47. Regulatory mechanisms driven by functional 3'-UTR variants in alcohol use disorder and related traits

Chen AB, Yu X, Rupp JM, Chu X, Thapa KS, Gao H, Reiter JL, Xuei X, Tsai AP, Landreth GE, Wang Y, Foroud TM, Tischfield JA, Lai D, Zhang P, Edenberg HJ, Liu Y.

Genome Biol. 2026 Jun 29. doi: 10.1186/s13059-026-04176-x. 

46. Magnesium as a bioenergetic checkpoint linking mitochondrial function, metabolic disease, and aging

Huang CW, Wen CY, Tsai AP, Wang B, Tsui KH, Hsu YJ, Li CJ.

Aging Cell. 2026 Jun;25(6):e70578. doi: 10.1111/acel.70578.

45. Cross-species transcriptomic integration reveals a MIRO1-mediated macrophage–T cell axis in glioma

Du Z, Li M, Bergsneider BH, Tsai AP, Cho KB, Kim LH, Choi J, Li G, Wyss-Coray T, Lim M, Wang X

Life Sci Alliance. 2026 May 13; 9(8):e202603749. doi: 10.26508/lsa.202603749.

44. Mitochondrial quality control as a central pharmacological target in aging

Tsui KH, Cheng SH, Wang B, Lin PH, Raj EN, Lin LT, Chang R, Wen ZH, Tsai AP, Li CJ

Pharmacol Res. 2026 Apr 7:108188. doi: 10.1016/j.phrs.2026.108188.

43. Toward actionable interventions in human aging

Aging (Albany NY). 2026 Apr 6;18(1):282-302. doi: 10.18632/aging.206368.

42. Mitoxyperilysis: Rethinking oxidative stress as a spatially constrained lethal signal.

Wen CY, Wu MY, Tsai AP, Yong SB, Li CJ.

Int J Biol Sci. 2026 Mar 30;22(8):4139-4143. doi: 10.7150/ijbs.130535.

41. PLCG2 signaling and genetic resilience in Alzheimer's disease

Tsai AP, Martin AK, Mi A, Yeh AE, Ramirez Lopez E, Wyss-Coray T.

Mol Neurodegener. 2026 Mar 26;21(1):20. doi: 10.1186/s13024-026-00935-3.

40. Simultaneous spatial transcriptomics and morphology profiling as tools to explore how microglia change with age

Henze DE, Tsai AP, Wyss-Coray T, Quake SR.

Nature Aging. 2026 Mar 10. doi: 10.1038/s43587-026-01089-z.

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39. Spatially gated oxidative killing: mitoxyperilysis redefines how ROS cause lytic cell death

Wu MY, Tsai AP, Yong SB, Li CJ.

Apoptosis. 2026 Feb 20 (Letter to Editor)

38. Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition

Navarro Negredo P, You J, Hauptschein M, Schroer AB, Richard DJ, Abhiraman GC, Tsai AP, Sun ED, Notarangelo G, Ramirez-Matias J, Zhou OY, Buckley MT, Malacon KE, Xu L, Sucharov J, Ramirez Lopez E, Picton L, Wyss-Coray T, Saxton RA, Fernandes RA, Villeda SA, Garcia KC, Brunet A.

Immunity. 2026 Jan 30:S1074-7613(26)00038-5. doi: 10.1016/j.immuni.2026.01.016. 

PMID: 41619730

37. Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging.

Tsai AP, Henze DE, Ramirez Lopez E, Haberberger J, Dong C, Lu N, Atkins M, Costa EK, Farinas A, Oh HS, Moran-Losada P, Le Guen Y, Isakova A, Quake SR, Wyss-Coray T.

Cell Rep. 2025 Dec 23;44(12):116624. doi: 10.1016/j.celrep.2025.116624. Epub 2025 Nov 26.

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36. Disruption of the cerebrospinal fluid-plasma protein balance in cognitive impairment and aging.

