Organoid Models

SPOTLIGHT: Human Organoids in Disease Research and Drug Discovery

CO Animation.mp4

Created and shared with permission by Vadym Lytvynov

Available Models

Cerebral Organoids: 1 - 9 months of age
Midbrain Organoids
Cerebellar Organoids: 1 - 2 months of age
Lung Organoids: 1 - 2 months of age

Human Cerebral Organoids (hCOs), whole or live sectioned samples available

H9 ESC - derived 2.5 week old hCO (10X brightfield)

Patient iPSC-derived ALS line was used to generate 1 month old human cerebral organoids (ca. 2 - 3 mm average organoid size) showing marker identification of some representative neural cell types

Human Cerebellar Organoids (hCerOs)

3 week old hCerOs (4X brightfield)

Whole human cerebellar organoids at one month of age (ca. 1.0 mm in size) derived from WTC-11 hPSCs were fixed, transferred into cryomolds and cryosectioned to generate 20 um slices on glass slides. Samples were further processed and stained according to standard protocols before imaging.

Immunofluorescence images courtesy of Drs. Shraddha Pai & Nishka Kishore, Ontario Institute for Cancer Research, https://www.shraddhapailab.com/

•Human cerebral, midbrain, cerebellar and lung organoid batch production capability for downstream applications

•Live sectioning and continuous culture (> several months)

•Organoid Vibratome or Cryosectioning Services

•Confocal Microscopy and Marker Analysis

•Data Analysis of Organoid-focused Datasets

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