Publications

 https://scholar.google.com/citations?hl=en&user=oW16WtYAAAAJ&view_op=list_works&sortby=pubdate

   2021

1.  Kumar S, Javed R, Claude-Taupin A, Mudd M, Pallikkuth S, Lidke KA, Jain A,  Rusten T-E,  Anonsen J, Lystad AH, Simonsen A, Guo L-W, Eskelinen E-L, Timmins G, and Deretic V. Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes. Cell Nov 24;184(24):5950-5969.

2. Kumar S*, Sánchez-Álvarez M, Lolo F-N, Trionfetti F, Strippoli R,* Cordani M. Autophagy and the Lysosomal System in Cancer. Cells 2021, 10, 2752. https://doi.org/10.3390/cells10102752

3. Kumar S, Jia J, Deretic V. Atg8ylation as a general membrane stress and remodeling response. Cell Stress. 2021 ;5(9):128-142.

4.   Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, da Silva GPD, Javed R, Gu Y, Allers L, Peters R, Wang F, da Costa LJ, Pallikkuth S, Lidke KA, Mauthe M, Verlhac P, Uchiyama Y, Salemi M, Phinney B, Tooze SA, Mari MC, Johansen T, Reggiori F, Deretic V. ATG9A protects the plasma membrane from programmed and incidental permeabilization. Nat Cell Biol. 2021 Aug;23(8):846-858.

5.  Cordani M, Somoza Á, Tafani M, Dando I, Kumar S. Editorial: Novel Cancer Treatments Based on Autophagy Modulation. Front Pharmacol. 2021 Apr 16;12:650559. doi: 10.3389/fphar.2021.650559.

  2020

6. Kumar S, Jain A, Choi SW, da Silva GPD, Allers L, Mudd MH, Peters RS, Anonsen JH, Rusten TE, Lazarou M, Deretic V.  Mammalian ATG8 proteins are upstream regulators of the lysosomal system by controlling mTOR and TFEB. Autophagy. 2020 Nov 10;:1-2. doi: 10.1080/15548627.2020.1837423. [Epub ahead of print] PubMed PMID: 33070669.

7. Kumar S, Jain A, Choi SW, da Silva GPD, Allers L, Mudd MH, Peters RS, Anonsen JH, Rusten TE, Lazarou M, Deretic V. Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens. Nat Cell Biol. 2020 Aug;22(8):973-985. doi: 10.1038/s41556-020-0549-1. Epub 2020 Aug 3. PubMed PMID: 32753672.

8. Sharma P, Dando I, Strippoli R, Kumar S, Somoza A, Cordani M, Tafani M. Nanomaterials for Autophagy-Related miRNA-34a Delivery in Cancer Treatment. Front Pharmacol. 2020 Jul 24;11:1141. doi: 10.3389/fphar.2020.01141. eCollection 2020.

2019   

9. Gu Y, Princely Abudu Y, Kumar S, Bissa B, Choi SW, Jia J, Lazarou M, Eskelinen EL, Johansen T, Deretic V. Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs. EMBO J. 2019 Nov 15;38(22):e101994. doi: 10.15252/embj.2019101994. Epub 2019 Oct 18. PubMed PMID: 31625181; PubMed Central PMCID: PMC6856626.

10. Kumar S, Gu Y, Abudu YP, Bruun JA, Jain A, Farzam F, Mudd M, Anonsen JH, Rusten TE, Kasof G, Ktistakis N, Lidke KA, Johansen T, Deretic V. Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation. Dev Cell. 2019 Apr 8;49(1):130-144.e6. doi: 10.1016/j.devcel.2019.01.027. Epub 2019 Feb 28. PubMed PMID: 30827897.

