2018, a new outbreak occurred in North Kivu province, DRC, on the other side of the country 2 from the April outbreak. With a case fatality rate of around 55%, 9 and treatments or vaccines licensed only in China and Russia (several candidates are now being considered by EMA and FDA), Ebola remains a biomedical research priority. 10 There is much that remains unknown about Ebola. Even after nearly 30 outbreaks, scientists still do not know what explains the pathogenicity of the virus or the exact route of zoonotic transmission, even for the 2013-15 outbreak. 11 Fruit bats appear to be the “most likely source of animal-to-human transmission”,9 although their exact role in the transmission cycle is still unclear. Ebola vaccines are licensed only in China and Russia based on limited clinical data, although licensure dossiers are pending before FDA and EMA and those experimental vaccines were authorized for emergency use for 2017 and 2018 outbreaks in the DRC. 12 Given the major knowledge gaps associated with Ebola, global collaboration and data sharing continue to be vital to understanding and controlling this recurrent infectious disease. b. Data-sharing during the Ebola outbreak: The failure to provide or share timely relevant data has been cited as one of the key impediments to mounting an effective response to the Ebola outbreak. 12,13 Although the outbreak was eventually contained, data sharing and communication breakdowns contributed to a significant delay in acknowledgment about the outbreak’s severity and corresponding response.7 Data sharing barriers were particularly high between medical and scientific researchers and between researchers and responders. Data sharing is important during public health emergencies “to help identify the causative agents; investigate and predict disease spread; define diagnostic criteria; and evaluate treatments and methods to contain further spread.”14 Experiences with influenza, MERS-CoV, and Zika as well as Ebola have all demonstrated that limitations on data sharing and data accessibility remain significant barriers to global epidemic preparedness and response.15 When NGOs, particularly Médecins Sans Frontières (MSF) on the ground in Guinea, called the Ebola outbreak “unprecedented”, the global health community and the World Health Organization doubted the claim in some measure because of incongruous methods of data collection and forms of data sharing. Because WHO maintained significant activities in Guinea, Liberia, and Sierra Leone and cases reported in Guinea and Liberia between April and May technically declined,16 WHO believed that “that the virus dynamics were not unlike those of past outbreaks, nor was the outbreak unprecedented.”7 But the perceived decline in cases was itself a result of inadequate data sharing between health ministries, health workers on the ground, and WHO. In addition to problems sharing data on the disease as cases exploded, especially in Sierra Leone, hospitals and health ministries refused to share lists for purposes of contact tracing and containment.7 The three most affected countries did not share data with each other, but relied upon WHO to act as liaison. In their statement following a meeting on data sharing during public health emergencies, focusing on Ebola, WHO noted several issues with data sharing during the outbreak: perception that pre-publication disclosure of key results may prejudice journal publication; inconsistent public disclosure of genome sequence data related to emerging pathogens; 3 delays introduced by data use agreements for evaluation of interventions before or during public health emergencies; delays introduced by clinical trial agreements for evaluation of interventions before or during public health emergencies; non-disclosure of epidemiologic data related to potential public health emergencies; non-disclosure of clinical trial data related to research and development in the context of public health emergencies; capacity development in resource-poor settings to support research and product development for emerging pathogens; ethical considerations focusing on research and product development prior to and during public health emergencies; and lack of awareness about pre-publication data and results sharing mechanisms.17 The perceived inadequacies of data sharing by biomedical firms and the countries in which they were located raised continuing issues of equity and commitment to response. 18 As a viral hemorrhagic pathogen first discovered in 1976, and with a history of relatively efficacious containment, but typically afflicting countries without developed healthcare infrastructure, the outbreak of Ebola is an important case study for data sharing practices during public health emergencies in low resource settings. The research response in the early days of the outbreak involved the identification of the pathogen (it was thought in early 2014 to possibly be influenza, Lassa fever, malaria, or typhoid among others), whether it was spreading through a vector or through human-to-human transmission, epidemiological investigations and the development of rapid diagnostics. Before the Ebola outbreak, there was little demographic information about the region so even data about populated villages and their location had to be collected and shared.