Axon Capture Download [EXCLUSIVE]

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Axon Capture Download

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I tried to implement a simple microservice with CQRS design pattern. i used axon framework and spring boot 3.1 for develop this. I divided query and command services into separate projects. At that moment event handler method is not hit by the event. When I check the event in the axon server. It successfully persists there and when I use the same event handler in the command side code base it is successfully working (The query services are working fine for the query handler).Command Service Command Service property file Query Service Query Service property file Shared Event

Axon, Axon Capture, Axon Fleet, Axon Citizen, Axon Evidence and the Delta Logo are trademarks of Axon Enterprise, Inc., some of which are registered in the US and other countries. For more information, visit www.axon.com/legal. All rights reserved.

The molecular mechanisms underlying the axon arborization of mammalian neurons are poorly understood but are critical for the establishment of functional neural circuits. We identified a pathway defined by two kinases, LKB1 and NUAK1, required for cortical axon branching in vivo. Conditional deletion of LKB1 after axon specification or knockdown of NUAK1 drastically reduced axon branching in vivo, whereas their overexpression was sufficient to increase axon branching. The LKB1-NUAK1 pathway controls mitochondria immobilization in axons. Using manipulation of Syntaphilin, a protein necessary and sufficient to arrest mitochondrial transport specifically in the axon, we demonstrate that the LKB1-NUAK1 kinase pathway regulates axon branching by promoting mitochondria immobilization. Finally, we show that LKB1 and NUAK1 are necessary and sufficient to immobilize mitochondria specifically at nascent presynaptic sites. Our results unravel a link between presynaptic mitochondrial capture and axon branching.

SCOTTSDALE, Ariz., June 6, 2018 /PRNewswire/ -- Axon (Nasdaq: AAXN), the global leader in connected law enforcement technologies, today announced a strategic partnership with Milestone Systems, a world-leading open platform IP video management software provider. Today, law enforcement agencies receive data from a multitude of digital video providers, which they then need to analyze and store across various platforms. The Axon and Milestone partnership allows agencies to ingest all that digital data, including data captured on non-Axon devices, into Evidence.com, providing one integrated solution for an efficient, unified workflow.

With the Axon Network, customers can securely and efficiently analyze photo and video footage captured on the Axon Capture smartphone app, body-worn, in-car and interview room cameras. The partnership with Milestone brings data from more than 6,000 models of cameras from 150 manufacturers, including CCTV footage, into that Axon ecosystem allowing for a combined holistic review of all evidence. The Milestone data is ingested into the Axon Network so customers can apply the same tools to all camera footage for the combined video evidence. This provides the ability to view and analyze video footage, redact in one single tool and quickly share case files with prosecutors.

"This partnership with Milestone will provide an invaluable service to our customers as it helps streamline the entire evidence analysis process," says Axon CEO and founder Rick Smith. "Milestone is a market leader in the video management software space. Law enforcement agencies will have the ability to ingest data from many more sources into the Axon Network, accelerating the capture-to-courtroom workflow."

We work hard for those who put themselves in harm's way for all of us. To date, there are more than 226,900 software seats booked on the Axon Network around the world and more than 200,000 lives and countless dollars have been saved with the Axon Network of devices, apps, and people. Learn more at www.axon.com or by calling (800) 978-2737.

Axon, Axon Network, Axon Capture, Evidence.com, the "Delta Logo," "Protect Life," and Smart Weapons are trademarks of Axon Enterprise, Inc., some of which are registered in the US and other countries. For more information, visit www.axon.com/legal. All rights reserved.

Neurons also face the additional challenge of maintaining this protein and organelle quality control over an extended landscape. Neurons have a highly polarized architecture with axons that can reach up to one meter in length. How degradative pathways respond to protein and organelle damage along the length of the axon is poorly understood. Where are autophagosomes generated in neurons? How do they mature into compartments capable of efficient degradation? Does autophagy require long-range transport along the axon or is it executed within a localized region? Most studies to date exploring the mechanisms of autophagy have focused on model systems that lack the extended and highly polarized processes that characterize neurons. Therefore, we set out to define the dynamics of autophagy along the axon of primary neurons in real time.