11.   Jia J, Abudu YP, Claude-Taupin A, Gu Y, Kumar S, Choi SW, Peters R, Mudd MH, Allers L, Salemi M, Phinney B, Johansen T, Deretic V. Galectins control MTOR and AMPK in response to lysosomal damage to induce autophagy. Autophagy. 2019 Jan;15(1):169-171. doi: 10.1080/15548627.2018.1505155. Epub 2018 Nov 5. PubMed PMID: 30081722; PubMed Central PMCID: PMC6287685.

2018

12.   Jia J, Abudu YP, Claude-Taupin A, Gu Y, Kumar S, Choi SW, Peters R, Mudd MH, Allers L, Salemi M, Phinney B, Johansen T, Deretic V. Galectins Control mTOR in Response to Endomembrane Damage. Mol Cell. 2018 Apr 5;70(1):120-135.e8. doi: 10.1016/j.molcel.2018.03.009. PubMed PMID: 29625033; PubMed Central PMCID: PMC5911935.

Preview on the article: Shin HR, Zoncu R. Finding Sugar in the Pantry: How Galectins Detect and Signal Lysosomal Damage. Mol Cell. 2018 Apr 5;70(1):5-7. 

13.  Kumar S, Jain A, Farzam F, Jia J, Gu Y, Choi SW, Mudd MH, Claude-Taupin A, Wester MJ, Lidke KA, Rusten TE, Deretic V.Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins. J Cell Biol. 2018 Mar 5;217(3):997-1013. doi: 10.1083/jcb.201708039. Epub 2018 Feb 2. PubMed PMID: 29420192; PubMed Central PMCID: PMC5839791.

Spotlight on the article: Tooze SA. SNAREing an ARP requires a LIR,  J Cell Biol. 2018 5;217(3):803-805.

2017

14.  Kumar S, Chauhan S, Jain A, Ponpuak M, Choi SW, Mudd M, Peters R, Mandell MA, Johansen T, Deretic V. Galectins and TRIMs directly interact and orchestrate autophagic response to endomembrane damage. Autophagy. 2017 Jun 3;13(6):1086-1087. doi: 10.1080/15548627.2017.1307487. Epub 2017 Apr 3. PubMed PMID: 28368693; PubMed Central PMCID: PMC5486367.

15.  Kimura T, Jia J, Claude-Taupin A, Kumar S, Choi SW, Gu Y, Mudd M, Dupont N, Jiang S, Peters R, Farzam F, Jain A, Lidke KA, Adams CM, Johansen T, Deretic V. Cellular and molecular mechanism for secretory autophagy. Autophagy. 2017 Jun 3;13(6):1084-1085. doi: 10.1080/15548627.2017.1307486. Epub 2017 Apr 3. PubMed PMID: 28368721; PubMed Central PMCID: PMC5486376.

2016

16.   Kimura T, Jia J, Kumar S, Choi SW, Gu Y, Mudd M, Dupont N, Jiang S, Peters R, Farzam F, Jain A, Lidke KA, Adams CM, Johansen T, Deretic V. Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy. EMBOJ. 2017 Jan 4;36(1):42-60. doi: 10.15252/embj.201695081. Epub 2016 Dec 8. PubMed PMID: 27932448; PubMed Central PMCID: PMC5210154.

17.  Chauhan S*, Kumar S*, Jain A, Ponpuak M, Mudd MH, Kimura T, Choi SW, Peters R, Mandell M, Bruun JA, Johansen T, Deretic V. TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. DevCell. 2016 Oct 10;39(1):13-27. doi: 10.1016/j.devcel.2016.08.003. Epub 2016 Sep 29. PubMed PMID: 27693506; PubMed Central PMCID: PMC5104201.* equal contribution

Preview on the article: Milana Fraiberg1 and Zvulun Elazar. A TRIM16-Galectin3 Complex Mediates Autophagy of Damaged Endomembranes . Dev Cell. 2016;39(1):1-2.

18.  Mandell MA, Jain A, Kumar S, Castleman MJ, Anwar T, Eskelinen EL, Johansen T, Prekeris R, Deretic V. TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation. J Cell Sci. 2016 Oct 1;129(19):3562-3573. doi: 10.1242/jcs.190017. Epub 2016 Aug 25. PubMed PMID: 27562068; PubMed Central PMCID: PMC5087653.

