Publications
‡ indicates equal contribution
Omar, I. Crotti, M., Li, C., Pisak, K., Czemerys, B. Ferla, S., van Noord, A. Paul, C. E, Karu, K., Ozbalci, C., Eggert, U., Lloyd, R., Barry, S. M.,* Castagnolo, D.* Insights into E. coli cyclopropane fatty acid synthase (CFAS) towards enantioselective carbene free biocatalytic cyclopropanation. Angewandte Chemie Accepted 2024
Anselmi, S. Carvalho, A. T.; Serrano-Sanchez, A., Ortega-Roldan, J. L., Caswell, J., Omar, I., Perez Ortiz, G., Barry, S. M., Moody, T., Castagnolo, D. Discovery and rational mutagenesis of methionine sulfoxide reductase (MsrA) biocatalysts to expand the substrate scope of the kinetic resolution of chiral sulfoxides. ACS Catal., 2023, 13, 7, 4742–4751
Perez-Ortiz G., Sidda J. ‡, Peate J. ‡, Ciccarelli D., Barry, S. M. Production of copropophyrin III, biliverdin and bilirubin by the rufomycin producer, Streptomyces atratus. Front. Microbiol. 2023, 14, 1092166
Ding, Y. Perez-Ortiz, G. Peate J., Barry S. M. Redesigning Enzymes for Biocatalysis: Exploiting Structural Understanding for Improved Selectivity Front. Mol. Biosci. 2022, 9, 90825
Perez-Ortiz, G. Sidda J., DeLosSantos , E. , Hubert, C. B., Barry, S. M. In vitro Elucidation of the Crucial but Complex Oxidative Tailoring Steps in Rufomycin Biosynthesis Enable One Pot Conversion of Rufomycin B to Rufomycin C Chem. Commun., 2021, 57, 11795 – 11798.
Anselmi, S. Liu, S. Kim, S-H, Barry, S. M., Moody, T. S., Castagnolo, D. A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent Org. Biomol. Chem. 2021,19, 156-161.
Savvas, L.‡, Barry, S. M.‡, Heyes, D. J., Qadri, M., Mubarak, E., Saqib Ali, H., Alkhalaf, L. M., Munro, A. W., Scrutton, N. S., Challis, G. L., de Visser, S. P. The catalytic mechanism of aromatic nitration by cytochrome P450 TxtE: Involvement of a ferric-peroxynitrite intermediate J. Am. Chem. Soc. 2020, 142, 37, 15764.
Alkhalaf, L. M. ‡, Barry, S. M.‡, Rea, D., Gallo. A., Griffiths, D., Lewandowski, J. R., Fulop, V., Challis, G. L. Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC J. Am. Chem. Soc. 2019, 141, 216-222.
Hubert, C. B.; Barry. S. M. New Chemistry from Natural Product Biosynthesis Biochem. Soc. Trans. 2016, 44, 738-744.
Devi P., Barry, S. M.; Houlihan, K., Murphy, M., Turner, P, Jensen, P., Rutlege P. J. Synthesis and structural characterisation of amides from picolinic acid and pyridine-2,6-dicarboxylic acid Scientific Reports 2015, 5, 9950.
Barry, S. M.; Challis, G. L. Mechanism and Catalytic Diversity of Rieske Oxygenases ACS Catalysis 2013, 3, 2362.
Barry, S. M.; Challis, G. L. Heme-dependent tailoring enzymes in natural product biosynthesis: Spectroscopic characterisation of the L-tryptophan-nitrating cytochrome P450 TxtE Meth. Enzymol. 2012, 516, 171.
Barry, S. M. ‡; Kers, J. A. ‡; Johnson, E. R.; Song, L.; Aston, P. R.; Patel, B.; Krasnoff, S. B.; Gibson, D. M.; Loria, R.; Challis, G. L. Cytochrome P450-catalysed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis. Nat. Chem. Biol. 2012, 8, 814. (Highlighted in Chem. Ind. 2012, 76, 11)
Barry, S. M.; Mueller-Bunz, H.; Rutledge, P. J. Investigating the cis-dihydroxylation of alkenes by non-heme iron enzyme mimics Org. Biomol. Chem. 2012, 10, 7372.
Dungan, V. J.; Wong, S. M.; Barry, S. M.; Rutledge, P. J. L-Proline-derived ligands to mimic the ‘2-His-1-carboxylate’ triad of the non-heme iron oxidase active site Tetrahedron 2012, 68, 3231.
Sydor, P. K.; Barry, S. M.; Odulate, O. M.; Barona-Gomez, F.; Haynes, S. W.; Song, L.; Challis, G. L. Regiodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes. Nat. Chem. 2011, 3, 342. (Highlighted in News and Views Nat Chem 2011, 3, 388).
Davis, C.; Carberry, S.; Schrettl, M.; Singh, I.; Stephens, J. C.; Barry, S. M.; Kavanagh, K.; Challis, G. L.; Brougham, D.; Doyle, S. The role of glutathione S-transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus Chem. Biol. 2011, 18, 542.
Barry, S. M.; Challis, G. L. Recent advances in siderophore biosynthesis. Curr. Opin. Chem. Biol. 2009, 13, 205
Barry, S. M.; Rutledge, P. J. cis-Dihydroxylation of alkenes by a non-heme iron enzyme mimic Synlett 2008, 2172.
Barry, S. M.; Mueller-Bunz, H.; Rutledge, P. J. tert-Butyldimethylsilanol hemihydrate Acta Cryst 2008, E64, o1174.
McManus, H. A.; Barry, S. M.; Andersson, P. G.; Guiry, P. J. Preparation of pyrrolidine-oxazoline containing ligands and their application in asymmetric transfer hydrogenation. Tetrahedron 2004, 60, 3405.