Dhiyebi H, Mbaye A, Thaniana A, Gilleran J, Eck T, Ashraf K, Kudyba K, Fan H, Seibold S, Battaile KP, Siekierka J, Johnson E, Roth A, De Rocher A, Lovell S, Miller EB, Roberge JY, Bhanot P. (2026) An orally available PfPKG inhibitor blocks Plasmodium's infection of the liver. PLoS Pathog. Jul;22(7):e1014322. doi: 10.1371/journal.ppat.1014322.
Khim M., Montgomery J., de Souza M.L., Delvillar M, Weible L.Y., Prabakaran M., Hulverson M.A., Eck T., Bheemanabonia R.Y., Alday P.H., Rotella D.P., Doggett J. S., Staker B.L., Ojo K.K. and Bhanot P. (2025) A versatile imidazole scaffold with potent activity against multiple apicomplexan parasites. ACS – Infectious Disease 11(6):1497-1507.
Gilleran J.A., Ashraf K., Delvillar M., Eck T., Fondekar R., Miller E.B., Hutchinson A., Dong A., Seitova A., De Souza M.L., Augeri D., Halabelian L., Siekierka J., Rotella D.P., Gordon J., Childers W.E., Grier M.C., Staker B.L., Roberge J.Y., and Bhanot P. (2024) Structure-Activity Relationship of Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. Journal of Medicinal Chemistry 67(5):3467-3503.
Imhoff R.D., Rosenthal M.R., Ashraf K., Bhanot P., Ng C.L., Flaherty D.P. (2023) Identification of covalent fragment inhibitors for Plasmodium falciparum UCHL3 with anti-malarial efficacy. Bioorg Med Chem Lett. 94:129458
Eck T., de Souza M.L., Bheemanaboina R.R.Y., Chakrasali R., Kreiss T., Siekierka J., Rotella D.P., Bhanot P.*, Goodey N.* (2022) Characterization of novel competitive inhibitors of P. falciparum cGMP-dependent protein kinase. Chembiochem 23(7):e202100704. *Co-corresponding authors
Bheemanaboina R.R.Y., de Souza M.L., Gonzalez M.L., Mahmood S.U., Eck T, Kreiss.T, Aylor S.O., Roth A., Lee P., Pybus B.S., Colussi D.J., Childers W.E., Gordon J., Siekierka J.J., Bhanot P.*, Rotella D.P.* (2021) Discovery of novel potent, cell-permeable inhibitors of P. falciparum cGMP-dependent protein kinase ACS Med Chem Lett. 12(12):1962-1967. *Co-corresponding authors
Govindasamy K. and Bhanot P. (2020) Overlapping and distinct roles of CDPK family members in the pre-erythrocytic cycle of the rodent malaria parasite, Plasmodium berghei. PLoS Pathogens 16(8):e1008131. PMID: 32866196
Shi X., Hai L., Govindasamy K., Gao J., Coppens I., Hu J., Wang Q. and Bhanot P. (2020) A Plasmodium homolog of ER tubule-forming proteins is required for parasite virulence. Molecular Microbiology 114(3):454-467. PMID: 32432369
Djokic V., Akoolo L., Primus S., Schlachter S., Kelly K., Bhanot P., Parveen N. (2019) Protozoan Parasite Babesia microti Subverts Adaptive Immunity and Enhances Lyme Disease Severity. Frontiers in Microbiology 10:1596. PMID: 31354683
Govindasamy K. , Khan R., Snyder M., Lou H.J., Du P., Kudyba H.M., Muralidharan M., Turk B.E., Bhanot P. (2018) Plasmodium falciparum Cyclic GMP-Dependent Protein Kinase Interacts with a Subunit of the Parasite Proteasome. Infection and Immunity 87(1): e00523-18. PMID: 30323024
Kirkman L., Zhan W., Visone J., Dziedziech A., Singh P.K., Fan H., Tong X., Bruzual I., Hara R., Kawasaki M., Imaeda T., Okamoto R., Sato K., Michino M., Alvaro E.F., Guiang L.F., Sanz L., Mota D.J., Govindasamy K., Wang R., Ling Y., Tumwebaze P.K., Sukenick G., Shi L., Vendome J., Bhanot P, Rosenthal P.J., Aso K., Foley M.A., Cooper R.A., Kafsack B., Doggett J.S., Nathan C., Lin G. (2018) Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. Proceedings National Academy of Sciences 115(29): E6863-E6870. PMID: 29967165
Akoolo L., Schlachter S., Khan R., Alter L., Rojtman A.D., Gedroic K., Bhanot P, Parveen N. (2017) A novel quantitative PCR detects Babesia infection in patients not identified by currently available non-nucleic acid amplification tests. BMC Microbiology. 17(1):16. PMID: 28088177
Govindasamy K., Jebiwott S., Jaijyan D.K., Davidow A., Ojo K.K., Van Voorhis W.C., Brochet M., Billker O. and Bhanot P (2016) Invasion of hepatocytes by Plasmodium sporozoites requires cGMP- dependent protein kinase and calcium dependent protein kinase 4. Molecular Microbiology 102(2): 349-363. PMID: 27425827
