研究業績

【論文】

2025年

Extravascular coagulation regulates haemostasis independently of activated platelet surfaces in an in vivo mouse model.

Sakata A, Tatsumi K, Matsumoto N, Mackman N, Harada S, Kawasaki R, Okuyama-Nishida Y, Soeda T, Nogami K, Shima M.

Commun Biol. 8(1):390. 2025

http://pubmed.ncbi.nlm.nih.gov/40055470/

2024年

β-hydroxybutyrate suppresses pathological changes of blood-induced  arthropathy  in rats.

Kawasaki R, Sakata A, Tatsumi K, Mitani S, Takeda M, Kasuda S, Matsumoto N, Harada S, Soeda T, Nishida Y, Yoshimura Y, Shima M.

Sci Rep. 14(1):29696. 2024

http://pubmed.ncbi.nlm.nih.gov/39614095/

Efficient generation of liver sinusoidal endothelial-like cells secreting coagulation factor VIII from human induced pluripotent stem cells.

Mitani S, Hosoda C, Onodera Y, Takabayashi Y, Sakata A, Shima M, Tatsumi K.

Mol Ther Methods Clin Dev. 32(4):101355. 2024

https://pubmed.ncbi.nlm.nih.gov/39559558/

MEK inhibitor PD0325901 upregulates CD34 expression in endothelial cells via inhibition of ERK phosphorylation.

Hosoda C, Mitani S, Sakata A, Kasuda S, Onodera Y, Takabayashi Y, Shima M, Tatsumi K.

Regen Ther. 26:654-662. 2024

https://pubmed.ncbi.nlm.nih.gov/39281105/ 

The pathogenesis of cancer-associated thrombosis.

Tatsumi K. 

Int J Hematol. 119(5):495-504. 2024

https://pubmed.ncbi.nlm.nih.gov/38421488/

Force-sensing treadmill gait analysis system can detect gait abnormalities in haemophilia patients without arthropathy.

Mawarikado Y, Sakata A, Inagaki Y, Harada S, Tatsumi K, Matsumoto N, Ogiwara K, Yada K, Yoshimura Y, Kido A, Tanaka Y, Shima M, Nogami K.

 Haemophilia. 30(3):780-790. 2024

https://pubmed.ncbi.nlm.nih.gov/38507270/

Terminus-selective Covalent Immobilization of Heparin on a Thermoresponsive Surface using Click Chemistry for Efficient Binding of Basic Fibroblast Growth Factor. 

Onodera Y, Kobayashi J, Mitani S, Hosoda C, Banno K, Horie K, Okano T, Shimizu T, Shima M, Tatsumi K.

Macromol Biosci. 24(2):e2300307. 2024

https://pubmed.ncbi.nlm.nih.gov/37774391/

2023年

Regulation of von Willebrand factor by ADAMTS13 ameliorates lipopolysaccharide-induced lung injury in mice. 

Onodera Y, Mitani S, Hosoda C, Takabayashi Y, Sakata A, Kawasaki R, Mori R, Ohshima C, Nishio K, Sugimoto M, Soejima K, Mackman N, Shima M, Tatsumi K.

Int J Hematol. 118(6):699-710. 2023

https://pubmed.ncbi.nlm.nih.gov/37759076/

Generation of functional liver sinusoidal endothelial-like cells from human bone marrow-derived mesenchymal stem cells. 

Mitani S, Onodera Y, Hosoda C, Takabayashi Y, Sakata A, Shima M, Tatsumi K.

Regen Ther. 24:274-281. 2023

https://pubmed.ncbi.nlm.nih.gov/37575681/

The use of infrared thermography for non-invasive detection of bleeding and musculoskeletal abnormalities in patients with hemophilia: an observational study. 

Kawasaki R, Sakata A, Hosoda C, Harada S, Soeda T, Nishida Y, Matsumoto N, Tatsumi K, Nogami K, Yoshimura Y, Shima M.

Thromb J. 21(1):70. 2023

https://pubmed.ncbi.nlm.nih.gov/37381012/

Involvement of monocyte-derived extracellular vesicle-associated tissue factor activity in convallatoxin-induced hypercoagulability. 

Morimoto M, Tatsumi K, Takabayashi Y, Sakata A, Yuui K, Terazawa I, Kudo R, Kasuda S.

Blood Coagul Fibrinolysis. 34(3):184-190. 2023

https://pubmed.ncbi.nlm.nih.gov/36966751/

2022年

Should patients with haemophilia receive gene therapy? 

VandenDriessche T, Tatsumi K, Shima M.

Lancet Haematol. 9(10):e722-e723. 2022

https://pubmed.ncbi.nlm.nih.gov/36174639/

2021年

Myeloid Protease-Activated Receptor-2 Contributes to Influenza A Virus Pathology in Mice. 

Gunther RC, Bharathi V, Miles SD, Tumey LR, Schmedes CM, Tatsumi K, Bridges MD, Martinez D, Montgomery SA, Beck MA, Camerer E, Mackman N, Antoniak S.

Front Immunol. 12:791017. 2021

https://pubmed.ncbi.nlm.nih.gov/34925374/

Role of tissue factor in delayed bone repair induced by diabetic state in mice. 

