Publications

[Siow Wee Chang] Low, J. S. Y., Teh, H. F., Thevarajah, T. M., Chang, S. W., & Khor, S. M. (2025). An AI-assisted microfluidic paper-based multiplexed surface-enhanced raman scattering (SERS) biosensor with electrophoretic removal and electrical modulation for accurate acute myocardial infarction (AMI) diagnosis and prognosis. Biosensors & bioelectronics, 270, 116949. https://doi.org/10.1016/j.bios.2024.116949 

[Duangrudee Tanramluk] Kluebsoongnoen, J., Tanramluk, D., Jozghorbani, M., Phetcharaburanin, J., Sarnowski, T. J., & Udomkit, A. (2025). Identification and functional characterization of a novel ovarian-specific Kelch domain-containing gene involved in the ecdysteroid signaling pathway of Penaeus monodon. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 308, 111914. https://doi.org/10.1016/j.cbpa.2025.111914

[Arunee Thitithanyanont] Tung, Y. W., Yang, Z. S., Wang, W. H., Hsu, Y. T., Tsui, C. I., Assavalapsakul, W., Thitithanyanont, A., Lin, C. Y., Chao, D. Y., Chen, Y. H., & Wang, S. F. (2025). An unexpected dengue outbreak in Taiwan, 2023: A retrospective analysis of potential risk factors. Journal of infection and public health, 18(11), 102939. https://doi.org/10.1016/j.jiph.2025.102939

[Hsien-Tai Chiu, Arunee Thitithanyanont] Singh, A., Xu, S. H., Tsai, Y. D., Yang, Z. S., Tang, H. J., Tsai, Y. J., Tsai, H. Y., Yuan, C. W., Chen, C. C., Thitithanyanont, A., Wang, S. F., & Chiu, H. T. (2025). Exploration of the anti-SARS-CoV-2 potential and expected mechanisms of small molecules from Antrodia cinnamomea by BT&D2 drug-targeting analysis. Bioorganic chemistry, 163, 108646. https://doi.org/10.1016/j.bioorg.2025.108646

[Dean Ho] Sumner, J., Mohamed Ali, J., Motani, M., Ang, A., Ho, D., & Mukhopadhyay, A. (2025). Artificial intelligence guided dosing decisions: a qualitative study on health care provider perspectives. BMJ health & care informatics, 32(1), e101461. https://doi.org/10.1136/bmjhci-2025-101461

[Durai Sundar] Kesarwani, P., & Sundar, D. (2025). Conformational changes induced by K949A mutation in the CRISPR-Cas12a complex drives an effective target-binding mechanism. Current research in structural biology, 10, 100173. https://doi.org/10.1016/j.crstbi.2025.100173

[Ivy Chung] Yeu, T. H., Omar, I. S., Kwong, S. C., Said, N. A. B. M., Abdul Sani, S. F., Abd Jamil, A. H., & Chung, I. (2025). Detecting metabolic signatures in endometrial cancer: potential applications of Raman spectroscopy. Future oncology (London, England), 21(20), 2663–2687. https://doi.org/10.1080/14796694.2025.2530920

[Dean Ho] Sapanel, Y., Cloutier, L. M., Morton, A., Lin, S., Seres, G., & Ho, D. (2025). Understanding Economic Decision-Making in Digital Therapeutics Development: Qualitative Approach. Journal of medical Internet research, 27, e79746. https://doi.org/10.2196/79746

[Jung-Hsin Lin] Wu, K. C., Lin, C. Y., Tran, T., Lin, J. H., Yeh, H. H., Ho, C. J., Chern, Y., & Lin, C. J. (2025). Preclinical Evaluation of a Novel Molecule Targeting Nucleoside Homeostasis to Restore Energy Metabolism and Cognitive Function in Alzheimer's Disease. Pharmacology research & perspectives, 13(5), e70176. https://doi.org/10.1002/prp2.70176

[Lee-Wei Yang, Durai Sundar] Radhakrishnan, N., Kaul, S. C., Wadhwa, R., Yang, L. W., & Sundar, D. (2025). Establishing a General Atomistic Model for the Stratum Corneum Lipid Matrix Based on Experimental Data for Skin Permeation Studies. International journal of molecular sciences, 26(2), 674. https://doi.org/10.3390/ijms26020674

