2025
Rodriguez LG, Rubio FJ, Burke MAM, Matheson CL, Ukpong E, Li X*, Nemes P* (2025) Deep proteome profiling of rat dorsal striatal synaptoneurosomes following methamphetamine exposure. ACS Chem Neurosci. doi: 10.1021/acschemneuro. 5c00679 *Co-senior author
Altshuler, RD, Burke MAM, Garcia, K, Class K, Cimbro R, Li X (2025) Profiling gene alterations in striatonigral neurons associated with incubation of methamphetamine craving by cholera toxin subunit B-based fluorescence-activated cell sorting. Frontier in Cellular Neuroscience 19: 1542508. https://doi.org/10.3389/fncel.2025.1542508
Brockett AT, Scilarillo X, Li X and Roesch MR (2025) Healthy aging in rats is associated with a decline in the ability to inhibit maladaptive responses, but not in measures of self-control by delayed gratification. Frontier Aging Neuroscience 17: doi: 10.3389/fnagi.2025.1579934.
Perry S, Sharalla PS, Sarubin DR, Li X, Roesch MR and Bockett (2025) Epigenetic manipulation of anterior insular cortex alters neural signals and cognitive control. Neuropsychopharmacology. https://doi.org/10.1038/s41386-025-02181-5
2024
Lin H, Olaniran A, Garmchi S, Firlie J, Rincon N, Li X (2024) The estrous cycle has no effect on incubation of methamphetamine craving and associated Fos expression in dorsomedial striatum and anterior intralaminar nucleus of thalamus. Addiction Neuroscience doi: 10.1016/j.addicn.2024.100158
Lin, H, Olaniran A, Luo, X, Strauch, J, Burke, MAM, Matheson, C, Li X (2024) Orbitofrontal cortex to dorsal striatum circuit is critical for incubation of oxycodone craving after forced abstinence. Addiction Biolology 29:e13440. https://doi.org/10.1111/adb.13440
2023
Olaniran A, Altshuler AD, Burke MAM, Lin H, Firlie J, Linshitz I, Li X (2023) Role of oestrous cycle and orbitofrontal cortex in oxycodone seeking after 15-day abstinence in female rats. Addiction Biology 28 (10), e13325
Fredriksson I, Tsai PJ, Shekara A, Duan Y, Appplebey SV, Minier-Toribio A, Batista A, Chow JJ, Altidor L, Barbier E, Cifani C, Li X, Reiver DJ, Rubio FJ, Hope BT, Yang Y, Bossert JM, Shaham Y (2023) Role of ventral subiculum neuronal ensembles in incubation of oxycodone craving after electric barrier-induced voluntary abstinence. Science Advances. DOI: 10.1126/sciadv.add8687
2022
Olaniran A , Garcia KT, Burke MAM, Lin H, Venniro M and Li X (2022) Operant social seeking to a novel peer after social isolation is associated with activation of nucleus accumbens shell in rats. Psychopharmacology. DOI: 10.1007/s00213-022-06280-9
2021
Pribut HJ, Vázquez D, Wei AD, Tennyson SS, Davis, IR, Roesch MR, Li X (2021) Overexpressing histone deacetylase 5 in rat dorsal striatum alters reward-guided decision-making and associated neural encoding. Journal of Neuroscience 41: 10080-10090. doi:https://doi.org/10.1523/JNEUROSCI.0916-21.2021
Venniro M, Reverte I, Ramsey LA, Papastrat KM, D'Ottavio G, Milella MS, Li X, Grimm JW, Caprioli D. Factors modulating the incubation of drug and non-drug craving and their clinical implications. Neurosci Biobehav Rev. 2021 Sep 28;131:847-864. doi: 10.1016/j.neubiorev.2021.09.050.
James M, McNally G, Li X (2021) Editorial: Role of thalamus in motivated behavior. Frontier in Behavioral Neuroscience. doi.org/10.3389/fnbeh.2021.720592
Altshuler RD, Garcia KT, Li X (2021) Incubation of oxycodone craving following adult-onset and adolescent-onset oxycodone self-administration in male rats. Frontier in Behavioral Neuroscience. doi: 10.3389/fnbeh.2021.697509
2020
Davis IR, Coldren SA, Li X (2020) Methamphetamine seeking after prolonged abstinence is associated with activated projections from anterior intralaminar nucleus of thalamus to dorsolateral striatum in female rats. Pharmacology Biochemistry and Behavior.