Farinas A, Rutledge J, Bot VA, Western D, Ying K, Lawrence KA, Oh HS, Yoon S, Ding DY, Tsai AP, Moran-Losada P, Timsina J, Le Guen Y; Global Neurodegeneration Proteomics Consortium (GNPC); Montgomery SB, Baker D, Poston KL, Wagner AD, Mormino E, Cruchaga C, Wyss-Coray T.

Nat Med. 2025 Aug;31(8):2578 - 2589. doi: 10.1038/s41591-025-03831-3. Epub 2025 Jul 15.

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Alzforum: Big Data Insights: Blood Signatures of Cognitive Decline, Aging, APOE4

Large-scale proteomics project seeks cures for neurodegenerative diseases

Global Neurodegeneration Proteomics Consortium

35. PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology.

Messenger EJ, Baar SA, Bedford LM, Tsai AP, Lin PB, Ferguson CA, Xu G, Wallace A, Landreth GE, Lamb BT, Bissel SJ.

Alzheimers Dement. 2025 May;21(5):e70231. doi: 10.1002/alz.70231.

PMID: 40346446

34. Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice.

Keck CHC, Schmidt EL, Roth RH, Floyd BM, Tsai AP, Garcia HB, Cui M, Chen X, Wang C, Park A, Zhao S, Liao PA, Casey KM, Reineking W, Cai S, Zhang LY, Yang Q, Yuan L, Baghdasaryan A, Lopez ER, Cooper L, Cui H, Esquivel D, Brinson K, Chen X, Wyss-Coray T, Coleman TP, Brongersma ML, Bertozzi CR, Wang GX, Ding JB, Hong G.

Proc Natl Acad Sci U S A. 2025 Sep 2;122(35):e2504264122. doi: 10.1073/pnas.2504264122. Epub 2025 Aug 26.

PMID: 40857313

33. A high-throughput assay platform to discover small molecule activators of the phospholipase PLC-γ2 to treat Alzheimer's disease.

Carr AJ, Hajicek N, Tsai AP, Acharya PP, Hardy PB, Meyer E, Wyss-Coray T, Pearce KH, Sondek J, Zhang Q.

J Biol Chem. 2025 Apr;301(4):108356. doi: 10.1016/j.jbc.2025.108356. Epub 2025 Feb 25.

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32. Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.

Kloske CM, Mahinrad S, Barnum CJ, Batista AF, Bradshaw EM, Butts B, Carrillo MC, Chakrabarty P, Chen X, Craft S, Da Mesquita S, Dabin LC, Devanand D, Duran-Laforet V, Elyaman W, Evans EE, Fitzgerald-Bocarsly P, Foley KE, Harms AS, Heneka MT, Hong S, Huang YA, Jackvony S, Lai L, Guen YL, Lemere CA, Liddelow SA, Martin-Peña A, Orr AG, Quintana FJ, Ramey GD, Rexach JE, Rizzo SJS, Sexton C, Tang AS, Torrellas JG, Tsai AP, van Olst L, Walker KA, Wharton W, Tansey MG, Wilcock DM.

Alzheimers Dement. 2025 Jan;21(1):e14291. doi: 10.1002/alz.14291. Epub 2024 Dec 18.

PMID: 39692624

31. Mitigating mitochondrial dysfunction and neuroinflammation by hematoma aspiration in a new surgical model for severe intracerebral hemorrhage.

Hu WF, Lee CH, Pang CY, Huang HY, Tsai ST, Wang PK, Shih MT, Cheah PY, Wu YF, Tsai AP, Tseng KY, Airavaara M, Liew HK.

Exp Neurol. 2025 Mar;385:115098. doi: 10.1016/j.expneurol.2024.115098. Epub 2024 Dec 7.

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30. CYP1B1-RMDN2 Alzheimer's disease endophenotype locus identified for cerebral tau PET.