[Dean Ho] Vogt, B. J., Wang, P., Chavez, M., Guo, P., Chow, E. K., Ho, D., & Aguado, B. A. (2025). Determining sex differences in aortic valve myofibroblast responses to drug combinations identified using a digital medicine platform. Science advances, 11(23), eadu2695. https://doi.org/10.1126/sciadv.adu2695

[Lee-Wei Yang] US20230122049A1, Yang, L. W., Tsai, K. L., HUANG, B. C., CHENG, Y. Y., & Chang, S. Y. (2025). "Method and combination for the suppression of COVID-19 virus. United States Patent", United States, July 29, 2025.

[Sheng-Fu Liang] Zhou, J., Leong, D., Cao, Z., Do, T., Liang, S. F., Jung, T. P., & Lin, C. T. (2025, October). MindSpeak: A Real-Time BCI System for Silent Speech. In Proceedings of the 33rd ACM International Conference on Multimedia (pp. 13549-13551).

[Lee-Wei Yang] Amaro, R. E., Åqvist, J., Bahar, I., Battistini, F., Bellaiche, A., Beltran, D., Biggin, P. C., Bonomi, M., Bowman, G. R., Bryce, R. A., Bussi, G., Carloni, P., Case, D. A., Cavalli, A., Chang, C. A., Cheatham, T. E., 3rd, Cheung, M. S., Chipot, C., Chong, L. T., Choudhary, P., …  Yang, L. W., Zacharias, M. & Orozco, M. (2025). The need to implement FAIR principles in biomolecular simulations. Nature methods, 22(4), 641–645. https://doi.org/10.1038/s41592-025-02635-0

[Dean Ho] Dai, Y., Wang, P., Mishra, A., You, K., Zong, Y., Lu, W. F., Chow, E. K., Preshaw, P. M., Huang, D., Chew, J. R. J., Ho, D., & Sriram, G. (2025). 3D Bioprinting and Artificial Intelligence-Assisted Biofabrication of Personalized Oral Soft Tissue Constructs. Advanced healthcare materials, 14(13), e2402727. https://doi.org/10.1002/adhm.202402727

[Ivy Chung] Bin Wan Mohd Nor, W. M. F. S., Kwong, S. C., Fuzi, A. A. M., Said, N. A. B. M., Jamil, A. H. A., Lee, Y. Y., Lee, S. C., Lim, Y. A., & Chung, I. (2025). Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review). International journal of molecular medicine, 55(3), 46. https://doi.org/10.3892/ijmm.2025.5487

[Dean Ho] Gan, T. R. X., Tan, L. W. J., Egermark, M., Truong, A. T. L., Kumar, K., Tan, S. B., Tang, S., Blasiak, A., Goh, B. C., Ngiam, K. Y., & Ho, D. (2025). AI-assisted warfarin dose optimisation with CURATE.AI for clinical impact: Retrospective data analysis. Bioengineering & translational medicine, 10(3), e10757. https://doi.org/10.1002/btm2.10757

[Sheng-Fu Liang] Lu, T. H., Hsieh, T. H., Wang, Y. H., Shaw, F. Z., Chen, P. S., & Liang, S. F. (2025). Evaluation of alpha neurofeedback training to enhance sleep in remitted depression and anxiety sufferers with persistent insomnia. Psychiatry research, 346, 116401. https://doi.org/10.1016/j.psychres.2025.116401

[Dean Ho] Dai, Y., Wang, P., Mishra, A., You, K., Zong, Y., Lu, W. F., Chow, E. K., Preshaw, P. M., Huang, D., Chew, J. R. J., Ho, D., & Sriram, G. (2025). 3D Bioprinting and Artificial Intelligence-Assisted Biofabrication of Personalized Oral Soft Tissue Constructs. Advanced healthcare materials, 14(13), e2402727. https://doi.org/10.1002/adhm.202402727

[Dean Ho] Sapanel, Y., Cloutier, L. M., Tremblay, G., Bourcet, A., Koerber, F., Lariviere, D., Tadeo, X., & Ho, D. (2025). A group concept mapping study of stakeholder perspectives on digital therapeutics economic value drivers. NPJ digital medicine, 8(1), 199. https://doi.org/10.1038/s41746-025-01600-7

[Sheng-Fu Liang] Hsieh, T. H., Chen, T. Y., & Liang, S. F. (2025, August). Drowsiness Detection based on Continuous State Transitions from Alertness to Sleep using Forehead EEG. In 2025 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB) (pp. 1-5). IEEE.

