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Health) – for middle or high school students ▪ Teachers: Classroom Resources on Drug Effects (National Institute on Drug Abuse for Teachers) ▪ smokeSCREEN: A smoking Prevention Videogame (play2PREVENT) – for ages 11-14 years old ▪ Tobacco 101 (Association for Nonsmokers – Minnesota) – for youth groups, middle or high school students ▪ Lesson Plan: Vaping and JUULing (Twin Cities Medical Society) ▪ Taking Down Tobacco (Campaign for Tobacco-Free Kids) – for youth groups, middle or high school students ▪ Everything You Need to Know about E-cigarettes, Vaping, and Hookahs (Botvin Life Skills Training) – for grades 7-College 9,449 students received a 156-item anonymous online survey which assessed the use of e-cigarettes (ever or past year), alcohol and drug use, mental health issues, and impulsive and compulsive traits. 3,572 university students (57.1% female) responded to the survey. The prevalence of past 12-month e-cigarette use was 9.2%, with 9.8% reporting having used more than 12 months ago. E-cigarette use was associated with the use of multiple other drugs (e.g., alcohol, opiates). Those who used e-cigarettes were significantly more likely to have mental health histories of ADHD, PTSD, gambling disorder, and anxiety, report low self-esteem, and endorse traits of impulsivity.Use of e-cigarettes is common in university students and appears to be associated with a variety of mental health and drug use problems. Clinicians should be aware that certain mental health conditions are more common in e-cigarette users. This study indicates the need for longitudinal research into the effects of chronic nicotine consumption on brain function and mental health, especially in young people, since such effects would be common to conventional tobacco smoking and vaping. E-cigarettes have grown in popularity around the world since 2003. Although marketed as a smoking cessation tool, e-cigarettes can lead to tobacco cigarette smoking in youth. In Canada, among all age groups, youth and young adults have the highest prevalence of e-cigarette use. The objective of this study was to assess the factors associated with e-cigarette use among youth and young adults in Canada, and to specifically examine the association between alcohol, marijuana and illicit drug use.Data from the 2017 Canadian Tobacco, Alcohol and Drugs Survey were used. The sample was restricted to those aged 15–24 years (n = 10,322), and main outcome defined as ‘E-cigarette use in the past 30-days’. Multivariable logistic regression was performed to assess the association between the main outcome and substance use variables (illicit drug, marijuana and alcohol use), tobacco exposure variables, and demographic and health-related factors.6.2% Canadians aged 15–24 reported using e-cigarettes in the past 30-days, while 23.9% reported having ever tried e-cigarettes. Twenty-three percent of the past 30-day users reported using e-cigarettes every day and 72.5% of the past 30-day users reported having nicotine in their last e-cigarette. Additionally, youth aged 15–17 were 4.95 times more likely to be e-cigarette users as compared to those aged 22–24 (OR: 4.95, 95% CI: 3.1–7.9). Moreover, e-cigarette use was significantly associated with marijuana use (OR:4.17, 95% CI: 2.6–6.7) and alcohol use (OR: 5.08, 95% CI: 2.9–9.0), and approached significance with illicit drug use (OR: 1.68, 95% CI: 1.0–2.9). Furthermore, being a current smoker (OR: 2.93, 95% CI: 1.8–4.7) and male (OR: 2.28, 95% CI: 1.5–3.4) was significantly associated with the outcome.This study is nationally representative and provides insight into e-cigarette use among youth and young adults aged 15–24 years. Given that e-cigarettes can be used as illicit drug delivery systems, more studies are needed to understand how Canadian youth and young adults are using e-cigarettes. Stricter restrictions on public e-cigarette smoking, and awareness campaigns informing youth of risks of e-cigarette smoking should be implemented. Keywords: E-cigarette, Vaping, Illicit drugs, Drugs, Youth, Young adults, Smoking, Alcohol, Canada Since their invention in 2003, electronic cigarettes, also known as e-cigarettes, vapes and vape pens, have consistently grown in popularity across the globe [1]. In 2016, the e-cigarette market earned more than 8 billion dollars in profits globally. This amount is expected to go up to 26 billion dollars by the year 2023 [2]. E-cigarettes were originally marketed as a cleaner and safer alternative to the traditional combustible cigarette [3]. However, since incorporating a wide variety of flavours, designs, nicotine levels, and drug delivery options, the e-cigarette market has grown rapidly to appeal to a large demographic of consumers [3–5]. Although media portray the e-cigarette as an ideal alternative to