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Example of the schematic for the novel animal model to study Cache Valley Virus using IFNAR-/- mice.
Pathogenesis Studies and Animal Model Development
We develop small mammal animal models to study virus pathogenesis, immunogenicity, transmission, and vaccine efficacy.
Approved Agents: WNV, MAYV, ZIKV, DENV, CVV, LACV, SARS CoV-2
Vaccine Development
Aripo-Zika (AZ) is a host-restricted chimeric vaccine meant to provide immunity against Zika virus. Danielle Porier and Manette Tanelus have conducted several experiments aimed at testing a central hypothesis: AZ vaccination is safe and will produce a robust immune response that will protect against lethal ZIKV infection.
We have some upcoming studies aimed at developing and characterizing chimeric vaccines for West Nile and/or Zika virus.
Aripo-Zika (AZ) genome structure
Manette Tanelus in ABSL-2 facility locker room
Example of PRNT plates
Example of 96 well plate labeling for PRNTs
Viral Surveillance
We currently conduct both mosquito and avian viral surveillance at multiple locations across the state of Virginia. We also have collaborators at various locations in the tropics that conduct mosquito viral surveillance screening.
Dr. Muller showing one of our undergraduate technicians (Dyess Harp) how to look for ectoparasites on birds.
Dr. Muller sorting mosquitoes from a recent sampling trip in Virginia
Krisangel López, Ph.D. Candidate in the Auguste Lab bird sampling
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