M. Santos, J.L.F.C. Lima, A pulsed sequential injection analysis flow system for the fluorimetric determination of indomethacin in pharmaceutical preparations, Anal. Chim. Acta, 539, 173-179 (2005).

J.L.M. Santos, A. Clausse, J.L.F.C. Lima, M.L.M.F.S. Saraiva, A.O.S. Rangel, Determination of ambroxol in an automated multi-pumping pulsed flow system, Anal. Sci., 21, 461-464 (2005).

P.C.A.G. Pinto, M.L.M.F.S. Saraiva, S. Reis, J.L.F.C. Lima, Automatic sequential determination of the hydrogen peroxide scavenging activity and evaluation of the antioxidant potential by the ABTS assay in wines by sequential injection analysis, Anal. Chim. Acta, 531, 25-32 (2005).

R. Pérez-Olmos, J.C. Soto, N. Zarate, A.N. Araújo, J.L.F.C. Lima, M.L.M.F.S. Saraiva, Application of sequential injection analysis (SIA) to food analysis, Food Chem., 90, 471-490 (2005).

P.C.A.G. Pinto, M.L.M.F.S. Saraiva, J.L.F.C. Lima, An enzymatic flow analysis methodology for the determination of nitrates and nitrites in waters, Intern. J. Environ. Anal. Chem., 85, 29-40 (2005).

R.M. Peña, J.L.F.C. Lima, M.L.M.F.S. Saraiva, Sequential injection análisis-based flow system for the enzymatic determination of aspartame, Anal. Chim. Acta, 514, 37-43 (2004).

C.K. Pires, P.B. Martelli, B.F. Reis, J.L.F.C. Lima, Multicommuted flow system for the determination of glucose in animal blood serum exploiting enzymatic reaction and chemiluminescence detection, J. of Autom. Meth. Mgmt. Chem , 25(5), 109-114 (2003).

P.C.A.G. Pinto, J.L.F.C. Lima, M.L.M.F.S. Saraiva, Sequential injection analysis of nitrites and nitrates in human serum using nitrate reductase, Clin. Chim. Acta, 337/1-2, 69-76 (2003).

C.K. Pires, P.B. Martelli, B.F. Reis, J.L.F.C. Lima, M.L.M.F.S. Saraiva, An automatic flow procedure for the determination of 3-hydroxybutyrate in animal serum and plasma, J. Agric. Food Chem., 51 (9), 2457-2460 (2003).

Book Chapters

M. L. C. Passos, M. C. Sarraguça, M. L. M. F. S. Saraiva, T. Prasada Rao, V. M. Biju, (2019). Spectrophotometry | Organic Compounds. In Worsfold, P., Poole, C., Townshend, A., Miró, M., (Eds.), Encyclopedia of Analytical Science, (3rd ed.).2019, vol. 9, pp 236–243, Elsevier.

Paula C.A.G. Pinto and M. Lúcia M.F.S. Saraiva, Chapter 1: Ionic liquids: a pharmaceutical perspective, page: 1-41. In: Ionic Liquids: synthesis, characterization and applications. Edited by Anson Brooks, Novapublishers, New York. 2014 (ISBN: 978-1-63117-717-0).

Paula C.A.G. Pinto, Célia M.G. Amorim, Alberto N. Araújo, M. Conceição B.S.M. Montenegro, and M. Lúcia, and M.F.S. Saraiva, (2016) Chapter 23: Determination of Aspartame and Sorbitol, pages 449-464. In: Flow Injection Analysis of Food Additives", CRCPress, Boca Raton Florida, USA.

Thesis

PhD

Development of automatic bioassays for the evaluation of ionic liquids' toxicity and

Biodegradability

Susana Patrícia Fontes da Costa – PhD fellowship: SFRH/BD/86381/2012

Dec. 2012 – May 2017. Defense: 25th July 2017

Supervision: M. Lúcia Saraiva; co-supervision: Paula Gomes Pinto

Biocatálise em meios líquidos iónicos e sua automatização

Edite Cristina Almeida Saraiva Reis Cunha

Dec. 2007 – March 2016. Defense: June 2016

Supervision: M. Lúcia Saraiva; co-supervision: Paula Gomes Pinto

Automatização de ensaios enzimáticos usando a análise por injecção sequencial

André Ricardo Tomás dos Santos Araújo Pereira – PhD fellowship SFRH/BD/23029/2005

Dec. 2005 – March 2011. Defense: June 2011

Supervision: M. Lúcia Saraiva; co-supervision: José Luís Fontes da Costa Lima

Metodologias analíticas de reduzido consumo de reagentes usando SIA como processo de gestão de fluidos

Marieta Leite de Castro Passos – PhD fellowship SFRH/BD/22752/2005

September 2005 – April 2010. Defense: June 2010

Supervision: M. Lúcia Saraiva; co-supervision: José Luís Fontes da Costa Lima

A Análise por Injecção Sequencial como Base de Sistemas Automáticos em Fluxo Contínuo

Paula Cristina de Azevedo Gomes Pinto- PhD fellowship SFRH/BD/2915/2000

July 2001 – November 2005. Defense: January 2006

Supervision: M. Lúcia Saraiva; co-supervision: José Luís Fontes da Costa Lima

MSc

Evaluation of inhibitor effect of some drugs in acetylcholinesterase

Thierno Moussa Ndongo,

22nd January – 20th June 2019

Supervision: Marieta Passos; co-supervision: M. Lúcia Saraiva

Automatização de um bioensaio para a determinação do colesterol total

Jucineide dos Santos Barbosa Coelho

16th December – 31th July 2017

Supervision: Maria das Graças Korn; co-supervision: M. Lúcia Saraiva

Development of an automatic system based on the sequential injection analysis for the monitorization of drugs carried on silica nanoparticles

Sarah Alexandra Pais Pereira

August 2017 - March 2018

Supervision: M. Lúcia Saraiva; co-supervision: André Araújo

Automatização do Estudo da Interação da Albumina do Soro Humano com Líquidos Iónicos com Atividade Anti-Inflamatória

Rosa Adelaide Tavares Ribeiro

September 2014 - October 2015

Supervision: M. Lúcia Saraiva; co-supervision: Paula Cristina Pinto

Automatização da extração e quantificação da melamina em amostras alimentares lácteas

Nuno Miguel Ferreira Lima Faustino

September 2011 - January2013

Supervision: M. Lúcia Saraiva; co-supervision: Paula Cristina Pinto

Metodologias Automáticas para Controlo de Qualidade de Formulações com Alopurinol Baseadas em Biocatalisadores

Cristina Isabel da Cunha Silvestre

October 2005 - December 2006

Supervision: M. Lúcia Saraiva; co-supervision: Prof. Marcela Alves Segundo)

Desenvolvimento de um sistema de análise por injecção sequencial (SIA) para a determinação de vanádio (V) em águas

Eliana Sousa da Silva

March 2008

Supervision: Paula Cristina Pinto; co-supervision: M. Lúcia Saraiva

Desenvolvimento de um Sistema de Análise por Injecção Sequencial para a Determinação de Tensioactivos Catiónicos em Águas

Marieta Leite de Castro Passos

January 2005

Supervision: M. Lúcia Saraiva