Sun S., Lv L., Yao Z., Bhanot P, Hu J. and Wang Q. (2016) Identification of endoplasmic reticulum- shaping proteins in Plasmodium parasites. Protein & Cell 7(8): 615-20. PMID: 27484902
Zhao J., Bhanot P, Hu J. and Wang Q (2016). A comprehensive analysis of Plasmodium circumsporozoite protein binding to hepatocytes. PLoS One 11(8): e0161607. PMID: 27560376
Li H., wan der Linden WA., Verdoes M., Florea BI., McAllister FE., Govindaswamy K., Elias JE., Bhanot P, Overkleeft H.S. and Bogyo M. (2014) Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes. ACS Chemical Biology 9(8):1869-76. PMID: 24918547
Lau A., Pedroni M., and Bhanot P (2013) Target specific-trisubstituted pyrrole inhibits Babesia erythrocytic growth. Experimental Parasitology 133: 365-68. PMID: 23274642
Towle T., Kerns R., Chang, I. and Bhanot P (2013) Toward the identification of protein targets of trisubstituted pyrroles in malaria-causing Plasmodium sporozoites. Bioorganic & Medicinal Chemistry Letters 23:1874-77. PMID: 23395653
Jebiwott S., Govindaswamy K., Mbugua A. and Bhanot P (2013) Plasmodium berghei Calcium Dependent Protein Kinase 1 is not required for host cell invasion. PLoS One 8(11): e79171. PMID: 24265753
Panchal D., Govindasamy K., Rana, A. and Bhanot P (2012). Improved Plasmodium berghei lines for conditional mutagenesis. Molecular and Biochemical Parasitology 184(1): 52-4. PMID: 22450301
Lacroix C., Giovannini D., Combe A., Bargieri D. Y., Späth S., Panchal D.,Tawk L., Thiberge S., Carvalho T.G., Barale J., Bhanot P and Ménard R. (2011). FLP/FRT-mediated conditional mutagenesis in pre-erythrocytic stages of Plasmodium berghei. Nature Protocols 6(9): 1412-28. PMID: 2188610513
Falae A., Combe A., Amaladoss A., Carvalho T., Menard R. and Bhanot P (2010) Role of Plasmodium berghei cGMP-dependent protein kinase in late liver stage development. Journal of Biological Chemistry 285(5): 3282-3288. PMID: 19940133
Panchal D. and Bhanot P (2010) Activity of a trisubstituted pyrrole in inhibiting sporozoite invasion and blocking malaria infection. Antimicrobial Agents and Chemotherapy 54(10): 4269-74. PMID: 20643897
Ono T., Cabrita-Santos L., Leitao R., Bettiol E., Purcell L.A., Diaz-Pulido O., Andrews L.B., Tadakuma T., Bhanot P, Mota M.M., Rodriguez A. (2008) Adenylyl cyclase alpha and camp signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection. PLoS Pathogens 4(2): e1000008. PMID: 18389080
Bhanot P*, Schauer K., Coppens I. and Nussenzweig V. (2005) A surface phospholipase is involved in the migration of Plasmodium sporozoites through cells. Journal of Biological Chemistry 280(8): 6752- 6760. PMID: 15590623 * corresponding author
Wang Q., Brown S., Roos, DS, Nussenzeig V. and Bhanot P * (2004) Transcriptome of axenic liver stages of Plasmodium yoelii. Molecular and Biochemical Parasitology 137(1): 161-168. PMID: 15279962 * corresponding author
Bhanot P, Frevert U., Nussenzweig V. and Persson C. (2003) Defective sorting of the Thrombospondin related anonymous protein (TRAP) inhibits Plasmodium infectivity. Molecular and Biochemical Parasitology 126(2): 263-273. PMID: 12615325
Persson C. Oliveira G., Sultan A., Bhanot P, Nardin E. and Nussenzweig V. (2002) A hybrid Plasmodium berghei parasite is a new tool to evaluate the efficacy of pre-erythrocytic P. falciparum malaria vaccines. Journal of Immunology 169(12): 6681-6685. PMID: 12471098
Bhanot P and Nussenzweig V. (2002) Plasmodium yoelii sporozoites infect Syndecan-1 deficient mice. Molecular and Biochemical Parasitology 123(2): 143-144. PMID: 12270630
Bhanot P, Fish M., Jemison J., Nusse R., Nathans J. and Cadigan K.M. (1999) Frizzled and Frizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development. Development 126(18): 4175-4186. PMID: 10457026
Andrew DJ., Baig A., Bhanot P, Smolik SM and Henderson KD. (1997) The Drosophila dCREB-A gene is required for dorsal/ventral patterning of the larval cuticle. Development 124(1): 181-193. PMID: 9006079
Bhanot P, Brink M., Samos CH., Hsieh JC., Wang Y., Macke JP., Andrew D., Nathans J. and Nusse R. (1996) A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382(6588): 225-230. PMID: 8717036