Altshuler RD, Hongyu Lin, Li X (2020) Neural mechanisms underlying incubation of methamphetamine craving: A mini-review. Pharmacology Biochemistry and Behavior. PMID: 33250444 (PDF)
Altshuler RD, Yang ES, Garcia KT, Davis IR, Olaniran A, Haile M, Razavi S, Li X (2020) Role of orbitofrontal cortex in incubation of oxycodone craving in male rats. Addiction Biology. PMID: 32570285 (PDF)
Werner CT, Altshuler RD, Shaham Y, Li X (2020) Epigenetic mechanisms in drug relapse. Biological Psychiatry. PMID: 33066961 (PDF)
2019
Li X, Davis IR, Lofaro OM, Zhang J, Cimbro R and Rubio FJ (2019) Distinct gene alterations between Fos‐expressing striatal and thalamic neurons after withdrawal from methamphetamine self‐administration. Brain and Behavior. PMID: 31364821 (PDF)
Rubio FJ, Quintana-Feliciano R, Warren BL, Li X, Witonsky KFR, Valle FSD, Selvam PV, Caprioli D, Vernniro M, Bossert JM, Shaham, Hope BT (2019) Prelimbic cortex is a common brain area activated during cue-induced reinstatement of cocaine and heroin seeking in polydrug self-administration rat model. European Journal of Neuroscience.PMID: 30307667 (PDF)
2018
Fredriksson I and Li X (2018) Rate matters: rapid cocaine delivery potentiates incubation of cocaine craving. Neuropsychopharmacology.
PMID: 30504798 (PDF)
Cates HM*, Li X*, Purushothaman I, Kennedy PJ, Shen L, Shaham Y, Nestler EJ (2018) Genome-wide transcriptional profiling of central amygadala and obitofrontal cortex during incubation of methamphetamine craving. Neuropsychopharmacology. (PDF) *Equal contribution
Li X, Witonsky K, Surjono F, Lofaro OM, Zhang J, Bossert JM, Shaham Y (2018) Role of anterior intralaminar nuclei of thalamus projections to dorsomedial striatum in incubation of methamphetamine craving. Journal of Neuroscience. PMID: 29371321 (PDF)
Li X, Carreria MB, Witonsky KF, Zeric T, Lofaro OM, Bossert JM, Zhang J, Surjono F, Richie CT, Harvey BK, Son H, Cowan CW, Nestler EJ, Shaham Y (2018) Role of dorsal striatal histone deacetylase 5 in incubation of methamphetamine craving. Biological Psychiatry 84: 213-222. PMID:29397902 (PDF)
2017
Zhang W, Daly KM, Liang B, Zhang LF, Li X, Li Y, Lin DT (2017) BDNF rescues prefrontal dysfunction elicited by pyramidal neuron-specific DTNBP1 deletion in vivo. Journal of Molecular Cell Biology 9: 117-131. PMID: 27330059 (PDF).
2016
Rubio FJ*, Li X*, Liu QR, Cimbro R, Hope BT (2016) Fluorescence activated cell sorting (FACS) and gene expression analysis of Fos-expressing neurons from fresh and frozen rat brain tissue. Journal of Visual Experiments doi:10.3791/54358. PMID: 27685012 (PDF). *Equal contribution
Li X, Venniro M, Shaham Y (2016) Translational research on incubation of cocaine craving. JAMA Psychiatry 73:1115-1116. PMID: 27604057 (PDF).
2015
Li X, Wolf ME (2015) Multiple faces of BDNF in cocaine addiction. Behavioral Brain Research 279C: 240-254. PMID: 25449839 (PDF).
Li X, Zeric T, Kambhampati S, Bossert JM, Shaham Y (2015) The central amygdala nucleus is critical for incubation of methamphetamine craving. Neuropsychopharmacology 40:1297-1306. PMID: 25475163 (PDF).