Ehara H, Tatsumi K, Takafuji Y, Kawao N, Ishida M, Okada K, Mackman N, Kaji H.

PLoS One. 16(12):e0260754. 2021

https://pubmed.ncbi.nlm.nih.gov/34855855/

Development of alternative gene transfer techniques for ex vivo and in vivo gene therapy in a canine model.

Noda M, Tatsumi K, Matsui H, Matsunari Y, Sato T, Fukuoka Y, Hotta A, Okano T, Kichikawa K, Sugimoto M, Shima M, Nishio K.

Regen Ther. 18:347-354. 2021

https://pubmed.ncbi.nlm.nih.gov/34584911/

Convallatoxin, the primary cardiac glycoside in lily of the valley (Convallaria majalis), induces tissue factor expression in endothelial cells.

Morimoto M, Tatsumi K, Yuui K, Terazawa I, Kudo R, Kasuda S.

Vet Med Sci. 7(6):2440-2444. 2021

https://pubmed.ncbi.nlm.nih.gov/34469053/

Role of plasminogen activator inhibitor-1 in muscle wasting induced by a diabetic state in female mice. 

Ehara H, Takafuji Y, Tatsumi K, Okada K, Mizukami Y, Kawao N, Matsuo O, Kaji H.

Endocr J. 68(12):1421-1428. 2021

https://pubmed.ncbi.nlm.nih.gov/34248092/

Effects of fluid flow shear stress to mouse muscle cells on the bone actions of muscle cell-derived extracellular vesicless. 

Takafuji Y, Tatsumi K, Kawao N, Okada K, Muratani M, Kaji H.

PLos One. 16(5):e0250741. 2021

https://pubmed.ncbi.nlm.nih.gov/33961664/

PAR1 regulation of CXCL1 expression and neutrophil recruitment to the lung in mice infected with influenza A virus. 

Antoniak S, Tatsumi K, Schmedes CM, Egnatz GJ, Auriemma AC, Bharathi V, Stokol T, Beck MA, Griffin JH, Palumbo JS, Mackman N.

J Thromb Haemost. 19(4):1103-1111. 2021

https://pubmed.ncbi.nlm.nih.gov/33346953/

MicroRNA-196a-5p in Extracellular Vesicles Secreted from Myoblasts Suppresses Osteoclast-like Cell Formation in Mouse Cells. 

Takafuji Y, Tatsumi K, Kawao N, Okada K, Muratani M, Kaji H.

Calcif Tissue Int. 108(3):364-376. 2021

https://pubmed.ncbi.nlm.nih.gov/33090325/

2020年

Extracellular vesicles secreted from mouse muscle cells suppress osteoclast formation: Roles of mitochondrial energy metabolism.

Takafuji Y, Tatsumi K, Ishida M, Kawao N, Okada K, Kaji H.

Bone. 134:115298. 2020

https://pubmed.ncbi.nlm.nih.gov/32092478/

Adipose Tissue-Derived Stem Cell Sheet Improves Glucose Metabolism in Obese Mice. 

Ishida M, Tatsumi K, Okumoto K, Kaji H.

Stem Cells Dev. 29(8):488-497. 2020

https://pubmed.ncbi.nlm.nih.gov/32075539/

2019年

Protease-activated receptor 4 protects mice from Coxsackievirus B3 and H1N1 influenza A virus infection. 

Tatsumi K, Schmedes CM, Houston ER, Butler E, Mackman N, Antoniak S.

Cell Immunol. 344:103949. 2019

https://pubmed.ncbi.nlm.nih.gov/31337508/

Patients with severe orthohantavirus cardiopulmonary syndrome due to Sin Nombre Virus infection have increased circulating extracellular vesicle tissue factor and an activated coagulation system.

Tatsumi K, Hisada Y, Connolly AF, Buranda T, Mackman N.

Thromb Res. 179:31-33. 2019

https://pubmed.ncbi.nlm.nih.gov/31075699/

Enhancement of Tissue Factor Expression in Monocyte-Derived Dendritic Cells by Pentraxin 3 and Its Modulation by C1 Esterase Inhibitor.

Kasuda S, Sakurai Y, Tatsumi K, Takeda T, Kudo R, Yuui K, Hatake K.

Int Arch Allergy Immunol. 179(2):158-164. 2019

https://pubmed.ncbi.nlm.nih.gov/30893690/

Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β-induced Serpine1.

McCann JV, Xiao L, Kim DJ, Khan OF, Kowalski PS, Anderson DG, Pecot CV, Azam SH, Parker JS, Tsai YS, Wolberg AS, Turner SD, Tatsumi K, Mackman N, Dudley AC.

J Clin Invest. 129(4):1654-1670. 2019

https://pubmed.ncbi.nlm.nih.gov/30855280/

Plasminogen activator inhibitor-1 deficiency suppresses osteoblastic differentiation of mesenchymal stem cells in mice.

Takafuji Y, Tatsumi K, Ishida M, Kawao N, Okada K, Matsuo O, Kaji H.

J Cell Physiol. 234(6):9687-9697. 2019

https://pubmed.ncbi.nlm.nih.gov/30387130/