Bikash R. Sahoo, Ph.D. Research Specialist, Howard Hughes Medical Institute
Affiliation: Molecular, Cellular, and Developmental Biology (MCDB), University of Michigan, MI, USA
Research Overview
Bikash R. Sahoo, Ph.D. Research Specialist, Howard Hughes Medical Institute
Affiliation: Molecular, Cellular, and Developmental Biology (MCDB), University of Michigan, MI, USA
Research Overview
My interest in biology began with understanding how genetic information is translated into cellular function. Over time, I became particularly drawn to the idea that biological outcomes are not determined by sequence alone, but by how molecules organize, interact, and adapt within the cell. Protein folding emerged as a central theme in this realization, as correct folding underlies normal cellular function, while disruptions in this process are associated with a wide range of human diseases.
As my scientific perspective developed, I became increasingly interested in how cells manage complexity and maintain balance under stress and disease. Rather than viewing proteins as static entities, I came to appreciate the importance of flexibility, regulation, and context in biological systems. This broader view naturally led me to questions about how cells tolerate disorder, coordinate molecular interactions, and respond to perturbations.
Currently, my work reflects this systems-oriented perspective, focusing on how proteins and functional nucleic acids interact to support cellular homeostasis. I am particularly interested in understanding how dynamic molecular assemblies contribute to regulation, adaptability, and resilience in living systems. Through this lens, my research seeks to connect molecular behavior to broader cellular outcomes in health and disease.
Research Interest: Biophysics | Biochemistry | Non-canonical Nucleic Acids | G-quadruplex | Structural Biology | Biomolecular Condensates | Protein Misfolding
Current affiliation: Howard Hughes Medical Institute/University of Michigan https://sites.lsa.umich.edu/bardwell-lab/
Past affiliation: University of Michigan, USA https://rams.biop.lsa.umich.edu/
- RIKEN Brain Science Institute, Japan https://bsi.riken.jp/en/
- Osaka University, Japan
Last-Modified: 05 May 2024
G-quadruplex Binding Protein
Ribonucleoprotein Condensates
Single Molecule Biophysics
Optical Tweezer-Droplet Fusion
HS-AFM of Amyloid Growth
Nanodisc Trap Toxic Amyloid
Dissolution of Amyloid Fibrils
Protein Folding