[Dean Ho] Su, C., Wang, P., Foo, N., & Ho, D. (2025). Optimizing metabolic health with digital twins. npj aging, 11(1), 20. https://doi.org/10.1038/s41514-025-00211-6

[Dean Ho] You, K., Binte Mohamed Yazid, N., Chong, L. M., Hooi, L., Wang, P., Zhuang, I., Chua, S., Lim, E., Kok, A. Z. X., Marimuthu, K., Vasoo, S., Ng, O. T., Chan, C. E. Z., Chow, E. K., & Ho, D. (2025). Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR. npj antimicrobials and resistance, 3(1), 12. https://doi.org/10.1038/s44259-025-00079-2

[Sheng-Fu Liang] Wong, C. E., Kuo, Y. C., Huang, D. W., Chen, P. W., Hsu, H. J., Lee, W. T., Hung, S. Y., Lee, J. S., & Liang, S. F. (2025). Human-Computer Vision Collaborative Measurement of Surgical Exposure and Length in Endonasal Endoscopic Skull Base Surgery. IEEE open journal of engineering in medicine and biology, 6, 480–487. https://doi.org/10.1109/OJEMB.2025.3587947

[Dean Ho] Blasiak, A., Truong, A. T. L., Foo, N., Tan, L. W. J., Kumar, K. S., Tan, S. B., Teo, C. B., Tan, B. K. J., Tadeo, X., Tan, H. L., Chee, C. E., Yong, W. P., Ho, D., & Sundar, R. (2025). Personalized dose selection platform for patients with solid tumors in the PRECISE CURATE.AI feasibility trial. NPJ precision oncology, 9(1), 49. https://doi.org/10.1038/s41698-025-00835-7

[Dean Ho] Kwek, S. P., Leong, Q. Y., Lee, V. V., Lau, N. Y., Vijayakumar, S., Ng, W. Y., Rai, B., Raczkowska, M. N., Asplund, C. L., Remus, A., & Ho, D. (2025). Exploring the General Acceptability and User Experience of a Digital Therapeutic for Cognitive Training in a Singaporean Older Adult Population: Qualitative Study. JMIR formative research, 9, e63568. https://doi.org/10.2196/63568

[Yang Zhang] Zheng, W., Wuyun, Q., Li, Y., Zhang, C., Freddolino, P. L., & Zhang, Y. (2024). Improving deep learning protein monomer and complex structure prediction using DeepMSA2 with huge metagenomics data. Nature methods, 21(2), 279–289. https://doi.org/10.1038/s41592-023-02130-4 

[Hsien-Sung Huang] Chen, T. Y., Lin, S. P., Huang, D. F., Huang, H. S., Tsai, F. C., Lee, L. J., Lin, H. Y., & Huang, H. P. (2024). Mature neurons from iPSCs unveil neurodegeneration-related pathways in mucopolysaccharidosis type II: GSK-3β inhibition for therapeutic potential. Cell death & disease, 15(4), 302. https://doi.org/10.1038/s41419-024-06692-9  

[Durai Sundar] Kalakoti, Y., Gawande, S., & Sundar, D. (2024). Estimating protein-ligand interactions with geometric deep learning and mixture density models. Journal of biosciences, 49, 97.

[Dar-Bin Shieh] Hsieh, C. H., Ho, P. S., Wang, W. L., Shih, F. H., Hong, C. T., Wang, P. W., Shieh, D. B., Chang, W. L., & Wang, Y. C. (2024). Decreased plasma gelsolin fosters a fibrotic tumor microenvironment and promotes chemoradiotherapy resistance in esophageal squamous cell carcinoma. Journal of biomedical science, 31(1), 90. https://doi.org/10.1186/s12929-024-01078-7 

