We are a computational research group in the Department of Genome Sciences at the University of Virginia. Our group conducts statistical genetics and multi-omics research to investigate the molecular bases of complex human diseases, focusing primarily on adult pulmonary and cardiovascular diseases. 

We are actively involved in genome-wide association analysis of pulmonary and cardiovascular phenotypes performed through the Multi-Ethnic Study of Atherosclerosis (MESA). We work on integrative 'omics combining genomic, transcriptomic, proteomic, metabolomic and other high-dimensional data sets from the NHLBI Trans-omics for Precision Medicine (TOPMed) project, the Genotype-Tissue Expression (GTEx) project, and others to identify causal genes and pathways influencing diseases of interest. We are also performing other types of post-GWAS research, including gene-environment interaction studies, fine mapping studies, and candidate gene investigations with collaborators who are experts in animal models and in vitro studies of more focused genetic pathways.