Nho K, Risacher SL, Apostolova LG, Bice PJ, Brosch JR, Deardorff R, Faber K, Farlow MR, Foroud T, Gao S, Rosewood T, Kim JP, Nudelman K, Yu M, Aisen P, Sperling R, Hooli B, Shcherbinin S, Svaldi D, Jack CR Jr, Jagust WJ, Landau S, Vasanthakumar A, Waring JF, Doré V, Laws SM, Masters CL, Porter T, Rowe CC, Villemagne VL, Dumitrescu L, Hohman TJ, Libby JB, Mormino E, Buckley RF, Johnson K, Yang HS, Petersen RC, Ramanan VK, Ertekin-Taner N, Vemuri P, Cohen AD, Fan KH, Kamboh MI, Lopez OL, Bennett DA, Ali M, Benzinger T, Cruchaga C, Hobbs D, De Jager PL, Fujita M, Jadhav V, Lamb BT, Tsai AP, Castanho I, Mill J, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Department of Defense Alzheimer’s Disease Neuroimaging Initiative (DoD-ADNI); Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN); Australian Imaging, Biomarker & Lifestyle Study (AIBL); Saykin AJ.

Nat Commun. 2024 Sep 20;15(1):8251. doi: 10.1038/s41467-024-52298-2.

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29. APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.

Haney MS, Pálovics R, Munson CN, Long C, Johansson PK, Yip O, Dong W, Rawat E, West E, Schlachetzki JCM, Tsai AP, Guldner IH, Lamichhane BS, Smith A, Schaum N, Calcuttawala K, Shin A, Wang YH, Wang C, Koutsodendris N, Serrano GE, Beach TG, Reiman EM, Glass CK, Abu-Remaileh M, Enejder A, Huang Y, Wyss-Coray T.

Nature. 2024 Apr;628(8006):154-161. doi: 10.1038/s41586-024-07185-7. Epub 2024 Mar 13.

PMID: 38480892

Alzforum: Lipid-Laden, Sluggish Microglia? Blame Aβ.

Stanford News: Rethinking Alzheimer's: How these tiny balls of fat factor in

Alzheimers.gov: Could brain fat droplets play a role in Alzheimer’s?

28. Deep learning-driven adaptive optics for single-molecule localization microscopy.

Zhang P, Ma D, Cheng X, Tsai AP, Tang Y, Gao HC, Fang L, Bi C, Landreth GE, Chubykin AA, Huang F.

Nat Methods. 2023 Nov;20(11):1748-1758. doi: 10.1038/s41592-023-02029-0. Epub 2023 Sep 28.

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27. Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.

Tsai AP, Dong C, Lin PB, Oblak AL, Viana Di Prisco G, Wang N, Hajicek N, Carr AJ, Lendy EK, Hahn O, Atkins M, Foltz AG, Patel J, Xu G, Moutinho M, Sondek J, Zhang Q, Mesecar AD, Liu Y, Atwood BK, Wyss-Coray T, Nho K, Bissel SJ, Lamb BT, Landreth GE.

Immunity. 2023 Sep 12;56(9):2121-2136.e6. doi: 10.1016/j.immuni.2023.08.008. Epub 2023 Sep 1.

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Preview: Plaque attack by microglial PLCγ2. Comer AL, Hammond TR. Immunity. PMID: 37703828

Alzforum: PLCγ2 Variants Toggle Microglial Plaque Compactors

Medicine Innovates: The complex role of PLCG2 variants in Alzheimer's Disease Pathogenesis

Indiana News: IU researchers identify new gene mutation that alters Alzheimer’s disease risk

Alzforum: Resilience Redefined: Sharp at Age 100, Still Sharp at 102

Alzforum: The Mutation You Want: It Protects the Brain, Extends Life

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26. Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis.

Pereira M, Ribeiro DR, Berg M, Tsai AP, Dong C, Nho K, Kaiser S, Moutinho M, Soares AR.

Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166857. doi: 10.1016/j.bbadis.2023.166857. Epub 2023 Aug 26.

