PAGE 6

Page 6

Consider potential adverse effects: respiratory depression, GI stasis, excitement (typically only at higher doses) and/or sedation. Drug Dose ( mg/kg) Route Interval (hours) Effect Notes Buprenorphine 0.05 - 0.1 0.1 - 0.25 *Buprenorphine SR (sustained release) is available for use at 0.5- 1.0 mg/kg. SC, IV PO SC 6-8 6 –8 48-72 postoperative pain relief maximum analgesic effect reached 30 min post injection; however, if using injectable anesthesia, it is recommended not to use buprenorphine until the mouse has recovered to the sternal position* Buprenorphine Extended Release (ER/XR) 3.25 mg/kg SC 48-72 Postoperative pain relief Animalgesiclabs.com Butorphanol 1.0 - 2.0 SC, IM 4 mild to moderate pain best used only preoperative or intraoperative due to short duration Morphine 2.0 – 5.0 SC hourly very effective analgesic 10 SC 2-4 NSAIDS - adverse effects may include blood dyscrasias, interference with platelet function and the targeting of GI, hepatic and renal tissues during prolonged administration. These effects are rarely of significance when treating for 2-3 days. Contraindicated in pregnant animals. Drug Dose ( mg/kg) Route Effect Notes Acetaminophen 200 PO mild pain, little antiinflammatoryaction Carprofen 5.0 5.0 SC PO 12 - 24 12 - 24 post-operativepain commonly used, wide safety margin; works well when combined with an opiate Ketoprofen 5.0 SC moderate pain commonly used Meloxicam 5.0 SC, PO 12 - 24 post-operative pain Ibuprofen 15 - 30 PO 24 Naproxen 57 - 350 PO 24 Updated July, 2014, September 2016. Local anesthetics - stop nerve transmission by blocking sodium channels; can reduce need for systemic postoperative analgesics and allow reduced dose of intraoperative anesthesia; epinephrine (vasoconstrictor) can be added (except in extremities) to reduce risk of systemic absorption Drug Dose ( mg/kg) Route Interval Effect Note Lidocaine max dose: 4.0 duration of effect: 60 - 90 min if epinephrine included at a 1:200,000 concentration, duration will be increased by 50% Bupivacaine max dose: 1.0 - 2.0 (less than 100ul of 0.25% solution) References: Handbook of laboratory animal science. Hau, Jann; Schapiro, Steven Jay. 3rd ed.

1 2 3 4 5 6