19.  Pathania AS, Guru SK, Kumar S, Kumar A, Ahmad M, Bhushan S, Sharma PR, Mahajan P, Shah BA, Sharma S, Nargotra A, Vishwakarma R, Korkaya H, Malik F. Interplay between cell cycle and autophagy induced by boswellic acid analog. Sci Rep. 2016 Sep 29;6:33146. doi: 10.1038/srep33146. PubMed PMID: 27680387; PubMed Central PMCID: PMC5041107.

20.   Husain I, Sharma A, Kumar S, Malik F. Purification and Characterization of Glutaminase Free Asparaginase from Enterobacter cloacae: In-Vitro Evaluation of Cytotoxic Potential against Human Myeloid Leukemia HL-60 Cells. PLoS One. 2016;11(2):e0148877. doi: 10.1371/journal.pone.0148877. eCollection 2016. PubMed PMID: 26891220; PubMed Central PMCID: PMC4758734.

21.  Husain I, Sharma A, Kumar S, Malik F. Purification and characterization of glutaminase free asparaginase from Pseudomonas otitidis: Induce apoptosis in human leukemia MOLT-4 cells. Biochimie. 2016 Feb;121:38-51. doi: 10.1016/j.biochi.2015.11.012. Epub 2015 Nov 17. PubMed PMID: 26597158.

2015

22.  Guru SK, Pathania AS, Kumar S, Ramesh D, Kumar M, Rana S, Kumar A, Malik F, Sharma PR, Chandan BK, Jaglan S, Sharma JP, Shah BA, Tasduq SA, Lattoo SK, Faruk A, Saxena AK, Vishwakarma RA, Bhushan S. Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade. Cancer Res. 2015 Jul 15;75(14):2886-96. doi: 10.1158/0008-5472.CAN-14-2312. Epub 2015 May 14. PubMed PMID: 25977334.

23.  Kumar S, Guru SK, Pathania AS, Manda S, Kumar A, Bharate SB, Vishwakarma RA, Malik F, Bhushan S. Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells. J Cell Biochem. 2015 Jun;116(6):985-97. doi: 10.1002/jcb.25053. PubMed PMID: 25561006.

24.  Singh B, Kumar A, Joshi P, Guru SK, Kumar S, Wani ZA, Mahajan G, Hussain A, Qazi AK, Kumar A, Bharate SS, Gupta BD, Sharma PR, Hamid A, Saxena AK, Mondhe DM, Bhushan S, Bharate SB, Vishwakarma RA. Colchicine derivatives with potent anticancer activity and reduced P-glycoprotein induction liability. Org Biomol Chem. 2015 May 28;13(20):5674-89. doi: 10.1039/c5ob00406c. Epub 2015 Apr 21. PubMed PMID: 25895604.

25.   Pathania AS, Wani ZA, Guru SK, Kumar S, Bhushan S, Korkaya H, Seals DF, Kumar A, Mondhe DM, Ahmed Z, Chandan BK, Malik F. The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA145 are potentiated by autophagy inhibitors. Mol Cancer. 2015 Jan 21;14:6. doi: 10.1186/1476-4598-14-6. PubMed PMID: 25608686; PubMed Central PMCID: PMC4509694.

26.  Kumar S, Guru SK, Venkateswarlu V, Malik F, Vishwakarma RA, Sawant SD, Bhushan S. A Novel Quinoline Based Second-generation mTOR Inhibitor that Induces Apoptosis and Disrupts PI3K-Akt-mTOR Signaling in Human Leukemia HL-60 Cells. Anticancer Agents Med Chem. 2015;15(10):1297-304. PubMed PMID: 25832358.