Li X, Rubio FJ, Zeric T, Bossert JM, Cates H, Kennedy P, Liu QR, Cimbro R, Nestler EJ, Hope BT, Shaham Y (2015) Incubation of methamphetamine craving is associated with selective increases in expression of BDNF and TrkB, glutamate receptors, and epigenetic enzymes in cue-activated Fos-expressing dorsal striatal neurons. Journal of Neuroscience 35, 8232-8244. PMID: 26019338 (PDF).
Caprioli D, Venniro M, Zeric T, Li X, Adhikary S, Madangopal R, Marchant NJ, Lucantonia F, Schoembaum G, Bossert JM, Shaham Y (2015) Effect of the novel positive allosteric modulator of mGluR2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence in a rat model. Biological Psychiatry 78:463-473. PMID: 25861699 (PDF).
Rubio FJ, Liu QR, Li X, Cruz F, Leao RM, Warren B, Kambhampati S, Babin K, McPherson K, Cimbro R, Bossert J, Shaham Y, Hope B (2015) Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons. Journal of Neuroscience 35:5625-5639. PMID: 25855177 (PDF).
2014
Loweth JA, Scheyer AF, Milovanovic M, Lacrosse AL, Flores-Barrera E, Werner CT, Li X, Ford KA, Le T, Olive MF, Szumlinski KK, Tseng KY, Wolf ME (2014) Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving. Nature Neuroscience 17, 73-80. PMID: 24270186 (PDF).
Li X, Caprioli D, Marchant NJ (2014) Recent updates on incubation of drug craving: a mini-review. Addiction Biology 20: 872-876. PMID: 25440081 (PDF).
Li X, Marchant NJ, Shaham, Y (2014) Opposing roles of cotransmission of dynorphin and hypocretin on reward and motivation. Proceedings of National Academy of Sciences of the United States of America 111: 5765-5766. PMID: 24706899 (PDF).
2013
Li X, DeJoseph MR, Urban JH, Bahi A, Dreyer JL, Meredith GE, Ford, KA, Loweth JA, Ferrario CR, Wolf ME (2013) Different roles of BDNF in nucleus accumbens core versus shell during the incubation of cue-induced cocaine craving and its long-term maintenance. Journal of Neuroscience 33, 1130-1142. PMID: 23325250 (PDF).
Theberge FR, Li X, Kambhampati S, Pickens CL, St Laurent R, Bossert JM, Baumann MH, Hutchinson MR, Rice KC, Watkins LR, Shaham Y (2013) Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biological Psychiatry 73, 729-737. PMID: 23384483 (PDF).
Marchant NJ, Li X, Shaham Y (2013) Recent developments in animal models of drug relapse. Current Opinion in Neurobiology 23, 675-683. PMID: 23374536 (PDF).
Plaza-Zabala A, Li X, Milovanovic M, Loweth JA, Maldonado R, Berrendero F, Wolf ME (2013) An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions after cocaine exposure. Neuroscience letters 557 Pt B, 101-106. PMID: 24262606 (PDF).
2011
Li X, Wolf ME (2011) Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens. European Journal of Neuroscience 34, 190-198. PMID: 21692887 (PDF).
Li X, Wolf ME (2011) Visualization of virus-infected brain regions using a GFP-illuminating flashlight enables accurate and rapid dissection for biochemical analysis. Journal of Neuroscience Methods 201, 177-179. PMID: 21816173 (PDF).
Ferrario CR, Li X, Wolf ME (2011) Effects of acute cocaine or dopamine receptor agonists on AMPA receptor distribution in the nucleus accumbens. Synapse 65, 54-63. PMID: 20506566 (PDF).
Hanson LR, Hafez D, Svitak AL, Burns RB, Li X, Frey WH 2nd, Marr RA (2011) Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice. Journal of Molecular Neuroscience 43,424-427. PMID: 20941644 (PDF).
2009
Ferrario CR, Li X, Wang X, Reimers JM, Uejima JL, Wolf ME (2009) The role of glutamate receptor redistribution in locomotor sensitization to cocaine. Neuropsychopharmacology 35, 818-833. PMID: 19924109 (PDF).