Dysanapsis Genetic Risk Predicts Lung Function Across the Lifespan
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Debban CL, Ambalavanan A, Ghosh A, Li Z, Buschur KL, Ma Y, George E, Pistenmaa C, Bertoni AG, Oelsner EC, Michos ED, Moraes TJ, Jacobs DR Jr, Christenson S, Bhatt SP, Kaner RJ, Simons E, Turvey SE, Vameghestahbanati M, Engert JC, Kirby M, Bourbeau J, Tan WC, Gabriel SB, Gupta N, Woodruff PG, Subbarao P, Ortega VE, Bleecker ER, Meyers DA, Rich SS, Hoffman EA, Barr RG, Cho MH, Bossé Y, Duan Q, Manichaikul A, Smith BM.. Am J Respir Crit Care Med. 2024 Dec 15;210(12):1421-1431. [https://pubmed.ncbi.nlm.nih.gov/38935874/]
Transcriptome-Wide Association Study of Idiopathic Pulmonary Fibrosis Survival Identifies PTPN9 and SNRPB2
Hu X, Kim JS, Saferali A, Huang Y, Ma SF, Bingham GC, Bonham CA, Flores C, Castaldi P, Hersh CP, Cho MH, IPF Survival GWAS Consortium, Noth I, Manichaikul A. Am J Respir Crit Care Med. 2024 Sep 1;210(5):683-686. [https://pubmed.ncbi.nlm.nih.gov/38626378/]
Genome-Wide Association Studies and fine-mapping identify genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts.
Yang C, Veenstra J, Bartz T, Pahl M, Hallmark B, Chen YI, Westra J, Steffen L, Brown C, Siscovick D, Tsai M, Wood A, Rich S, Smith C, O'Connor T, Mozaffarian D, Grant S, Chilton F, Tintle N, Lemaitre R, Manichaikul A. Commun Biol. 2023 Aug 16;6(1):852. [https://pubmed.ncbi.nlm.nih.gov/37587153/]
Other recent publications:
Hu X, Qiao D, Kim W, Moll M, Balte PP, Lange LA, ...[41 authors]..., Wheeler HE, TOPMed Lung Working Group, Cho MH, Im HK, Manichaikul A. Polygenic transcriptome risk scores improve cross-ethnic portability for COPD and lung function in the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. Am J Hum Genet. 2022 May 5;109(5):857-870. dor: 10.1016/j.ajhg.2022.03.007
Yang C, Hallmark B, Chai JC, O’Connor TD, Reynolds LM, Wood AC, Seeds M, Chen YI, Steffen LM, Tsai MY, Kaplan RC, Daviglus ML, Mandarino LJ, Fretts AM, Lemaitre RN, Coletta DK, Blomquist SA, Johnstone LM, Tontsch C, Qi Q, Ruczinski I, Rich SS, Mathias RA, Chilton FH, Manichaikul A. Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations. Commun Biol. 2021 Jul 28;4(1):918. doi: 10.1038/s42003-021-02431-4.
Taliun D, Harris DN, Kessler MD, Carlson J, Szpiech ZA, Torres R, Taliun SAG, Corvelo A, Gogarten SM, Kang HM, Pitsillides AN, LeFaive J, Lee SB, Tian X, Browning BL, Das S, Emde AK, Clarke WE, Loesch DP, Shetty AC, Blackwell TW, Smith AV, Wong Q, Liu X, Conomos MP, Bobo DM, …, Manichaikul A, …, Arnett DK, Ashley-Koch AE, Barnes KC, Boerwinkle E, Gabriel S, Gibbs R, Rice KM, Rich SS, Silverman EK, Qasba P, Gan W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Papanicolaou GJ, Nickerson DA, Browning SR, Zody MC, Zöllner S, Wilson JG, Cupples LA, Laurie CC, Jaquish CE, Hernandez RD, O’Connor TD, Abecasis GR. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021 Feb;590(7845):290-299. doi: 10.1038/s41586-021-03205-y.
Zhao X, Qiao D, Yang C, Kasela S, Kim W, Ma Y, Shrine N, Batini C, Sofer T, Taliun SAG, Sakornsakolpat P, Balte PP, Prokopenko D, Yu B, Lange LA, Dupuis J, Cade BE, Lee J, Gharib SA, Daya M, Laurie CA, Ruczinski I, Cupples LA, Loehr LR, Bartz TM, Morrison AC, Psaty BM, Vasan RS, Wilson JG, Taylor KD, Durda P, Johnson WC, Cornell E, Guo X, Liu Y, Tracy RP, Ardlie KG, Aguet F, VanDenBerg DJ, Papanicolaou GJ, Rotter JI, Barnes KC, Jain D, Nickerson DA, Muzny DM, Metcalf GA, Doddapaneni H, Dugan-Perez S, Gupta N, Gabriel S, Rich SS, O’Connor GT, Redline S, Reed RM, Laurie CC, Daviglus ML, Preudhomme LK, Burkart KM, Kaplan RC, Wain LV, Tobin MD, London SJ, Lappalainen T, Oelsner EC, Abecasis GR, Silverman EK, Barr RG; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Lung Working Group, Cho MH, Manichaikul A. Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants. Nat Commun. 2020 Oct 14;11(1):5182. doi: 10.1038/s41467-020-18334-7.
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