PMID: 37640114

25. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation.

Moutinho M, Coronel I, Tsai AP, Di Prisco GV, Pennington T, Atwood BK, Puntambekar SS, Smith DC, Martinez P, Han S, Lee Y, Lasagna-Reeves CA, Lamb BT, Bissel SJ, Nho K, Landreth GE.

Genome Med. 2023 Feb 20;15(1):11. doi: 10.1186/s13073-023-01160-z.

PMID: 36805764

24. INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease.

Lin PB, Tsai AP, Soni D, Lee-Gosselin A, Moutinho M, Puntambekar SS, Landreth GE, Lamb BT, Oblak AL.

Alzheimers Dement. 2023 Jun;19(6):2528 - 2537. doi: 10.1002/alz.12849. Epub 2022 Dec 16.

PMID: 36524682

23. Integrating multimodality magnetic resonance imaging to the Allen Mouse Brain Common Coordinate Framework.

Wang N, Maharjan S, Tsai AP, Lin PB, Qi Y, Wallace A, Jewett M, Liu F, Landreth GE, Oblak AL.

NMR Biomed. 2023 May;36(5):e4887. doi: 10.1002/nbm.4887. Epub 2022 Dec 22.

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22. Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging.

Maharjan S, Tsai AP, Lin PB, Ingraham C, Jewett MR, Landreth GE, Oblak AL, Wang N.

Front Neurosci. 2022 Aug 17;16:964654. doi: 10.3389/fnins.2022.964654. eCollection 2022.

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21. Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer's Disease-Relevant Phenotypes in Mice.

Oblak AL, Kotredes KP, Pandey RS, Reagan AM, Ingraham C, Perkins B, Lloyd C, Baker D, Lin PB, Soni DM, Tsai AP, Persohn SA, Bedwell AA, Eldridge K, Speedy R, Meyer JA, Peters JS, Figueiredo LL, Sasner M, Territo PR, Sukoff Rizzo SJ, Carter GW, Lamb BT, Howell GR.

Front Aging Neurosci. 2022 Jun 24;14:886575. doi: 10.3389/fnagi.2022.886575. eCollection 2022.

PMID: 35813947

20. The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.

Moutinho M, Puntambekar SS, Tsai AP, Coronel I, Lin PB, Casali BT, Martinez P, Oblak AL, Lasagna-Reeves CA, Lamb BT, Landreth GE.

Sci Transl Med. 2022 Mar 23;14(637):eabl7634. doi: 10.1126/scitranslmed.abl7634. Epub 2022 Mar 23.

PMID: 35320002

19. PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer's disease.

Tsai AP, Dong C, Lin PB, Messenger EJ, Casali BT, Moutinho M, Liu Y, Oblak AL, Lamb BT, Landreth GE, Bissel SJ, Nho K.

Genome Med. 2022 Feb 18;14(1):17. doi: 10.1186/s13073-022-01022-0.

PMID: 35180881

18. The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model.

Claes C, England WE, Danhash EP, Kiani Shabestari S, Jairaman A, Chadarevian JP, Hasselmann J, Tsai AP, Coburn MA, Sanchez J, Lim TE, Hidalgo JLS, Tu C, Cahalan MD, Lamb BT, Landreth GE, Spitale RC, Blurton-Jones M, Davtyan H.

Alzheimers Dement. 2022 Oct;18(10):1765-1778. doi: 10.1002/alz.12577. Epub 2022 Feb 9.

PMID: 35142046

17. Moderate Ethanol Pre-treatment Mitigates ICH-Induced Injury via ER Stress Modulation in Rats.

Lin PB, Wang PK, Pang CY, Hu WF, Tsai AP, Oblak AL, Liew HK.

Front Mol Neurosci. 2021 Jun 25;14:682775. doi: 10.3389/fnmol.2021.682775. eCollection 2021.

PMID: 34248500

16. Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration.