We found that autophagosomes are preferentially generated at the neurite tip via a constitutive mechanism. GFP-LC3-positive puncta appear and grow progressively into ring structures ~800 nm in diameter, a size and shape typical for autophagosomes. Following biogenesis, distal autophagosomes move bidirectionally. Occasionally autophagosomes escape from this distal pool and initiate unidirectional movement toward the cell soma. Along the axon, autophagosomes exhibit robust, primarily retrograde motility driven by the dynein/dynactin motor complex. However, kinesin motors remain bound while autophagosomes move processively in the retrograde direction. We hypothesize that the initial bidirectional motility exhibited by newly formed autophagosomes at the neurite tip is due to the competing activities of bound dynein and kinesin motors acting in a tug-of-war. Kinesin then becomes inactivated, possibly by adopting an autoinhibited conformation, allowing for robust dynein-driven transport.

As autophagosomes exit from the distal region, they acquire markers for late endosomes/lysosomes and become positive for the acidotropic probe LysoTracker-Red. Therefore, it is likely that fusion between autophagosomes and late endosomes/lysosomes occurs distally in the axon. Use of a dual-color LC3 reporter construct sensitive to compartment pH revealed that autophagosomes mature as they move distally to proximally along the axon as also shown by the Nixon laboratory. Proximal to the cell soma, they are fully acidified, consistent with the formation of an autolysosomal compartment that may more effectively degrade cargo. This maturation into autolysosomes is accompanied by a shift in dynamics to the primarily bidirectional motility characteristic of lysosomes.

Thus, we find that autophagosome formation and maturation is spatially and temporally regulated along the axon, and the stages of maturation are accompanied by discrete changes in motility (Fig. 1). We propose that fusion between autophagosomes and late endosomes/lysosomes elicits a signal to initiate transport toward the cell soma. Upon arrival at the cell soma, autophagosomes are fully acidified. This acidification may be a continuous process that occurs during the journey and might entail fusion with additional lysosomes. Delivery to the cell soma ensures that efficient cargo degradation occurs in the region where components can be rapidly recycled in proximity to primary sites of protein synthesis.

Figure 1. Model for autophagosome formation and maturation along the axon of primary neurons. Autophagosomes are generated at the neurite tip in a constitutive process. Soluble and organelle cargoes become enveloped within newly forming autophagosomes. These autophagosomes initially move bidirectionally (green and purple arrows denote motor activity), but then switch to robust retrograde motility driven by dynein. This transition to retrograde motility is accompanied by fusion with late endosomes/lysosomes (gray arrows denote transitions between compartment maturation). En route to the cell soma, autophagosomes may collect additional cargoes along the axon. As they move distally to proximally, autophagosomes mature and become increasingly acidified as denoted by the change in color from yellow to red. This maturation into autolysosomes, a compartment that may more effectively degrade cargo, is accompanied by a switch back to the bidirectional motility characteristic of lysosomes. Delivery of autolysosomes to the cell soma ensures that digested contents are recycled to primary sites of protein and lipid synthesis.

DURHAM REGION, Canada and SCOTTSDALE, Ariz., Aug. 11, 2016 /PRNewswire/ -- Axon Public Safety Canada Inc., a subsidiary of TASER International (NASDAQ: TASR) and the global leader in digital evidence management solutions with the leading body-worn camera, today announced that the Durham Regional Police Service (DRPS) is the first Ontario police service to pilot Axon Capture and Evidence.com. The pilot is designed to improve how the agency captures, stores and manages their digital evidence in the field.

"Digital evidence management is a major issue for all police services in Ontario and across Canada," said Chief Paul Martin. "We have been looking for an innovative solution that would improve how we capture evidence such as still photos, video and audio statements. After conducting research for a solution we are pleased to have selected Axon Capture from Axon Public Safety Canada for a pilot through the remainder of 2016. Axon Capture provides us both the flexibility and ease of use we were looking for at a reasonable price," concluded Chief Paul Martin. 006ab0faaa