Welcome to Bikash Sahoo's Webpage
In high school, I learned that DNA transcribes into RNA, which then translates into protein—the so-called "building blocks of life." However, it wasn't until college that I unearthed a vital aspect: protein folding. This intricate process shapes the ultimate function of a protein, as its biological activity hinges on the correct folding of its linear amino acid chain. Conversely, protein misfolding is often associated with various human diseases, including 'Diabetes, Alzheimer's disease, Parkinson's disease, and Prion disease'.
My early research was dedicated to deciphering the mechanistic and structural underpinnings of protein misfolding and its impact on disease progression at the molecular level, particularly at the membrane interface. This approach was initially linear, tracing the path from protein misfolding to disease. Over time, my focus expanded to include the natural evolution of protein intrinsic disorder and its biological significance.
Currently, my research delves into the physiological functions of small disordered human proteins, with a keen interest in their structural interaction with functional nucleic acid structures such as G-quadruplexes and microRNAs.
Research Interest: Protein Misfolding | Structural Biology | Membrane Biophysics | Biomolecular Condensates | Functional Nucleic Acids | Cell Biology | G-quadruplex
Current affiliation: Howard Hughes Medical Institute/University of Michigan https://sites.lsa.umich.edu/bardwell-lab/
Past affiliation: University of Michigan, USA https://rams.biop.lsa.umich.edu/
- RIKEN Brain Science Institute, Japan https://bsi.riken.jp/en/
- Osaka University, Japan
Last-Modified: 05 May 2024
RESEARCH at a GLANCE
G-quadruplex Binding Protein
Ribonucleoprotein Condensates
Single Molecule Biophysics
Optical Tweezer-Droplet Fusion
HS-AFM of Amyloid Growth
Nanodisc Trap Toxic Amyloid
Dissolution of Amyloid Fibrils
Protein Folding
Latest News
- Check out our recent paper "Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation" published in Nucleic Acids Research (2024).
- Check out our recent NMR study of human SERF2 protein published in Biomolecular NMR Assignments (2024).
- Received the "Elsevier Journal Award" (2020)
- Best Oral Presentation Award at University of Miami, FL, USA (2019)
- Received the "Isadore and Margaret Mezey Junior Investigator Award" from the Michigan Alzheimer’s Disease Center, Michigan, USA (2019)
- Second time in a row - 'Hans Neurath Outstanding Promise Award' The Protein Society, 2019, Seattle, USA
Highlights
INVITED TALK: Slovenia NMR Center - 2023 Ljubljana, Slovenia
INVITED TALK: Nanodiscs: Useful tool to probe protein misfolding and amyloid aggregation. American Chemical Society Meeting, Spring 2020, PA (USA)
PRESENTATION: NMR Gateway Meeting, 2019 Nanodiscs: Application in study protein misfolding and amyloid aggregation
INVITED TALK: Real-time Monitoring of Inhibition of Human Amylin Aggregation using High-Speed AFM" organized by Asylum Group at University of Michigan.
PRESENTATION: Design of dual-action lipid-Nanodiscs in controlling amylin aggregation involved in type-2 diabetes" organized by 'The Protein Society 2019' Seattle, USA
INVITED Lecture: Biomolecular Interfaces: Biophysics, Bioinformatics, and Nanoscience. BJB Autonomoous College, 2020, Bhubaneswar (INDIA)