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I support all Black, Brown, Indigenous, LGBTQIA2S+, low SES, first-gen, visibly/nonvisibly disabled, and neurodiverse colleagues, and all intersecting identities. Please reach out to me if there is any way I can use my position to help facilitate your goals and success.
I support all Black, Brown, Indigenous, LGBTQIA2S+, low SES, first-gen, visibly/nonvisibly disabled, and neurodiverse colleagues, and all intersecting identities. Please reach out to me if there is any way I can use my position to help facilitate your goals and success.
Education and Training
Education and Training
Internship/Postdoctoral Training: I am currently a postdoctoral fellow at the University of California San Francisco Clinical Psychology Training Program and Edward and Pearl Fein Memory and Aging Center under the supervision of Dr. Kate Possin. I previously completed a one-year clinical neuropsychological internship through this program.
Internship/Postdoctoral Training: I am currently a postdoctoral fellow at the University of California San Francisco Clinical Psychology Training Program and Edward and Pearl Fein Memory and Aging Center under the supervision of Dr. Kate Possin. I previously completed a one-year clinical neuropsychological internship through this program.
Graduate Training: I received my Ph.D. in Clinical Psychology from the San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology working with Dr. Mark Bondi and Dr. Kelsey Thomas with a major area of study in Neuropsychology and a Quantitative Emphasis.
Graduate Training: I received my Ph.D. in Clinical Psychology from the San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology working with Dr. Mark Bondi and Dr. Kelsey Thomas with a major area of study in Neuropsychology and a Quantitative Emphasis.
Undergraduate Training: I received my B.A. in Philosophy-Neuroscience-Psychology and Psychological & Brain Sciences from Washington University in St. Louis.
Undergraduate Training: I received my B.A. in Philosophy-Neuroscience-Psychology and Psychological & Brain Sciences from Washington University in St. Louis.
Research
Research
My graduate school research largely focused on improving the characterization of cognitive and biological changes that occur during the preclinical period of Alzheimer's disease (AD). In particular, my dissertation studies centered around the dynamics of amyloid and tau accumulation in the context of AD and related pathologic changes (e.g., PART), including how these pathologies may act both independently and synergistically to promote neurodegeneration and cognitive decline. I also examined how biological and environmental factors moderate these biomarker-cognition associations, and assisted conceptually and statistically on several studies assessing the role of social and structural determinants of health in aging and Alzheimer's disparities. Additionally, I was awarded a National Science Foundation Graduate Research Fellowship (NSF GRFP) to study the role of the locus coeruleus in cognitive aging, with a particular interest in the role of subcortical neuromodulatory systems of noradrenaline and acetylcholine in modulating attentional changes in aging.
My graduate school research largely focused on improving the characterization of cognitive and biological changes that occur during the preclinical period of Alzheimer's disease (AD). In particular, my dissertation studies centered around the dynamics of amyloid and tau accumulation in the context of AD and related pathologic changes (e.g., PART), including how these pathologies may act both independently and synergistically to promote neurodegeneration and cognitive decline. I also examined how biological and environmental factors moderate these biomarker-cognition associations, and assisted conceptually and statistically on several studies assessing the role of social and structural determinants of health in aging and Alzheimer's disparities. Additionally, I was awarded a National Science Foundation Graduate Research Fellowship (NSF GRFP) to study the role of the locus coeruleus in cognitive aging, with a particular interest in the role of subcortical neuromodulatory systems of noradrenaline and acetylcholine in modulating attentional changes in aging.
Currently, during fellowship at the UCSF MAC, my research is centered on improving early detection and clinical staging, differential diagnosis, and clinical heterogeneity of AD and related dementias. I have particular interest in combining multimodal clinical assessments and neuropathology data to improve clinical conceptualization of disorders of aging (e.g., AD, LATE).
Currently, during fellowship at the UCSF MAC, my research is centered on improving early detection and clinical staging, differential diagnosis, and clinical heterogeneity of AD and related dementias. I have particular interest in combining multimodal clinical assessments and neuropathology data to improve clinical conceptualization of disorders of aging (e.g., AD, LATE).
Clinical Work
Clinical Work
My primary clinical interest is the neuropsychological assessment of individuals across the lifespan, from children with neurodevelopmental conditions (e.g., ADHD, SLD) to older adults with neurodegenerative syndromes (e.g., AD, PPAs, bvFTD), although most of my experience clinically, as with research, comes from conditions of aging.
My primary clinical interest is the neuropsychological assessment of individuals across the lifespan, from children with neurodevelopmental conditions (e.g., ADHD, SLD) to older adults with neurodegenerative syndromes (e.g., AD, PPAs, bvFTD), although most of my experience clinically, as with research, comes from conditions of aging.
I also have an interest in the use of Dialectical Behavioral Therapy (DBT) for a range of presenting symptoms in higher acuity cases, as well as techniques rooted in Cognitive Behavioral Therapy (CBT) for the management of ADHD. My approach to clinical assessment and intervention stems from a biopsychosocial model, with the flexible adaptation of evidence-based tools based on individual experiences, circumstances, and identities across intrapersonal, interpersonal, and systemic levels of influence.
I also have an interest in the use of Dialectical Behavioral Therapy (DBT) for a range of presenting symptoms in higher acuity cases, as well as techniques rooted in Cognitive Behavioral Therapy (CBT) for the management of ADHD. My approach to clinical assessment and intervention stems from a biopsychosocial model, with the flexible adaptation of evidence-based tools based on individual experiences, circumstances, and identities across intrapersonal, interpersonal, and systemic levels of influence.
Data Analysis
Data Analysis
I have a special interest in statistical methods and data analysis. To this end, I have obtained a quantitative emphasis in my graduate program, and have been selected to attend multiple statistical conferences and workshops such as the Advanced Psychometrics of Cognitive Aging (PsyMCA) workshop and Methods for Longitudinal Research on Dementia (MELODEM) conference. I have particular interest in longitudinal modeling (e.g., mixed effects models, survival analysis techniques) to examine trajectories of change in cognitive, functional, and biological outcomes, as well as clustering techniques (e.g., latent profile analysis) to distill heterogeneous data into data-driven components that may reflect distinct phenotypic patterns. I am currently learning network analytic theory and application for an additional method of phenotypically characterizing neurodegenerative conditions.
I have a special interest in statistical methods and data analysis. To this end, I have obtained a quantitative emphasis in my graduate program, and have been selected to attend multiple statistical conferences and workshops such as the Advanced Psychometrics of Cognitive Aging (PsyMCA) workshop and Methods for Longitudinal Research on Dementia (MELODEM) conference. I have particular interest in longitudinal modeling (e.g., mixed effects models, survival analysis techniques) to examine trajectories of change in cognitive, functional, and biological outcomes, as well as clustering techniques (e.g., latent profile analysis) to distill heterogeneous data into data-driven components that may reflect distinct phenotypic patterns. I am currently learning network analytic theory and application for an additional method of phenotypically characterizing neurodegenerative conditions.
Catch me on Twitter @alexjweigand
Catch me on Twitter @alexjweigand
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