[Iskandar Abdullah] Tehami, M., Imam, H. T., Abdullah, I., Hosford, J., Wong, X. J., Rahman, N. A., & Wong, L. S. (2024). Biocatalytic Generation of o-Quinone Imines in the Synthesis of 1,4-Benzoxazines and Its Comparative Green Chemistry Metrics. ACS sustainable chemistry & engineering, 12(7), 2678–2685. https://doi.org/10.1021/acssuschemeng.3c06758 

[Yang Zhang] Zhang, C., Zhang, X., Freddolino, P. L., & Zhang, Y. (2024). BioLiP2: an updated structure database for biologically relevant ligand-protein interactions. Nucleic acids research, 52(D1), D404–D412. https://doi.org/10.1093/nar/gkad630 

[Che-Hung Shen] Wu, C. K., Shiu, J. L., Wu, C. L., Hung, C. F., Ho, Y. C., Chen, Y. T., Tung, S. Y., Yeh, C. F., Shen, C. H., Liaw, H., & Su, W. P. (2024). APLF facilitates interstrand DNA crosslink repair and replication fork protection to confer cisplatin resistance. Nucleic acids research, 52(10), 5676–5697. https://doi.org/10.1093/nar/gkae211 

[Che-Hung Shen] Hsu, S. H., Tsai, Y. L., Wang, Y. T., Shen, C. H., Hung, Y. H., Chen, L. T., & Hung, W. C. (2024). RNF43 Inactivation Enhances the B-RAF/MEK Signaling and Creates a Combinatory Therapeutic Target in Cancer Cells. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11(12), e2304820. https://doi.org/10.1002/advs.202304820  

[Yang Zhang] Zheng, W., Wuyun, Q., & Zhang, Y. (2024). One step forward towards deep-learning protein complex structure prediction by precise multiple sequence alignment construction. Clinical and translational medicine, 14(6), e1689. https://doi.org/10.1002/ctm2.1689 

[Yu-Chih Lo] Yang, C. Y., Tseng, Y. C., Tu, Y. F., Kuo, B. J., Hsu, L. C., Lien, C. I., Lin, Y. S., Wang, Y. T., Lu, Y. C., Su, T. W., Lo, Y. C., & Lin, S. C. (2024). Reverse hierarchical DED assembly in the cFLIP-procaspase-8 and cFLIP-procaspase-8-FADD complexes. Nature communications, 15(1), 8974. https://doi.org/10.1038/s41467-024-53306-1  

[Ji-Yen Cheng] Santoso, F., De Leon, M. P., Kao, W. C., Chu, W. C., Roan, H. Y., Lee, G. H., Tang, M. J., Cheng, J. Y., & Chen, C. H. (2024). Appendage-resident epithelial cells expedite wound healing response in adult zebrafish. Current biology : CB, 34(16), 3603–3615.e4. https://doi.org/10.1016/j.cub.2024.06.051

[Syarul Nataqain Binti Baharum] Mediani, A., & Baharum, S. N. (2024). Metabolomics: Challenges and Opportunities in Systems Biology Studies. Methods in molecular biology (Clifton, N.J.), 2745, 77–90. https://doi.org/10.1007/978-1-0716-3577-3_5 

[Yu-Chih Lo] Yang, C. Y., Lien, C. I., Tseng, Y. C., Tu, Y. F., Kulczyk, A. W., Lu, Y. C., Wang, Y. T., Su, T. W., Hsu, L. C., Lo, Y. C., & Lin, S. C. (2024). Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis. Nature communications, 15(1), 3791. https://doi.org/10.1038/s41467-024-47990-2   

[Woei-Jer, Chuang] Hsieh, K. H., Chao, C. H., Cheng, Y. L., Lai, Y. C., Chuang, Y. C., Wang, J. R., Chang, S. Y., Hung, Y. P., Chen, Y. A., Liu, W. L., Chuang, W. J., & Yeh, T. M. (2024). Enhancement of NETosis by ACE2-cross-reactive anti-SARS-CoV-2 RBD antibodies in patients with COVID-19. Journal of biomedical science, 31(1), 39. https://doi.org/10.1186/s12929-024-01026-5 

[Dean Ho] Leong, Q. Y., Lee, V. V., Ng, W. Y., Vijayakumar, S., Lau, N. Y., Mauritzon, I., Blasiak, A., & Ho, D. (2024). Older Adults' Perspectives and Experiences With Digital Health in Singapore: Qualitative Study. JMIR human factors, 11, e58641. https://doi.org/10.2196/58641

