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Professors Hsien-Tai Chiu and Arunee Thitithanyanont, Members of The APBA, Discovered Natural Small-Molecule Compounds with Antiviral Activity in Natural Products.
APBA members Professor Hsien-Tai Chiu and Professor Arunee Thitithanyanont, in collaboration with the Kaohsiung Medical University Center for Tropical Medicine and Infectious Diseases and the Department of Medical Research at Chi Mei Hospital, as well as other internationally renowned academic and clinical institutions, jointly conducted a research project.
In 2025, the research team published their findings in the prestigious international journal Bioorganic Chemistry, attracting significant attention from both the academic and industrial communities worldwide.The study demonstrated the potential of small-molecule compounds in the field of antiviral research, showing that these compounds effectively inhibit two key SARS-CoV-2 replication enzymes—3C-like protease (3CLpro) and papain-like protease (PLpro)—thereby markedly reducing viral replication efficiency and infectivity.More importantly, the research team successfully completed the total synthesis of the compound and confirmed its potent inhibitory effects against multiple viral variants, including the Omicron strain.
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