Zhou L, Nho K, Haddad MG, Cherepacha N, Tubeleviciute-Aydin A, Tsai AP, Saykin AJ, Jesper Sjöström P, LeBlanc AC.

Sci Rep. 2021 Jun 16;11(1):12695. doi: 10.1038/s41598-021-91367-0.

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15. INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia.

Tsai AP, Lin PB, Dong C, Moutinho M, Casali BT, Liu Y, Lamb BT, Landreth GE, Oblak AL, Nho K.

Neurobiol Dis. 2021 Jun;153:105303. doi: 10.1016/j.nbd.2021.105303. Epub 2021 Feb 22.

PMID: 33631273

News (Alzforum): Alzheimer’s Microglial Risk Gene INPP5D Revs Up Inflammasome

14. Metabolic Defects Caused by High-Fat Diet Modify Disease Risk through Inflammatory and Amyloidogenic Pathways in a Mouse Model of Alzheimer's Disease.

Reilly AM, Tsai AP, Lin PB, Ericsson AC, Oblak AL, Ren H.

Nutrients. 2020 Sep 29;12(10):2977. doi: 10.3390/nu12102977.

PMID: 33003412 Free PMC article.

13. The Role of Urocortins in Intracerebral Hemorrhage.

Choy KW, Tsai AP, Lin PB, Wu MY, Lee C, Alias A, Pang CY, Liew HK.

Biomolecules. 2020 Jan 7;10(1):96. doi: 10.3390/biom10010096.

PMID: 31935997

12. Over-Activated Proteasome Mediates Neuroinflammation on Acute Intracerebral Hemorrhage in Rats.

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Cells. 2019 Oct 27;8(11):1326. doi: 10.3390/cells8111326.

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11. Contrast Media Induced Kounis Syndrome: A Case Report.

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Diagnostics (Basel). 2019 Oct 18;9(4):154. doi: 10.3390/diagnostics9040154.

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10. Severe Type of Minocycline-Induced Hyperpigmentation Mimicking Peripheral Arterial Occlusive Disease in a Bullous Pemphigoid Patient.

Wu MY, Hou YT, Yiang GT, Tsai AP, Lin CH.

Antibiotics (Basel). 2019 Jul 16;8(3):93. doi: 10.3390/antibiotics8030093.

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9. Advanced Evolution of Pathogenesis Concepts in Cardiomyopathies.

Li CJ, Chen CS, Yiang GT, Tsai AP, Liao WT, Wu MY.

J Clin Med. 2019 Apr 16;8(4):520. doi: 10.3390/jcm8040520.

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8. Epithelial to Mesenchymal Transition and Cell Biology of Molecular Regulation in Endometrial Carcinogenesis.

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J Clin Med. 2019 Mar 30;8(4):439. doi: 10.3390/jcm8040439.

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7. An engineered arginine-rich α-helical antimicrobial peptide exhibits broad-spectrum bactericidal activity against pathogenic bacteria and reduces bacterial infections in mice

Yang CH, Chen YC, Peng SY, Tsai AP, Lee TJ, Yen JH, Liou JW.

Sci Rep. 2018 Oct 2;8(1):14602. doi: 10.1038/s41598-018-32981-3.

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6. Current Mechanistic Concepts in Ischemia and Reperfusion Injury

Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng YL, Cheng PW, Li CY, Li CJ.

Cell Physiol Biochem. 2018;46(4):1650-1667. doi: 10.1159/000489241. Epub 2018 Apr 20.

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5. Molecular Regulation of Bone Metastasis Pathogenesis

Wu MY, Li CJ, Yiang GT, Cheng YL, Tsai AP, Hou YT, Ho YC, Hou MF, Chu PY.

Cell Physiol Biochem. 2018;46(4):1423-1438. doi: 10.1159/000489184. Epub 2018 Apr 18.

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Liew HK, Huang LC, Yang HI, Peng HF, Li KW, Tsai AP, Chen SY, Kuo JS, Pang CY.

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