[Dean Ho] Leong, Q. Y., Lee, V. V., Ng, W. Y., Vijayakumar, S., Lau, N. Y., Mauritzon, I., Blasiak, A., & Ho, D. (2024). Older Adults' Perspectives and Experiences With Digital Health in Singapore: Qualitative Study. JMIR human factors, 11, e58641. https://doi.org/10.2196/58641

[Dean Ho] Ng, W. Y., Lau, N. Y., Lee, V. V., Vijayakumar, S., Leong, Q. Y., Ooi, S. Q. D., Su, L. L., Lee, Y. S., Chan, S. Y., Blasiak, A., & Ho, D. (2024). Shaping Adoption and Sustained Use Across the Maternal Journey: Qualitative Study on Perceived Usability and Credibility in Digital Health Tools. JMIR human factors, 11, e59269. https://doi.org/10.2196/59269

[Dean Ho] Blasiak, A., Tan, L. W. J., Chong, L. M., Tadeo, X., Truong, A. T. L., Senthil Kumar, K., Sapanel, Y., Poon, M., Sundar, R., de Mel, S., & Ho, D. (2024). Personalized dose selection for the first Waldenström macroglobulinemia patient on the PRECISE CURATE.AI trial. NPJ digital medicine, 7(1), 223. https://doi.org/10.1038/s41746-024-01195-5

[Dean Ho] Chong, L. M., Wang, P., Lee, V. V., Vijayakumar, S., Tan, H. Q., Wang, F. Q., Yeoh, T. D. Y. Y., Truong, A. T. L., Tan, L. W. J., Tan, S. B., Senthil Kumar, K., Hau, E., Vellayappan, B. A., Blasiak, A., & Ho, D. (2024). Radiation therapy with phenotypic medicine: towards N-of-1 personalization. British journal of cancer, 131(1), 1–10. https://doi.org/10.1038/s41416-024-02653-3

[Durai Sundar] Peter, S. C., Kalakoti, Y., & Sundar, D. (2024). Identifying High-Quality Leads among Screened Anticancerous Compounds Using SMILES Representations. ACS omega, 9(28), 30645–30653. https://doi.org/10.1021/acsomega.4c02801

[Dean Ho] Toh, T. B., Thng, D. K. H., Bolem, N., Vellayappan, B. A., Tan, B. W. Q., Shen, Y., Soon, S. Y., Ang, Y. L. E., Dinesh, N., Teo, K., Nga, V. D. W., Low, S. W., Khong, P. L., Chow, E. K., Ho, D., Yeo, T. T., & Wong, A. L. A. (2024). Evaluation of ex vivo drug combination optimization platform in recurrent high grade astrocytic glioma: An interventional, non-randomized, open-label trial protocol. PloS one, 19(7), e0307818. https://doi.org/10.1371/journal.pone.0307818

[Dean Ho] Tang, L. K., Yobas, P., Wong, D. N. X., Pikkarainen, M., Zhang, R., Ho, D., & He, H. G. (2024). Personal and work-related factors associated with post-traumatic growth in nurses: A mixed studies systematic review. Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing, 56(4), 563–584. https://doi.org/10.1111/jnu.12973

[Durai Sundar] Kumar, V., Shefrin, S., & Sundar, D. (2024). Molecular insights into the binding interactions and energetics of the omicron spike variant with hACE2 and a neutralizing antibody. Journal of structural biology, 216(2), 108087. https://doi.org/10.1016/j.jsb.2024.108087

[Dean Ho] Wang, P., Tadeo, X., Chew, H. S. J., Sapanel, Y., Ong, Y. H., Leung, N. Y. T., Chow, E. K., & Ho, D. (2024). N-of-1 health optimization: Digital monitoring of biomarker dynamics to gamify adherence to metabolic switching. PNAS nexus, 3(6), pgae214. https://doi.org/10.1093/pnasnexus/pgae214

[Durai Sundar] Vora, D. S., Bhandari, S. M., & Sundar, D. (2024). DNA shape features improve prediction of CRISPR/Cas9 activity. Methods (San Diego, Calif.), 226, 120–126. https://doi.org/10.1016/j.ymeth.2024.04.012