27.   Kumar D, Nepali K, Bedi PM, Kumar S, Malik F, Jain S. 4,6-diaryl Pyrimidones as Constrained Chalcone Analogues: Design, Synthesis and Evaluation as Antiproliferative Agents. Anticancer Agents Med Chem. 2015;15(6):793-803. PubMed PMID: 25783964.

2014

28.   Pathania AS, Kumar S, Guru SK, Bhushan S, Sharma PR, Aithagani SK, Singh PP, Vishwakarma RA, Kumar A, Malik F. The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells. PLoS One. 2014;9(11):e110411. doi: 10.1371/journal.pone.0110411. eCollection 2014. PubMed PMID: 25383546; PubMed Central PMCID: PMC4226462.

29.  Goswami A, Shah BA, Kumar A, Rizvi MA, Kumar S, Bhushan S, Malik FA, Batra N, Joshi A, Singh J. Antiproliferative potential of a novel parthenin analog P16 as evident by apoptosis accompanied by down-regulation of PI3K/AKT and ERK pathways in human acute lymphoblastic leukemia MOLT-4 cells. Chem Biol Interact. 2014 Oct 5;222:60-7. doi: 10.1016/j.cbi.2014.08.011. Epub 2014 Sep 6. PubMed PMID: 25196075.

2013

30.  Pathania AS, Joshi A, Kumar S, Guru SK, Bhushan S, Sharma PR, Bhat WW, Saxena AK, Singh J, Shah BA, Andotra SS, Taneja SC, Malik FA, Kumar A. Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059. Apoptosis. 2013 Dec;18(12):1561-73. doi: 10.1007/s10495-013-0889-4. PubMed PMID: 23948751.

31.   Kumar S, Guru SK, Pathania AS, Kumar A, Bhushan S, Malik F. Autophagy triggered by magnolol derivative negatively regulates angiogenesis. Cell Death Dis. 2013 Oct 31;4:e889. doi: 10.1038/cddis.2013.399. PubMed PMID: 24176847; PubMed Central PMCID: PMC3920944.

32.  Pieme CA, Guru SK, Ambassa P, Kumar S, Ngameni B, Ngogang JY, Bhushan S, Saxena AK. Induction of mitochondrial dependent apoptosis and cell cycle arrest in human promyelocytic leukemia HL-60 cells by an extract from Dorstenia psilurus: a spice from Cameroon. BMC Complement Altern Med. 2013 Sep 10;13:223. doi: 10.1186/1472-6882-13-223. PubMed PMID: 24016040; PubMed Central PMCID: PMC3847675.

33.   Lambu MR, Kumar S, Yousuf SK, Sharma DK, Hussain A, Kumar A, Malik F, Mukherjee D. Medicinal chemistry of dihydropyran-based medium ring macrolides related to aspergillides: selective inhibition of PI3Kα. J Med Chem. 2013 Aug 8;56(15):6122-35. doi: 10.1021/jm400515c. Epub 2013 Jul 29. PubMed PMID: 23845251.

34.  Kumar S, Kumar A, Pathania AS, Guru SK, Jada S, Sharma PR, Bhushan S, Saxena AK, Kumar HM, Malik F. Tiron and trolox potentiate the autophagic cell death induced by magnolol analog Ery5 by activation of Bax in HL-60 cells. Apoptosis. 2013 May;18(5):605-17. doi: 10.1007/s10495-013-0805-y. PubMed PMID: 23494480.

36. Sharma P, Kumar S, Ali F, Satti N. Synthesis and biologic activities of some novel heterocyclic chalcone derivatives. Medicinal Chemistry Research. 2013 August; 22(8):3969-3983. doi: https://doi.org/10.1007/s00044-012-0401-7.

2012

37.  Jada S, Doma MR, Singh PP, Kumar S, Malik F, Sharma A, Khan IA, Qazi GN, Kumar HM. Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds. Eur J Med Chem. 2012 May;51:35-41. doi: 10.1016/j.ejmech.2011.12.039. Epub 2012 Jan 30. PubMed PMID: 22424614.