Alexandra J.  Weigand

She/They | Alzheimer's Research | Neuropsychology Focus


I support my Black, Brown, Indigenous, LGBTQIA2S+, low SES, first-gen, visibly/nonvisibly disabled, neurodiverse colleagues, and all intersecting identities. Please reach out to me if there is anything I can do to help you succeed.

Education and Training

I am an incoming clinical fellow at the University of California San Francisco Clinical Psychology Training Program and Memory and Aging Center under the supervision of Dr. Kate Possin and Dr. Gil Rabinovici. I am also currently enrolled in the San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology working with Dr. Mark Bondi and Dr. Kelsey Thomas. I previously obtained a B.A. in Philosophy-Neuroscience-Psychology and Psychological & Brain Sciences from Washington University in St. Louis. 

Research

My current research focuses on improving the characterization of cognitive and biological changes that occur during the preclinical period of Alzheimer's disease. In particular, I study the spatiotemporal dynamics of amyloid and tau accumulation in the context of AD, how these pathologies may act both independently and synergistically to promote neurodegeneration and cognitive decline, and biological and environmental factors that moderate these associations.

I have also been awarded a National Science Foundation Graduate Research Fellowship (NSF GRFP) to study the role of the locus coeruleus in cognitive aging. 

Clinical Work

My primary clinical interest is the neuropsychological assessment of individuals across the lifespan, from children with neurodevelopmental conditions to older adults with neurodegenerative disorders. I also have an interest in the use of Dialectical Behavioral Therapy (DBT) for a range of presenting symptoms. My approach to clinical assessment an intervention stems from a biopsychosocial model, with the flexible adaptation of evidence-based tools treatments based on individual experiences, circumstances, and identities across intrapersonal, interpersonal, and systemic levels of influence.

Statistics

I have a strong interest in quantitative statistical methods and their application to data analysis. To this end, I have obtained a quantitative emphasis in my graduate program, and have attended multiple statistical conferences/workshops (e.g., Advanced Psychometrics of Cognitive Aging, Methods in Longitudinal Dementia Research). I have particular interest in multilevel modeling to examine longitudinal trajectories of change, as well as clustering techniques such as latent profile analysis to identify unique latent patterns that emerge from a range of indicator variables to distill heterogeneous data into distinct components.

Catch me on Twitter @alexjweigand