Overview
Overview
Angli Xue is a Postdoc Scientist at the Computational Genomics Laboratory, Garvan-Weizmann Centre for Cellular Genomics (GWCCG), at the Garvan Institute of Medical Research. His current research project is involved in identifying genetic control of gene expression at the single-cell level. He obtained his PhD degree in 2021 at Institute for Molecular Bioscience (IMB), The University of Queensland (UQ). He received his bachelor's in 2015 from Zhejiang University (ZJU), China, which was followed by a one-year research assistant at the Institute of Bioinformatics, ZJU.
Please find his CV here.
Research focuses
Genetic architecture of complex traits and diseases (e.g. type 2 diabetes, skin cancer, substance use, Parkinson's disease)
Integrative analyses of multi-omics data (e.g. SNP, gene expression, DNA methylation, and histone modification)
Genetic correlation among substance and behavioural addiction (e.g. smoking, alcohol consumption, and cannabis use)
Method development of Mendelian Randomization for causal inference
Causal association between addictive behaviours/physical activities and common diseases
Qualifications
Ph.D. in Statistical Genetics, The University of Queensland, 2016 - 2021
Bachelor in Agronomy, Zhejiang University, 2011 - 2015
Selected Publications
Angli Xue, Longda Jiang, Zhihong Zhu, Naomi R. Wray, Peter M. Visscher, Jian Zeng, Jian Yang. Genome-wide analyses of behavioural traits biased by misreports and longitudinal changes. Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes. Nature Communications. 12, 6450. 2021. (Highlighted by Nature Asia)
Angli Xue, Yang Wu, Zhihong Zhu, Futao Zhang, Kathryn E Kemper, Zhili Zheng, Loic Yengo, Luke R. Lloyd-Jones, Julia Sidorenko, Yeda Wu, eQTLGen Consortium, Allan F McRae, Peter M Visscher, Jian Zeng*, Jian Yang*. Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nature Communications. 2018. 9 (1), 1-14.
Christelle Adolphe, Angli Xue (Co-first author), Atefeh Taherian Fard, Laura A. Genovesi, Jian Yang, Brandon Wainwright. Genetic and functional interaction network analysis reveal global enrichment of regulatory T Cell genes influence basal cell carcinoma susceptibility. Genome Medicine. 13.1 (2021): 1-12. [GWAS catalog]
Tumor mutational burden is polygenic and genetically associated with complex traits and diseases
Xiwei Sun, Angli Xue, Ting Qi, Dan Chen, Dandan Shi, Yang Wu, Zhili Zheng, Jian Zeng and Jian Yang. Tumor mutational burden is polygenic and genetically associated with complex traits and diseases. Cancer Research. 81.5 (2021): 1230-1239. (Featured as the cover story)
Jian Zeng, Angli Xue, Longda Jiang, Luke R Lloyd-Jones, Yang Wu, Huanwei Wang, Zhili Zheng, Loic Yengo, Kathryn E Kemper, Naomi R Wray, Peter M Visscher, Jian Yang. Widespread signatures of natural selection across human complex traits and functional genomic categories. 12.1 (2021): 1-12.