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GUMBOS and NanoGUMBOS
GUMBOS (Group of Uniform Materials Based on Organic Salts) is a novel class of materials that exhibits similar features to those of ionic liquids, but have melting points between 25 and 250 °C. GUMBOS can be easily converted into nanomaterials (nanoGUMBOS), with advantages of working at nanoscale. Due to the huge number of possible cation-anion combinations, these materials can be multifunctional and designed for a specific task.
Our work intend to expand the knowledge and application of NanoGUMBOS, by exploiting the synthesis of new materials, and use them as APIs and probes to be used in pharmaceutical and analytical applications.
This work includes three main steps: the synthesis and characterization of GUMBOS/nanoGUMBOS (1), assessment of their toxicity and antibacterial activity (2) as well as the study of their application as materials for discriminating protein biomarkers and fighting against bacterial infections (3).
The toxicity and antibacterial activity of developed compounds were evaluated by use of an automated yeast-based spectrophotometric assay, MIC, and MBC tests. It is intended to improve the sensitivity and simplicity of the analytical methods for the discrimination of proteins and provide novel alternatives for combating bacterial infections.
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