Research

The Biomechanics of Growth & Remodeling Laboratory uses a combined experimental and computational approach to better understand, describe, and predict soft tissue remodeling in response to various biochemomechanical stimuli including normal processes (e.g., aging and pregnancy), disease, and injury. To this end, our research utilizes model systems with varying restraints on regenerative capability (postnatal development, pregnancy, postpartum, and aging) as well as genetically modified animals. We utilize sophisticated mechanical testing techniques and computational growth and remodeling models to elucidate dynamic structure-function relationships in evolving collagenous tissues in both maintenance (homeostatic) states and maladaptive remodeling (e.g., fibrosis, degeneration). In particular, we are interested in identifying the appropriate biochemomechanical stimuli and matrix components necessary for proper collagen fibrillogenesis and elastogenesis in adult tissues. Further, experiments and computational models are used to identify potential treatments and the appropriate timecourse for clinical interventions to prevent maladaptive remodeling, improve adult response to injury, and advance tissue engineering strategies. Our primary areas of research include women’s reproductive health, wound healing, and orthopaedics (tendon and ligament).

Women's Reproductive Health

The goal of this area of study is to gain a better understanding of the relationship between reproductive tissue extracellular matrix constituents and mechanical properties of the vagina, cervix, and uterus. These studies will evaluate the contribution of collagen, elastin, smooth muscle, and glycosaminoglycans to reproductive tissue function. The results of this study will enable scientists to better understand the relationship between structure and function (mechanical properties: strength) of the reproductive system to gain valuable insights toward understanding remodeling during pregnancy, postpartum recovery, and aging to identify potential causes of cervical insufficiency and pelvic organ prolapse. These studies will help design treatments to prevent premature birth and pelvic organ prolapse and improve the clinical treatment of cervical insufficiency.

Projects

Biaxial Mechanical Assessment of the Role of Fibulin-5 in the Murine Vagina

Dynamic Role of Elastic Fibers in Response to In Situ Altered Intraluminal Pressure in the Murine Cervix and Vagina

Mechanisms of pelvic floor structural integrity: Biaxial Mechanical Properties of the Postmenopausal Uterosacral Ligament in Patients with and without Pelvic Organ Prolapse

Collaborations

G Protein-Coupled Estrogen Receptor in Arterial Stiffening - Sarah H. Lindsey, Ph.D. - Tulane University , Pharmacology