dangerous for certain groups of people, like very sick people or infants. It is important to follow instructions to prevent the VSV virus from being passed to others. And since you will not know whether or not you have received this vaccine, everyone needs to do the following: You must try not to expose other people to your blood and body fluids for 6 weeks after each vaccination. To do this, you and your partner should use condoms during any form of sex and you should avoid sharing needles, razors, forks, spoons, cups, toothbrushes, etc, with anyone. You must also avoid open-mouth kissing. If you should develop mouth sores, we may ask you to follow the above directions for a longer time until the sores go away. You should not donate blood for one year after getting the study injections. You should also follow routine precautions to protect yourself from other diseases such as typhoid and malaria. For example, wash commonly consumed leaves with chlorine, drink clean water, and protect yourself from mosquito bites. WHAT DO I NEED TO KNOW ABOUT PREGNANCY AND/OR BREASTFEEDING DURING THE STUDY? Women: You cannot be in this study if you are pregnant or breastfeeding. We do not know the effects of the study vaccine in pregnancy or in a nursing baby. If you get pregnant around the time you get the study vaccine, we don’t know if there may be effects on you or your baby. Therefore, you must avoid getting pregnant for 3 months after receiving the study vaccine. You will have a pregnancy test done before participating in the study and before each injection. You will need to use birth control, unless you are not able to get pregnant. If you think that you have gotten pregnant during the study, tell the study team right away, and seek medical care for your pregnancy. If you get pregnant during the first 90 days of the study, we will follow you until delivery. Men: The effect of the vaccine on sperm is not known. Therefore, you should not get a sexual partner pregnant after you get the vaccination. You need to use a latex condom every time you have sex for 3 months after receiving each study vaccine. HOW WILL MY BLOOD BE TESTED? Blood will be taken by inserting a new, clean needle into a vein in your arm. You may feel a pinch when the needle goes through your skin. This doesn’t last long and we PREVAC Version 4 Page 6 of 9 will put a bandage on your skin once the needle is taken out. A bruise may appear where the needle was put in. This is common and should go away in a couple of days. Your blood will be tested to know if the vaccines will work to prevent Ebola. We will also test your blood for syphilis and for infection with HIV, which is the virus that causes AIDS. If you have HIV infection or syphilis, you are at least 18 years old, and the investigator determines you are in good health, you can still be in this study. We will tell you what the test results mean for you and how to find care. WHAT WILL HAPPEN TO MY BLOOD? After we do our research tests on your blood samples, we will keep your leftover samples for future research that may help us learn more about developing vaccines against Ebola. You will not get any information from this. If you change your mind and decide you do not want us to store your blood samples anymore, please let us know. We will do our best to follow your wishes but cannot promise that we will always be able to destroy all your samples. For example, if your sample was already used, we would not be able to destroy it. Your blood samples will be labeled with a code and not with your name. Your coded samples might be sent to other scientists, including scientists outside of your home country, for research. Other information, such as your sex, age, or health history might also be shared, but your name will not. Your blood samples will not be sold. You will not be paid for any products that result from this research. The only risk of allowing us to store your samples would be an accidental release of your identity. WHAT DO I NEED TO DO FOR FOLLOW-UP ON THIS STUDY? If you feel sick at any time during the study, it is important that you quickly call the study contact number on your ID card. We may ask you to return to the clinic for a medical exam. We do not know yet if the Ebola vaccines work to protect people against Ebola. If you get one of these vaccines, you may be protected from Ebola, but you may not. If you get the placebo, you will not be protected from Ebola. You must continue to protect yourself from contact with Ebola. We will give you information on how to prevent Ebola. If you experience anything that seems like symptoms of Ebola, such as fever, diarrhea, vomiting, or unexplained bleeding, it is very important that you get medical care as soon as possible, and let the study team know you are sick. If we find out anything new during this study that may be related to your health or to your decision to continue in the study, we will discuss this new information with you. WHAT ARE THE BENEFITS OF BEING IN THIS STUDY? Based on results from previous studies, it was found that those who received one of the experimental vaccines produced antibodies that may potentially protect against PREVAC Version 4 Page 7 of 9 Ebola. We do not know how long those antibodies will last in your body which is one of the reasons we are doing this study. However, if you are in the placebo